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- 저자 : ( Pengcheng Wang ) (검색결과 42 건)
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Pengcheng Tu,Yalan Pan,Lining Wang,Bin Li,Xiaoxian Sun,Zhongqing Liang,Mengmin Liu,Zitong Zhao,Chengjie Wu,Jianwei Wang,Zhifang Wang,Yu Song,Yafeng Zhang,Yong Ma,Yang Guo 한국생체재료학회 2024 생체재료학회지 Vol.28 No.00
Background: In the environment of cartilage injury, the activation of vascular endothelial cell (VEC), marked with excessive CD62E and reactive oxygen species (ROS), can affect the formation of hyaluronic cartilage. Therefore, we developed a CD62E- and ROS-responsive drug delivery system using E-selectin binding peptide, Thioketal, and silk fibroin (ETS) to achieve targeted delivery and controlled release of Clematis triterpenoid saponins (CS) against activated VEC, and thus promote cartilage regeneration. Methods: We prepared and characterized ETS/CS and verified their CD62E- and ROS-responsive properties in vitro. We investigated the effect and underlying mechanism of ETS/CS on inhibiting VEC activation and promoting chondrogenic differentiation of bone marrow stromal cells (BMSCs). We also analyzed the effect of ETS/CS on suppressing the activated VEC-macrophage inflammatory cascade in vitro. Additionally, we constructed a rat knee cartilage defect model and administered ETS/CS combined with BMSC-containing hydrogels. We detected the cartilage differentiation, the level of VEC activation and macrophage in the new tissue, and synovial tissue. Results: ETS/CS was able to interact with VEC and inhibit VEC activation through the carried CS. Coculture experiments verified ETS/CS promoted chondrogenic differentiation of BMSCs by inhibiting the activated VEC-induced inflammatory cascade of macrophages via OPA1-mediated mitochondrial homeostasis. In the rat knee cartilage defect model, ETS/CS reduced VEC activation, migration, angiogenesis in new tissues, inhibited macrophage infiltration and inflammation, promoted chondrogenic differentiation of BMSCs in the defective areas. Conclusions: CD62E- and ROS-responsive ETS/CS promoted cartilage repair by inhibiting VEC activation and macrophage inflammation and promoting BMSC chondrogenesis. Therefore, it is a promising therapeutic strategy to promote articular cartilage repair.
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Traceable Ciphertet-Policy Attribute-Based Encryption with Constant Decryption
( Guangbo Wang ),( Feng Li ),( Pengcheng Wang ),( Yixiao Hu ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.9
We provide a traceable ciphertext-policy attribute based encryption (CP-ABE) construction for monotone access structures (MAS) based on composite order bilinear groups, which is secure adaptively under the standard model. We construct this scheme by making use of an "encoding technique" which represents the MAS by their minimal sets to encrypt the messages. To date, for all traceable CP-ABE schemes, their encryption costs grow linearly with the MAS size, the decryption costs grow linearly with the qualified rows in the span programs. However, in our traceable CP-ABE, the ciphertext is linear with the minimal sets, and decryption needs merely three bilinear pairing computations and two exponent computations, which improves the efficiency extremely and has constant decryption. At last, the detailed security and traceability proof is given.
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Weiqi Wang,Yicheng Ye,Qihu Wang,Xiaoyun Liu,Zhouhao Yuan,Pengcheng Li 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.2
The deformation and failure of composite rock masses at the contact zone can cause serious safety hazards in underground engineering. Therefore, uniaxial compression experiment and numerical studies of composite samples were conducted. Combined with theoretical analysis, the effects of differences in the mechanical properties of two media on the mechanical properties and failure form of composite samples were investigated. The results show that the difference in mechanical properties of two media weakened the strength and elastic modulus of the composite sample and resulted in complex failure form of the sample. Additionally, the peaks of the AE frequencies of the two media occurred successively after the peak stress of the sample. At the macrolevel, the two media failed successively. These effects are more pronounced as the degree of difference in the mechanical properties of the two media increased. The difference in mechanical properties of the two media resulted in uncoordinated deformation and constrained stress near the contact interface, and the difference in Poisson's ratio is the main factor. The influence (enhanced or weakened) of uncoordinated deformation on the mechanical properties of the composite sample is affected by differences in the elastic modulus and Poisson's ratios of the two media.
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Zou, Yi,Chen, Linying,Wang, Xingfu,Chen, Yupeng,Hu, Liwen,Zeng, Saifan,Wang, Pengcheng,Li, Guoping,Huang, Ming,Wang, Liting,He, Shi,Li, Sanyan,Jian, Lihui,Zhang, Sheng The Korean Gastric Cancer Association 2019 Journal of gastric cancer Vol.19 No.1
Purpose: The significance of neuroendocrine differentiation (NED) in gastric carcinoma (GC) is controversial, leading to ambiguous concepts in traditional classifications. This study aimed to determine the prognostic threshold of meaningful NED in GC and clarify its unclear features in existing classifications. Materials and Methods: Immunohistochemical staining for synaptophysin, chromogranin A, and neural cell adhesion molecule was performed for 945 GC specimens. Survival analysis was performed using the log-rank test and univariate/multivariate models with percentages of NED ($P_{NED}$) and demographic and clinicopathological parameters. Results: In total, 275 (29.1%) cases were immunoreactive to at least 1 neuroendocrine (NE) marker. GC-NED was more common in the upper third of the stomach. $P_{NED}$, and Borrmann's classification and tumor, lymph node, metastasis stages were independent prognostic factors. The cutoff $P_{NED}$ was 10%, beyond which patients had significantly worse outcomes, although the risk did not increase with higher $P_{NED}$. Tumors with ${\geq}10%$ NED tended to manifest as Borrmann type III lesion with mixed/diffuse morphology and poorer histological differentiation; the NE components in this population mainly grew in insulae/nests, which differed from the predominant growth pattern (glandular/acinar) in GC with <10% NED. Conclusions: GC with ${\geq}10%$ NED should be classified as a distinct subtype because of its worse prognosis, and more attention should be paid to the necessity of additional therapeutics for NE components.
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Yi Zou,Linying Chen,Xingfu Wang,Yupeng Chen,Liwen Hu,Saifan Zeng,Pengcheng Wang,Guoping Li,Ming Huang,Liting Wang,Shi He,Sanyan Li,Lihui Jian,Sheng Zhang 대한위암학회 2019 Journal of gastric cancer Vol.19 No.1
Purpose: The significance of neuroendocrine differentiation (NED) in gastric carcinoma (GC) is controversial, leading to ambiguous concepts in traditional classifications. This study aimed to determine the prognostic threshold of meaningful NED in GC and clarify its unclear features in existing classifications. Materials and Methods: Immunohistochemical staining for synaptophysin, chromogranin A, and neural cell adhesion molecule was performed for 945 GC specimens. Survival analysis was performed using the log-rank test and univariate/multivariate models with percentages of NED (PNED) and demographic and clinicopathological parameters. Results: In total, 275 (29.1%) cases were immunoreactive to at least 1 neuroendocrine (NE) marker. GC-NED was more common in the upper third of the stomach. PNED, and Borrmann's classification and tumor, lymph node, metastasis stages were independent prognostic factors. The cutoff PNED was 10%, beyond which patients had significantly worse outcomes, although the risk did not increase with higher PNED. Tumors with ≥10% NED tended to manifest as Borrmann type III lesion with mixed/diffuse morphology and poorer histological differentiation; the NE components in this population mainly grew in insulae/nests, which differed from the predominant growth pattern (glandular/acinar) in GC with <10% NED. Conclusions: GC with ≥10% NED should be classified as a distinct subtype because of its worse prognosis, and more attention should be paid to the necessity of additional therapeutics for NE components.
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Pengcheng Qin,Jie He,Changjian Zhang,Yuntao Ye,Hao Zhang,Mingnian Wang,Tao Yan 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.9
Extra-long tunnels have adverse effects on driving performance since drivers will be affected by the enclosed, dimly lit, and monotonous environment for a longer time. In the context of the increasing number of extra-long tunnels, this study aims to investigate the effects of extra-long freeway tunnels with a length of 20 km on driving performance using driving simulation tests. Factors including the tunnel environment, driving time, traffic flow, and gender were considered as influencing factors. Performance indicators including the brake reaction time, standard deviation of driving speed, and standard deviation of lateral position were collected. A total of 60 drivers were recruited for the driving simulation study, and the relationships between the driving performance indicators and influencing factors were analyzed by establishing linear mixed models with random intercept. The results demonstrate that driving performance significantly degraded after 5 − 6 min of driving in the extra-long tunnel although drivers were more cautious and presented a better performance when just entering the tunnel. Moderately higher traffic flow could improve driving performance in the extra-long tunnel but not on the open road. Meanwhile, female drivers had better lateral and longitudinal stability in the extra-long tunnel, while no significant difference was witnessed in reaction ability and driving performance on the open road.
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Pengcheng Han,Xiaoqiong He,Zhiqin Zhao,Haolun Yu,Yi Wang,Xu Peng,Zeliang Shu 전력전자학회 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.1
This study proposes a new modulation strategy to deal with unbalanced output voltage that is based on three-levelneutral-point-clamped cascaded rectifiers. The fundament idea is to reallocate the value of the voltage levels generated by each ofthe modules on the basis of space vector pulse width modulation. This proposed modulation strategy can reduce the switchingfrequency while maintaining the mutual-module voltage balance. First, an analysis of unbalanced output voltage is reflected. Then a new modulation strategy is introduced in detail. Internal module capacitor voltages are balanced by the selection ofredundant vectors. Moreover, the voltage balance ability is calculated. Finally, the feasibility of this modulation strategy isverified through experimental results.
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Stability analysis of prestressed stayed steel columns with split-up crossarm systems
Pengcheng Li,Zhiqiang Li,Bin Jia,Hao Wang 국제구조공학회 2020 Steel and Composite Structures, An International J Vol.34 No.5
A Prestressed stayed steel column is an efficient and lightweight way with regard to enhancing the stability behaviour of a compression column. In the past, researchers primarily concentrated on investigating the behaviour of stayed steel columns with horizontal crossarms. However, this article focuses on prestressed stayed steel columns with split-up crossarm system, in which the crossarms are aslant and rotational symmetrically arranged. A mathematical formula calculating the optimal pretension that corresponds to the maximum critical buckling load was established according to geometric analysis based on the small deformation assumption. It was demonstrated that critical buckling mode of this stayed column is different from the one with horizontal crossarms. The governing imperfection direction that should be adopted in the nonlinear buckling analysis was determined in this work. In addition, the effects of crossarm inclination, stay diameter, and crossarm length on the stability behaviour were investigated. An influencing factor denotes the ratio of the load carrying capacity of the prestressed stayed steel column to the Euler load of the main column was also obtained.
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