촉지적 공간을 통한 시간성에 관한 연구(2)

박미영(Park, Miyoung) 한국실내디자인학회 2014 한국실내디자인학회논문집 Vol.23 No.1

The purpose of this study is to investigate Seonyudo Park and Kkummaru in terms of haptic space. This is also an attempt to explore temporality of appearing in architectural spaces with reference to cinematic expression in which time is visible and perceptible. The film of Chris Marker’s La Jetee depicts temporal relationship by indeterminate continuum, reading the space on the disjunctive relationships of visual and auditory, and aberrance of time and space. Based on the three categories that is derived from those discussions, this study analyzes the experience of non-chronological time induced by architectural devices: the bifurcation of indeterminate circulation, the readability of space on the disjunction of visual and auditory, and the border-dismantling. Therefore, this study have a relationship with the contemporary discourse on time and events as transformation and becoming, and it means to escape from the deterministic thinking to emphasize invariability and space rather than variation and time.

촉지적 공간을 통한 시간성에 관한 연구

박미영(Park, Miyoung) 한국실내디자인학회 2013 한국실내디자인학회논문집 Vol.22 No.6

The purpose of this study is to investigate Seonyudo Park and Kkummaru in terms of haptic space. This is an attempt to escape from the limits of optical space that identifies the space with abstract concepts. Haptic perception of the space refers to feeling the space with all the senses through non-hierarchical interactions. Time of the haptic space is revealed by Deleuze’s crystalline description and Bergson’s pure recollection that is not useful to identify objects. According to two concepts, the running present forks into the past and the future, and the nature of time appears at the point of indiscernibility in which the past, present, and future coexist. Thought on time about the architecture provides a valid point of view to understand the relationship of visitor’s sensory experience of space, recollection, and emotion. In this respect, it can be said that Joh sung-yong’s two works explored for new areas of architectural experience by building up the potential image of the subject which is placed in the human memory. And then this study shows that two works recover the relationship between the past and the present so that they give an opportunity to consider the meaning of time in the architecture.

Do TRPV1 antagonists increase the risk for skin tumourigenesis? A collaborative in vitro and in vivo assessment

Park, Miyoung,Naidoo, Anita A.,Burns, Angie,Choi, Jin Kyu,Gatfield, Kelly M.,Vidgeon-Hart, Martin,Bae, Il-Hong,Lee, Chang Seok,Choi, Gyeyoung,Powell, Andrew J.,Park, Young-Ho,Fagg, Rajni Springer-Verlag 2018 Cell biology and toxicology Vol.34 No.2

<P>A recent hypothesis suggesting that the pharmacological target TRPV1 (transient receptor potential vanilloid subfamily, member 1) may function as a tumour suppressor, which potentially impacts the development of TRPV1 antagonist therapeutics for a range of conditions. However, little is known about the long-term physiologic effects of TRPV1 blockade in the skin. In vitro and in vivo studies suggested that the potent TRPV1 competitive antagonist AMG-9810 promoted proliferation in N/TERT1 cells (telomerase-immortalised primary human keratinocytes 1) and tumour development in mouse skin that was mediated through EGFR/Akt/mTOR signalling. We attempted to reproduce the reported in vitro and in vivo findings to further explore this hypothesis to understand the underlying mechanism and the risk associated with TRPV1 antagonism in the skin. In vitro proliferation studies using multiple methods and topical application with AMG-9810 and structurally similar TRPV1 antagonists such as SB-705498 and PAC-14028 were performed. Although we confirmed expression of TRPV1 in primary human epidermal keratinocytes (HEKn) and spontaneously immortalised human keratinocytes (HaCaT), we were unable to demonstrate cell proliferation in either cell type or any clear evidence of increased expression of proteins in the EGFR/Akt/mTOR signalling pathway with these molecules. We were also unable to demonstrate skin tumour promotion or underlying molecular mechanisms involved in the EGFR/Akt/mTOR signalling pathway in a single-dose and two-stage carcinogenesis mouse study treated with TRPV1 antagonists. In conclusion, our data suggest that inhibiting the pharmacological function of TRPV1 in skin by specific antagonists has not been considered to be indicative of skin tumour development.</P>

Total Energy Intake with Physical Activity, Especially Walking, is the Considerable Determinants of the Prevalence of Metabolic Syndrome in Korean Aged 19-64 Men -Based on 2014-2015 Korean National Health and Nutrition Survey-

Miyoung Park,Soyoung Sung,Juhee Kim,Minjee Lee,Myoungsook Lee 한국식생활문화학회 2019 한국식생활문화학회학술대회논문집 Vol.2019 No.05

Mediating Effect of Psychological Empowerment on the Causal Relationship between High-Performance Work System and Organizational Citizenship Behavior in Social Welfare Organizations

Miyoung, Park 국제문화기술진흥원 2020 International Journal of Advanced Culture Technolo Vol.8 No.1

The study is to examine the mediating effect of psychological empowerment on the causal relationship between high-performance work system and organizational citizenship behavior. This study collected data from public organizations that are responsible for social welfare provision in Daegu, Gyeongsangbuk-Do, and Pusan in South Korea. This study employs confirmatory factor analysis in Amos 21 to find the discriminant validity of all constructs and regression analysis by Baron and Kenny (1986) to test that psychological empowerment is a mediator of the causal relationship between high-performance work system and organizational citizenship behavior. As the result of the analysis, psychological empowerment has a significant mediating effect on the relationship between high-performance work system and organizational citizenship behavior. The study suggests to the managers in social welfare organizations how they need to enhance organizational citizenship behavior through psychological empowerment themselves.

A Conceptual Analysis of Impatience of Cancer Patients

Miyoung Park,Hana Yoo,Myung Soon Joo 한국간호과학회 2009 한국간호과학회 학술대회 Vol.2009 No.10

Concurrent p16 methylation pattern as an adverse prognostic factor in multiple myeloma: a methylation-specific polymerase chain reaction study using two different primer sets.

Park, Geon,Kang, Seong Ho,Lee, Jae Hoon,Suh, Cheolwon,Kim, Miyoung,Park, Seung Man,Kim, Tae Young,Oh, Bora,Min, Hyun Jung,Yoon, Sung Soo,Yang, In Chul,Cho, Han Ik,Lee, Dong Soon Springer International 2011 Annals of hematology Vol.90 No.1

<P>Disruption of cell cycle control genes, including p16, is known to contribute to the cancerogenesis of multiple myeloma (MM). We investigated the methylation status of p16 and its association with common cytogenetic changes, clinicolaboratory findings, and survival in MM. Methylation-specific polymerase chain reaction was performed in 99 newly diagnosed MM patients using two different sets of primers (p16M1 and p16M2). Four patterns of p16 promoter methylation were observed: (1) concurrent methylation of p16M1 and p16M2 (P1P2), 27.3%; (2) methylation of p16M1 alone (P1N2), 7.1%; (3) methylation of p16M2 alone (N1P2), 26.3%; and (4) no methylation (N1N2), 39.4%. Patients with p16P1P1 showed shorter survivals than those with the other methylation patterns (P1N2, N1P2, or N1N2; median survival, 12 vs. 43 months; P < 0.001), regardless of the treatment protocol. In a multivariate analysis, p16P1P2 was an independent prognostic factor of adverse outcome in MM. According to International Staging System (ISS), the study population could be divided into 21.2% (20/94) for stage I, 22.3% (21/94) for stage II, and 56.4% (53/94) for stage III (P = 0.003). ISS can divide patients into prognostic groups. Of note, in patients older than 60 years, ISS was not reflective of disease stage (P = 0.114). If p16P1P2 sets up as stage 4 of ISS, modified ISS could be a more reliable staging system irrespective of age in Korean MM patients (P = 0.003 and P = 0.004 in patients younger than 60 years and in patients older than 60 years, respectively). Our study suggests the potential use of p16 methylation status in predicting the outcome of MM patients and the applicability of demethylating agents in MM.</P>

Current Status of Flow Cytometric Immunophenotyping of Hematolymphoid Neoplasms in Korea

Park Mikyoung,Lim Jihyang,Ahn Ari,Oh Eun-Jee,Song Jaewoo,Kim Kyeong-Hee,Han Jin-Yeong,Choi Hyun-Woo,Park Joo-Heon,Shin Kyung-Hwa,Kim Hyerim,Kim Miyoung,Hwang Sang-Hyun,Kim Hyun-Young,Cho Duck,Kang Eun 대한진단검사의학회 2024 Annals of Laboratory Medicine Vol.44 No.3

Background: Flow cytometric immunophenotyping of hematolymphoid neoplasms (FCI-HLN) is essential for diagnosis, classification, and minimal residual disease (MRD) monitoring. FCI-HLN is typically performed using in-house protocols, raising the need for standardization. Therefore, we surveyed the current status of FCI-HLN in Korea to obtain fundamental data for quality improvement and standardization. Methods: Eight university hospitals actively conducting FCI-HLN participated in our survey. We analyzed responses to a questionnaire that included inquiries regarding test items, reagent antibodies (RAs), fluorophores, sample amounts (SAs), reagent antibody amounts (RAAs), acquisition cell number (ACN), isotype control (IC) usage, positive/negative criteria, and reporting. Results: Most hospitals used acute HLN, chronic HLN, plasma cell neoplasm (PCN), and MRD panels. The numbers of RAs were heterogeneous, with a maximum of 32, 26, 12, 14, and 10 antibodies used for acute HLN, chronic HLN, PCN, ALL-MRD, and multiple myeloma-MRD, respectively. The number of fluorophores ranged from 4 to 10. RAs, SAs, RAAs, and ACN were diverse. Most hospitals used a positive criterion of 20%, whereas one used 10% for acute and chronic HLN panels. Five hospitals used ICs for the negative criterion. Positive/negative assignments, percentages, and general opinions were commonly reported. In MRD reporting, the limit of detection and lower limit of quantification were included. Conclusions: This is the first comprehensive study on the current status of FCI-HLN in Korea, confirming the high heterogeneity and complexity of FCI-HLN practices. Standardization of FCI-HLN is urgently needed. The findings provide a reference for establishing standard FCI-HLN guidelines.

Dynamic changes in clinical biomarkers of cardiometabolic diseases by changes in exercise behavior, and network comparisons: a community-based prospective cohort study

Park JooYong,Choi Jaesung,Kim Ji-Eun,Park Sang Min,Cho Joo-Youn,강대희,Lee Miyoung,최지엽 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: Lifestyles, including exercise behaviors, change continually over time. This study examined whether the clinical biomarkers (CBs) related to cardiometabolic diseases (CMDs) and their relationships differed with changes in exercise behavior. METHODS: The Ansan-Ansung cohort study (third to fifth phases; n=2,668) was used in the current study. Regular exercise behavior was investigated using a yes/no questionnaire. Changes in exercise behavior were classified into 4 groups: Y-N, N-Y, Y-Y, and N-N, with “Y” indicating that a participant regularly engaged in exercise at a given time point and “N” indicating that he or she did not. Fourteen CBs related to CMDs were used, and the associations between changes in exercise behavior and relative changes in CBs were examined. CB networks were constructed and topological comparisons were conducted.RESULTS: Y-N was associated with increases in fasting blood sugar and insulin levels in men, and increased total cholesterol and low-density lipoprotein cholesterol levels in women. Meanwhile, N-Y was inversely associated with body fat percentage, visceral fat percentage, fasting insulin, and triglyceride level. Waist circumference played a central role in most networks. In men, more edges were found in the N-Y and Y-Y groups than in the N-N and Y-N groups, whereas women in the N-Y and Y-Y groups had more edges than those in the N-N and Y-N groups. CONCLUSIONS: Consistent exercise or starting to engage in regular exercise had favorable effects on CBs related to CMDs, although their network patterns differed between the sexes.

케냐의 지속가능한 모자보건 증진을 위한 감염병 퇴치 도전과 성과

박미영(Miyoung Park),정명애(Myung-Ae Chung),안경숙(Kyungsook Ahn) 적정기술학회 2022 적정기술학회지(Journal of Appropriate Technology) Vol.8 No.3

케냐에서는 임산부 무상 케어 프로그램인 ‘린다 마마 프로그램’을 시행하고 있지만, 2017년 기준 출생아 10만 명 당 임산부 사망률이 342에 달하며 에이즈, B형 간염, 매독 등 감염률이 높은 상황이다. 신속간이검사(래피드진단)를 중심으로 진단이 이루어지고 있으나 정확도가 떨어지고 있어, 정확하고 신속한 진단 방법이 필요하다. 이에 한국국제협력단(KOICA)의 혁신적 기술 프로그램(CTS)을 통해 병원 이외에 학교, 지역 보건소 등에서 최소 교육으로도 검사가 가능한 에이즈, B형 간염, 매독을 진단할 수 있는 다중면역진단기기 및 다중진단키트를 개발하였다. 진단키트의 민감도 및 특이도는 각 90% 이상으로 나타났으며 이는 신속진단키트 대비 20% 이상 향상된 것이다. 가격경쟁력을 갖춘 진단기기와 키트 보급으로 15세 이상 49세 이하 가임여성들의 에이즈, B형 간염, 매독 감염에 대한 지속적인 모니터링이 가능해짐으로서 모자 보건 증진에 기여할 수 있을 것이다. In Kenya, the ‘Linda Mama Program’, a free care program for pregnant women, is being implemented, but as of 2017, maternal deaths per 100,000 live births reached 342, and the infection rate such as AIDS, hepatitis B, and syphilis is high. Diagnosis is being made centering on a quick simple test (rapid diagnosis), but the reliability is low, so an accurate and quick diagnosis method is needed. Through the Innovative Technology Program (CTS) of Korea International Cooperation Agency (KOICA), we developed a multi-immune diagnostic device and multi-diagnostic kit that can diagnose AIDS, hepatitis B, and syphilis, which can be tested with minimal education at schools and local public health centers in addition to hospitals. The sensitivity and specificity of the diagnostic kit were each 90% or more, which was improved by more than 20% compared to the rapid diagnostic kits. The supply of cost-competitive diagnostic devices and test kits will enable continuous monitoring of AIDS, hepatitis B, and syphilis infections among women of childbearing age between the ages of 15 and 49, thereby contributing to the improvement of maternal and child health.