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Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions
Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8
Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.
A New Sesame Variety, “Kangbaek” with Disease Resistance, Lodging Tolerence and High Yield
Kang-Bo Shim,Churl-Whan Kang,Suk-Bok Pae,Si-Kyu Lim,Yu-Young Lee,Duck-Yong Suh,Jae-Whan Rho,Jin Song,Dong-Whi Kim,Ho-Young Kim 한국육종학회 2005 한국육종학회지 Vol.37 No.5
A new sesame variety Kangbaek was developed from Yeongnam Agricultural Research Institute in 2004. Cros wasmade by lodging resistant SP9003-3 line to the F1with high yielding capacity, folowed by pedigree selection, yield test and RYT by the sesame breeding team at the National Insti-tute of Crop Science up to 2003. The variety showed higher disease resistance, especially phytophothra disease, and lodging resis-respectively. It's 1000 grains weight was about 2.54 g indicating 0.03 g heavier than that of Yangbaekkae, and it's oil content wasabout 52%. Kangbaek also contained total 7.65mg/g of such lignans as sesamin and sesamolin. The average yield of Kang-baek was 82 kg per 10a at the national-wide regional performance.
二次元 畵面解析을 이용한 三次元空間의 固體粒子 濃度 測定範圍
강석호 嶺南大學校 工業技術硏究所 1982 연구보고 Vol.10 No.2
Optical measurements of particle size, its distribution, concentration, and velocity in the particulate handling processes are of great significance in recent years. The 2-dimensional optical images observed provide, with little precision, the particle characteristics in the 3-dimensional space of the volume element, in which the particle concentratioin plays a remarkable role in data acquisition of particle size concerned. Geometrical relationships between the 3-dimensional volume concentration and the 2-dimensional photographic obscuration are mathematically discussed, and the concentration criteria of the possible observation range to be applicable in particle characterization are experimentally determined. Above 5% of particle concentration in volume, the photographic images do not provide any sufficient results in the particle size measurement by the optical method.
치환된 알킬요드화물 또는 크산테이트 화합물과 에틸 아크릴산 또는 메틸 비닐케톤과의 분자간 라디칼 탄소-탄소 결합형성반응
강석구,박영원,박천호,조일환,오원택 성균관대학교 1992 論文集 Vol.42 No.2
생리활성천연물인 lipoxin A, carpenter bee 페로몬, 뇌염모기 페로몬, exobrevicomin 등의 합성의 주요 키탈 중간체들을 치환된 요드화물 또는 크산테이트 화합물과 에틸아크릴산 또는 메틸비닐케톤과의 분자간 라디칼 탄소-탄소 형성 반응에 의해 합성하였다. The chiral building blocks for the synthesis of biologically active natural products such as lipoxin A, carpenter bee pheromone, mosquito ov-iposition pheromone, and exo-brevicomins were synthesized by intermol-ecular radical C-C bond formation of the appropriate substituted iodides or xanthates with ethyl acrylate or methyl vinyl ketone.
Pd(0)를 이용한 고리 카보네이트의 친핵성 치환 반응 연구
강석구,박동철,전제호,노호식 성균관대학교 기초과학연구소 1993 論文集 Vol.44 No.2
촉매량의 Pd(0)존재하의 chiral allylic 그리고 dienylic 고리 카보네이트와 여러 가지 친핵성 치환체들의 치환 반응을 연구하였는데 이 치환 반응은 친핵체에 따라서 α-, γ-, 또는 ε-위치에 치환된 높은 위치 및 diastereoselection이 있는 반응임을 알았고 또한 이의 입체화학을 결정하였다. We studied the reactions of chiral allylic and dienylic cyclic carbonates with various nucleophiles in the presence of Pd(0)catalyst and found that substitution occurred at α-, γ-, ε-position with high regio-and diasteroselectirity depending on nucleophiles used.
Pd 촉매 하에서 terminal alkynes, aryl, alkenyl 혹은 alkynyl iodine 화합물의 수용성 조건에서 cross-coupling에 관한 연구
강석구,이홍우,장수범,호필수 성균관대학교 기초과학연구소 1995 論文集 Vol.46 No.2
The ligand-free Pd(OAc)_2-catalyzed coupling reaction of aryl-, alkenyl-, and alkynyliodonium tetrafluoroborate and iodanes with terminal alkynes proceeds readily in the presence of NaHCO_3 in aqueous medium to afford the substituted alkynes in high yields under mild conditions.
Flowable 및 microfill 복합레진으로 충전된 제 5급와동에서 load cycling 전,후의 미세변연누출 비교
강석호,김오영,오명환,조병훈,엄정문,권혁춘,손호현 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.2
Low-viscosity composite resins may produce better sealed margins than stiffer compositions (KempScholte and Davidson, 1988; Crim, 1989). Flowable composites have been recommended for use in Class V cavities but it is also controversial because of its high rates of shrinkage. On the other hand, in the study comparing elastic moduli and leakage, the microfil had the least leakage (Rundle et al. 1997). Furthermore, in the 1996 survey of the Reality Editorial Team, microfills were the clear choice for abfraction lesions. The purpose of this study was to evaluate the microleakage of 6 composite resins (2 hybrids, 2 microfills, and 2 flowable composites) with and without load cycling. Notch-shaped Class V cavities were prepared on buccal surface of 180 extracted human upper premolars on cementum margin. The teeth were randomly divided into non-load cycling group (group 1) and load cycling group(group 2) of 90 teeth each. The experimental teeth of each group were randomly divided into 6 subgroups of 15 samples. All preparations were etched, and Single bond was applied. Preparations were restored with the following materials (n=15) : hybrid composite resin [Z250(3M Dental Products Inc. St.Paul, USA), Denfil(Vericom, Ahnyang, Korea)], microfil [Heliomolar RO(Vivadent, Schaan, Liechtenstein), Micronew(Bisco Inc. Schaumburg, IL, USA)], and flowable composite[AeliteFlo(Bisco Inc. Schaumburg, IL, USA), Revolution(Kerr Corp. Orange, CA, USA)]. Teeth of group 2 were subjected to occlusal load (100N for 50,000 cycles) using chewing simulator(MTS 858 Mini Bionix Ⅱ system, MTS Systems Corp., Minn, USA). All samples were coated with nail polish 1mm short of the restoration, placed in 2% methylene blue for 24 hours, and sectioned with a diamond wheel. Enamel and dentin/cementum margins were analyzed for microleakage on a sclale of 0 (no leakage) to 3 (3/3 of wall). Results were statistically analyzed by Kruskal-Wallis One way analysis, Mann-Whitney U-test, and Student-Newmann-Keuls method. (p=0.05) Results: 1. There was significantly less microleage in enamel margins than dentinal margins of all groups. (p<0.05) 2. There was no significant difference between six composite resin in enamel margin of group 1. 3. In dentin margin of group 1, flowable composite had more microleakage than others but not of significant differences. 4. There was no significant difference between six composite resin in enamel margin of group 2. 5. In dentin margin of group 2, the microleakage were R>A=H=M>D>Z. But there was no significant differences. 6. In enamel margins, load cycling did not affect the marginal microleakage in significant degree. 7. In dentin margins, load cycling did affect the marginal microleakage only in Revolution. (p<0.05)
강석호 嶺南大學校 工業技術硏究所 1988 연구보고 Vol.16 No.1
The commercially available nonwoven fibrous filter mats are used to collect the CaCO₃sample dust from the air stream. The collection efficiency and the grade efficiency in the air filtration are experimentally determined and compared with the analogous results calculated by the theoretical equations proposed by other researchers. The pressure drop measured across the filter mat is also discussed with the theoretically estimated one. The comparison between the two results are in a good agreement with each other. Effects of the fibre diameter and the inlet air velocity on the separation efficiency and on the pressure drop are also discussed.
구리촉매를 이용한 유기주석화합물 및 유기붕소화합물과 다가 요오드 화합물과의 Cross-Coupling과 Carbonylative Cross-Coupling에 관한 연구
강석구,야마구치토쿠타로,김태현,호필수 성균관대학교 기초과학연구소 1996 論文集 Vol.47 No.2
The copper-catalyzed cross-coupling and carbonylative cross-coupling of organostannanes(aryl-, alkenyl-, alkynyl-, allylstannanes) and anoboranes(aryl-, alkenylboranes)with hypervalent aryl- and alkenyliodonium tetrafluoroborates were achieved at mild conditions.
(E)-γ-히드록시-α,β-불포화 슬폰과 니트릴의 합성
강석구,전제호 성균관대학교 기초과학연구소 1992 論文集 Vol.43 No.2
β,γ-에폭시슬폰과 β,γ-에폭시느트릴을 -78℃에서 THF를 용매로 LDA를 사용하여 탈 양성자-제거반응을 유도하면 선택적으로(E)-히드록시-α, β-불포화 니트릴을 좋은 수율로 각각 얻을 수 있었다. Deprotection-elimination of β, γ-epoxy sulfone and β, γ-epoxy nitrile with LDA in THF at -78℃ afforded (E)-γ-hydroxy-α, β-unsaturated sulfone and (E)-γ-hydroxy-α, β-unsaturated nitrile in good yields, respectively.