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데페록사민 전처치가 토끼 심근경색 크기의 감소에 미치는 효과
양관모,오동렬,박승현,박규남,이원재,김형국,황두영,최승필,채장성 대한응급의학회 1998 대한응급의학회지 Vol.9 No.4
Background: Reperfusion of ischemic myocardium has been postulated to result in a specific oxygen radical mediated tissue injury. Iron may liberate during ischemia and we hypothesized that administration of the iron chelator, deferoxamine during ischemia would result in improved recovery after postischemic reperfusion. Purpose: To test whether iron-catalyzed processes contribute to myocardial necrosis during ischemia and reperfusion, deferoxamine was administered to block iron catalyzed hydroxyl radical formation in rabbits. Methods: Eleven rabbits were divided into two groups : control group (n=5) and deferoxamine pretreatment group (n=6). The left circumflex coronay artery was ligated for 30 minutes and reperfused for 180 minutes. Area at risk (AR) was measured by non-stained area with methylene blue injection into left atrium after left circumflex coronary artery ligation. Infarct size was measured by weighing after triphenyltetrazolium chloride staining. Heart rate was measured using electrocardiographic recording and systemic blood pressure was monitored by pressure transducer connected to the catheter in the left ventricle. Results: 1. There was no significant difference of heart rate and blood pressure in deferoxamine pretreatment group compared with control group. 2. There was significant decrease of serum iron concentration after continuous infusion of deferoxamine compared with serum iron concentration before ligation of coronary artery(P<0.05). 3. There was no significant difference of area at risk between control and deferoxamine pretreatment group. 4. Area at necrosis to area at risk was significantly reduced in deferoxamine pretreatment group compared with control group(P<0.05). The results suggest that deferoxamine infusion prior to coronary artery occlusion has a significant benefit in reducing infarct size in this model.
이선장,박남환,강승호 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1
The purpose of this study was to invesigate the effects of music types on the relative intensity(heart rate) and variation of mood state in taekwondo poomse training. ten apparently healthy volunteers from keimyung university taekwondo student signed a standard informed consent to participate in this study. Each subject performed the taekwondo poomse(teaguc poomse 1-8) two times following positve and nagative music and white noise in a random order for 8-9min at a pace that would be used during normal training. the music samples were differently associated with emotion. fast-tempo, loud song were rate as positive and slow-tempo, soft songs were identified as nagative. To evaluate HRmax, it was use graded maximal test, continuous heart rate measures were recorded throughout the teakwondo poomse drill with recovery period. the variation of mood state were investigated by question-naire. The experimental data was analyzed by one-way ANOVA with repeated measures. Based on the finding of the study, the following conclusion has been derived. 1. The change of the heart rate during taekwondo poomse drill: HR as exercise intensity of movement of taekwondo drill, fast-tempo, loud song group have shown significantly higher(p<.01) than white noise and soft song group at various periods. 2. The change of the RPE during taekwondo poomse drill: White noise and soft song groups were significantly lower(p<.01) than fast-tempo, loud song group during taekwondo poomse drill 3. The change of the mood state after taekwondo poomse drill: Tension of mood state was siginificant difference between white noise and soft song group but other variable were no significant differences in groups. In conclusion, this study provides some support the hypothesis that fast, loud music increase physiological (heart rate) or psychological arouse.(Mood state)
Special Lecture : Liver Transplantation for Hepatocellular Carcinoma-Korean Experience
Seung Gyu Lee,Chul Soo Ahn,Tae Yong Ha,Deok Bog Moon,Kun Moo Choi,Gi Won Song,Dong Hwan Chung,Gil Chun Park,Young Dong Yu,Nam Kyu Choi,Kwan Woo Kim,Ki Hun Kim,Shin Hwang 대한간암연구회 2009 대한간암연구회 학술심포지엄 Vol.12 No.-
Hepatocellular Carcinoma (HCC) is the second most common cause of male cancer death in Korea where the major etiology, chronic hepatitis B virus infection, is endemic. With a high incidence of unresectable HCC and a low cadaveric organ donation rate, the number of adult living donor liver transplantation (LDLT) has increased rapidly to 10-fold over the last 10 years as an alternative of deceased donor liver transplantation (DDLT) in Asia as well as Korea. Currently, HCC comprises >40% of the indication for adult LDLT as the associated decompensation cirrhosis or the unresectable HCC with 2.8% perioperative mortality in our institute. In determining eligibility for LDLT, the Milan criteria which has a major aim to reduce the wastage of cadaveric liver grafts still remains the gold standard. Our published results with 168 adult LDLTs shows no difference with that of the comparing DDLT for HCC meeting the Milan criteria. However, since a substantial proportion of adult LDLT patients not fulfilling the Milan criteria has been found to survive longer and a live donor organ is a private gift, most LDLT programs in Korea accept HCC patients beyond the Milan criteria, and the reported 3-year survival rate are approximately 63%. Our new proposal for expanded criteria (Asan criteria; diameter ≤5 cm, number of lesion ≤6, no gross vascular invasion) in LDLT has focused on extending the number limits but keeps the maximum tumor size at 5 cm, because even modest expansion of tumor size limits beyond the Milan criteria adversely affected survival. The overall 5-year patient survival rates were 76.3% and only 18.9% within and beyond Asan criteria, respectively which broadens the indications for patient selection and can more accurately identify patients who will benefit from LDLT than the convential Milan criteria and the University of California at San Francisco (UCSF) criteria. In Asia where option for DDLT is minimal or negligible, LDLT with the modest expanded selection criteria will continue to provide a chance of long-term survival for some patients with advanced HCC.
Effects of Ampelopsis Radix Extracts on Tumor Immunity
Park Seung Man,Cho Jung Hyo,Son Chang Gue,Shin Jang Wo,Lee Yeon Weo,Yoo Hwa Seung,Lee Nam Heon,Yun Dam Hee,Ahn Sang Woo,Cho Chong Kwan The Society of Korean Medicine 2005 대한한의학회지 Vol.26 No.4
Objectives: This experimental study was carried out to evaluate the immune modulating and anti-tumor activity of Ampelopsis Radix extracts (ARE). Materials and Methods: To elucidate the effects of ARE on the macrophage and NK cell activity, we analyzed NO production, NK cytotoxicity and gene expressions of cytokine related with macrophage and NK cell activity. Results: ARE activated and promoted macrophages to product NO in part. And, ARE has significant properties to activate macrophages and NK cells by promoting related cytokines like IL-1, IL-12, IFN-$\gamma$, iNOS and TNF-$\alpha$ gene expressions. We also observed that ARE promoted protein expression of IFN-$\gamma$, and TNF-$\alpha$ in mice splenocytes. Conclusions: ARE is an effective herbal drug for immune modulating and anti-cancer by promoting activity of macrophages and NK cells.