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Namgung, Seung,Yoon, Jung Joo,Yoon, Chi-Su,Han, Byung Hyuk,Choi, Eun Sik,Oh, Hyuncheol,Kim, Youn-Chul,Lee, Yun Jung,Kang, Dae Gill,Lee, Ho Sub Institute for Advanced Research in Asian Science a 2017 The American journal of Chinese medicine Vol. No.
<P>Diabetic nephropathy is both the most common complication and the leading cause of mortality associated with diabetes. <I>Prunella vulgaris</I>, a well-known traditional medicinal plant, is used for the cure of abscess, scrofula, hypertension and urinary diseases. This study confirmed whether an aqueous extract of <I>Prunella vulgaris</I> (APV) suppresses renal inflammation and fibrosis. In human mesangial cell (HMC), pretreatment of APV attenuated 25<TEX>$ \,$</TEX>mM HG-induced suppressed TGF-<TEX>$ \beta $</TEX> and Smad-2/4 expression; it increased the expression level of Smad-7. Connective tissue growth factor (CTGF) and collagen IV, fibrosis biomarkers, were significantly decreased by APV. APV suppressed inflammatory factors such as intracellular cell adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1). APV inhibited activation and translocation of nuclear factor kappa-B (NF-<TEX>$ \kappa $</TEX>B) in HG-stimulated HMCs. Moreover, APV significantly improved HG-induced ROS in a dose-dependent manner. In diabetic rat models, APV significantly decreased blood glucose, blood urea nitrogen (BUN) and ameliorated plasma creatinine (PCr). APV reduced the PAS positivity staining intensity and basement membrane thickening in glomeruli of diabetic rats. Fibrosis related proteins such as collagen IV and TGF-<TEX>$ \beta $</TEX>1 were also inhibited by APV. These results suggest that APV has a significant protective effect against diabetic renal dysfunction including inflammation and fibrosis through disruption of the TGF-<TEX>$ \beta $</TEX>/Smad signaling. Therefore, APV may be useful in potential therapies that target glomerulonephritis and glomerulosclerosis, which lead to diabetic nephropathy.</P>
논문 : 플라즈마 전해산화 처리된 마그네슘 합금의 내부식성에 미치는 코팅층 내 지르코니아 입자 영향
남궁승 ( Seung Namgung ),고영건 ( Young Gun Ko ),신기룡 ( Ki Ryoung Shin ),신동혁 ( Dong Hyuk Shin ) 대한금속재료학회 ( 구 대한금속학회 ) 2010 대한금속·재료학회지 Vol.48 No.9
In current automobile and electronic industries, the use of magnesium alloys where both energy and weight saving are attainable is increasing. Despite their light weight, there has been an inherent drawback arising from the surface vulnerable to be oxidized with ease, specifically under corrosive environments. To protect magnesium alloy from corrosion, the present work deals with the electrochemical response of the oxide layer on magnesium alloy specimen prepared by plasma electrolytic oxidation (PEO) method in an electrolyte with zirconia powder. Surface observation using scanning electron microscopy evidences that a number of zirconia particles are effectively incorporated into oxide layer. From the results of potentio-dynamic tests in 3.5 wt% NaCl solution, the PEO-treated sample containing zirconia particles shows better corrosion properties than that without zirconia, which is the result of zirconia incorporation into the coating layer. Corrosion resistance is also measured by utilizing salt spray tests for 120 hrs.
Namgung, Ho,Kim, Choongho,Kim, Yujun,Kim, Jongho,Lee, Taek Seung American Scientific Publishers 2016 Journal of Nanoscience and Nanotechnology Vol.16 No.8
<P>We report the synthesis of a fluorescent polymer containing the rhodamine 6G (Rh6G) derivative as a side chain. The rhodamine (Rh) moiety in the polymer had a ligand interaction with Al3+, which allowed the polymer to be used for detection of Al3+. The Rh moiety (in closed form) was non-fluorescent and colorless, whereas the open form of the Rh derivative showed strong fluorescence. Upon exposure to Al3+, the green-emitting polymer backbone had a spectral overlap with the absorption of the open form of Rh in the side chain, leading to an energy transfer from the polymer backbone to the Rh moiety. Upon addition of Al3+ to the polymer solution, the emission of the polymer backbone (green) has gradually decreased and, concomitantly, the red emission of Rh has increased via Forster resonance energy transfer (FRET). As the fluorescence of the polymer varied in the presence of Al3+ ions, the polymer could be used as a FRET-based sensor for detecting Al3+.</P>
Synthesis of Prussian blue-embedded porous polymer for detection and removal of Cs ions
Namgung, Ho,Gwon, Young Jin,Kim, Jongho,Jang, Geunseok,Pepper, Sarah E.,Ogden, Mark D.,Whittle, Karl R.,Harwood, Laurence M.,Lee, Taek Seung Elsevier 2018 Polymer Vol.158 No.-
<P><B>Abstract</B></P> <P>A Prussian blue (PB)-embedded coordination polymer (COP) was prepared by simple incorporation of PB into a COP composed of 1,1,2,2-tetrakis(4-carboxyphenyl)ethane and the Zn ion during the synthesis of COP. The PB-COP was prepared as micro-sized particles with green emission (490 nm) from the strongly fluorescent tetraphenylethene group in the solid state through aggregation-induced emission. The PB-COP showed particle shape with sizes ranging from 1 to 6 μm. As the PB in PB-COP efficiently adsorbed Cs ions, the microstructure of PB-COP was degraded to smaller particles, along with a concomitant decrease in the green fluorescence of the PB-COP. Such a decrease in the green emission of PB-COP was used as a signal for the presence of Cs ions, in which the limit of detection for Cs ions was found to be 73.8 ppb. The hybridized material of the PB-COP can be used as both an efficient adsorbent and a sensor for Cs ions, achieving simultaneous removal and detection.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A hybrid material was prepared with coordination polymer (COP) and Prussian blue (PB). </LI> <LI> COP was prepared by ionic interaction between COOH of organic molecules and Zn ions. </LI> <LI> The hybrid materials could remove efficiently Cs ions via adsorption on PB. </LI> <LI> The fluorescence of COP in hybrid materials also decreased upon exposure to Cs ions. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
남궁준,이승철,이승훈,이현경,정재용,김홍주,박원도 인제대학교 2000 仁濟醫學 Vol.21 No.1
In this case report we described the case of an unexplainable newsy developed ascites following renal allograft transplantation in the patient who was free of ascites during a period of peritoneal dialysis. This case suggests that ascites in the patients with end-stage renal failure is not limited to the period of maintenance dialysis and that renal transplantation may paradoxically followed by development of ascites. There has been no previous reported in Korea, so we report this case along with the brief review of the literature.
Lee, Seung Ihm,Jeong, Soo Ryeong,Kang, Young Mi,Han, Dae Hee,Jin, Byung Kwan,Namgung, Uk,Kim, Byung G. Wiley Subscription Services, Inc., A Wiley Company 2010 Journal of neuroscience research Vol.88 No.11
<P>Traumatic spinal cord injury (SCI) triggers inflammatory reactions in which various types of cells and cytokines are involved. Several proinflammatory cytokines are up-regulated after SCI and play crucial roles in determining the extent of secondary tissue damage. However, relatively little is known about antiinflammatory cytokines and their roles in spinal cord trauma. Recent studies have shown that an antiinflammatory cytokine, interleukin-4 (IL-4), is expressed and exerts various modulatory effects in CNS inflammation. We found in the present study that IL-4 was highly expressed at 24 hr after contusive SCI in rats and declined thereafter, with concurrent up-regulation of IL-4 receptor subunit IL-4α. The majority of IL-4-producing cells were myeloperoxidase-positive neutrophils. Injection of neutralizing antibody against IL-4 into the contused spinal cord did not significantly affect the expression levels of proinflammatory cytokines such as IL-1β, IL-6, and tumor necrosis factor-α or other antiinflammatory cytokines such as IL-10 and transforming growth factor-β. Instead, attenuation of IL-4 activity led to a marked increase in the extent of ED1-positive macrophage activation along the rostrocaudal extent at 7 days after injury. The enhanced macrophage activation was preceded by an increase in the level of monocyte chemoattractant protein-1 (MCP-1/CCL2). Finally, IL-4 neutralization resulted in more extensive cavitation at 4 weeks after injury. These results suggest that endogenous expression of antiinflammatory cytokine IL-4 regulates the extent of acute macrophage activation and confines the ensuing secondary cavity formation after spinal cord trauma. © 2010 Wiley-Liss, Inc</P>
토복령이 IL-1β 와 TNF-α로 유발된 Inflammatory Cytokines의 발현 및 생성에 미치는 영향
오승규 ( Seung Kyu Oh ),박종오 ( Jong Oh Park ),남궁욱 ( Uk Namgung ),강탁림 ( Tak Lim Kang ),김동희 ( Dong Hee Kim ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.1
목적 : 土茯령의 메탄올 抽出이 培養된 인간 synovial 細胞內에서 Interleukin-1β와 Tumor necrosis factor-α로 誘發된 다양한 inflammatory cytokine의 mRNA 發顯과 生成에 미치는 影響을 알아보기 위해 이루어졌다. 방법 : 먼저 정상세포에 대한 세포독성을 평가한 후 RT-PCR, FACS 및 ELISA LEADER 등을 이용해 인간 synovial 細胞內 pro-inflammatory cytokine인 TNF-α, IL-6, IL-1β, iNOS와 COX-2 등의 발현 및 생성에 대한 억제효과를 측정하였다. 결과 : 土茯령의 메탄올 抽出物은 mouse의 lung fibroblast 細胞와 사람 fibroblast -like synoviocytes 細胞에 對해서 毒性을 나타내지 않았다. IL-1β, iNOS와 COX-2의 발현이 낮은 dosage(1㎍/ml)에서 억제되었으며, IL-1β와 IL-6의 생성양 역시 대조군에 비하여 유의성있게 억제되었다. 결론 : 土茯령이 관절염의 병기로 작용하는 다양한 inflammatory cytokine들에 對한 抗炎證 效果를 나타냄으로써 Rheumatoid arthritis 등의 염증성 질환의 豫防과 治療에 有用하게 應用될 수 있을 것으로 보인다. 또한 이 같은 결과에 준하여 향 후 유기 용매 분획을 통하여 효과적인 단일 물질 탐색에 대한 연구가 지속되어야 할 것으로 사료된다. N/A
KSNP^+ Reactor Vessel Head Drop Analysis for a 5.5M Free Fall
Ihn Namgung,Seung Ha Jeong,Dae Hee Lee,Taek Sang Choi 대한기계학회 2005 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.19 No.1
The KSNP^+ RV closure head drop analysis was carried out to assess the reactor core coolability in case of the RV closure head drop accident during the refueling operation. The analysis consists of a number of different RV head drop scenarios as the postulated accident events during refueling that include a concentric head drop case and three different cases of laterally offset head drop cases. The analysis was initiated due to the adoption of the IHA (Integrated Head Assembly) in the KSNP^+ reactor design, which increases the weight of the RV closure head assembly. Four different analysis models were developed that correspond to the RV head drop analysis scenarios. An in-house dynamic analysis code was used for the RV head drop analysis. The entire reactor internals and fuel assemblies are modeled by using lumped masses and spring elements. Because of the extreme load exerted by RV head drop, most members experience stresses that are beyond the elastic limits. A separate elastic-plastic analysis for some members was carried out and the resulting load-deflection curve was used as the stiffness of the element. The effect of water above the reactor vessel in the refueling pool was ignored for the conservative estimation of the analysis. The analysis shows that the concentric head drop is the most severe case of loading condition. It also reveals that the local deformation of some reactor internals and the fuel assemblies is occurred; however the primary membrane stresses are within the bound of allowable stress limits. Consequently the reactor core remains in coolable state.