탐라산수국(Hydrangea macrophylla var. acuminata ) 원예용 신품종 선발

성문석(Moon-Seok Sung),박영철(Young-Chul Park),김정선(Jeong-Sun Kim),강성근(Sung-Gun Kang),고성준(Sung-Joon Ko),김공호(Gong-Ho Kim),고문환(Moon-Hwan Ko) 한국원예학회 2008 한국원예학회 학술발표요지 Vol.2008 No.5

FC 2-14 Clinical study of hypopigmentation induced by intra-articular corticosteroid injection

( Sang-jin Cheon ),( Hyun Ju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Jeong-min Kim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Background: Intra-articular corticosteroid injection (IACI) is commonly used in the field of orthopedic surgery and rheumatology for management of the joint disease. However, there have been very limited data about IACI-induced hypopigmentation. Objectives: The purpose of present study was to investigate characteristics of IACI-induced hypopigmentation. Methods: 43 patients who were diagnosed as IACI-induced hypopigmentation at Pusan National University Hospitals (Busan and Yangsan) from 2004 to 2016. Results: Of the 43 patients, 53 lesions were analyzed in this study, the male to female ratio was 1:7.8 and the mean age at diagnosis was 46.4 ± 13.5 years. The most common (24/43, 56%) impression at the local clinics was vitiligo. Mean number of injection 1.8 times and the interval from injection to the onset of IACI-induced hypopigmentation was 3.3 months. Wrist was the most commonly affected site (18/53, 34%), followed by elbow (13/53, 25%), ankle (11/53, 21%) and knee (7/53, 13%). All of the lesions showed hypopigmentation accompanying promient underlying veins (28/53, 52.8%), skin atrophy (27/53, 50.9%), telangiectasia (10/53, 18.9%). Hypopigmented patches clinically showed various figures such as polygonal-linear (23/53, 43%), polygonal (16/53, 30%), and linear (14/53, 26%) appearances. And, they mostly had speculated border (43/53, 81%). Conclusion: Dermatologists need to be familiar with IACI-induced hypopigmentation in order to avoid incorrect management under misdiagnosis of vitiligo.

Mycoplasma pneumoniae -induced rash and mucositis

( Sung Min Park ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ),( Hyun Chang Ko ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Mycoplasma pneumoniae (M. pneumoniae)is one of the most common causes of respiratory tract infections in pediatric and adult populations worldwide. In dermatologic disorder, M. pneumoniae infection is known to be associated with erythema multiforme (EM) and Stevens-Johnson syndrome (SJS) in children and young adults. Recently, several cases with M. pneumoniae-associated mucositis with lacks typical target lesions have been reported. The term of Mycoplasma-induced rash and mucositis (MIRM) was suggested to revise from M. pneumoniae-associated mucocutaneous disease including EM and SJS because of distinct morphology, mild disease course, and potentially important clinical implications regarding treatment.Herein, we report a patient with MIRM. A 5-year-old boywas referred to the department of dermatology forerythematous maculopapuleson the face, trunk, and extremities. Physical examination revealed swollen eyelids with conjunctival injection, swollen lips, and erythematous erosive patch on the penile tip and perianal area.Histopathologic finding showed subepidermal blister with epidermal necrosis, and perivascular lymphohistiocytic infiltrations.Chest radiograph demonstrated localized infiltration in the right upper lobe, and M. pneumoniaeIgM antibodies was positive. Hewas treated with antibiotics, intravenous immunoglobulins, and showed rapid recovery within 2 weeks without any sequelae. Keyword: Mycoplasma pneumoniae, Mucositis, Rash, Stevens-Johnsons syndrome, Erythema multiforme

The use of ingenol mebutate gel as adjuvant therapy for large or multiple Bowen disease

( Sang Jin Cheon ),( Hyun Ju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Hoon Soo Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Bowen disease (BD) is squamous cell carcinoma in situ, which may progress to invasive carcinoma if not adequately managed. In single and small BD, many therapeutic options are available including excision, curettage, cryotherapy, and topical agents such as 5-fluorouracil and imiquimod. But in the case with large or multiple lesions, therapeutic choice is restrictive. Herein, we experienced two cases of large or multiple BD successfully managed with ingenol mebutate gel. A 81-year-old woman was diagnosed as BD for large lesion on the right calf measuring 7 x 10 cm. We applied ingenol mebutate gel 0.05% on the affected area once daily for 2 consecutive days. 1 month after treatment, crust fell out and only focal small lesion was remained. After additional cryotherapy was done twice and clinically resolved large BD during follow-up 6 months.. A 54-years-old woman was diagnosed as BD for multiple hyperkeratotic plaques on the both palms. We applied ingenol mebutate gel 0.05% once daily for 2 consecutive days. After 3 months, only a few lesions were remained. Following three times additional cryotherapy, the lesions were improved enough to be controlled cryotherapy. Through our experience, we suggest ingenol mebutate gel could be effective adjuvant therapy option for large or multiple BD.

Inexplicable but real phenomenon: rapidly regressed

( Sung Min Park ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Gun Wook Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Kaposi’s sarcoma (KS) is a type of spindle cell malignancy that arises from the vascular endothelium, usually presenting as violaceous papules and plaques. KS development is invariably linked with human herpesvirus (HHV)-8 infection. Almost spontaneous regressions of KS have been previously described in the iatrogenic type. Herein, we present a classic KS in immunocompetent patient showing rapid regression after biopsy. A 78-year-old male presented with relatively well-defined erythematous patches on forehead, Rt. upper eyelid and chin, and violaceous papule on nose. His medical and family histories were noncontributory. The patient denied history of recent overseas travel, homosexual or unnatural sexual practices, and serum anti-HIV antibody was negative. A histopathologic examination from the nose revealed typical findings of KS and tumor cells showed positive staining for CD31, CD34, and factor VIII-related antigen. Polymerase chain reaction in a biopsy specimen was positive for HHV-8. Without specific treatment, the lesion rapidly regressed within 2 weeks. It is generally accepted that immune status plays an important role for KS. As viral wart disappear after biopsy occasionally, it is possible that the biopsy may have then exposed antigens and induced an immunologic reaction, which led to the rapid regression of KS.

Hydrophilic surface modification of poly(methyl methacrylate)-based ocular prostheses using poly(ethylene glycol) grafting

Ko, JaeSang,Cho, Kanghee,Han, Sang Won,Sung, Hyung Kyung,Baek, Seung Woon,Koh, Won-Gun,Yoon, Jin Sook Elsevier 2017 Colloids and surfaces Biointerfaces Vol.158 No.-

<P><B>Abstract</B></P> <P>Ocular prostheses are custom-made polymeric inserts that can be placed in anophthalmic sockets for cosmetic rehabilitation. Prosthetic eye wearers have reduced tear amount, and they often experience dry eye symptoms including dryness, irritation, discomfort, and discharge. Most modern ocular prostheses are made of poly(methyl methacrylate) (PMMA), which is highly hydrophobic. Previous research has shown that improving the wettability of contact lens materials decreases its wearers discomfort by increasing lubrication. Therefore, hydrophilic modification of PMMA-based ocular prostheses might also improve patient discomfort by improving lubrication. We modified the surfaces of PMMA-based ocular prostheses using poly(ethylene glycol) (PEG), which is hydrophilic. To do this, we used two strategies. One was a “grafting from” method, whereby PEG was polymerized from the PMMA surface. The other was a “grafting to” method, which involved PEG being covalently bonded to an amine-functionalized PMMA surface. Assessments involving the water contact angle, ellipsometry, and X-ray photoelectron spectroscopy indicated that PEG was successfully introduced to the PMMA surfaces using both strategies. Scanning electron microscopy and atomic force microscopy images revealed that neither strategy caused clinically significant alterations in the PMMA surface morphology. In vitro bacterial adhesion assessments showed that the hydrophilic modifications effectively reduced bacterial adhesion without inducing cytotoxicity. These results imply that hydrophilic surface modifications of conventional ocular prostheses may decrease patient discomfort and ocular prosthesis-related infections.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Surfaces of PMMA-based ocular prosthesis were modified via PEG grafting. </LI> <LI> The hydrophilic surface modifications effectively inhibited bacterial adhesion. </LI> <LI> These modifications of ocular prostheses may decrease discomfort and infections. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Evaluation of the Acromioclavicular Joint Morphology for Minimizing Subacromial Erosion after Surgical Fixation of the Joint Using a Clavicular Hook Plate

Sung-Jae Kim,Young-Moon Kee,Dong-Hyuck Park,Young-Il Ko,Bong-Gun Lee 대한견주관절의학회 2018 대한견주관절의학회지 Vol.21 No.3

Background: Subacromial erosion remains a major concern after surgical fixation of acromioclavicular (AC) joint using a clavicular hook plate. To minimize postoperative subacromial erosion, we investigated the structural relationship between distal clavicle and acromion around the AC joint by considering the surgical fixation of the joint using the hook plate technique. Methods: Computed tomography scans of 101 AC joints without any inherent pathology were analyzed. The angle between the distal clavicle and acromion around the AC joint (AC angle), depth of the acromion, differences in height between distal clavicle and acromion(AC height difference), and thickness of distal clavicle and acromion at the AC joint were measured. Descriptive statistics were calculated for each anatomical parameter, and all results were compared between gender groups. Results: The mean AC angle was 17.1°(range, -8.0° to 39.0°), and the mean AC height difference was 3.5 mm (range, -0.7 to 8.7 mm). Both factors showed very high variability (coefficients of variation=62.6% and 46.6%, respectively). The mean AC angle was significantly higher in the female gender than in the male gender (19.8° vs. 13.8°, p=0.048). The mean acromion thickness and distal clavicular thickness were both significantly thinner in the female group than in the male group (p<0.001). Conclusions: Taken together, we believe our results might be helpful in minimizing postoperative subacromial erosion when performing surgical fixation of the AC joint using the hook plate, and be valuable in improving future design of the hook plate.

Capillary malformation on midline of forehead: nevus simplex or medial fronto-facial capillary malformation ?

( Sang-jin Cheon ),( Hyunju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Jeong-min Kim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun-chang Ko ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Background: Nevus simplex, a part of capillary malformation (CM), is one of the common birthmark. Nevus simplex known as salmon patch or angel’s kiss is located on glabella, upper eyelid, and nape and tends to fade around the ages of 1-4 years. However, medial fronto-facial capillary malformation differs from typical nevus simplex by (1) wider location on forehead, (2) more intense color, and (3) incomplete involution. Objectives: The aim of this study was to investigate clinical features and natural history of CM on midline of forehead. Methods: We prospectively recruited patients with CM on midline of forehead from 2009 to 2016. We checked clinical features including age, date of visit, birth history, family history, shape, location, size, concurrent anomalies, and natural course. Results: Sixty-four patients (41 girls; 65.0%) were included. The mean age at initial visit was 7.5 years (20 days to 45 years). Lesions on the forehead were band or linear shaped (54.0%), V-shaped (25.4%) and ill-defined oval to geographic (15.9%). Family history of CM was checked in 9.4% (6/64). 28.1% (18/64) of patients accompanied infantile hemangioma. Neurological abnormality was observed in 4.6%. In 36 infantile patients who were regularly followed up until the ages of 4 years, incomplete resolution were found in 94.4% (60/64) and unchanging in 5.6% (4/64). Conclusion: We found CM on midline of forehead is different from nevus simplex considering its peculiar presentation and incomplete resolution.

Salt and pepper appearance of the skin associated with mixed connective tissue disease

( Sang-hyeon Won ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

The salt-and-pepper appearance of skin is composed of salt (vitiligo-like depigmentation) and pepper(perifollicular pigmentation). This characteristic feature can be a clinical clue for the diagnosis of systemic sclerosis. Mixed connective tissue disease(MCTD) is a distinct disease entity with mixed features of systemic lupus erythematosus, systemic sclerosis, myositis and rheumatoid arthritis with high titers of antibodies to U1 small nuclear ribonucleoprotein(U1 snRNP). Therefore, MCTD is known to have a wide spectrum of cutaneous manifestations which may be the presenting signs of the disease. However, there are few reports of pigmentary changes in MCTD. A 51-year old woman presented with variably sized hypopigmented macules along with relative hyperpigmentation of the perifollicular areas. She was diagnosed with MCTD by Raynaud’s phenomenon and high titer anti-RNP corresponding to a speckled antinuclear antibody of 1:1280 in Rheumatology clinic. A biopsy specimen showed dermal sclerosis. Pigment loss and melanophages were observed in the papillary dermis. Hypo- and hyperpigmentation were confirmed histologically by S100 and Fontana-Masson stain. To our knowledge, ‘salt and pepper appearance of the skin’ has rarely been reported in MCTD. The diagnosis of MCTD can be challenging due to its diverse characteristics. Therefore, we suggest that MCTD should be regarded as a differential diagnosis in patient with this pigmentary change.

Mossbauer spectroscopy에 의한 제주 토기의 물리적 특성 연구

고정대,강애신,최원준,윤태건,홍성락 濟州大學校 基礎科學硏究所 1999 基礎科學硏究 Vol.12 No.1

In this study we are reporting the results of measurement of the X-ray diffraction and ?? Mossbauer spectrum for the four plain coarse pottery sherds, Which are unearthed from the Gosanli, Sangmoli and Bukchonli district in Cheju Island. By the X-ray diffraction spectrum at room temperature, the principal minerals of the four plain coarse pottery sherd samples are silicate minerals which are equal to SiO₂, including a little Magnetite, Hematite, Goethite, and Maghemitite. The result of analysis by Mossbauer spectroscopy shows ?? at three regional neolithic era pottery, it is presumed to come out by magnetic hyperfine splitting. For four plain coarse pottery sherd samples taken from three region, the ratio of ?? by Mossbauer spectrum at room temperature is zero therefore we presume that the plain coarse pottery sherds were fired in the atmosphere.