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      • Establishment and Clinical Application of an Electronic Database for Breast Cancer in China

        Lv, Yong-Gang,Huang, Mei-Ling,Xiao, Jing-Jing,Ling, Rui Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.2

        Purpose: To establish a database for breast cancer patients to save and manage clinical data and to preliminarily investigate its clinical application. Materials and Methods: Information on breast cancer patients hospitalized in our department from 2008.01 to 2013.01 were input into our breast cancer management system. SPSS 16.0 software was used as a convenient reference to evaluate the accuracy of the newly built database. Results: A database of 2403 breast cancer patients was successfully established. Information in the database clearly displayed capabilities of storage, addition, retrieval, statistical analysis and other functions. As the continuously updated database showed, the distribution of age, sex, nationality, allergy history, pausimenia and marriage of patients was identical to that achieved by SPSS analysis, indicating reliable and accurate data analysis. Conclusions: The described database is easy and convenient to operate and manage, and should prove suitable for application in clinical research and treatment.

      • KCI등재

        Combined Use of Automatic Tube Voltage Selection and Current Modulation with Iterative Reconstruction for CT Evaluation of Small Hypervascular Hepatocellular Carcinomas: Effect on Lesion Conspicuity and Image Quality

        Peijie Lv,Jie Liu,Rui Zhang,Yan Jia,Jianbo Gao 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.3

        To assess the lesion conspicuity and image quality in CT evaluation of small (≤ 3 cm) hepatocellular carcinomas (HCCs) using automatic tube voltage selection (ATVS) and automatic tube current modulation (ATCM) with or without iterative reconstruction. One hundred and five patients with 123 HCC lesions were included. Fifty-seven patients were scanned using both ATVS and ATCM and images were reconstructed using either filtered back-projection (FBP) (group A1) or sinogram-affirmed iterative reconstruction (SAFIRE) (group A2). Forty-eight patients were imaged using only ATCM, with a fixed tube potential of 120 kVp and FBP reconstruction (group B). Quantitative parameters (image noise in Hounsfield unit and contrast-to-noise ratio of the aorta, the liver, and the hepatic tumors) and qualitative visual parameters (image noise, overall image quality, and lesion conspicuity as graded on a 5-point scale) were compared among the groups. Group A2 scanned with the automatically chosen 80 kVp and 100 kVp tube voltages ranked the best in lesion conspicuity and subjective and objective image quality (p values ranging from < 0.001 to 0.004) among the three groups, except for overall image quality between group A2 and group B (p = 0.022). Group A1 showed higher image noise (p = 0.005) but similar lesion conspicuity and overall image quality as compared with group B. The radiation dose in group A was 19% lower than that in group B (p = 0.022). CT scanning with combined use of ATVS and ATCM and image reconstruction with SAFIRE algorithm provides higher lesion conspicuity and better image quality for evaluating small hepatic HCCs with radiation dose reduction.

      • KCI등재

        Maximum weighted likelihood for discrete choice models with a dependently censored covariate

        Xiaofeng Lv,Gupeng Zhang,Qinghai Li,Rui Li 한국통계학회 2017 Journal of the Korean Statistical Society Vol.46 No.1

        This study considers discrete choice models with a censored covariate under dependent censoring where the censoring mechanism depends on the outcomes of choice models. We estimate the parameter vector using maximum weighted likelihood (MWL). The weights are obtained through the Aalen’s estimator. Our estimator for the parameter vector in choice models is consistent and asymptotically normal. Simulations show that MWL performs well. Finally, the proposed MWL method is applied to a real data set.

      • SCIESCOPUSKCI등재

        Effect of inlet throttling on thermohydraulic instability in a large scale water-based RCCS: An experimental study

        Qiuping Lv,Matthew Jasica,Darius Lisowski,Zhiee Jhia Ooi,Rui Hu,Mitch Farmer Korean Nuclear Society 2024 Nuclear Engineering and Technology Vol.56 No.2

        The objective of the present experimental study is to investigate the effect of inlet throttling on the thermohydraulic stability of a large scale water-based Reactor Cavity Cooling System (RCCS). The test was performed using the water-based Natural convection Shutdown heat removal Test Facility (NSTF) at Argonne, which represented a ½ axial scale and 12.5° sector slice of the full scale Framatome 625 MW<sub>t</sub> SC-HTGR RCCS concept. A two-phase steady state was first established through direct condensate refill, followed by increased inlet throttling over 10 stages, corresponding to a loss coefficient K over the range of 0.05-653. With the inlet throttling gradually increased, the system experienced a unique transition process between stabilization and destabilization. Through a stability analysis, three instability mechanisms were identified in the present test, including a compound mechanism due to both natural circulation oscillations (NCOs) and density wave oscillations (DWOs), Type-II DWOs, and geysering.

      • KCI등재

        Defect Detection in the Winding Layer of CNG Composite-Wound Cylindersvirtue of minimal mechanism is that it allows

        Hui Lv,Gongtian Shen,Yue Yu,Lixiong Zhu,Rui Zhou 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.12

        Natural gas vehicles have been widely used around the world as a mode of green transportation. The defect detection method for a vehicle cylinder, which is the energy storage component of a natural gas vehicle, is essential for ensuring safety. Current vehicle cylinder testing methods are relatively simple and cannot quickly and accurately detect internal defects in the winding layer of the cylinder. In this study, the effect of winding layer defects on the temperature behavior of cylinders during filling was studied using finite element simulation and infrared thermal imaging technology. The results show that a defect in the winding layer acts as a source of thermal resistance that hinders heat transfer. The more serious the defect is, the greater the hindrance of the heat transfer is. According to this principle, an evaluation model based on the R parameter was developed for the temperature changes due to defects, and a method for quantitatively correlating the maximum R value with the defect depth was established, thereby providing a practical approach for the rapid detection and evaluation of defects in cylinder winding layers.

      • SCIESCOPUSKCI등재

        Validation of Methods for Isolation and Culture of Alpaca Melanocytes: A Novel Tool for In vitro Studies of Mechanisms Controlling Coat Color

        Bai, Rui,Sen, Aritro,Yu, Zhihui,Yang, Gang,Wang, Haidong,Fan, Ruiwen,Lv, Lihua,Lee, Kyung-Bon,Smith, George W,Dong, Changsheng Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.4

        The objective of the present studies was to develop and validate a system for isolation, purification and extended culture of pigment-producing cells in alpaca skin (melanocytes) responsible for coat color and to determine the effect of alpha melanocyte stimulating hormone treatment on mRNA expression for the melanocortin 1 receptor, a key gene involved in coat color regulation in other species. Skin punch biopsies were harvested from the dorsal region of 1-3 yr old alpacas and three different enzyme digestion methods were evaluated for effects on yield of viable cells and attachment in vitro. Greatest cell yields and attachment were obtained following dispersion with dispase II relative to trypsin and trypsin-EDTA treatment. Culture of cells in medium supplemented with basic fibroblast growth factor, bovine pituitary extract, hydrocortisone, insulin, 12-O-tetradecanolphorbol-13-acetate and cholera toxin yielded highly pure populations of melanocytes by passage 3 as confirmed by detection of tyrosinase activity and immunocytochemical localization of melanocyte markers including tyrosinase, S-100 and micropthalmia-associated transcription factor. Abundance of mRNA for tyrosinase, a key enzyme in melanocyte pigment production, was maintained through 10 passages showing preservation of melanocyte phenotypic characteristics with extended culture. To determine hormonal responsiveness of cultured melanocytes and investigate regulation of melanocortin 1 receptor expression, cultured melanocytes were treated with increasing concentrations of ${\alpha}$-melanocyte stimulating hormone. Treatment with ${\alpha}$-melanocyte stimulating hormone increased melanocortin receptor 1 mRNA in a dose dependent fashion. The results demonstrated culture of pure populations of alpaca melanocytes to 10 passages and illustrate the potential utility of such cells for studies of intrinsic and extrinsic regulation of genes controlling pigmentation and coat color in fiber-producing species.

      • KCI등재

        Fabrication of Columnar NaNbO3‑Based Particles Through Topochemical Microcrystal Conversion

        Liangliang Liu,Rui Lv,Zhuangzhuang Guo,Yongqiang Wang 대한금속·재료학회 2020 ELECTRONIC MATERIALS LETTERS Vol.16 No.1

        The columnar NaNbO3-based particles with a perovskite structure were successfully synthesized through topochemical microcrystal conversion. First, the precursor was fabricated by facile MSS in the Nb2O5–KCl system. A good dispersion and high aspect ratio were satisfed simultaneously with a small amount of SrCO3 and KSr2Nb5O15 (KSN) seed. Then, columnar NaNbO3-based particles, 10 μm in length and 1 μm in diameter, were obtained via the simple molten salt reaction from the precursor. The results of NaNbO3-based ceramics suggested that the as-synthesized NaNbO3-based particles had the good mechanical properties and homogeneous chemical composition.

      • KCI등재

        The Effect of Chickpea Dietary Fiber on Lipid Metabolism and Gut Microbiota in High-Fat Diet-Induced Hyperlipidemia in Rats

        Jia Han,Rui Zhang,Dina Muheyati,Mei Xia Lv,Wubulikasimu Aikebaier,Bing Xin Peng 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.2

        Hyperlipidemia is a metabolic disorder characterized by high lipid levels, which may lead to cardiovascular diseases. Evidence suggests that improving the gut microbiota homeostasis is of great importance in lipid metabolism. Dietary fiber may positively regulate blood lipid and intestinal microbiota, therefore, we have investigated the effect of chickpea dietary fiber (CDF) on high-fat diet (HFD)-induced hyperlipidemia and gut bacterial dysbiosis. Fifty male Sprague Dawley rats purchased for this study were randomly divided into 5 groups of 10 rats each. The control group was fed with normal diet (ND), while the other four groups were all fed with HFD for inducing hyperlipidemia. Then one of the four HFD groups continued to be fed with only HFD, and the other three groups were fed with CDF in different doses: high CDF (30 g CDF/kg of HFD), medium CDF (15 g CDF/kg of HFD), and low CDF (5 g CDF/kg of HFD). After CDF treatment, the lipid level in serum was determined through biochemical methods, and microbial content of the fecal sample was determined by 16S rDNA sequencing. We found that CDF could decrease the levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol and increase the level of high-density lipoprotein cholesterol significantly. The diversity of gut microbiota in the ND group and CDF-treated groups were higher than HFD group. The β-diversity analysis showed that there were significant differences in gut microbiota among HFD-, ND-, and CDF-treated groups. Rats in CDF groups tended to be similar and interactive. CDF can effectively increase the abundance of Bacteroides and Lactobacillus in rats and increase the level of propionic acid. These results indicated that CDF might affect serum lipid and gut bacterial ecosystem positively.

      • Application of Lobaplatin in Trans-catheter Arterial Chemoembolization for Primary Hepatic Carcinoma

        Wang, Nan,Lv, Yin-Zhang,Xu, An-Hui,Huang, Yan-Rong,Peng, Ling,Li, Jia-Rui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

        Objective: To explore the efficiency of single application of lobaplatin in tran-scatheter arterial chemoembolization (TACE) for patients with a primary hepatic carcinoma who were unable or unwilling to undergo surgery. Methods: 173 patients with primary hepatic carcinoma diagnosed by imaging or pathology were randomly divided into experimental and control groups and respectively treated with lobaplatin and pirarubicin hydrochloride as chemotherapeutic drugs for TACE. The amount of iodipin was regulated according to the tumor number and size, and then gelatin sponge or polyvinyl alcohol particles were applied for embolisms. The efficiency of treatment in the two groups was compared with reference to survival time and therapeutic response. Results: The experimental group (single lobaplatin as chemotherapy drug) was superior to control group (single pirarubicin hydrochloride as chemotherapy drug) in the aspects of survival time and therapeutic response, with statistical significance. Conclusions: Single lobaplatin can be as a chemotherapy drug in TACE and has better efficiency in the aspects of mean survival time and therapeutic response, deserving to be popularized in the clinic.

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