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최소현,감상범,조숙행 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1
연구목적 : 여성 정신분열병 환자에서 월경전기의 증상변화 여부와 그 변화양상을 알아보고자 본 연구를시행하였다. 방법 : DSM-lV 진단기준에 부합되며 규칙적인 월경주기와 월경기간을 보인 여성 정신분열병 환자 30명을 대상으로 한 번의 월경주기 동안 연구가 시행되었다. 매일평가서(Daily Rating Form)는 대상자들이 매일 작성 하였고 BPRS는 각 월경기(월경전기, 월경기, 월경후기)에 한차례씩 평가되었다. 연구기간동안 매일평가서를 올바르고 완전하게 작성한 24명에 대한 자료분석이 시행되었다. 결과 : 전체대상군의 총BPRS 평균정수는 세 월경기 간에 유의한 차이가 있었는데, 월경전기가 가장 높고 월경후기가 가장 낮았다. 그러나 증상군별로 볼 때 정신병적 증상군에 대한 전체대상군의 BPRS 평균점수가 각 월경기 사이에 유의한 차이가 없는 반면 불안-우울군과 위축-지연군에 대해서는 각 월경기 간에 유의한 차이가 있었다. 매일평가서 상에서 30% 변화기준을 적용하여 월경전기에 악화되었다고 판정되는 항목들 중 우울한 기분, 불안초조와 예민, 적개심과 공격성, 활동성지연등의 정서와 행동증상 항목이 높은 빈도를 보였다. 또한 복통, 유방통, 두통의 신체증상 항목도 월경전기에 악화되는 소견을 보였다. 결국 월경전기에 BPRS 상에서 정신병적 증상의 변화는 거의 나타나지 않는 반면 매일평가서와 BPRS 모두에서 이 시기에 정서 및 행동증상의 변화는 두드러졌다. 결론 : 본 연구의 소견들은 여성 정신분열병 환자에서 월경전기 증상의 악화가 정신병적 증상 그 자체의악화라기 보다는 정서적, 행동적, 신체적 증상들을 특징으로 하는 특정 증상군이 이 시기에 중첩되는 것에 기인할 수도 있음을 시사해 준다.
Early Cardiac Valvular Changes in Ankylosing Spondylitis: A Transesophageal Echocardiography Study
So-Hee Park,손일석,Byung-Hyun Joe,Hui-Jeong Hwang,Chang-Bum Park,진은선,조진만,Chong-Jin Kim,Jong-Hoa Bae,이상훈 한국심초음파학회 2012 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.20 No.1
Background: This study was conducted to determine the early cardiac valvular changes in young male ankylosing spondylitis (AS) patients. Methods: A total of 70 AS patients on treatment without clinical cardiac symptoms were divided into group I (< 10 years, n =50) and group II (≥ 10 years, n = 20) depending on their disease duration after first diagnosis. Twenty-five healthy volunteers were selected as control subjects. All the subjects underwent transthoracic and transesophageal echocardiography, electrocardiography, and rheumatologic evaluation for AS patients. Results: The thickness of both the aortic and mitral valve was more increased in AS patients than in controls. Aortic valve thickness over 1.3 mm could predict AS with a sensitivity of 73% and specificity of 76%. The prevalence of aortic valve thickening was higher in the AS group compared to the controls. The prevalence of aortic and mitral regurgitation was very low and there was no difference between the controls and the patients. The aortic valve thickening was related to longer disease duration, high blood pressure, disease activity and inflammatory markers. Conclusion: Thickening of the aortic and mitral valve was observed without regurgitation in male AS patients early in the course of their disease without clinical cardiac manifestations. This subclinical change of aorto-mitral valve in early AS should be considered and followed up to determine its prognostic implication and evolution.
Effect of Combined Bevacizumab and Temozolomide Treatment on Intramedullary Spinal Cord Tumor
Gwak, So-Jung,An, Sung Su,Yang, Moon Sul,Joe, Eunhae,Kim, Dong-Hyun,Yoon, Do Heum,Kim, Keung Nyun,Ha, Yoon by Lippincott Williams Wilkins 2014 1528-1159) Vol.39 No.2
STUDY DESIGN.: C6 glioma cells and an intramedullary spinal cord tumor model were used to evaluate the effect of bevacizumab (Avastin) or temozolomide (TMZ). OBJECTIVE.: In this study, we hypothesized that treatment with bevacizumab accelerates the therapeutic effect of TMZ on intramedullary gliomas in an animal model. SUMMARY OF BACKGROUND DATA.: Recently therapies for the management of intramedullary malignant gliomas include surgery, chemotherapy, and radiotherapy. Concurrent or adjuvant TMZ has been considered an emerging new treatment for intramedullary malignant gliomas; however, high-dose application of TMZ has limitation of side effect. METHODS.: C6 glioma cells were injected into the T5 level of the spinal cord, and TMZ and bevacizumab were administered 5 days after C6 inoculation (n = 7 for each group). Tumor size was analyzed using histology and magnetic resonance imaging at 13 days after tumor inoculation. RESULTS.: Histological analyses and magnetic resonance imaging findings showed that combined treatment with TMZ and bevacizumab reduced tumor mass. The tumor volume of control group was 2.8-fold higher than combined therapy (P < 0.05). Neurological outcomes demonstrated that combined therapy improved hind limb function more than TMZ-alone group or control group (P < 0.05). CONCLUSION.: This study shows that bevacizumab could be useful in combination with TMZ to increase the therapeutic benefits of TMZ for intramedullary spinal cord tumors.Level of Evidence: N/A
Rah So-Young,Joe Yeonsoo,Park Jeongmin,Ryter Stefan W.,Park Chansu,Chung Hun Taeg,Kim Uh-Hyun 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Hepatic glucose production by glucagon is crucial for glucose homeostasis during fasting, yet the underlying mechanisms remain incompletely delineated. Although CD38 has been detected in the nucleus, its function in this compartment is unknown. Here, we demonstrate that nuclear CD38 (nCD38) controls glucagon-induced gluconeogenesis in primary hepatocytes and liver in a manner distinct from CD38 occurring in the cytoplasm and lysosomal compartments. We found that the localization of CD38 in the nucleus is required for glucose production by glucagon and that nCD38 activation requires NAD+ supplied by PKCδ-phosphorylated connexin 43. In fasting and diabetes, nCD38 promotes sustained Ca2+ signals via transient receptor potential melastatin 2 (TRPM2) activation by ADP-ribose, which enhances the transcription of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase 1. These findings shed light on the role of nCD38 in glucagon-induced gluconeogenesis and provide insight into nuclear Ca2+ signals that mediate the transcription of key genes in gluconeogenesis under physiological conditions.
증례 : 감염 ; 면역력이 정상인 환자에서 발생한 중추신경계의 아스페르길루스증 1예
조병현 ( Byung Hyun Joe ),황은정 ( Eun Jung Hwang ),박소연 ( So Youn Park ),손준성 ( Jun Sung Son ),이미숙 ( Mi Suk Lee ) 대한내과학회 2011 대한내과학회지 Vol.80 No.5
침습성 아스페르길루스증은 면역학적으로 저하되어 있는 경우에 흔한 것으로 알려져 있으나 최근 면역학적으로 정상인 자에서 발생하는 빈도가 과거에 비해 증가 추세이며 중추신경계에서 발생하는 경우 그 임상양상이나 방사선학적 소견이 다양하기 때문에 초기 진단이 쉽지 않다. 본 저자들은 면역학적으로 정상인 환자에서 뇌종양 양상으로 중추신경계에 발생한 침습성 아스페르길루스증을 경험하였기에 이를 보고하는 바이다.