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Liu-Jing Wei,Ji-lai Zhou,Dan-ni Zhu,Bai-yi Cai,Jin-Ping Lin,Qiang Hua,Dong-Zhi Wei 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.6
In this study a new insight was provided to understand the functions of membrane-bound alcohol dehydrogenase (mADH) and aldehyde dehydrogenase (mALDH) in the bio-oxidation of primary alcohols, diols and poly alcohols using the resting cells of Gluconobacter oxydans DSM 2003 and its mutant strains as catalyst. The results demonstrated that though both mADH and mALDH participated in most of the oxidation of alcohols to their corresponding acid, the exact roles of these enzymes in each reaction might be different. For example,mADH played a key role in the oxidation of diols to its corresponding organic acid in G. oxydans, but it was dispensable when the primary alcohols were used as substrates. In contrast to mADH, mALDH appears to play a relatively minor role in organic acid-producing reactions because of the possible presence of other isoenzymes. Aldehydes were, however, found to be accumulated in the mALDH-deficient strain during the oxidation of alcohols.
Qiang Zhao,Yunpeng Bai,Dan Liu,Nan Zhao,Huiyuan Gao,Xiaozhe Zhang 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.5
Background: Peptides have diverse and important physiological roles in plants and are ideal markers for species identification. It is unclear whether there are specific peptides in Panax quinquefolius L. (PQ). The aims of this study were to identify Quinetides, a series of diverse posttranslational modified native peptides of the ribonuclease-like storage protein (ginseng major protein), from PQ to explore novel peptide markers and develop a new method to distinguish PQ from Panax ginseng. Methods: We used different fragmentation modes in the LTQ Orbitrap analysis to identify the enriched Quinetide targets of PQ, and we discovered Quinetide markers of PQ and P. ginseng using ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry analysis. These “peptide markers” were validated by simultaneously monitoring Rf and F11 as standard ginsenosides. Results: We discovered 100 Quinetides of PQ with various post-translational modifications (PTMs), including a series of glycopeptides, all of which originated from the protein ginseng major protein. We effectively distinguished PQ from P. ginseng using new “peptide markers.” Four unique peptides (Quinetides TP6 and TP7 as markers of PQ and Quinetides TP8 and TP9 as markers of P. ginseng) and their associated glycosylation products were discovered in PQ and P. ginseng. Conclusion: We provide specific information on PQ peptides and propose the clinical application of peptide markers to distinguish PQ from P. ginseng.
Liu, Wen-Long,Wu, Meng-Qiang,Zhou, Ru-Chao,Yan, Li-Dan,Zhang, Shu-Ren,Zhang, Qi-Yi Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.12
The chalcopyrite-type $CuInSe_2$ is a remarkable material for thin film solar cells owing to its electronic structure and optical response. Single-phase sphere-like $CuInSe_2$ nanocrystallite particles were prepared by a facile noninjection method with triethanolamine as the complexing agent and the solvent simultaneously. The period of the reaction was the key to form single-phase $CuInSe_2$ nanocrystals at $240^{\circ}C$. TEM, XRD, XPS, EDX investigations were performed to characterize the morphology and the detailed structure of as-synthesized $CuInSe_2$ nanocrystals. All of the analysis results proved that the synthesized nanocrystals were pure phase and close to the stoichiometric ratio rather than a simple mixture. The band gap of the obtained $CuInSe_2$ nanocrystals was $1.03{\pm}0.03$ eV.
Polymorphisms in MHC class Ia genes and resistance to IHNV in rainbow trout (Oncorhynchus mykiss)
Zhe Liu,Dan Dan Hu,Shu Juan Shao,Juan Yang,Jian Fu Wang,Jin Qiang Huang 한국유전학회 2013 Genes & Genomics Vol.35 No.5
Infectious haematopoietic necrosis virus (IHNV) is detrimental to the farming of rainbow trout (Oncorhynchus mykiss) and other salmonids in the Northern hemisphere. The major histocompatibility complex (MHC) plays a key role in immune response in invertebrates, as evidenced by the close correlation of MHC polymorphisms with disease resistance/susceptibility. To analyse the correlation between rainbow trout resistance and susceptibility to IHNV and genetic variation in exon 2 of MHC class Ia gene, UBA, we employed two approaches, namely, polymerase chain reaction-single strand conformation polymorphism analysis and cloning/sequencing. From 102 resistant and 82 susceptible individuals, a total of 12 alleles in UBA exon 2 (GenBank: JX136662–JX136673) were identified, including 11 novel alleles. The maximum number of these alleles in a single individual was four, suggesting that UBA exon 2 most likely resides on at least two loci in the genome. Most of the variations in UBA exon 2 were located in the peptide-binding region and were determined to have been subject to positive selection during evolution. Correlation analysis revealed that Onmy-UBA*0111 and Onmy-UBA*0107 are highly associated with IHNV susceptibility (P = 0.001), whereas Onmy-UBA*0101, Onmy-UBA*0102, and Onmy-UBA*0103 are highly related to IHNV resistance (P = 0.000). In addition, the three resistant alleles were predominant in the IHNV disease-resistant population; thus, these molecular markers can be used for anti-IHNV breeding of rainbow trout.
Zhihang Peng,Qiang Chen,Dan Liu,Yadan Wang,Dinquan Xiao,Jian-guo Zhu 한국물리학회 2013 Current Applied Physics Vol.13 No.7
Aurivillius type (NaBi)0.5x(LiCe)xBi2Nb2O9 ceramics were prepared by the standard ceramics route. The single crystal structural ceramics were achieved for all compositions and lattice distortion was decreased by (LiCe) dopants. The temperature dependent dielectric properties revealed that all compositions possess a high Curie-temperature (>780 ℃). A modified CurieeWeiss relationship is used to study the diffuseness behavior of a ferroelectric phase transition indicating the degree of diffuseness of NBN-based ceramics increased with (LiCe) modifications. The degradation of resistance implied a plausible model that Ce4þ ions entered into the B-site of the pseudo-perovskite structure and acted as acceptor doping. Further investigation demonstrated that both electrical conduction and dielectric relaxation processes were associated with the oxygen vacancies produced by the substitution of Nb5+ ions by the Ce4+ ions.
Selecting the Optimal Hidden Layer of Extreme Learning Machine Using Multiple Kernel Learning
( Wentao Zhao Pan Li ),( Qiang Liu Dan Liu ),( Xinwang Liu ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.12
Extreme learning machine (ELM) is emerging as a powerful machine learning method in a variety of application scenarios due to its promising advantages of high accuracy, fast learning speed and easy of implementation. However, how to select the optimal hidden layer of ELM is still an open question in the ELM community. Basically, the number of hidden layer nodes is a sensitive hyperparameter that significantly affects the performance of ELM. To address this challenging problem, we propose to adopt multiple kernel learning (MKL) to design a multi-hidden-layer-kernel ELM (MHLK-ELM). Specifically, we first integrate kernel functions with random feature mapping of ELM to design a hidden-layer-kernel ELM (HLK-ELM), which serves as the base of MHLK-ELM. Then, we utilize the MKL method to propose two versions of MHLK-ELMs, called sparse and non-sparse MHLK-ELMs. Both two types of MHLK-ELMs can effectively find out the optimal linear combination of multiple HLK-ELMs for different classification and regression problems. Experimental results on seven data sets, among which three data sets are relevant to classification and four ones are relevant to regression, demonstrate that the proposed MHLK-ELM achieves superior performance compared with conventional ELM and basic HLK-ELM.
Zhihang Peng,Dongxu Yan,Qiang Chen,Deqiong Xin,Dan Liu,Dingquan Xiao,Jian-guo Zhu 한국물리학회 2014 Current Applied Physics Vol.14 No.12
Aurivillius phase Bi3Ti1xTaxNb1xWxO12 high temperature piezoceramics were prepared by a conventional solid state reaction method. The crystal structure, dielectric, electrical conduction and piezoelectric properties were systematically studied. Pure or modified Bi3TiNbO9 ceramics revealed the presence of only two-layered Aurivillius phase, indicating that Ta/W doping entered into the B-site of pseudo-perovskite structure and formed solid solutions. The Curie temperature had a strong reliance on the structural distortion. Furthermore, Ta/W dopants act as a donor doping, decrease the number of oxygen vacancies and facilitate the domain wall motion. As a result, Ta/W modifications significantly increase the DC resistivity and piezoelectric properties. Bi3Ti0.98Ta0.02Nb0.98W0.02O12 ceramics possess the optimum d33 value (~12.5 pC/N) together with a high TC point (~893 C). Moreover, the resonance eantiresonance spectra demonstrate that the Ta/W-BTN ceramics are indeed piezoelectric in nature at 600 C. The d33 value of BTTNW-2 ceramic remains ~12.2 pC/N after annealing at 700 C. These factors suggest that the BTTNW-based ceramic is a promising candidate for ultra-high temperature sensor applications.
Promoter demethylation mediates the expression of ZNF645, a novel cancer/testis gene
( Gang Bai ),( Yun Qiang Liu ),( Hao Zhang ),( Dan Su ),( Da Chang Tao ),( Yuan Yang ),( Yong Xin Ma ),( Si Zhong Zhang ) 생화학분자생물학회 2010 BMB Reports Vol.43 No.6
Cancer/testis (CT) antigens exhibit highly tissue-restricted expression and are considered promising targets for cancer vaccines. Here we identified a novel CT gene ZNF645 which restrictively expresses in normal human testes and lung cancer patients (68.3%). To investigate the promoter methylation status of ZNF645, we carried out bisulfite genomic sequencing and found that the CpG island in its promoter was heavily methylated in normal lung tissues without the expression of ZNF645, whereas there was high demethylation in normal human testes and lung carcinoma tissues with its expression. Also ZNF645 could be remarkably activated in A549 and HEK293T cells treated by DNA demethylation agent 5`-aza-2`-deoxycytidine. And the dual luciferase assay revealed that the promoter activity of the ZNF645 was inhibited by methylation of the CpG island region. Therefore, we proposed that ZNF645 is a CT gene and activated in human testis and lung cancers by demethylation of its promoter region. [BMB reports 2010; 43(6): 400-406]