Trends in the prevalence of chronic liver disease in the Korean adult population, 1998–2017

Seung Ha Park,Lindsay D. Plank,석기태,Yong Eun Park,Jin Lee,Joon Hyuk Choi,Nae Yun Heo,Jongha Park,Tae Oh Kim,Young Soo Moon,Hyun Kuk Kim,Hang Jea Jang,Ha Young Park,김동준 대한간학회 2020 Clinical and Molecular Hepatology(대한간학회지) Vol.26 No.2

Background/Aims: Data on the trends in the prevalence of chronic liver disease (CLD) in Korea are scarce. This study aimed to evaluate whether the CLD prevalence changed between 1998–2001 and 2016–2017. Methods: Data were extracted from the Korea National Health and Nutrition Examination Survey (1998–2001 to 2016– 2017; n=25,893). Non-alcoholic fatty liver disease (NAFLD) was defined as a hepatic steatosis index >36 in the absence of any other evidence of CLD. The definition of alcohol-related liver disease (ALD) was excessive alcohol consumption (≥210 g/week for men and ≥140 g/week for women) and an ALD/NAFLD index >0. Results: The prevalence of NAFLD increased from 18.6% (95% confidence interval [CI], 17.8–19.5%) in 1998–2001 to 21.5% (95% CI, 20.6–22.6%) in 2016–2017. During the same time period, increases were observed in the prevalence of obesity (27.0 vs. 35.1%), central obesity (29.4 vs. 36.0%), diabetes (7.5 vs. 10.6%), and excessive drinking (7.3 vs. 10.5%). ALD prevalence also increased from 3.8% (95% CI, 3.4–4.2%) to 7.0% (95% CI, 6.4–7.6%). In contrast, chronic hepatitis B decreased from 5.1% (95% CI, 4.6–5.5%) to 3.4% (95% CI, 3.0–3.8%). The prevalence of chronic hepatitis C was approximately 0.3% in 2016–2017. Conclusions: The prevalence of NAFLD and ALD increase among Korean adults. Our results suggest potential targets for interventions to reduce the future burden of CLD.

Blood pressure control in diabetic kidney disease: a post-hoc analysis of the FANTASTIC trial

Park Cheol Ho,홍순준,Kim Sung Gyun,Shin Seok Joon,Kim Dong Ki,Lee Jung Pyo,Han Sang Youb,Lee Sangho,Won Jong Chul,Kang Young Sun,Park Jongha,Han Byoung-Geun,Na Ki-Ryang,Hur Kyu Yeon,Kim Yong-Jin,Park Sun 대한고혈압학회 2024 Clinical Hypertension Vol.30 No.-

Background The target blood pressure (BP) value is unclear for diabetic kidney disease (DKD). Therefore, we aimed to evaluate the efect of strict BP control or‘on treatment’ BP on clinical outcomes in patients with DKD. Methods A post-hoc analysis of the prespecifed secondary outcomes of the FimAsartaN proTeinuriA SusTaIned reduCtion in comparison with losartan in diabetic chronic kidney disease (FANTASTIC) trial, a randomized multi‑ center double-blind phase III trial. Eligible patients were aged≥19 years with DKD. We assigned 341 participants with DKD to BP control strategy (standard-systolic BP [SBP]<140 mmHg versus strict-SBP<130 mmHg). The outcome was the occurrence of cardiovascular events and renal events. Separate analyses were performed to compared the risk of outcome according to achieved average BP levels. Results A total of 341 participants were included in the analysis. Over a median follow-up of 2.8 years, cardiovascu‑ lar/renal events were observed in 25 (7.3%) participants. Mean (SD) SBPs in the standard and strict BP control group were 140.2 (11.6) and 140.2 (11.9) mmHg, respectively. The strict BP control group did not show signifcantly reduced risk of cardiovascular/renal events (HR 1.32; 95% CI 0.60–2.92]). In the post-hoc analyses using achieved BP, achieved average SBP of 130–139 mmHg resulted in reduced risk of cardiovascular/renal events (HR 0.15; 95% CI 0.03–0.67) compared to achieved average SBP≥140 mmHg, whereas further reduction in achieved average SBP<130 mmHg did not impart additional benefts. Conclusion In patients with DKD, targeting a SBP of less than 130 mmHg, as compared with less than 140 mmHg, did not reduce the rate of a composite of cardiovascular and renal events. Achieved SBP of 130–139 mmHg was asso‑ ciated with a decreased risk for the primary outcome in patients with DKD. Trial registration ClinicalTirals.gov Identifer: NCT02620306, registered December 3, 2015. (https://clinicaltrials.gov/study/NCT02620306).

Kidney disease and obesity paradox

( Jongha Park ) 대한신장학회 2017 Kidney Research and Clinical Practice Vol.36 No.1

UDP-glucose pyrophosphorylase(UGP) targeting inhibitors as potential pesticides against Xanthomonas oryzae pv. oryzae

Jongha Lee,Hyunjae Park,Diem Quynh Nguyen,Yoonsik Park,Seunghwan Kim,Jeong-Gu Kim,Lin-Woo Kang 한국농약과학회 2018 한국농약과학회 학술발표대회 논문집 Vol.2018 No.10

A Review on the Effectiveness of Rehabilitation : For Evidence-Based Practices of the Korean Rehabilitation System

Park, Jongha,Cheong, Jinseong 아시아교정포럼 2015 교정담론 Vol.9 No.2

본 연구는 교정교화사업의 효과성에 대한 국내외 실증연구를 광범위하게 검토함으로써 우리나라 교정교화사업이 성공적으로 뿌리내리는데 기여하고자 했다. 교정교화의 개념적 발달과정과 이론적 토대에 대해 살펴보고, 교정교화사업의 유형과 범죄자의 특성을 중심으로 문헌분석을 실시한 결과, 처벌위주의 정책에 비해 교정교화사업이 훨씬 효과적인 대안임을 알 수 있었다. 그 가운데서도 다체계 치료법(Multisystemic Therapy : MST)과 종교기반 프로그램(Faith-Based Programs) 등이 재범률(재복역율) 감소에 가장 성공적인 것으로 드러났는바, 이와 같이 효과적인 정책들의 공통점은 범죄자 개인사에 대한 탐구를 통해 개별 특성을 파악한 후 심리적이고 환경적인 치유를 동시에 진행하는 것, 즉 개별화 접근이 핵심이었다. 사회학습이론이 주장하는 것처럼 교정교화사업이 소기의 성과를 거두기 위해서는 범죄자의 사고방식을 긍정적으로 변화시키는 것이 중요했는바, 이를 위해서는 학자들과 교정행정관들에게 장기적 관점에서 개별화된 전략을 지속 수행할 수 있는 깊은 지식과 강한 책임감이 요구되었다. 비록 우리 국민의 정서가 범죄에 관대한 것을 매우 꺼려하지만 이에 편승해 단기적이고 임시적인 처방에만 의존하는 접근법은 피해야 하며 반드시 서구와 같은 증거기반 운영이 정착되어야 한다는 결론에 이르게 되었다. This study made a comprehensive review of empirical research on the effectiveness of offender rehabilitation to contribute to the successful settlement of Korean rehabilitation policy. The review of conceptualization, underlying theory, and past studies of rehabilitation revealed sufficient evidence to claim that rehabilitation is the most effective intervention strategy, as opposed to its punitive counterparts. Some models of rehabilitative intervention such as Multisystemic Therapy (MST) and Faith- Based Programs have been proved to be particularly successful in reducing recidivism. The key element of the success appeared to be an individualized approach that considers each offender’s unique pathways to criminal behavior and improves his/her life both internally and environmentally. As the social learning theory posits, it is crucial that offenders change their cognitive processes in a positive direction, which is what must be secured by any rehabilitation program to be successful. To this end, scholars and practitioners need to have a strong professional knowledge and responsibility to keep administering long-term individualized tactics, which proved not only effective but even more efficient than short-term temporary expedient, particularly prevalent in Korea. This way the evidence-based practice of rehabilitation is to be settled in Korea in spite of public fear against softness on crime.

Exfoliated HNb₃O₈ nanosheets of enhanced acidity prepared by efficient contact of K₂CO₃ with Nb₂O₅

Park, Jongha,Lee, Jae-Hong,Chung, Young-Min,Suh, Young-Woong Elsevier 2017 Advanced powder technology Vol.28 No.10

<P><B>Abstract</B></P> <P>Although exfoliated HNb<SUB>3</SUB>O<SUB>8</SUB> nanosheet (e-HNb<SUB>3</SUB>O<SUB>8</SUB>) is known to be a powerful catalyst in acid-catalyzed reactions, the preparation technique has limitations in its high-yield production. We herein report the enhanced exfoliation efficiency and recovery of e-HNb<SUB>3</SUB>O<SUB>8</SUB> by contacting Nb<SUB>2</SUB>O<SUB>5</SUB> solid with a diluted K<SUB>2</SUB>CO<SUB>3</SUB> solution before ball milling (mechanochemical activation). The so-obtained e-HNb<SUB>3</SUB>O<SUB>8</SUB> showed a larger specific surface area, a higher density of total acid sites and an improved catalytic performance in the dehydration of 2-heptanol and formic acid, compared to the corresponding sample prepared by the conventional solid-state mixing. The ball-milled K<SUB>2</SUB>CO<SUB>3</SUB>–Nb<SUB>2</SUB>O<SUB>5</SUB> mixtures, layered KNb<SUB>3</SUB>O<SUB>8</SUB>, ion-exchanged HNb<SUB>3</SUB>O<SUB>8</SUB> and exfoliated HNb<SUB>3</SUB>O<SUB>8</SUB> samples were characterized by PXRD, TEM-EDS, TGA-MS and SEM-EDS. The characterization results revealed more intercalated K<SUP>+</SUP> ions in KNb<SUB>3</SUB>O<SUB>8</SUB> particles as well as more homogeneous K<SUB>2</SUB>CO<SUB>3</SUB>–Nb<SUB>2</SUB>O<SUB>5</SUB> mixture when the employed preparation technique was used. This is achieved by more infiltration of K<SUB>2</SUB>CO<SUB>3</SUB> into Nb<SUB>2</SUB>O<SUB>5</SUB> lattice before ball milling, thereby resulting in the above positive findings. Therefore, our approach has great potential to be extended to other niobate-containing nanosheet-type materials.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Nb<SUB>2</SUB>O<SUB>5</SUB> solid was in contact with a more diluted K<SUB>2</SUB>CO<SUB>3</SUB> solution before ball-milling. </LI> <LI> This mixture was more homogeneous than that prepared by the solid-state mixing. </LI> <LI> Intercalated K<SUP>+</SUP> ions were more present in KNb<SUB>3</SUB>O<SUB>8</SUB> obtained from this mixture. </LI> <LI> The so-obtained exfoliated HNb<SUB>3</SUB>O<SUB>8</SUB> (e-HNb<SUB>3</SUB>O<SUB>8</SUB>) contained more acid sites. </LI> <LI> This e-HNb<SUB>3</SUB>O<SUB>8</SUB> showed better catalytic performance in the dehydration reactions. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

An Empirical Study about Variance Ratio in Different Pattern of Intraday Trading Volume and Volatility

Jonghae Park,Youngtae Byun,Aejin Ha 한국무역통상학회 2012 무역통상학회지 Vol.12 No.3

How Can We Achieve Good Compliance for Bowel Preparation?

Jongha Park,Tae Oh Kim 대한소화기내시경학회 2019 Clinical Endoscopy Vol.52 No.1

IT산업지수와 타 산업지수간의 선도지연관계에 관한 실증분석

박종해(Jonghae Park),조동환(Donghwan Cho) 한국인터넷전자상거래학회 2015 인터넷전자상거래연구 Vol.15 No.1

This article examines the lead-lag relationship between IT index and other industrial indicies and figure out the way to make portfolio strategy using results. The reason why we investigate this relationship is that the IT industry has been increasing more than other industries and affect macroeconomics more. This paper employs daily return of 9 industrial(sector) indices data from January 2, 2007 to August 14, 2014 totally 1,895 days. The methodology used in this paper is VAR(vector auto regressive) and Granger causality model. The major results are as follows; According to empirical test based on the Granger causality, there is a evidence that the IT index was leading other indices and the indices related with IT index in stock market(KOSPI) was leading KOSDAQ IT index. This result is different with our prediction we expected. We supposed that the size of IT index has been growing and become more important industry in Korean economy.

Preparation and electrochemical performance of titanium nitride-graphene nanocomposite with high Ti contents and tailored morphology

Lee, Jongha,Sohn, Yeonsun,Park, Jin Hoo,Lee, Soohyung,Kim, Byung-Su,Park, In-Su,Kim, Pil Elsevier 2019 Current Applied Physics Vol.19 No.9

<P><B>Abstract</B></P> <P>Titanium nitride (TiN) - graphene (G) nanocomposites are promising for electrochemical charge storage where a high content of Ti species is desired. Herein, we propose an effective method for the preparation of TiN-G nanocomposites with a high concentration of Ti species. These nanocomposites can be successfully achieved through a further deposition of Ti on Ti-graphene oxide (GO) or a thermally exfoliated Ti-GO. Depending on the annealing condition employed (NH<SUB>3</SUB> and N<SUB>2</SUB>), two types of TiN-G nanocomposites (NH<SUB>3</SUB> annealing for TiN/G and TiN/G-TE, TE: thermal exfoliation) and a TiO<SUB>2</SUB>-G nanocomposite (N<SUB>2</SUB> annealing for TiO<SUB>2</SUB>/G-TE) were prepared. These nanocomposites were then investigated for potential application as an electrochemical supercapacitor. Compare with TiO<SUB>2</SUB>/G-TE, the TiN-G nanocomposites both exhibited a higher specific capacitance, although one of these nanocomposites had a lower surface area than TiO<SUB>2</SUB>/G-TE. Among the nanocomposites prepared, TiN/G-TE delivered the best electrochemical performance. The relationship between the physical properties and the capacitive performance of the nanocomposites were systematically evaluated.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Efficient preparation of TiN-Graphene (TiN/G) nanocomposites was suggested. </LI> <LI> Thermal exfoliation of GO was effective for achieving high Ti contents. </LI> <LI> Better electrochemical performance of TiN/G compared with TiO2/G. </LI> </UL> </P>