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Coactosin-like protein 1 inhibits neuronal migration during mouse corticogenesis
Guohong Li,Yupeng Yin,Jiong Chen,Yanle Fan,Juhong Ma,Yingxue Huang,Chen Chen,Pengxiu Dai,Shulin Chen,Shanting Zhao 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.1
Coactosin-like protein 1 (Cotl1), a member of the actin-depolymerizing factor (ADF)/cofilin family, was first purified from a soluble fraction of Dictyostelium discoideum cells. Neuronal migration requires cytoskeletal remodeling and actin regulation. Although Cotl1 strongly binds to F-actin, the role of Cotl1 in neuronal migration remains undescribed. In this study, we revealed that Cotl1 overexpression impaired migration of both early- and late-born neurons during mouse corticogenesis. Moreover, Cotl1 overexpression delayed, rather than blocked, neuronal migration in late-born neurons. Cotl1 expression disturbed the morphology of migrating neurons, lengthening the leading processes. This study is the first to investigate the function of Cotl1, and the results indicate that Cotl1 is involved in the regulation of neuronal migration and morphogenesis.
Research on Large Customer Satisfaction Evaluation of China Netcom Corporation Daqing Branch
Yanling Xial,Yingxue Li,Yujuan He 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10
In the paper, a large customer satisfaction evaluation index system is constructed, which involves five broad categories including corporate image, service attitude service quality, and 21 individual indexes, for example popularity, Value for money and so on. By using fuzzy theory, the fuzzy evaluation model of large customer satisfaction is been established. And then, based on a questionnaire survey for the main districts and counties in Daqing, the paper completes large customer satisfaction evaluation of the China Netcom Corporation Daqing branch and gives the advantages and disadvantages in the customer service, in order to further improving the large customer satisfaction.
Research on the safeguard mechanism of trust for supply chain partners based on system constraints
Yanling Xiao,Xu Yang,Yingxue Li 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10
Trust is risky. If the two sides is not enough high trust, or is asymmetirc in trust each other, it is easy totrigger a trust crisis, and which bring risks to the supply chain and its members. The guarantee mechanism of trust can manage and control trust risk. The paper firstly introduces the risk under the supply chain environment, analyses the risk of trust. Then, it analyzes the trust insurance mechanism based on the system constraints by using the game theory, as well as the insufficiency of system restraints.
Design and Implementation of a Novel Horizontal AFM Probe Utilizing a Quartz Tuning Fork
Yifu Chen,Yingzi Li,Guanqiao Shan,Yingxu Zhang,Zhenyu Wang,Mubing Wang,Hua Li,Jianqiang Qian 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.19 No.1
This paper presents a new structure of a novel horizontal atomic force microscope probe utilizing a quartz tuning fork. The horizontal structure exhibits high resistance to environmental noise, and thus the probe can maintain good stability throughout the imaging work. The quartz tuning fork, which is utilized as a force sensor due to its simple mechanical structure and self-actuating and self-sensing characteristics, can significantly simplify the mechanical structure of the probe. The probe is divided into three parts: an approximation device, a force sensor, and a three-dimensional scanner. Each part is carefully designed to guarantee the imaging performance. It is verified that the proposed horizontal AFM probe is stable by conducting finite-element analysis, including modal analysis and noise analysis. Furthermore, the probe is fabricated and the experiments are performed to verify its stability. The proposed horizontal AFM probe combined with the existing control system in the frequency modulation succeeds in imaging within 25 μm × 25 μm and 20 μm × 20 μm ranges stably.
Mi Zhang,Xindong Shui,Xiaoqing Zheng,Jong Eun Lee,Yingxue Mei,Ruomeng Li,Yuan Tian,Xiuzhi Zheng,Quling Wang,Long Wang,Dongmei Chen,Tao Zhang,Byeong Mo Kim,Jungho Kim,Tae Ho Lee 대한약학회 2023 Archives of Pharmacal Research Vol.46 No.11
Breast cancer is one of the major malignancies in women, and most related deaths are due to recurrence, drug resistance, and metastasis. The expression of the mouse double minute 2 (MDM2) oncogene is upregulated in breast cancer; however, its regulatory mechanism has yet to be fully elucidated. Herein, we identified the tumor suppressor death-associated protein kinase 1 (DAPK1) as a novel MDM2 regulator by unbiased peptide library screening. DAPK1 is directly bound to MDM2 and phosphorylates it at Thr419. DAPK1-mediated MDM2 phosphorylation promoted its protein degradation via the ubiquitin–proteasome pathway, resulting in upregulated p53 expression. DAPK1 overexpression, but not its kinase activity-deficient form, decreased colony formation and increased doxorubicin-induced cell death; however, DAPK1 knockdown produced the opposite effects in human breast cancer cells. In a xenograft tumorigenesis assay, DAPK1 overexpression significantly reduced tumor formation, whereas inhibition of DAPK1 kinase activity reduced its antitumorigenic effect. Finally, DAPK1 expression was negatively correlated with MDM2 levels in human breast cancer tissues. Thus, these results suggest that DAPK1-mediated MDM2 phosphorylation and its protein degradation may contribute to its antitumorigenic function in breast cancer.
중국과 한국여성에서 나이에 따른 인유두종바이러스의 유병률과 분포
김지혁 ( Geehyuk Kim ),김성현 ( Sunghyun Kim ),박선영 ( Sunyoung Park ),박상정 ( Sangjung Park ),( Han Lin ),( Yubo Ren ),( Li Yingxue ),이인수 ( In Soo Lee ),이재달 ( Jae Dal Lee ),이동섭 ( Dongsup Lee ) 대한임상검사과학회 2015 대한임상검사과학회지(KJCLS) Vol.47 No.4
Cervical cancer is the third most common cancer among women worldwide. Cervical cancer is significantly associated with human papillomavirus (HPV) infection. The prevalence of HPV infection is influenced by geography, immune status, sexual history and genetic factors. For example, geographically, HPV prevalence varies from 1.5% to 39%. However, little is known about the relationship between HPV prevalence and age. An analysis of HPV prevalence by age will help determine when high-risk groups are exposed to HPV. Such an analysis could also demonstrate a correlation between specific HPV genotypes and age. In addition, the analysis might clarify the optimum age for using vaccines. In this study, HPV prevalence and genotype distribution among Korean and Chinese women are analyzed by age. The REBA HPV-IDⓡ assay (YD diagnostics, Yong-in, Republic of Korea) was used for detecting HPV genotypes in uterine cervical liquid-based cytology samples from 533 women from Korea and 324 from East China (Western Shandong province. Women with severe dysplasia such as SCC (Squamous cell carcinoma) and HSIL (High-grade squamous intraepithelial lesion) groups were primarily in their 40s and 50s, whereas women with mild and moderate dysplasia (ASCUS and LSIL groups) were primarily in their 30s and 40s. Women with HPV genotype 16 and 18 infections were primarily in their 40s. The results suggest that HPV infection is associated with certain age groups in the Korean population.
Wang, Hye-young,Lee, Dongsup,Park, Sunyoung,Kim, Geehyuk,Kim, Sunghyun,Han, Lin,Yubo, Ren,Li, Yingxue,Park, Kwang Hwa,Lee, Hyeyoung Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17
Background: Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide and it is responsible for most cases of cervical uterine cancer. Although HPV infections of the cervix do not always progress to cancer, 90% of cervical cancer cases have been found to be associated with high risk HPV (HR-HPV) infection. HPV DNA testing is widely used, along with Papanicolaou (Pap) testing, to screen for cervical abnormalities. However, there are no data on the prevalence of genotype-specific HPV infections assessed by measuring HPV E6/E7 mRNA in women representative of the Chinese population across a broad age range. Materials and Methods: In the present study, we compared the results with the CervicGen HPV RT-qDx assay, which detects 16 HR-HPV genotypes (Alpha-9: HPV 16, 31, 33, 35, 52, and 58; Alpha-7: HPV 18, 39, 45, 51, 59, and 68; and Alpha-5, 6: HPV 53, 56, 66, and 69), and the REBA HPV-ID assay, which detects 32 HPV genotypes based on the reverse blot hybridization assay (REBA) for the detection of oncogenic HPV infection according to cytological diagnosis. We also investigated the prevalence and genotype distribution of HPV infection with a total of 324 liquid-based cytology samples collected in western Shandong province, East China. Results: The overall HPV prevalences determined by HPV DNA and HPV E6/E7 mRNA assays in this study were 79.9% (259/324) and 55.6% (180/324), respectively. Although the positivity of HPV E6/E7 mRNA expression was significantly lower than HPV DNA positivity, the HPV E6/E7 mRNA assay showed greater specificity than the HPV DNA assay (88.6% vs. 48.1%) in normal cytology samples. The prevalence of Alpha-9 (HPV 16, 31, 33, 35, 52, and 58) HPV infection among these women accounted for up to 80.3% and 76.1% of the high-grade lesions detected in the HPV mRNA and DNA tests, respectively. The HR-HPV genotype distribution, based on HPV DNA and E6/E7 mRNA expression by age group in patients with cytologically confirmed lesions, was highest in women aged 40 to 49 years (35.9% for cytologically confirmed cases, Pearson correlation r value=0.993, p<0.001) for high-grade lesions. Among the oncogenic HR-HPV genotypes for all age groups, there was little difference in the distribution of HPV genotypes between the HPV DNA (HPV -16, 53, 18, 58, and 33) and HPV E6/E7 mRNA (HPV -16, 53, 33, 58, and 18) assays. HPV 16 was the most common HPV genotype among women with high-grade lesions. Conclusions: Our results suggest that the HPV E6/E7 mRNA assay can be a sensitive and specific tool for the screening and investigation of cervical cancer. Furthermore, it may provide useful information regarding the necessity for early cervical cancer screenings and the development of additional effective HPV vaccines, such as one for HPV 53 and 58. Additionally, gaining knowledge of HPV distribution may also inform us about ecological changes in HPV after the vaccination.
Dongsup Lee,Geehyuk Kim,Sunghyun Kim,Sunyoung Park,Hye-young Wang,Sangjung Park,Lin Han,Ren Yubo,Yingxue Li,Kwang Hwa Park,Hyeyoung Lee 대한의생명과학회 2015 Biomedical Science Letters Vol.21 No.2
Cervical cancer is the third most common cancer in women worldwide and there is a significant association between human papillomavirus (HPV) infection and cervical cancer. Certain HPV groups, labeled high-risk (HR) HPV groups, are strongly associated with malignancies of the human cervix. HPV prevalence and genotype distribution were analyzed using the REBA HPV-ID<SUP>®</SUP> (YD Diagnostics, Yongin, Korea) assay based on the reverse blot hybridization assay (REBA) with a total of 324 liquid-based cytology samples from women in Western Shandong Province, East China and results were compared with cytological diagnosis. Most of the HPV genotypes that were detected in high-grade cervical lesions were HR-HPV genotypes such as HPV 16, 18, 33, 53, and 58. The prevalence of these HR-HPV genotypes increased in high-grade cervical lesions. However, from low- to high-grade cervical lesions, the ability to detect LR-HPV genotypes decreased. Additionally, in general, the single HPV genotype infection rate increases in proportion to the severity of the lesion. The study findings suggest that a currently available preventive vaccine against HPV 16 and 18 may have limited effectiveness for prevention of all HPV infection in this province. Finally, based on these findings, these data could guide national or regional vaccination programs in the Western Shandong Province of East China to substantially reduce the burden of cervical lesions.