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Kim, Tae-Hoon,Lee, Kwan Yong,Choi, Young,Park, Ha-Wook,Lee, Young Soo,Koh, Yoon Seok,Park, Hun-Jun,Kim, Pum-Joon,Chang, Kiyuk,Chung, Wook Sung,Kim, Dong-Bin,Her, Sung-Ho,Park, Chul Soo,Lee, Jong Min,K Wolters Kluwer Health, Inc. All rights reserved. 2016 Coronary artery disease Vol.27 No.2
<P>Background Mitral regurgitation (MR) is a frequent complication of left-ventricular dysfunction, with an incidence ranging from 13 to 59% after acute myocardial infarction (AMI), which is associated with poor clinical outcome. The aim of this study was to assess the clinical and angiographic characteristics associated with MR, the incidence and predictors of MR, and the outcomes of MR after AMI in those who were successfully treated with primary percutaneous coronary intervention (PCI) using a drug-eluting stent. Methods We analyzed a multicenter all-comer AMI registry and identified 4748 patients between January 2004 and December 2009. Of these, 1894 patients were treated with PCI using a drug-eluting stent and had MR. The association between MR and the composite of major adverse cardiac and cerebrovascular events (MACCE; all-cause death, recurrent nonfatal myocardial infarction, stroke, and any revascularization) was examined. Results Patients with MR after the index PCI showed significantly higher cumulative incidence of MACCE compared with no-MR patients over the 5-year survival period (P=0.002). When the MR groups were compared on the basis of the severity of MR, ranging from mild to severe grades, a higher grade of MR was found to be associated with a higher incidence of MACCE (P<0.001). Multivariate Cox proportional hazard analysis revealed that no reflow, left-ventricular ejection fraction less than 50%, and anemia, in addition to MR, were consistently associated with increased all-cause death during the 5-year period (adjusted hazard ratio 1.408, 95% confidence interval 1.052-1.884, P=0.021). Conclusion MR after AMI in patients successfully treated with primary PCI was associated with poor long-term outcome regardless of ST-segment elevation at diagnosis during the drug-eluting stent era. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.</P>
Kim, Chan Joon,Choi, Ik-Jun,Park, Hun-Jun,Kim, Tae Hoon,Kim, Pum-Joon,Chang, Kiyuk,Baek, Sang Hong,Chung, Wook Sung,Seung, Ki-Bae S. Karger AG 2016 Cardiorenal medicine Vol.6 No.4
<P>Background: Dysfunctional interplay between the heart and kidneys may lead to the development of anemia. The aim of this study was to evaluate the impact of cardiorenal anemia syndrome (CRAS) on short- and long-term outcomes among patients hospitalized with heart failure (HF). Methods: We enrolled 303 patients hospitalized with HF. We divided the patients into two groups: a CRAS group (n = 64) and a non-CRAS group (n = 239). We defined CRAS as HF accompanied by (1) an estimated glomerular filtration rate <60 ml/min/1.73 m(2) calculated by the Modification of Diet in Renal Disease at admission and (2) a hemoglobin level <12 g/dl for females and <13 g/dl for males at admission. The primary outcome was a composite of cardiac death, non-fatal myocardial infarction and rehospitalization for HF. Results: During a median follow-up period of 25.6 months (range 0.1-35.3 months), the patients with CRAS had a significantly increased risk for the primary outcome (27.5 vs. 10.7%, p < 0.001) compared with the patients in the non-CRAS group. Using Cox proportional hazard analyses, the hazard ratio (HR) for the presence of CRAS was found to be 1.874 (95% confidence interval [CI] 1.011-3.475, p = 0.046); HRs were also computed for the presence of diabetes mellitus (HR = 2.241, 95% CI 1.221-4.112, p = 0.009), New York Heart Association class III or IV HF (HR = 2.948, 95% CI 1.206-7.205, p = 0.018) and the use of intravenous loop diuretics (HR = 2.286, 95% CI 0.926-5.641, p = 0.073). Conclusions: Renal dysfunction and anemia are a fatal combination and are associated with poor prognosis in patients with HF. (C) 2016 S. Karger AG, Basel.</P>
성인에서 반복적인 복부통증을 유발한 Meckel 게실염에 의한 복막유착
김영수(Young Soo Kim),신용운(Yong Woon shin),문희용(Hee Yong Moon),김명식(Myong Sik Kim),권계숙(Kye Sook Kwon),방제소(Jei So Bang),조현근(Hyeon Geun Cho),김범수(Pum Soo Kim),김준미(Joon Mee Kim) 대한소화기학회 1997 대한소화기학회지 Vol.30 No.6
Meckel,s diverticulum is generally acknowledged to be the most prevalent congenital anomaly of the gastrointestinal tract. In the autopsy series, the incidence ranged from 0.5 to 2 percent. The preoperative diagnosis of Meckels divemiculum is difficult, especially in the adult, because of the lesions ability to masquerade as one of a variety of much more common abdominal pathologies. The diagnostic accuracy may be affected by the age of the patient and by complications of diverticulum. The complications that may result include ulcer bleeding, intestinal obstruction, perforation, diverticulitis, stone, and neoplasm. The ways a Meckels diverticulum can cause bowel obstruction are different. Recently we experienced a case of Meckels diverticulitis causing intlammatory reaction and adhesion with the abdominal wall and causing recurrent abdominal pain and obstruction in a 22-year-old woman. Therefore, we present this case with a brief review of the related literature. (Korean J Gastroenterol 1997; 30:826-830)
Park, Hoon Suk,Kim, Chan Joon,Yi, Jeong-Eun,Hwang, Byung-Hee,Kim, Tae-Hoon,Koh, Yoon Seok,Park, Hun-Jun,Her, Sung-Ho,Jang, Sung Won,Park, Chul-Soo,Lee, Jong Min,Kim, Hee Yeol,Jeon, Doo Soo,Kim, Pum-Jo S. Karger AG 2015 Cardiorenal medicine Vol.5 No.1
<P>Abstract</P><P><B><I>Background:</I></B> Considering that contrast medium is excreted through the whole kidney in a similar manner to drug excretion, the use of raw estimated glomerular filtration rate (eGFR) rather than body surface area (BSA)-normalized eGFR is thought to be more appropriate for evaluating the risk of contrast-induced acute kidney injury (CI-AKI). <B><I>Methods:</I></B> This study included 2,189 myocardial infarction patients treated with percutaneous coronary intervention. Logistic regression analysis was performed to identify the independent risk factors. We used receiver-operating characteristic (ROC) curves to compare the ratios of contrast volume (CV) to eGFR with and without BSA normalization in predicting CI-AKI. <B><I>Results:</I></B> The area under the curve (AUC) of the ROC curve for the model including all the significant variables such as diabetes mellitus, left ventricular ejection fraction, preprocedural glucose, and the CV/raw modification of diet in renal disease (MDRD) eGFR ratio was 0.768 [95% confidence interval (CI), 0.720-0.816; p < 0.001]. When the CV/raw MDRD eGFR ratio was used as a single risk value, the AUC of the ROC curve was 0.650 (95% CI, 0.590-0.711; p < 0.001). When the CV/MDRD eGFR ratio with BSA normalization ratio was used, the AUC of the ROC curve further decreased to 0.635 (95% CI, 0.574-0.696; p < 0.001). The difference between the two AUCs was significant (p = 0.002). <B><I>Conclusions:</I></B> Raw eGFR is a better predictor for CI-AKI than BSA-normalized eGFR.</P><P>© 2015 S. Karger AG, Basel</P>
한국인에서 Helicobacter pylori 감염의 혈청학적 역학 연구
김현수 ( Hyun Soo Kim ),이용찬 ( Yong Chan Lee ),이홍우 ( Hong Woo Lee ),유효민 ( Hyo Min Yoo ),이천균 ( Chun Gyon Lee ),김준명 ( Joon Myung Kim ),이광재 ( Kwang Jae Lee ),김범수 ( Pum Soo Kim ),문병수 ( Byung Soo Moon ),박효진 ( 대한소화기학회 1999 대한소화기학회지 Vol.33 No.2
Background/Aims: The aims of this study were to investigate the seroprevalence of H. pylori infec-tion and to find out the various epidemiologic factors related to H. pylori infection in Korea. Methods: From May, 1997 to July, 1997, 2,449 healthy subjects from 5 health center responded to the self- administered questionnaires for various epidemiologic factors. At the same time, H. pylori IgG level in serum were tested by ELISA (GAP test) and proved to be H. pylori 'positive' in cases whose cut-off values were over 15 μ/mL. Results: The overall seroprevalence of H. pylori infection was 44.8%. In relation to age, the seroprevalence of H. pylori infection was 57.8% in adults (age>18), and 15.3% in children (age, 1-18). The seroprevalence was 1.1% in younger group than 5, 12.8% in group aged between 5 and 9, 20.4% in group aged between 10 and 14, 33.3% in group aged between 15 and 19, and 66.7% in the 20' s. The results mean that the prevalence increases with age (p<0.001). Besides age, the other significant epidemiological factors affecting the seroprevalence of H. pylori infection were occupation, water source, presence of gastrointestinal symptoms in adults and FH of PUD and number of family members in children. Conclusions: In this study, the seropre-valence of H. pylori infection in adults was 57.8% which is lower than that of previous reports Further epidemiologic studies is needed to identify the role of epidemiologic factors of childhood and adolescent period, the major affected periods. (Kor J Gastroenterol 1999;33:170 - 182)
Park, Mahn-Won,Her, Sung Ho,Kim, Ho-Sook,Choi, Yun-Seok,Park, Chul-Soo,Koh, Yoon-Seok,Park, Hun-Jun,Kim, Pum-Joon,Kim, Chan Joon,Jeon, Doo Soo,Shin, Dong Il,Seo, Suk Min,Yoo, Ki-Dong,Kim, Dong Bin,Kim Wolters Kluwer Health | Lippincott Williams Wilkin 2013 Pharmacogenetics and genomics Vol.23 No.10
The impact of the CYP2C19*17 polymorphism on the clinical outcome in Asians undergoing percutaneous coronary intervention (PCI) is unknown. We sought to assess the long-term impact of CYP2C19*17 on the risk for adverse clinical events in 2188 Korean patients taking clopidogrel after PCI. The prevalence of the CYP2C19*17 allele [*wt/*17: 2.4% (n=53), *17/*17: 0%] was very low. The 2-year cumulative event rates for bleeding [*wt/*17 vs. *wt/*wt: 2 vs. 2.3%; adjusted hazard ratio (HR), 1.23; 95% confidence interval (CI), 0.16–9.45], stent thrombosis (2 vs. 1.1%; HR, 3.98; 95% CI, 0.49–31.6) or composite of any death, and myocardial infarction or stroke (5.4 vs. 7.1%; HR, 1.37; 95% CI, 0.32–5.73) did not differ on the basis of the presence of CYP2C19*17. In conclusion, in our study population of Asian patients, the CYP2C19*17 polymorphism was not associated with adverse clinical outcomes after PCI because of its low prevalence, the rarity of homozygotes, and the relatively low rate of adverse clinical events.
Lee, Kwan Yong,Hwang, Byung-Hee,Kim, Tae-Hoon,Kim, Chan Jun,Kim, Jin-Jin,Choo, Eun-Ho,Choi, Ik Jun,Choi, Young,Park, Ha-Wook,Koh, Yoon-Seok,Kim, Pum-Joon,Lee, Jong Min,Kim, Mi-Jeong,Jeon, Doo Soo,Cho, American Diabetes Association 2017 Diabetes Care Vol. No.
<P>OBJECTIVEWe investigated the efficacy of coronary computed tomography angiography (CCTA) in predicting the long-term risks in asymptomatic patients with type 2 diabetes and compared it with traditional risk factors.RESEARCH DESIGN AND METHODSWe analyzed 933 patients with asymptomatic type 2 diabetes who underwent CCTA. Stenosis was considered obstructive (50%) in each coronary artery segment using CCTA. The extent and severity scores for coronary artery disease (CAD) were evaluated. The primary end point was major adverse cardiovascular events (MACE), including all-cause mortality, nonfatal myocardial infarction, and late coronary revascularization during a mean follow-up period of 5.5 2.1 years.RESULTSNinety-four patients with MACE exhibited obstructive CAD with a greater extent and higher severity scores (P < 0.001 for all). After adjusting for confounding risk factors, obstructive CAD remained an independent predictor of MACE (hazard ratio 3.11 [95% CI 2.00-4.86]; P < 0.001]). The performance of a risk prediction model based on C-statistics was significantly improved (C-index 0.788 [95% CI 0.747-0.829]; P = 0.0349) upon the addition of a finding of obstructive CAD using CCTA to traditional risk factors, including age, male, hypertension, hyperlipidemia, smoking, estimated glomerular filtration rate, and HbA(1c). Both integrated discrimination improvement (IDI) and net reclassification improvement (NRI) analyses further supported this finding (IDI 0.046 [95% CI 0.020-0.072], P < 0.001, and NRI 0.55 [95% CI 0.343-0.757], P < 0.001). In contrast, the risk prediction power of the coronary artery calcium score remained unimproved (C-index 0.740, P = 0.547).CONCLUSIONSBased on our data, the addition of CCTA-detected obstructive CAD to models that include traditional risk factors improves the predictions of MACE in asymptomatic patients with type 2 diabetes.</P>
Significance of Inflammatory Markers in Diabetic Patients with Stable Coronary Artery Disease
( Hyo Jin Lee ),( Sung Ho Her ),( Yun Sun Im ),( Kang Yeon Won ),( Sun Hong Yoo ),( Dong Bin Kim ),( Dong Il Shin ),( Pum Joon Kim ),( Ki Bae Seung ),( Jae Hyung Kim ),( Keon Yeop Kim ) 대한내과학회 2009 The Korean Journal of Internal Medicine Vol.24 No.3
Background/Aims: Patients with diabetes are prone to coronary artery disease (CAD); however, the majority of diabetic patients show normal coronary arteries. We examined differences in the clinical aspects of diabetic patients with insignificant and with significant stenosis of the coronary artery. Methods: A total of 418 consecutive diabetic patients with stable angina who had undergone coronary angiography from January 2004 to March 2007 were included in this study. Patients were subdivided into control and CAD groups and then clinical characteristics and CAD-associated factors were evaluated. Results: A total of 92 (22%) patients were assigned to the control group and 326 (78%) patients were assigned to the CAD group. Using univariate regression analysis, we found that patients with CAD were significantly older (control vs. CAD; 59±21 vs. 64.7±33.7, years, p<0.001), had a longer duration of diabetes (8.2±21.8 vs. 10.2±29.8, years, p=0.027), higher titers of high sensitivity C-reactive protein (hsCRP; 0.3±6.79 vs. 0.9±12.6, mg/dL, p=0.015), and increased hemoglobin A1c (HbA1c) levels (7.1±3.8 vs. 7.5±4.8, %, p=0.007) compared to control patients. Multivariate regression analysis showed that only differences in age, hsCRP, and HbA1c were statistically significant. When patients were subdivided into groups based on hsCRP levels (208 patients in the low group [49.8%], 210 patients in the high group [50.2%]), we found that patients with higher hsCRP levels showed more frequent multivessel disease. Conclusions: In diabetic patients, age, hsCRP, and HbA1c were associated with stable CAD. Among these factors, hsCRP levels were significantly correlated with multivessel involvement in diabetic CAD. Therefore, high hsCRP levels may be a strong predictor for atherosclerotic progression of the coronary arteries in diabetic patients, suggesting that regular screening tests should be performed. (Korean J Intern Med 2009;24:212-219)
Kim, Jeong Kyu,Kim, Pum Joon,Jung, Kwang Hwa,Noh, Ji Heon,Eun, Jung Woo,Bae, Hyun Jin,Xie, Hong Jian,Shan, Jin Mei,Ping, Wang Ying,Park, Won Sang,Lee, Jung Young,Nam, Suk Woo Spandidos Publications 2010 ONCOLOGY REPORTS Vol.24 No.3
<P>Gastric carcinoma is the most common neoplasm in Southeast Asian populations and is the second leading cause of cancer death worldwide. Annexins are a family of cytosolic calcium and membrane binding proteins that have been implicated in a wide variety of cell functions. Recent studies have suggested that Annexin A10 (ANXA10), a member of the Annexin protein family, is down-regulated in specific types of cancer. However, the underlying molecular mechanisms of the dysregulation of ANXA10 remain to be elucidated. In the present study, to investigate the biological effects of ANXA10 on gastric carcinoma, aberrant expression of ANXA10 was evaluated by Western blot analysis, reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry (IHC), in gastric cancer tissues and cell lines. Decreased expression of ANXA10 was observed in five selected gastric cancer tissues compared to the normal surrounding mucosa. In the cancer cell lines, seven out of nine selected gastric cancer cell lines had no detectable ANXA10 by RT-PCR. Among these, when an ANXA10 expressing plasmid was introduced into MKN-1 cells, cell growth was suppressed and apoptosis augmented. The results of this study demonstrated that ANXA10 was aberrantly regulated in gastric carcinoma and suggests that down-regulation of ANXA10 might be involved in gastric carcinogenesis. In addition, ANXA10 may play a role, as a tumor suppressor, in the development and progression of gastric cancer.</P>