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김희현,최지엽,오민경,김은영,김종률,최석진,신재국,Kim, Hee Hyun,Choi, Ji Yeob,Oh, Min Kyung,Kim, Eun Young,Ghim, Jong Ryul,Choi, Seok Jin,Shin, Jae Gook 대한임상약리학회 2012 臨床藥理學會誌 Vol.20 No.2
Background: This study was performed to evaluate the prevalence and risk factors on the adverse reactions caused by iodinated contrast media (CM) for computed tomography (CT) examination in a university hospital. Methods: Clinical and demographic data among outpatients with CM use were collected at 0000 University Busanpaik Hospital in Busan, Korea between 2008 and 2010. Adverse reaction rate was calculated by the number of adverse reaction among total outpatients with CM use, which was stratified by seasons and sex. The association of risk factors on adverse reaction was investigated using logistic regression model. Results: The total outpatients and events of administered CMs were 27,587 and 48,616, respectively. The administered CMs were iopromide, iohexol, iobitridol, and iodixanol. Adverse reactions occurred in 300 outpatients among the total outpatients (1.1 %). The number of outpatients administered CM more than twice were 8,348. Among them, outpatients who experienced adverse reaction(s) more than once and twice were 124 (1.5 %) and 26 (0.3 %), respectively. Adverse reaction rate was significantly different by sex(p=0.01). The other risk factors were cancer history (OR 2.57, 95 % CI 2.00-3.31) and previous CM administration (OR 1.89, 95 % CI 1.47-2.44). Urticaria was the most frequent symptoms. Conclusion: Total adverse reaction rate was 1.1 % with most common symptom in skin system. Related risk factors were female, cancer history, and previous CM administration. These results were similar to previous studies and will be contribute to clinical practice and future research especially in Koreans.
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김희현,최지엽,오민경,김은영,김종률,최석진,신재국 대한임상약리학회 2012 Translational and Clinical Pharmacology Vol.20 No.2
Background: This study was performed to evaluate the prevalence and risk factors on the adverse reactions caused by iodinated contrast media (CM) for computed tomography (CT) examination in a university hospital. Methods: Clinical and demographic data among outpatients with CM use were collected at 0000 University Busanpaik Hospital in Busan, Korea between 2008 and 2010. Adverse reaction rate was calculated by the number of adverse reaction among total outpatients with CM use, which was stratified by seasons and sex. The association of risk factors on adverse reaction was investigated using logistic regression model. Results: The total outpatients and events of administered CMs were 27,587 and 48,616, respectively. The administered CMs were iopromide, iohexol, iobitridol, and iodixanol. Adverse reactions occurred in 300 outpatients among the total outpatients (1.1 %). The number of outpatients administered CM more than twice were 8,348. Among them, outpatients who experienced adverse reaction(s) more than once and twice were 124 (1.5 %) and 26 (0.3 %), respectively. Adverse reaction rate was significantly different by sex(p=0.01). The other risk factors were cancer history (OR 2.57, 95 % CI 2.00-3.31) and previous CM administration (OR 1.89, 95 % CI 1.47-2.44). Urticaria was the most frequent symptoms. Conclusion: Total adverse reaction rate was 1.1 % with most common symptom in skin system. Related risk factors were female, cancer history, and previous CM administration. These results were similar to previous studies and will be contribute to clinical practice and future research especially in Koreans.
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최형진,최지엽,조선욱,강대희,한기옥,김상완,김성연,정윤석,신찬수 연세대학교의과대학 2010 Yonsei medical journal Vol.51 No.2
Purpose: Genetic factor is an important predisposing element influencing the susceptibility to osteoporosis and related complications. The purpose of the present study is to investigate whether genetic polymorphisms of farnesyl diphosphate synthase (FDPS) or geranylgeranyl diphosphate synthase (GGPS)genes were associated with the response to bisphosphonate therapy. Materials and Methods: In the present study, 144 Korean women with osteoporosis were included. Among 13 genetic polymorphisms found within the FDPS and GGPS1gene, 4 genetic polymorphisms with frequencies > 5% were selected for further study. Bone mineral density (BMD) response after 1 year treatment of bisphosphonate therapy was analyzed according to the genotypes. Results:Women with 2 deletion allele of GGPS1 -8188A ins/del (rs3840452) had significantly higher femoral neck BMD at baseline compared with those with one or no deletion allele (0.768 ± 0.127 vs. 0.695 ± 0.090 respectively; p =0.041). The response rate of women with 2 deletion allele of GGPS1 -8188A ins/del (28.6%) was significantly lower than the rate of women with one (81.4%)or no deletion allele (75.0%) (p = 0.011). Women with 2 deletion allele of GGPS1 -8188A ins/del had 7-fold higher risk of non-response to bisphosphonate therapy compared with women with other genotypes in GGPS1 -8188 after adjusting for baseline BMD (OR = 7.48; 95% CI = 1.32-42.30; p = 0.023). Other polymorphisms in FDPS or GGPS1 were not associated with lumbar spine BMD or femoral neck BMD. Conclusion: Our study suggested that GGPS1 -8188A ins/del polymorphism may confer susceptibility to femoral neck BMD response to bisphosphonate therapy in Korean women. However, further study should be done to confirm the results in a larger population.
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박형석,최지엽,이미정,박세호,여창우,이상섭,신재국,박병우 대한의학회 2011 Journal of Korean medical science Vol.26 No.8
The aim of the study was to evaluate the association between genetic polymorphisms of CYP2D6 and outcomes in breast cancer patients with tamoxifen treatment. We evaluated the CYP2D6 genetic polymorphisms in 766 breast cancer patients. Among them, 110patients whose samples were prospectively collected before surgery and treated with tamoxifen were included to evaluate the association between CYP2D6 and outcomes. The genotypes of CYP2D6 were categorized as extensive metabolizer (EM), intermediate metabolizer (IM), and poor metabolizer (PM) according to the activity score. The clinicopathologic features of 110 patients were not significantly different among the three groups except for the T-stage and nodal status. The high T-stage and axillary metastasis were more frequent in the PM group. While recurrence-free and overall survival in the PM group was poorer than the other groups, there was no significant difference between the EM and the IM group. The difference between the PM and the other groups on univariate analysis disappeared on multivariate analysis. These conflicting results suggest that the clinical value of CYP2D6 polymorphisms is still unclear and more large-sized and comprehensively designed trials are necessary.
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기계학습을 적용한 신체활동 웨어러블 디바이스의 정확성 검증
이광희,김재명,최지엽,이정민,이미영 한국체육측정평가학회 2019 한국체육측정평가학회지 Vol.21 No.3
The method of machine learning could serve as a powerful source to analyze the physical activity data more accurately than traditional analyses. The purpose of this study was to evaluate the accuracy of wearable physical activity tracker through several machine learning algorithms to classify different types of physical activity. A total of 48 participants were asked to perform a series of physical activity including sitting, standing, mopping, walking, brisk walking, and the moving object while wearing the SenseWear Mini Armband (BodyMedia Inc, Jawbone, CA, USA). The data from motion and heat-related sensors were processed and summarized into 1-min epoch by using the software (SenseWear 8.0). The machine learning algorithms of k-Nearest Neighbors (k-NN), Random Forest (RF), Support Vector Machine (SVM), logistic regression, and Decision Tree (DT) were applied to classify physical activity. The algorithm of RF (71.43%) and SVM (70.12%) were more accurate than others. k-NN, DT showed 61.86%, 50.46% accordingly which resulted in higher accuracy than logistic regression; the lowest accuracy of 47.31%. Also, the accuracy was the highest when information on accelerometer, skin temperature, and galvanic skin response was collectively included as feature variables. The use of machine learning algorithms, especially RF and SVM were proven to be useful for the classification of physical activity through the wearable physical activity tracker. Researchers need to consider applying the enhanced method of analyzing physical activity data. 기계학습 (machine learning)은 다양한 학문영역에서 빠르게 확산되고 있으나 신체활동 관련 자료 분석에는 한정적으로 적용되어 왔다. 이 연구에서는 기계학습 방식을 통해 신체활동 웨어러블 디바이스의 정확성을 검증하는데목적이 있다. 성인 남녀 48명을 대상으로 앉기, 서기, 물걸레질, 물건 옮기기, 걷기, 빠르게 걷기 등과 같은 일련의신체활동을 수행하는 동안 신체활동량을 측정하였다. 모든 신체활동 정보는 신체활동 웨어러블 디바이스 SenseWear Armband Mini (BodyMedia Inc, Jawbone, CA, USA)를 이용하여 수집되었고, 전용 소프트웨어 (SenseWear 8.0)를 통해 가속도기반 물리적 변인과 피부 온도와 같은 생리학적 변인의 자료가 60초 epoch으로 저장되었다. 얻어진 자료는 k-인접이웃분류 (k-Nearest Neighbor), 서포트 벡터 머신 (Support Vector Machine), 랜덤 포레스트 (Random Forest), 의사결정나무 (Decision Tree) 의 4가지 기계학습 알고리즘 분석방식과 전통적으로 이용된통계방법인 로지스틱 회귀 (Logistic Regression)이 적용되어 신체활동을 얼마나 정확하게 분류되는지 비교되었다. 분석결과에 의하면 랜덤 포레스트 (71.43%)와 서포트 벡터 머신 (70.12%)이 다른 알고리즘 보다 상대적으로 높은분류 정확도를 보였다. k-인접이웃분류와 의사결정나무는 각각 61.86%, 50.46%의 정확도를 보였고, 전통적 분석방법인 로지스틱 회귀분석 결과가 가장 낮은 정확도 (47.31%)를 보였다. 또한, 가속도계 기반 자료 하나만을 이용하는것보다 가속도 데이터, 피부 온도 및 피부 반사에 관한 정보를 동시에 사용하였을 때 상대적으로 높은 신체활동 분류 정확도를 보였다. 결론적으로 기계학습을 통한 신체활동 분류 시 랜덤 포레스트와 서포트 벡터 머신 방법 적용이보다 적절하고 가속도계 기반 변인 하나보다 다양한 생리학적 변인의 반영이 필요함을 시사한다.
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성호경,마승현,최지엽,황윤지,안충현,김병기,김용만,김재원,강석범,김재훈,김태진,유근영,강대희,박수경 대한예방의학회 2016 예방의학회지 Vol.49 No.6
Objectives: We conducted a systematic review and meta-analysis to summarize current evidence regarding the association of parity and duration of breastfeeding with the risk of epithelial ovarian cancer (EOC). Methods: A systematic search of relevant studies published by December 31, 2015 was performed in PubMed and EMBASE. A random-effect model was used to obtain the summary relative risks (RRs) and 95% confidence intervals (CIs). Results: Thirty-two studies had parity categories of 1, 2, and ≥3. The summary RRs for EOC were 0.72 (95% CI, 0.65 to 0.79), 0.57 (95% CI, 0.49 to 0.65), and 0.46 (95% CI, 0.41 to 0.52), respectively. Small to moderate heterogeneity was observed for one birth (p<0.01; Q=59.46; I2=47.9%). Fifteen studies had breastfeeding categories of <6 months, 6-12 months, and >13 months. The summary RRs were 0.79 (95% CI, 0.72 to 0.87), 0.72 (95% CI, 0.64 to 0.81), and 0.67 (95% CI, 0.56 to 0.79), respectively. Only small heterogeneity was observed for <6 months of breastfeeding (p=0.17; Q=18.79, I2=25.5%). Compared to nulliparous women with no history of breastfeeding, the joint effects of two births and <6 months of breastfeeding resulted in a 0.5-fold reduced risk for EOC. Conclusions: The first birth and breastfeeding for <6 months were associated with significant reductions in EOC risk.
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Adherence to the Recommended Intake of Calcium and Colorectal Cancer Risk in the HEXA Study
이지유,신애선,최지엽,강대희,이종구 대한암학회 2021 Cancer Research and Treatment Vol.53 No.1
Purpose Dietary calcium intake has been suggested to be protective against the development of colorectal cancer. The mean dietary calcium intake of Koreans is 490 mg/day, which is far below the recommended calcium intake of 700-800 mg/day. In this study, we explored the relationship between dietary calcium intake and colorectal cancer development in Koreans with relatively low calcium intake compared with individuals in Western countries. Materials and Methods The Health Examinees Study, a large-scale genomic community-based prospective cohort study, was designed to identify the general characteristics of major chronic diseases in Koreans. A total of 119,501 participants aged 40-69 years recruited between 2004 and 2013 were included in this analysis. The calcium intake level was categorized using the Dietary Reference Intakes for Koreans (KDRIs). The Cox proportional hazards regression model was used to estimate the hazard ratio (HR) and the corresponding 95% confidence intervals (CIs) for colorectal cancer risk, adjusting for potential confounders. Results In the multivariable-adjusted model, compared with the group that consumed less than the recommended amount of calcium, the group that consumed more than the recommended intake of calcium showed a significant reduction in the risk of colorectal cancer in women. (HR, 0.54; 95% CI, 0.31 to 0.95). Among men, however, no significant association was observed between dietary calcium intake and colorectal cancer risk (HR, 0.89; 95% CI, 0.54 to 1.45). Conclusion Korean women who adhere to the recommended intake of calcium showed a reduced risk of colorectal cancer.
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