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Lee, Min‐,Jeong,Seo, Da‐,Young,Wang, In‐,Chun,Chun, Nan‐,Hee,Lee, Hea‐,Eun,Jeong, Myung‐,Yung,Kim, Woo‐,Sik,Choi, Guang J. Wiley Subscription Services, Inc., A Wiley Company 2012 journal of pharmaceutical sciences Vol.101 No.4
<P><B>Abstract</B></P><P>The in‐line monitoring of pharmaceutical processes with high risk, such as crystallization, has been one of the most popular research topics in recent years. Sulfamerazine (SMZ), a well‐known sulfonamide antibacterial agent was investigated to examine the mechanism of polymorphic conversion by solvent‐mediated polymorphic transformation (SMPT). The primary purpose of this study is to monitor the polymorphic transformation through in‐line near‐infrared (NIR) measurements and concurrently interpret the whole process quantitatively with off‐line characterizations. Samples taken at every hour during SMPT were analyzed by X‐ray diffractometry (XRD) and differential scanning calorimetry (DSC). NIR spectra in the range of 7500–4900 cm<SUP>−1</SUP> were taken into account for multivariate analysis, which included partial least square (PLS) regression and principal component analysis (PCA). In brief, the form II content was estimated very accurately and reproducibly during the SMPT process not only by XRD but also by the DSC measurements. In addition, the form II content values were predicted very accurately by separate experiments at two designated time points. In a separate study, it was demonstrated that PCA could be employed to explain a complicated process such as SMPT mechanistically by several stages. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:1578–1586, 2012</P>
Evaluation of characteristics on titanium surface treatment for absorption of functional groups.
Jin, Guang-Chun,Park, Rl-Song,Park, Hyeoung-Ho,Seo, Jae-Min,Lee, Sook-Jeong,Lee, Min-Ho Chinese Medical Assn 2010 Chinese medical journal : CMJ Vol.123 No.21
<P>In order to bind or fix bioactive materials directly to the surface of a Ti implant, the prior binding process of functional groups (FGs, -COOH and -OH) to the implant surface is necessary. Conventional binding processes are so high-cost and complex, so it is essential to find a simple and effective procedure for Ti-FG binding.</P>
Understanding the Formation of Indomethacin–Saccharin Cocrystals by Anti-Solvent Crystallization
Lee, Min-Jeong,Chun, Nan-Hee,Wang, In-Chun,Liu, J. Jay,Jeong, Myung-Yung,Choi, Guang J. American Chemical Society 2013 Crystal Growth & Design Vol.13 No.5
<P>Pharmaceutical cocrystals are a novel drug form with the potential to enhance pharmaceutical properties, including the solubility and dissolution behavior for BCS class II drug substances such as indomethacin (IMC). Recently, we reported that pure indomethacin–saccharin (IMC–SAC) cocrystals were prepared via anti-solvent crystallization. In this study, we investigated the solubility behavior of IMC–SAC cocrystals and individual components in methanol–water cosolvent. Also, the phase solubility diagram (PSD) of the cocrystal was determined to increase our understanding of cocrystallization. The criterion for pure IMC–SAC cocrystal formation was proposed and verified through supporting experiments performed with different concentrations. We also found that <I>S</I><SUB>cocrystal</SUB> and <I>S</I><SUB>cocrystal</SUB>/<I>S</I><SUB>drug</SUB> are critical factors for the design of the cocrystallization process via anti-solvent addition. Real-time monitoring of the cocrystallization process was performed using an in-line near-infrared (NIR) system. Principal component analysis (PCA) was applied to NIR spectral analysis. Based on the PCA results, distinct differences were observed in the pathways of IMC–SAC cocrystal formation depending on the initial concentrations.</P><P>The inequation, [coformer]<SUB>tr</SUB> ≤ [coformer]<SUB>0</SUB> − [drug]<SUB>0</SUB>, can be a useful criterion for pure cocrystal formation using anti-solvent crystallization.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cgdefu/2013/cgdefu.2013.13.issue-5/cg400135a/production/images/medium/cg-2013-00135a_0012.gif'></P>
Adaptive CVT-Based Reduced-Order Modeling of Burgers Equation
Guang Ri Piao,Qiang Du,Hyung Chun Lee 한국산업응용수학회(구 한국산업정보응용수학회) 2009 한국산업정보응용수학회 Vol.13 No.2
In this article, we consider a weighted CVT-based reduced-order modelling for Burgers equation. Brief review of the CVT (centroidal Voronoi tessellation) approaches to reduced-order bases are provided. In CVT-reduced order modelling, we start with a snapshot set just as is done in a POD (Proper Orthogonal Decomposition)-based setting. So far, the CVT was researched with uniform density (p(y)=1) to determine the basis elements for the approximating subspaces. Here, we shall investigate the technique of CVT with nonuniform density as a procedure to determine the basis elements for the approximating subspaces. Some numerical experiments including comparison of two CVT (CVT-uniform and CVT-nonuniform)-based algorithm with numerical results obtained from FEM(finite element method) and POD-based algorithm are reported.
ADAPTIVE CVT-BASED REDUCED-ORDER MODELING OF BURGERS EQUATION
GUANG-RI PIAO,QIANG DU,HYUNG-CHUN LEE 한국산업응용수학회 2009 Journal of the Korean Society for Industrial and A Vol.13 No.2
In this article, we consider a weighted CVT-based reduced-order modelling for Burgers equation. Brief review of the CVT (centroidal Voronoi tessellation) approaches to reduced-order bases are provided. In CVT-reduced order modelling, we start with a snapshot set just as is done in a POD (Proper Orthogonal Decomposition)-based setting. So far, the CVT was researched with uniform density (p(y) = 1) to determine the basis elements for the approximating subspaces. Here, we shall investigate the technique of CVT with nonuniform density as a procedure to determine the basis elements for the approximating subspaces. Some numerical experiments including comparison of two CVT (CVT-uniform and CVT-nonuniform)-based algorithm with numerical results obtained from FEM(finite element method) and POD-based algorithm are reported.
Distributed Feedback Control of the Benjamin-Bona-Mahony-Burgers Equation by a Reduced-Order Model
Piao, Guang-Ri,Lee, Hyung-Chun Global Science Press 2015 East Asian Journal on Applied Mathematics Vol.5 No.1
<B>Abstract</B><P>A reduced-order model for distributed feedback control of the Benjamin-Bona-Mahony-Burgers (BBMB) equation is discussed. To retain more information in our model, we first calculate the functional gain in the full-order case, and then invoke the proper orthogonal decomposition (POD) method to design a low-order controller and thereby reduce the order of the model. Numerical experiments demonstrate that a solution of the reduced-order model performs well in comparison with a solution for the full-order description.</P>
에폭시/폴리옥시프로필렌 디아민계의 경화 반응속도 및 동역학 특성 분석
황광춘(Guang Chun Huang),이종근(Jong Keun Lee) 한국고분자학회 2011 폴리머 Vol.35 No.3
비스페놀 A 에폭시 수지와 폴리옥시프로필렌 디아민 경화제계의 경화 반응속도를 시차주사열량계을 이용하여 승온 및 등온 경화조건에서 조사하였다. 승온실험에서는 Ozawa와 Kissinger법을 이용하여 다양한 가열속도에서 얻어진 발열피크의 이동으로부터 활성화 에너지를 구하였다. 또한 등온실험에서 얻어진 데이터는 자촉매 효과를 고려한 Kamal의 속도모델로 분석하였으며, 그 결과 경화반응 초기의 속도우세 구간에서 실험데이터와 잘 맞았다. 반응 후기의 확산우세 구간에서는 확산효과를 적용하여 경화의 전체과정을 기술하였다. 또한 동역학분석을 이용하여 경화 후 저장 탄성률과 가교점간의 평균분자량을 측정하였다. The cure kinetics of a bisphenol A epoxy resin and polyoxypropylene diamine curing agent system are investigated in both dynamic and isothermal conditions by differential scanning calorimetry (DSC). In dynamic experiments, the shift of exothermic peaks obtained at different heating rates is used to obtain activation energy of overall cure reaction based on the methods of Ozawa and Kissinger. Isothermal DSC data at different temperatures are fitted to an autocatalytic Kamal kinetic model. The kinetic model is in a good agreement with the experimental data in the initial stage of cure. A diffusion effect is incorporated to describe the later stage of cure, predicting the cure kinetics over the whole range of curing process. Also, dynamic mechanical analysis is performed to evaluate the storage modulus and average molecular weight between crosslinkages.