Comparison of controlled ovarian stimulation outcomes for fertility preservation in women with breast cancer according to KI-67, histologic grade, pathologic type, and cancer stage

( Eun Ji Oh ),( Yeon Hee Hong ),( Seul Ki Kim ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: This study aims to analyze that specific prognostic factors such as Ki-67 value, histologic grade, pathology type, and cancer stage can affect controlled ovarian stimulation outcomes(COS) for fertility preservation in women with breast cancer. Methods: This retrospective cohort study included 92 patients with breast cancer aged 21-44 who underwent COS from August 2012 to April 2020, excluding patients with previous gonadotoxic therapy history. All COS cycles were conducted letrozole-combined random start GnRH antagonist protocol. COS outcomes were compared according to prognostic factors;Ki-67 (< 30% vs. ≥ 30%), histologic grade (low vs. high), and pathologic type (intraductal carcinoma(IDC) vs. triple-negative breast cancer(TNBC)), and cancer stage (early (I, II) vs. advanced (III, IV)). Multivariate analysis was also conducted to find any parameter that can impact over 10 mature oocytes acquisition. Results: Among the 92 patients, 42 were Ki-67≥30% compared to 49 of Ki-67<30%. The number of oocytes, and initial mature oocytes were comparable between Ki-67<30% and ≥30 group. The maturation rate was significantly higher in Ki-67≥30% group than Ki-67<30% group (57.4±36.8% vs. 44.8±28.3%, p=0.041). The same results were drawn when divided according to IDC or TNBC. The maturation rate was significantly higher in TNBC than the IDC group (73.0±17.6% vs. 47.0±28.1% p=0.001). However, the histologic grade or stage did not show any difference in COS outcomes between high and low grade or early and advanced stages. With multivariate analysis, age and AMH are parameters associated with the acquisition of over 10 mature oocytes (OR 0.863, 95% CI [0.755-0.987], OR 1.408, 95% CI [1.145-1.732], respectively). Conclusion: Either Ki-67 or pathologic type can be a potential reliable marker for predicting COS outcome, especially maturation rate. Further study with larger sample size with specific conditions is necessary to clarify the correlation between breast cancer prognostic factors and COS outcomes.

Possibility of Empowerment in The Surrendered by Chang-rae Lee

Seul Ki Lee Ewha Institute of English and American Studies 2022 Journal of English and American studies Vol.20 No.1

This paper supports the interpretation that the main characters in Chang-rae Lee’s The Surrendered find liberation in being surrendered. As a novel written by a recognized Korean-American writer about The Korean War, The Surrendered received many reviews concentrating on the author’s writing style and artistry. These early critics stated that the novel’s varying temporal and geographical shifts and the fact that the novel revolves around three different characters make the novel unnecessarily complex. In addition, the scholarly works that do analyze the novel concentrate on the trauma, disability, and post-traumatic stress disorder resulting from the violence. Although prior research touched upon the characters and the symbolism within the setting, I would like to do a more in depth analysis. I use the concept of “abjection” to analyze the symbolism of the three main characters: June, Hector, and Sylvia. All three characters have distinct individuals while also representing others who have survived the social situations they faced. Therefore, it is meaningful to analyze three characters and how they use their status as abjects to find a form of liberation and empowerment.

The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated Cytotoprotection

Choi, Seul-Ki,Mun, Gil-Im,Choi, Eun,Kim, Seo-Young,Kwon, Youngjoo,Na, Younghwa,Lee, Yun-Sil American Society of Pharmacognosy 2017 Journal of natural products Vol.80 No.8

<P>Coniferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1 (HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 using the derivatives coniferyl alcohol (2), 4-hydroxy-3-methoxyphenylpropanal (3), and 4-hydroxy-3-methoxyphenylpropanol (4). Both 1 and 2 resulted in increased survival days after a lethal radiation (IR) dose. The decrease in bone marrow (BM) cellularity and Ki67-positive BM cells by IR was also significantly restored by 1 or 2 in mice. These results suggested that the vinyl moiety of 1 and 2 is necessary for inducing HSF1, which may be useful for developing small molecules for cytoprotection of normal cells against damage by cytotoxic drugs and radiation.</P>

초등학교 고학년 학생의 장애아동에 대한 인식 조사

김보람,김호영,손유라,오진주,윤슬기,이효정,장문영 대한감각통합치료학회 2011 대한감각통합치료학회지 Vol.9 No.1

목적 : 초등학교 고학년 학생의 장애아동에 대한 인식을 알아보는 것이다. 연구방법 : 연구 대상은 김해시에 소재한 통합교육을 실시하지 않는 초등학교의 4, 5, 6학년의 비장애 아동이었다. 연구 기간은 2008년 10월 2일부터 10월 17일까지였으며, 설문지를 사용하였다. 설문지의 하위 영역은 사귐, 활 동, 학업 영역의 세 부분으로 각 10문항으로 이루어져 있으며 SPSS 12.0을 사용하여 분석하였다. 결과 : 장애아동에 대한 인식조사 결과 첫째, 성별에 따른 인식은 남학생보다 여학생의 평균 점수가 높았으나 통계 적으로 유의미한 차이는 없었다. 둘째, 학년에 따른 인식은 4학년의 평균 점수가 가장 높았고 6학년이 가장 낮았으 며 통계적으로 유의미한 차이가 있었다(F=3.546, p<0.05). 셋째, 장애인 접촉 유무에 따른 인식은 접촉 경험이 없 는 학생이 있는 학생보다 평균점수가 높았으나 통계적으로 유의미한 차이는 없었다. 결론 : 비장애학생의 장애아동에 대한 인식은 학년에 따라 차이가 있었다. 본 연구는 작업치료사들에게 장애아동에 대한 또래집단의 인식에 대한 정보를 제공함으로써 학교환경에 대한 이해를 도울 수 있을 것이다. Objective : The purpose of this study was to investigate attitude of grade-schoolers toward children with disabilities. Methods : The subjects of this study were grade-schoolers who have not received an inclusive education in Gim-hae. The study was surveyed from October second to 17th in 2008. The survey was categorized into three parts; comradeship, activity, and study. Each part of the survey consists of 10 questions. Data were analyzed by SPSS (version 12.0). Results : The results were as follows; First, the attitude of girls toward disabled students was non-significant compared to boys. Second, the order of attitude degree in grade of students was 4, 6, and 5. The attitude toward children with disabilities showed statistically significant difference according to grade(F=3.546, p<0.05). Third, the attitude of students who have experience of contact with people with disabilities was non-significant compared to non-experienced students. Conclusion : In conclusion, therefore peer groups in lower class levels showed more positive attitude toward the children with disabilities. The result will be useful information for understanding disabled children and making positive attitude. Also it is expected that occupational therapists help disabled children to participate in school life successfully using these information.

Clear cell papulosis: one of the hypopigmentation disorders in early childhood

( Seul Ki Lim ),( Hae Eul Lee ),( Myung Im ),( Young Joon Seo ),( Jeung Hoon Lee ),( Young Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Clear cell papulosis (CCP) is a rare condition in early childhood with hypopigmented macules or palpable papules on pubic region, lower abdomen, and anterior trunk. A 2-year-old girl visited our clinic for asymptomatic hypopigmented macules and flat topped papules on the inguinal area, suprapubic area and anterior trunk. The patient had no history of trauma or inflammation. Histopathological examination showed the clear cells which were round and oval shape with abundant pale cytoplasm. These cells were mostly located in basal layers and occasionally in spinous layers. Fontana-Masson stain showed decreased pigmentation compared with adjacent normal skin. The patient was diagnosed as CCP with clinical manifestation and characteristic histologic findings. CCP often can be confused with tinea versicolor, anectoderma, idiopathic guttate hypomelanosis or chicken pox scars. Though it is a rare disease entity, CCP should be kept in mind as one of the differential diagnoses of localized hypopigmented macules on trunk in early childhood.

Clinicopathologic evaluation of myofibroblastoma: A study in two hospitals

( Seul Ki Kim ),( Ji Sun Lee ),( Su Been Hong ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

목적: To report various anatomic locations and clinical characteristics of pathologically proven myofibroblastoma in Koran patients. 방법: Pathologic reports of patients who underwent surgeries at two centers (Seoul National University Hospital and Seoul National University Bundang Hospital) between April 2003 and March 2016 were retrieved from the electronic medical record system of the hospital. Pathologic reports were included after performing a search using the key- word “myofibroblastoma”. 결과: The cohort consisted of 11 subjects and included eight female and three male individuals. The patients’ ages ranged from 9 to 66 years. Tumors were located in the vagina in three patients and presented in the breast in seven patients. One case presented with an abdominal mass. The tumors ranged in mean size from 4.0 to 53.0 mm. Despite a relatively long-term follow-up, no case had evidence of tumor recurrence. 결론: We evaluated the various anatomic locations of pathologically proven myofibroblastoma in Korean patients. As an extremely rare tumor, physicians should pay special attention to differential diagnosis. Surgical resection is the preferred method for a cure, and the recurrence rate is extremely low.

IgG4 related skin disease

( Seul Ki Lim ),( Myung Im ),( Young Lee ),( Young Joon Seo ),( Jeung Hoon Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

IgG4-related disease (IgG4-RD) is a new disease entity which is characterized by elevated serum IgG4 and infiltration of IgG4+ plasma cell in tissue. IgG4-RD can involve various organs, and skin also could be affected. The manifestations of IgG4-related skin disease (IgG4-RSD) are not characteristic, however it usually shows multiple erythematous nodules or plaques with itching sensation. We report a case which was similar as pseudolymphoma, however finally diagnosed as IgG4-RSD. 64 year-old male had multiple erythematous nodules on trunk and extremities. These skin lesions first appeared at 2 years ago, and have been getting worse. He also has history of IgG4-related dacryoadenitis which was proven by serum IgG4 level and magnetic resonance imaging(MRI). On histological study of skin lesion, there was lots of plasma cells infiltration with mononuclear cells in entire dermis. Some of plasma cells were strongly positive for IgG4 stain. Here, we report the IgG4-RSD patient who had been considered as pseudolymphoma. The skin features of IgG4-RSD are not pathognomonic and easy to misdiagnosed as lymphoma or pseudolymphoma. Thus clinician should be careful to examination and conduct systemic evaluation, serologic test and IgG4 stain.

Genomic Analysis of the Extremely Halophilic Archaeon Halobacterium noricense CBA1132 Isolated from Solar Salt That Is an Essential Material for Fermented Foods

( Seul Ki Lim ),( Joon Yong Kim ),( Hye Seon Song ),( Min-sung Kwon ),( Jieun Lee ),( Young Jun Oh ),( Young-do Nam ),( Myung-ji Seo ),( Dong-gi Lee ),( Jong-soon Choi ),( Changmann Yoon ),( Eunju Soh 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.8

The extremely halophilic archaeon Halobacterium noricense is a member of the genus Halobacterium. Strain CBA1132 (= KCCM 43183, JCM 31150) was isolated from solar salt. The genome of strain CBA1132 assembled with 4 contigs, including three rRNA genes, 44 tRNA genes, and 3,208 open reading frames. Strain CBA1132 had nine putative CRISPRs and the genome contained genes encoding metal resistance determinants: copper-translocating P-type ATPase (CtpA), arsenical pump-driving ATPase (ArsA), arsenate reductase (ArsC), and arsenical resistance operon repressor (ArsR). Strain CBA1132 was related to Halobacterium noricense, with 99.2% 16S rRNA gene sequence similarity. Based on the comparative genomic analysis, strain CBA1132 has distinctly evolved; moreover, essential genes related to nitrogen metabolism were only detected in the genome of strain CBA1132 among the reported genomes in the genus Halobacterium. This genome sequence of Halobacterium noricense CBA1132 may be of use in future molecular biological studies.

Poly(vinylidenefluoride)-hexafluoropropylene–methyl N-methylpyrrolidinium-N-acetate trifluoromethanesulfonylimide–lithium trifluoromethanesulfonylimide gel electrolytes

Ki-Sub Kim,Seul Bee Lee,Hoon Sik Kim,Youngwoo Lee,Kwangsoo Kwack,Hyunjoo Lee 한국공업화학회 2009 Journal of Industrial and Engineering Chemistry Vol.15 No.5

New polymer-ionic liquid-lithium salt gel electrolytes (PILGEs) were prepared using poly(vinylidenefluoride)-hexafluoropropylene copolymer (PVdF(HFP)), methyl N-methylpyrrolidinium-N-acetate trifluoromethanesulfonimide ([MMEPyr][TFSI]), and lithium trifluoromethanesulfonylimide (LiTFSI) in order to investigate the effects of ionic liquids containing an ester group on the electrochemical properties of polymer gel electrolytes. Free standing ionic gels consisting of PVdF(HFP), [MMEPyr][TFSI], and LiTFSI were prepared in a range of weight ratio of polymer/[MMEPyr][TFSI]/LiTFSI = 1/2/0.1 1. Ionic conductivities for the prepared PILGEs were measured with changing temperature and weight ratio of LiTFSI and the obtained values were found to be reasonable (104 S ㎝1) over the operating temperatures.

Synergistically enhanced osteoconductivity and anti-inflammation of PLGA/β-TCP/Mg(OH)₂ composite for orthopedic applications

Lee, Seul Ki,Han, Cheol-Min,Park, Wooram,Kim, Ik Hwan,Joung, Yoon Ki,Han, Dong Keun Elsevier 2019 Materials Science and Engineering C Vol.94 No.-

<P><B>Abstract</B></P> <P>Synthetic biodegradable polymers including poly(lactide-<I>co</I>-glycolide) (PLGA) have been widely used as alternatives to metallic implantable materials in the orthopedic field due to their superior biocompatibility and biodegradability. However, weak mechanical properties of the biodegradable polymers and inflammatory reaction caused by the acidic degradation products have limited their biomedical applications. In this study, we have developed a PLGA composite containing beta-tricalcium phosphate (β-TCP) and magnesium hydroxide (Mg(OH)<SUB>2</SUB>) as additives to improve mechanical, osteoconductivity, and anti-inflammation property of the biopolymer composite simultaneously. The β-TCP has an osteoconductive effect and the Mg(OH)<SUB>2</SUB> has a pH neutralizing effect. The PLGA/inorganic composites were uniformly blended <I>via</I> a twin extrusion process. The mechanical property of the PLGA/β-TCP/Mg(OH)<SUB>2</SUB> composite was improved compared to the pure PLGA. In particular, the addition of Mg(OH)<SUB>2</SUB> suppressed the inflammatory reaction of normal human osteoblast (NHOst) cells and also inhibited the differentiation of pre-osteoclastic cells into osteoclasts. Moreover, synergistically upregulated late osteogenic differentiation of NHOst cells was observed on the PLGA/β-TCP/Mg(OH)<SUB>2</SUB> composite. Taken all together, we believe that the use of β-TCP and Mg(OH)<SUB>2</SUB> as additives with synthetic biodegradable polymers has great potential by the synergistic effect in orthopedic applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PLGA composites containing β-TCP and Mg(OH)<SUB>2</SUB> were successfully fabricated by a twin screw extrusion technique. </LI> <LI> The PLGA/inorganic composites exhibited improved mechanical properties and superior pH neutralization effect. </LI> <LI> PLGA composite showed significantly improved osteogenesis as well as reduced inflammation and osteoclastogenesis. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>