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논문 : 플라즈마 전해산화 처리된 마그네슘 합금의 내부식성에 미치는 코팅층 내 지르코니아 입자 영향
남궁승 ( Seung Namgung ),고영건 ( Young Gun Ko ),신기룡 ( Ki Ryoung Shin ),신동혁 ( Dong Hyuk Shin ) 대한금속재료학회 ( 구 대한금속학회 ) 2010 대한금속·재료학회지 Vol.48 No.9
In current automobile and electronic industries, the use of magnesium alloys where both energy and weight saving are attainable is increasing. Despite their light weight, there has been an inherent drawback arising from the surface vulnerable to be oxidized with ease, specifically under corrosive environments. To protect magnesium alloy from corrosion, the present work deals with the electrochemical response of the oxide layer on magnesium alloy specimen prepared by plasma electrolytic oxidation (PEO) method in an electrolyte with zirconia powder. Surface observation using scanning electron microscopy evidences that a number of zirconia particles are effectively incorporated into oxide layer. From the results of potentio-dynamic tests in 3.5 wt% NaCl solution, the PEO-treated sample containing zirconia particles shows better corrosion properties than that without zirconia, which is the result of zirconia incorporation into the coating layer. Corrosion resistance is also measured by utilizing salt spray tests for 120 hrs.
위령탕(胃?湯) 추출물의 사람 유래 신장 메산지움 세포에서의 당뇨병성 신장 손상 개선 효과
윤정주 ( Jung Joo Yoon ),한병혁 ( Byung Hyuk Han ),최은식 ( Eun Sik Choi ),남궁승,( Seung Namgung ),정다혜 ( Da Hye Jeong ),김혜윰 ( Hye Yoom Kim ),안유미 ( You Mee Ahn ),이윤정 ( Yun Jung Lee ),강대길 ( Dae Gill Kang ),이호섭 ( H 대한본초학회 2016 大韓本草學會誌 Vol.31 No.5
Objectives : Diabetic nephropathy is one of the most common chronic complications of diabetes and a leading cause of end-stage renal failure in the world. Mesangial cell proliferation is known as the major pathologic features such as glomerulosclerosis and renal fibrosis. Wiryeongtang (WRT) is a well-known traditional herbal formula as therapeutic agents for chronic edema and dysuresia of renal homeostasis. In the present study, we investigated whether WRT inhibits high glucose (HG)-induced renal dysfunction by TGF-β/Smads signal regulation in cultured mesangial cells. Methods : Inhibitory effect of WRT (10-50 ㎍/ml) on HG-stimulated mesangial cells proliferation and dysfunction were evaluated by [3H]-thymidine incorporation, Western blot, and RT-qPCR. Results : WRT significantly decreased HG-accelerated thymidine incorporation in human renal mesangial cell in a dose-dependent levels. WRT induced down-regulation of cyclins/CDKs and up-regulation of CDK inhibitor, p21waf1/cip1 and p27kip1 expression. In addition, HG enhanced expression of dysfunction biomarker such as collagen IV and CTGF, which was markedly attenuated by WRT. WRT decreased TGF-β1 and Smad-2/Smad-4 expression, whereas increased Smad-7 expression under HG. Furthermore, WRT inhibited HG-induced inflammatory factors level such as ICAM-1 and MCP-1 as well as NF-κB p65 nuclear translocation and intracellular ROS production. Conclusions : These results suggested that WRT may alleviate mesangial proliferation and inflammation possibly involved in renal fibrotic process, further diabetic nephropathy through disturbing TGF-β1/Smad signaling and NF-κB/ROS pathway. Thus, WRT might prove to be effective in the treatment of renal dysfunction leading to diabetic nephropathy.