노년 청각손상자와 청각장애의 삶의 질 관련성 연구

劉俊榮,張勝成 대구대학교 특수교육재활과학연구소 2006 再活科學硏究 Vol.24 No.2

The hearing impairment happened extensively in the elderly and often resulted in the hearing handicap. A lot of study confused the hearing impairment with the hearing handicap and replaced the score of quality of life by the hearing handicap score to calculate the quality adjusted life years and analyzed the cost-utility of aural rehabilitation. In this study, the confusion of hearing impairment and hearing handicap was clarified, and the relevance between hearing handicap and quality of life was explored in order to examine the fitness of replacing the score of quality of life by the hearing handicap score. The result of this study indicated that the correlation between the hearing handicap and the quality of life. The fitness of correlating model of the hearing handicap and the quality of life was not accepted. So, it was not suggested that replacing the score of quality of life by the hearing handicap score. The inventory of disease-specific quality of life should be developed. Secondly, the poor fitness of correlating model of the hearing handicap and the quality of life could be resulted from the other variables that shall be included in the model. It was proposed to include relevant variables into the model in the future. 청각손상은 노년기에 광범위하게 발생하는 문제이다. 심각한 청각장애를 자주 일으킨다. 많은 연구는 청각손상과 청각장애를 혼돈하는 것 뿐 만아니라 자주 청각장애 검목표의 득점으로 피실험자의 생활 품질을 대표한다. 심지어 청각장애 검목표의 득점으로 생활 품질 조정년을 계산한다. 이것으로 청각 재활의 성공 효과를 분석한다. 본 연구는 청각 손상과 청각장애의 다른 점을 밝히는 것 외에도 주요 목적은 청각장애와 생활 품질의 관련성을 이해하고자 하는 것이다. 이것으로 청각장애 검목표를 생활 품질을 삼는 정당성을 관찰한다. 연구결과에 나타나는 것은 청각 표현과 생활품질의 관련성은 높지 않은 결과를 얻었다. 이 두 가지의 관련 양식은 일반화 하기는 제한점을 갖는다. 그래서 이론적 개념에서 청각 표현과 생활품질은 각자 다른 내용을 갖추고 있다. 자료 통계의 분석 결과도 이 두 가지의 관련 양식에 대해서 유의한 결과를 얻지 못했다. 그래서 청각표현 능력으로 피실험자의 생활 품질을 대신할 수 없다. 마땅히 청각 손상자에게 맞는 적합한 생활 품질 설문지를 발행해야한다. 그 다음에 두 가지의 관련 양식의 관련도 적다. 아마도 청각 손상자의 청각 표현과 생활 품질 간에는 많은 변인의 영향이 존재하기 때문이다. 미래의 연구는 더 많은 상관 관련 인소를 귀납해서 이 이론구조를 검증해야한다는 것을 건의한다.

The Clinical Observation of Inflammation Theory for Depression: The Initiative of the Formosa Long COVID Multicenter Study (FOCuS)

Shu-Tsen Liu(Shu-Tsen Liu),Sheng-Che Lin(Sheng-Che Lin),Jane Pei-Chen Chang(Jane Pei-Chen Chang),Kai-Jie Yang(Kai-Jie Yang),Che-Sheng Chu(Che-Sheng Chu),Chia-Chun Yang(Chia-Chun Yang),Chih-Sung Liang( 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

There is growing evidence that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risks of psychiatric sequelae. Depression, anxiety, cognitive impairments, sleep disturbance, and fatigue during and after the acute phase of COVID-19 are prevalent, long-lasting, and exerting negative consequences on well-being and imposing a huge burden on healthcare systems and society. This current review presented timely updates of clinical research findings, particularly focusing on the pathogenetic mechanisms underlying the neuropsychiatric sequelae, and identified potential key targets for developing effective treatment strategies for long COVID. In addition, we introduced the Formosa Long COVID Multicenter Study (FOCuS), which aims to apply the inflammation theory to the pathogenesis and the psychosocial and nutrition treatments of post-COVID depression and anxiety.

Centromere protein U enhances the progression of bladder cancer by promoting mitochondrial ribosomal protein s28 expression

Liu, Bei-Bei,Ma, Tao,Sun, Wei,Gao, Wu-Yue,Liu, Jian-Min,Li, Li-Qiang,Li, Wen-Yong,Wang, Sheng,Guo, Yuan-Yuan The Korean Society of Pharmacology 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.2

Bladder cancer is one of the most common types of cancer. Most gene mutations related to bladder cancer are dominantly acquired gene mutations and are not inherited. Previous comparative transcriptome analysis of urinary bladder cancer and control samples has revealed a set of genes that may play a role in tumor progression. Here we set out to investigate further the expression of two candidate genes, centromere protein U (CENPU) and mitochondrial ribosomal protein s28 (MRPS28) to better understand their role in bladder cancer pathogenesis. Our results confirmed that CENPU is up-regulated in human bladder cancer tissues at mRNA and protein levels. Gain-of-function and loss-of-function studies in T24 human urinary bladder cancer cell line revealed a hierarchical relationship between CENPU and MRPS28 in the regulation of cell viability, migration and invasion activity. CENPU expression was also up-regulated in in vivo nude mice xenograft model of bladder cancer and mice overexpressing CENPU had significantly higher tumor volume. In summary, our findings identify CENPU and MRPS28 in the molecular pathogenesis of bladder cancer and suggest that CENPU enhances the progression of bladder cancer by promoting MRPS28 expression.

ALMA Reveals Sequential High-mass Star Formation in the G9.62+0.19 Complex

Liu, Tie,Lacy, John,Li, Pak Shing,Wang, Ke,Qin, Sheng-Li,Zhang, Qizhou,Kim, Kee-Tae,Garay, Guido,Wu, Yuefang,Mardones, Diego,Zhu, Qingfeng,Tatematsu, Ken’ichi,Hirota, Tomoya,Ren, Zhiyuan,Liu, Sheng-Yu American Astronomical Society 2017 The Astrophysical journal Vol.849 No.1

<P>Stellar feedback from high-mass stars (e.g., H II regions) can strongly influence the surrounding interstellar medium and regulate star formation. Our new ALMA observations reveal sequential high-mass star formation taking place within one subvirial filamentary clump (the G9.62 clump) in the G9.62+0.19 complex. The 12 dense cores (MM1-MM12) detected by ALMA are at very different evolutionary stages, from the starless core phase to the UC H II region phase. Three dense cores (MM6, MM7/G, MM8/F) are associated with outflows. The mass-velocity diagrams of the outflows associated with MM7/G and MM8/F can be well-fit by broken power laws. The mass-velocity diagram of the SiO outflow associated with MM8/F breaks much earlier than other outflow tracers (e.g., CO, SO, CS, HCN), suggesting that SiO traces newly shocked gas, while the other molecular lines (e.g., CO, SO, CS, HCN) mainly trace the ambient gas continuously entrained by outflow jets. Five cores (MM1, MM3, MM5, MM9, MM10) are massive starless core candidates whose masses are estimated to be larger than 25 M-circle dot, assuming a dust temperature of <= 20 K. The shocks from the expanding H II regions ('B' and 'C') to the west may have a great impact on the G9.62 clump by compressing it into a filament and inducing core collapse successively, leading to sequential star formation. Our findings suggest that stellar feedback from H II regions may enhance the star formation efficiency and suppress low-mass star formation in adjacent pre-existing massive clumps.</P>

Modified adaptive complementary sliding mode control for the longitudinal motion stabilization of the fully-submerged hydrofoil craft

Liu, Sheng,Niu, Hongmin,Zhang, Lanyong,Xu, Changkui The Society of Naval Architects of Korea 2019 International Journal of Naval Architecture and Oc Vol.11 No.1

This paper presents a Modified Adaptive Complementary Sliding Mode Control (MACSMC) system for the longitudinal motion control of the Fully-Submerged Hydrofoil Craft (FSHC) in the presence of time varying disturbance and uncertain perturbations. The nonlinear disturbance observer is designed with less conservatism that only boundedness of the derivative of the disturbance is required. Then, a complementary sliding mode control system combined with adaptive law is designed to reduce the bound of stabilization error with fast convergence. In particularly, the modified complementary sliding mode surface which contains the estimation of the disturbance can reduce the switching gain and retain the normal performance of the system. Moreover, a hyperbolic tangent function contained in the control law is utilized to attenuate the chattering of the actuator. The global asymptotic stability of the closed-loop system is demonstrated utilizing the Lyapunov stability theory. Ultimately, the simulation results show the effectiveness of the proposed approach.

Mouse Nerve Growth Factor Facilitates the Growth of Interspinal Schwannoma Cells by Activating NGF Receptors

Liu, Shu Yi,Liu, Sheng Ze,Li, Yu,Chen, Shi The Korean Neurosurgical Society 2019 Journal of Korean neurosurgical society Vol.62 No.6

Objective : Nerve growth factor (NGF) is a member of the neurotrophic factor family and plays a vital role in the physiological processes of organisms, especially in the nervous system. Many recent studies have reported that NGF is also involved in the regulation of tumourigenesis by either promoting or suppressing tumor growth, which depends on the location and type of tumor. However, little is known regarding the effect of NGF on interspinal schwannoma (IS). In the present study, we aimed to explored whether mouse nerve growth factor (mNGF), which is widely used in the clinic, can influence the growth of interspinal schwannoma cells (ISCs) isolated from IS in vitro. Methods : ISCs were isolated, cultured and identified by S-100 with immunofluorescence analysis. S-100-positive cells were divided into five groups, and separately cultured with various concentrations of mNGF (0 [phosphate buffered saline, PBS], 40, 80, 160, and 320 ng/mL) for 24 hours. Western blot and quantantive real time polymerase chain reaction (PCR) were applied to detect tyrosine kinase A (TrkA) receptor and p75 neurotrophin receptor ($p75^{NTR}$) in each group. Crystal violet staining was selected to assess the effect of mNGF (160 ng/mL) on ISCs growth. Results : ISCs growth was enhanced by mNGF in a dose-dependent manner. The result of crystal violet staining revealed that it was significantly strengthened the cells growth kinetics when cultured with 160 ng/mL mNGF compared to PBS group. Western blot and quantantive real time PCR discovered that TrkA receptor and mRNA expression were both up-regualated under the condition of mNGF, expecially in 160 ng/mL, while the exoression of $p75^{NTR}$ demonstrated no difference among groups. Conclusion : From these data, we conclude that exogenous mNGF can facilitate ISC growth by activating both TrkA receptor and $p75^{NTR}$. In addition, patients who are suffering from IS should not be administered mNGF in the clinic.

The role of HABTC’s hydroxamate and dithiocarbamate groups in chalcopyrite flotation

Sheng Liu,Guangyi Liu,Hong Zhong,Xianglin Yang 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.52 No.-

In this paper, S-[(2-hydroxyamino)-2-oxoethyl]-N,N-dibutyl-dithiocarbamate (HABTC) wasfirst synthesizedand characterized by 1H NMR, 13C NMR and FTIR. The role of HABTC’s hydroxamate anddithiocarbamate groups in chalcopyriteflotation was evaluated by micro-flotation, bench-scaleflotation,adsorption experiments, zeta potential and X-ray photoelectron spectroscopy (XPS). HABTC exhibitedexcellent affinity to chalcopyrite particles under pH 6–10 and achieved superiorflotation recovery ofcopper minerals in comparison with sodium isobutyl xanthate (SIBX). The adsorption thermodynamicsand kinetics elucidated that HABTC adsorption on to chalcopyrite surfaces was a spontaneouslyendothermic chemisorption process. Zeta potential demonstrated that HABTC might chemisorb on to thepositive sites of chalcopyrite surfaces. XPS spectra further revealed that both dithiocarbamate andhydroxamate groups of HABTC anchored on chalcopyrite surfaces through Cu(II)-hydroxamate and Cu(I)-dithiocarbamate configurations, resulting in an enhanced collecting power of HABTC to chalcopyriteparticles.

The TOP-SCOPE Survey of <i>Planck</i> Galactic Cold Clumps: Survey Overview and Results of an Exemplar Source, PGCC G26.53+0.17

Liu, Tie,Kim, Kee-Tae,Juvela, Mika,Wang, Ke,Tatematsu, Ken’ichi,Francesco, James Di,Liu, Sheng-Yuan,Wu, Yuefang,Thompson, Mark,Fuller, Gary,Eden, David,Li, Di,Ristorcelli, I.,Kang, Sung-ju,Lin, Yuxin Published by the University of Chicago Press for t 2018 The Astrophysical journal Supplement series Vol.234 No.2

<P>The low dust temperatures (< 14 K) of Planck Galactic cold clumps (PGCCs) make them ideal targets to probe the initial conditions and very early phase of star formation. 'TOP-SCOPE' is a joint survey program targeting similar to 2000 PGCCs in J = 1-0 transitions of CO isotopologues and similar to 1000 PGCCs in 850 mu m continuum emission. The objective of the 'TOP-SCOPE' survey and the joint surveys (SMT 10 m, KVN 21 m, and NRO 45 m) is to statistically study the initial conditions occurring during star formation and the evolution of molecular clouds, across a wide range of environments. The observations, data analysis, and example science cases for these surveys are introduced with an exemplar source, PGCC G26.53+0.17 (G26), which is a filamentary infrared dark cloud (IRDC). The total mass, length, and mean line mass (M/L) of the G26 filament are similar to 6200 M-circle dot, similar to 12 pc, and similar to 500 M-circle dot pc(-1), respectively. Ten massive clumps, including eight starless ones, are found along the filament. The most massive clump as a whole may still be in global collapse, while its denser part seems to be undergoing expansion owing to outflow feedback. The fragmentation in the G26 filament from cloud scale to clump scale is in agreement with gravitational fragmentation of an isothermal, nonmagnetized, and turbulent supported cylinder. A bimodal behavior in dust emissivity spectral index (beta) distribution is found in G26, suggesting grain growth along the filament. The G26 filament may be formed owing to large-scale compression flows evidenced by the temperature and velocity gradients across its natal cloud.</P>

synthesis of Polyurethane Foam containing SO₃H for Ion Exchange Membrane

Sheng Zhou Liu,안준환,조영선,이재석 한국고분자학회 2001 한국고분자학회 학술대회 연구논문 초록집 Vol.2001 No.4

Influence of wire mesh electrodes on the volume and surface characteristics of dielectric barrier discharge of atmospheric pressure helium

Liu Sheng,Li Jiamao,Zeng Yiyang,Chi Fangting,Xiao Chengjian 한국물리학회 2022 Current Applied Physics Vol.44 No.-

The dielectric barrier discharge of helium in a 6 mm gap at atmospheric pressure was studied. In this paper, the influence of electric field distribution on the uniformity of DBD is analyzed theoretically and verified by experiments. The experimental results show that the mesh electrode produces a local enhancement effect by affecting the electric field and then produces corona discharge, which provides seed electrons for the subsequent discharge process. The effects of mesh diameter and size on discharge uniformity and stability are analyzed, the electrode structure parameters are optimized, the method of a segmented electrode is proposed, and the discharge process and charge distribution are studied. The electrical diagnosis results of plasma technology show that the segmented mesh electrode reduces the breakdown voltage of DBD and increases the charge deposition.