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- 저자 : ( Sang-hyeok Cho ) (검색결과 368 건)
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Perirenal Fat and Kidney Function Deterioration in Patients With Acute Decompensated Heart Failure
Cho In-Jeong,Wi Jin,Lee Sang Eun,Kim Dong-Hyeok,Pyun Wook Bum 대한심부전학회 2023 International Journal of Heart Failure Vol.5 No.1
Background and Objectives The thick perirenal fat pad can induce high intracapsular pressure and cause compression of the renal vasculature and resultant congestive nephropathy. The current study investigated the association of perirenal fat thickness with kidney dysfunction in patients with acute decompensated heart failure (ADHF). Methods Data from 266 patients hospitalized with ADHF were analyzed. Patients were divided into two groups according to the glomerular filtration rate (GFR) at admission (preserved kidney function [GFR ≥60 mL/min/1.73 m2] and reduced kidney function [GFR <60 mL/min/1.73 m2] groups). Right and left posterior perirenal fat thicknesses were measured using computed tomography, and their average values were calculated. Associated factors with reduced kidney function was assessed by logistic regression model, presenting with odds ratio (OR) and confidence interval (CI). Results Increasing age (OR, 1.08; 95% CI, 1.04–1.12; p<0.001), diabetes mellitus (OR, 2.46; 95% CI, 1.18–5.12; p<0.017), increased log N-terminal pro-B-type natriuretic peptide (NT-proBNP) (OR, 1.82; 95% CI, 1.32–2.52; p<0.001), and increased average perirenal fat thickness (OR, 1.11; 95% CI, 1.06–1.16; p<0.001) were independently associated with reduced kidney function. In the subgroup analyses, patients over 70 years old, the ratio of mitral-to-mitral annular velocity >15, elevated log NT-proBNP had a significantly higher association with increased perirenal fat thickness with reduced kidney function. Conclusions Thick perirenal fat pads were independently associated with kidney function deterioration in patients hospitalized with ADHF. Background and Objectives The thick perirenal fat pad can induce high intracapsular pressure and cause compression of the renal vasculature and resultant congestive nephropathy. The current study investigated the association of perirenal fat thickness with kidney dysfunction in patients with acute decompensated heart failure (ADHF). Methods Data from 266 patients hospitalized with ADHF were analyzed. Patients were divided into two groups according to the glomerular filtration rate (GFR) at admission (preserved kidney function [GFR ≥60 mL/min/1.73 m2] and reduced kidney function [GFR <60 mL/min/1.73 m2] groups). Right and left posterior perirenal fat thicknesses were measured using computed tomography, and their average values were calculated. Associated factors with reduced kidney function was assessed by logistic regression model, presenting with odds ratio (OR) and confidence interval (CI). Results Increasing age (OR, 1.08; 95% CI, 1.04–1.12; p<0.001), diabetes mellitus (OR, 2.46; 95% CI, 1.18–5.12; p<0.017), increased log N-terminal pro-B-type natriuretic peptide (NT-proBNP) (OR, 1.82; 95% CI, 1.32–2.52; p<0.001), and increased average perirenal fat thickness (OR, 1.11; 95% CI, 1.06–1.16; p<0.001) were independently associated with reduced kidney function. In the subgroup analyses, patients over 70 years old, the ratio of mitral-to-mitral annular velocity >15, elevated log NT-proBNP had a significantly higher association with increased perirenal fat thickness with reduced kidney function. Conclusions Thick perirenal fat pads were independently associated with kidney function deterioration in patients hospitalized with ADHF.
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Scoliosis Screening through a Machine Learning Based Gait Analysis Test
Cho, Jae-sung,Cho, Young-Shin,Moon, Sang-Bok,Kim, Mi-Jung,Lee, Hyeok Dong,Lee, Sung Young,Ji, Young-Hoon,Park, Ye-Soo,Han, Chang-Soo,Jang, Seong-Ho Springer-Verlag 2018 International Journal of Precision Engineering and Vol.19 No.12
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Sung-Ho Yoon,Min Jong Kil,Jun-Hyeok Jeon,Hyun-Mi Kim,Seul-Gi Kim,Jiye Han,Eui-Sung Lee,Youngmo An,Jin Woo Cho,Jihwan An,Jae-Boong Choi,Il Jeon,Hyeongkeun Kim 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.10 No.5
A novel rotary-type atomic layer deposition (ALD) process for coating platinum thin film on three-dimensional (3D) substrates is demonstrated. High uniformity and conformability of the platinum thin-film deposition on 3D substrates were confirmed, ensuring the controllability of the new ALD technique. The results for this technique surpassed those of the conventional wet method and ordinary atomic layer deposition, which both have a limited specific surface area. To demonstrate the application of this new technology, Pt nano-film coated γ-Al2O3 was produced using the rotary-type ALD and applied to diesel oxidation catalysts (DOCs). The produced DOCs showed high Pt content when the number of ALD cycles was increased, and thereby exhibited more complete combustion of gaseous pollutants, such as CO, C3H8, and NO, even at lower temperatures. Pt nano-film deposition by the rotary-type ALD process was first optimised on Si wafer substrates. The process was controlled by four parameters: processing temperature, number of ALD cycles, precursor pulse time, and reactant pulse time. Deposition of the Pt nano-film was mainly determined by the processing temperature and the number of ALD cycles. The average growth per cycle and density of the Pt nano-film were found to be 0.8 Å/cycle and 21.0 g/cm3, respectively. The same procedure and conditions were applied to 3D γ-Al2O3 powder substrates for DOCs, which demonstrated greater conversion performance compared with conventional Pt-used DOCs.
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Basic, HCC basic : PO-21 ; Increased apolipoprotein E in hepatocellular carcinoma
( Hyeok Choon Kwon ),( Seung Woo Nam ),( Jae Youn Cheong ),( Soon Sun Kim ),( Marie Yeo ),( Dong Kyu Kim ),( Sung Won Cho ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Hepatocellular carcinoma (HCC) is one of the most malignant tumors worldwide. The goal of our study was to identify new biomarkers for HCC for early detection and for gaining an improved understanding of hepatocarcinogenesis by performing a comparative proteomic analysis of HCC and adjacent non-tumor tissue. Methods: Pairs of tumor and adjacent non-tumor tissue were obtained from 167 HCC patients after surgical resection at Ajou University Hospital, Korea. We assessed the histopathological features and additional clinical data. Proteomic analysis of tumor and non-tumor tissue revealing differential expression using 2D electrophoresis and MALDI-TOF MS analysis reveals some xenobiotic enzymes and apo E was selected. The associations between the expression of apoE and the clinical and pathological parameters were analyzed using SPSS. Results: One of the xenobiotic enzymes, apoE was significantly increased in tumor tissue compared with surrounding nontumor tissue. Paired T-test showed significant high level of apoE in tumor compared with non-tumor (209.91 vs 87.59, p < .01). Oneway ANOVA revealed that levels of apoE were elevated independently among different Child classes, etiologies, sex and consumption of alcohol. Conclusions: We compared the protein profiles between tumor and non-tumor tissue in HCC patients. This study revealed that apoE was significantly higher in HCC than in non-tumor tissue. The multivariate analysis confirmed apoE was higher in regardless of Child class, etiology, sex and alcohol consumption. ApoE has long been known as plasma lipoproteins responsible for cholesterol transport and metabolism. Plasma apoE is produced mainly in the liver but also in the brain, adrenal glands, kidney, and macrophage and not increased in gene expression and serum level in patients with HCC. Some proteomic studies reports a strong relationship between other cancers and apoE. We suppose that this report add a clue to understand hepatocarcinogenesis from hepatic steatosis to consequently hepatic carcinoma.
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Dependence of the RFQ Output Beam Current on the Proton Injector Operation Parameters
Hyeok-Jung Kwon,Han-Sung Kim,Dae-Il Kim,Ji-Ho Jang,Yong-Sub Cho 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.54 No.5
A 20-MeV proton accelerator has been developed by the Proton Engineering Frontier Project (PEFP). It consists of a 50-keV proton injector, a 3-MeV radio-frequency quadrupole (RFQ) and a 20-MeV drift tube linac (DTL). An ion source and a low-energy beam transport (LEBT) system constitute the proton injector. The main roles of the proton injector are to generate the proton beams and to transport and match the beam from the ion source into the RFQ. The output beam current and the transmission of the RFQ are directly influenced by the operation parameters of the proton injector, especially the two solenoid magnets. The output beam current of the RFQ was measured for various values of the solenoid magnet current and the results were compared with that of the simulation.
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Metatranscriptome Analysis of Margalefidinium polykrikoides Harmful Algal Bloom
Sang-Hyeok CHO,Yujin JEONG,Eunju LEE,Sangrak JIN,So-Ra KO,Seung Ho BAEK,Chi-Yong AHN,Hee-Mock OH,Byung-Kwan CHO,Suhyung CHO 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Harmful algal bloom (HAB) is an abnormal algal outbreak occurring in various aquatic environments, destroying the marine industry and ecosystem and damaging humans through the food web. To control HAB, it is critical to understand both the intracellular changes of the bloom-forming algae and their interactions with the symbiotic organisms. Here, we analyzed the metatranscriptome of the HAB comprising Margalefidinium polykrikoides (formerly Cochlodinium polykrikoides) with other bloom-associated microorganisms. Our comprehensive analysis predicted that M. polykrikoides in the HAB preferred propagation through asexual replication rather than reductive reproduction for fast blooming. In particular, the combined transcriptomic expression patterns of increased transcription, translation, mitosis, and asexual division with the decreased meiotic cell cycle genes such as MEI2 were found. The transcriptome analysis of M. polykrikoides analysis also showed evidence of free ferric species exchange under HAB conditions. Through the metatranscriptome analysis during HABs, we analyzed the bacterial community co-habiting with M. polykrikoides during HAB and further suggested potential roles of bacteria such as mutualistic, opportunistic, or even algicidal interactions. Notably, the abundant bacterial species are responsible for ferric ion exchange with algae. Collectively, our results provide a genetic understanding of the bloom compromising algae and algal-bacterial interactions.
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( Sang-hyeok Cho ),( Yujin Jeong ),( Eunju Lee ),( So-ra Ko ),( Chi-yong Ahn ),( Hee-mock Oh ),( Byung-kwan Cho ),( Suhyung Cho ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.4
Erythrobacter species are extensively studied marine bacteria that produce various carotenoids. Due to their photoheterotrophic ability, it has been suggested that they play a crucial role in marine ecosystems. It is essential to identify the genome sequence and the genes of the species to predict their role in the marine ecosystem. In this study, we report the complete genome sequence of the marine bacterium Erythrobacter sp. 3-20A1M. The genome size was 3.1 Mbp and its GC content was 64.8%. In total, 2998 genetic features were annotated, of which 2882 were annotated as functional coding genes. Using the genetic information of Erythrobacter sp. 3-20A1M, we performed pangenome analysis with other Erythrobacter species. This revealed highly conserved secondary metabolite biosynthesis-related COG functions across Erythrobacter species. Through subsequent secondary metabolite biosynthetic gene cluster prediction and KEGG analysis, the carotenoid biosynthetic pathway was proven conserved in all Erythrobacter species, except for the spheroidene and spirilloxanthin pathways, which are only found in photosynthetic Erythrobacter species. The presence of virulence genes, especially the plant-algae cell wall degrading genes, revealed that Erythrobacter sp. 3-20A1M is a potential marine plant-algae scavenger.
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Post-translational modification of OCT4 in breast cancer tumorigenesis
Cho, Yunhee,Kang, Hyeok Gu,Kim, Seok-Jun,Lee, Seul,Jee, Sujin,Ahn, Sung Gwe,Kang, Min Jueng,Song, Joon Seon,Chung, Joon-Yong,Yi, Eugene C.,Chun, Kyung-Hee Nature Publishing Group 2018 CELL DEATH AND DIFFERENTIATION Vol. No.
<P>Recurrence and drug resistance of breast cancer are still the main reasons for breast cancer-associated deaths. Cancer stem cell (CSC) model has been proposed as a hypothesis for the lethality of breast cancer. Molecular mechanisms underlying CSC maintenance are still unclear. In this study, we generated mammospheres derived from breast cancer MDA-MB231 cells and MCF7 cells to enrich CSCs and performed DNA microarray analysis. We found that the expression of carboxy terminus of HSP70-interacting protein (CHIP) E3 ubiquitin ligase was significantly downregulated in breast CSCs. CHIP depletion increased mammosphere formation, whereas CHIP overexpression reversed this effect. We identified interactomes by mass spectrometry and detected CHIP directly interacted with OCT4, a stemness factor. CHIP overexpression decreased OCT4 stability through proteasomal degradation. CHIP induced OCT4 ubiquitination, whereas H260Q, a catalytic CHIP mutant, did not. Interestingly, we determined that OCT4 was ubiquitinated at lysine 284, and CHIP overexpression did not degrade K284R mutant OCT4. CHIP overexpression decreased the proliferation and side population of breast cancer cells, but these were not occurred in K284R mutant OCT4 overexpressed cells. Only 1000 cells showing CHIP depletion or OCT4 overexpression sufficiently generated breast tumors and lung metastases in xenografted mice. Ubiquitination-defective mutant of OCT4(K284R) overexpressed cells drastically generated tumor burdens in mice. Patients with breast cancer who showed low CHIP expression had poor survival probability. Taken together, we suggest that CHIP-induced OCT4 ubiquitination is important in breast CSCs. Regulation of CHIP expression and OCT4 protein stability is a considerable approach for breast cancer therapy.</P>
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