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The Synthesis and Preliminary Activity Assay In Vitro of Peptide-like Derivatives as APN Inhibitors
Li, Shao-Hua,Li, Gang,Huang, Hui-Ming,Xiong, Fang,Liu, Cheng-Mei,Tu, Guo-Gang 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.10
Both the aminopeptidase N (APN) and matrix metalloproteinase (MMP) are essential metallopeptidases in the development of tumor invasion and angiogenesis. A series of novel peptide-like derivatives were designed and synthesized as antitumor agents. Their structures were confirmed by IR, MS, and $^1H$-NMR. These compounds exhibited potent inhibitory activities against APN and low activity against MMP in vitro. The derivatives with methoxy group show better activities than those with other substituted group and could be used as lead compounds for exploring new APN inhibitors in the future.
Mei-Jia Li,Yuan-Yuan Deng,Li-Hua Pan,Shui-Zhong Luo,Zhizheng Jiang 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.1
Highbush blueberries (HB) and rabbiteye blueberries (RB) were separated into peels, flesh, and seeds to assess the compositions of nutriment, anthocyanins, soluble sugars and fatty acids, and the in vitro digesting abilities. Total phenolics contents (TPC) of 51–56 mg GAE/g DW were found in blueberry peels. Compared with HB peels, RB peels showed much higher TPC, but only contained 35 phenolics and lacked peonidin-3-O-rutinoside. Glucose, fructose, and sucrose were all present in HB and RB, but RB flesh had a higher acid-sugar ratio. Unsaturated fatty acid concentrations in HB and RB seeds were comparable (26.65 and 26.43 mg/g, respectively). However, HB seeds have 35 fatty acids, but RB seeds lacked cis-4,7,10,13,16,19-docosahexaenoic acid and cis-10-pentadecenoic acid. The in vitro digestion test showed that the whole fruit/peels/flesh of RB had a higher recovery and bioavailability index of phenolics and anthocyanins. Therefore, the reuse of blueberry pomace needs to be emphasized.
Shao-Mei Yang,Fu-Nan Li,Zhi-Ning Huang,Zhong-Shi Zhou,Jin Hou,Man-Yi Zheng,Li-Juan Wang,Yu Jiang,Xin-Yi Zhou,Qiu-Yue Chen,Shan-Hua Li 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10
To identify novel therapeutic agents to treatcancer, we synthesized a series of diaryl ether derivatives. Structure–activity relationship studies revealed that thepresence of a chlorine or hydroxyl at the para-position onthe phenyl ring (5h or 5k) significantly enhanced antitumoractivity. Compound 5h had stronger growth inhibitory activityin HepG2, A549, and HT-29 cells than compound 5k,with IC50 values of 2.57, 5.48, and 30.04 lM, respectively. Compound 5h also inhibited the growth of other cells lines,including Hep3B, PLC/PRF5, SMMC-7721, HeLa, andA375, with IC50 values of 2.76, 4.26, 29.66, 18.86, and10.21 lM, respectively. The antitumor activity of compound5h was confirmed by a colony forming assay. Further,our results indicated that the antitumor activity ofcompound 5h may be mediated by enhancing expression ofp21 and cl-caspase3, and leading to apoptosis of cancercells.
이매화(Li, Mei Hua) 건국대학교 인문학연구원 2015 통일인문학 Vol.61 No.-
1992년 한 · 중 수교 이후부터 많은 중국 조선족들은 경제적인 부를 축적하기 위해 한국으로 입국하기 시작했다. 더욱 나은 삶의 기회를 모색하기 위해 이동하는 과정에서 조선족들은 예상의 이익을 얻었지만, 그들의 이동은 일련의 사회문제를 야기했으며 그것은 조선족 사회변화의 주요한 요소로 되었다. 본고에서는 “코리안 드림”을 이루고자 한국으로 이동하는 중국 조선족들에 초점을 맞추어 현재 중국 조선족의 이동에 관한 연구의 주요한 관점, 연구 시각들을 정리한 기초 위에서 향후 연구의 방향과 과제를 제시하고자 한다. Since the establishment of Sino- Korean diplomatic relations in 1992, more and more Korean Chinese have been leaving China for South Korea(ROK), dreaming for making more money than in China. In the course of migration which pursues the better living chance, Korean Chinese has got imaginary profit, but also made a discordant sounds. This paper tries to focus on the continual migration of Korean Chinese for the“Korean Dream”, reviews the existing predominate viewpoints, research perspective and conclusions on the related findings in Chinese academia, and therefore raising the future research subjects for the academic circle.
재한 중국인 유학생들의 자기이해를 위한 집단미술치료 경험에 대한 현상학적 연구
이매화(Li Mei-hua),한경아(Han Kyeong-a) 한국미술치료학회 2019 美術治療硏究 Vol.26 No.5
본 연구는 중국인 미술치료사가 진행한 집단미술치료에서 재한 중국인 유학생들이 어떠한 경험을 하며, 그 경험의 본질이 무엇인지를 탐구하는 데 목적이 있다. 이를 위해 집단미술치료 경험이 있는 재한 중국인 유학생 8인을 대상으로 2018년 11월부터 2019년 5월까지 심층 면담을 통해 자료를 수집하였다. Max van Manen의 해석학적 현상학적 연구 방법 절차에 근거하여 6개의 본질적 주제와 15개의 하위 주제가 도출되었으며, 이를 바탕으로 한 결론은 다음과 같다. 첫째, 재한 중국인 유학생들은 타국에서 같은 언어를 사용하는 집단원들과 함께 하는 미술활동과 나눔을 통해 위로를 받고 그 안에서 소속감을 갖게 됨으로써 유학생활의 적응을 높이는 정서적 지지체계를 확장하게 되었다. 둘째, 재한 중국인 유학생들은 자신을 지지해주는 안전한 공간에서 미술을 매개로 솔직한 감정을 탐색하고 자신도 미처 알지 못했던 새로운 알아차림은 유학생활의 적응을 높일 뿐만 아니라 미래를 계획하는 자원이 되었다. 셋째, 재한 중국인 유학생들은 집단미술치료에서 자기 생각을 정리하는 시간을 통해 생각을 변화하여 더 나은 삶을 위해 노력을 하게 되었다. 본 연구에서는 재한 중국인 유학생들이 집단미술치료 안에서 상징적인 이미지 탐색을 통해 자기이해를 높임으로써 대학생 시기에 성취해야 하는 진로와 미래에 대한 계획을 세우고 희망을 갖는 경험을 보여주었다는 데 의미가 있다. The purpose of this study is to examine the experiences of Chinese students in Korea during the group art therapy carried out by a Chinese art therapist and to explore the essence of such an experience. For the research, this study collected data by conducting in-depth interviews from November 2018 to May 2019 on eight Chinese students in Korea with experience of group art therapy. After in-depth interviews, 6 essential themes and 15 sub-themes were derived based on the hermeneutic phenomenological research method suggested by Max van Manen. Results indicated that Chinese students in Korea received comfort and grew sense of belonging during art activities and sharing with group members using same language in a foreign country. As a result, art therapy expanded emotional support systems helping students adapt to studying abroad. In addition, Chinese students in Korea explored their honest feelings through art with a safe space supporting them. Such new awareness promoted adaptation methods for studying abroad and it became a resource for planning future. Also, Chinese students in Korea had a time to organize their thoughts in group art therapy. This brought changes in thoughts and caused students to seek a better life. This study holds significance as it demonstrates how Chinese students in Korea explore symbolic images, promote self-understanding, think about career choices during college life, plan for the future, and grow hopes while experiencing group art therapy.
Factors that Influence the Presciption of Antipsychotics for Patients with Schizophrenia in China
Tian-Mei Si,Liang Shu,Ke-Qing Li,Xie-He Liu,Qi-Yi Mei,Gao-Hua Wang,Pei-Shen Bai,Li-Ping Ji,Xian-Sheng Chen,Cui Ma,Jian-Guo Shi,Hong-Yan Zhang,Hong Ma,Xin Yu 대한정신약물학회 2011 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.9 No.3
Objective: To investigate the patterns of antipsychotic use in China and to analyze the factors that influence antipsychotic prescriptions. Methods: A standardized survey was conducted from May 20 to 24 2002 in five different regions of China with varying economic levels. The patterns of antipsychotic medication use were analyzed in a sample of 4,779 patients with schizophrenia. The survey gathered information on demographic characteristics, clinical profiles, and antipsychotic medications prescribed. Multiple logistic regression was used to analyze factors related to patterns of antipsychotic medication use. Results: A plurality of patients with schizophrenia was treated with clozapine (39%); this was followed by risperidone, sulpride,chlorpromazine, perphenazine, and haloperidol. More than 56.3% of patients were treated with only one atypical antipsychotic. The mean daily dose of chlorpromazine was 365±253 mg (mean±standard deviation), and 6.5% of patients were treated with depot injections of typical antipsychotic medications. A total of 73.7% (n=3,523) of patients with schizophrenia received monotherapy,24.8% (n=1,183) received two antipsychotics, 1.1% (n=52) received three antipsychotics, and one received four different antipsychotics. Patients often simultaneously received other classes of medications including anticholinergic agents, benzodiazepines,β-blockers, antidepressants, and mood stabilizers. Economic status and clinical symptoms were the main factors that contributed to the patterns of antipsychotic prescription. Conclusion: The present study suggests that atypical antipsychotic medications, especially clozapine, are the primary psychiatric treatments of choice in the management of schizophrenia in China. Moreover, the economic status and clinical profile of the patient are the major factors affecting the prescription of antipsychotic medication.