Tripolycyanamide-2,4,6-triformyl pyrogallol covalent organic frameworks with many coordination sites for detection and removal of heavy metal ions

Jiajia Han,Longsheng Pei,Yan Du,Yongmei Zhu 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.107 No.-

Here, tripolycyanamide (TPA) and 2,4,6-triformyl pyrogallol (TDBA) are used to prepare a highly crystallinecovalent-organic frameworks based on imine linkages (COFTDBA-TPA) for heavy metal ions (HMIs)detection and removal. Each unit of COFTDBA-TPA had 6 adsorption sites for HMIs (–C@O, –NH2, –C@N),which could selectively capture HMIs. The typical lamellar structure made COFTDBA-TPA have a largerspecific surface area, and the mesoporous structure provided numerous channels for the adsorption ofHMIs. Therefore, the COFTDBA-TPA-based electrochemical sensor could realize the detection of Cd2+,Cu2+, Pb2+, Hg2+ and Zn2+ in drinking water, simultaneously. The limits of detection for five HMIs wereas low as 0.922 nM, 0.450 nM, 0.309 nM, 0.208 nM and 0.526 nM, respectively. The adsorption capacityof COFTDBA-TPA for each HMI was as high as 711.6 mg/g, 716.9 mg/g, 603.7 mg/g and 618.3 mg/g, respectively. Compared with other adsorbents, it had higher capacity and faster adsorption kinetics. After beingrecycled five times, the adsorption performance was maintained. This not only provides a reliable platformfor the removal of HMIs in wastewater, but also provides new ideas for the use of COFs in the electrochemicalfield.

Alpha radionuclide-chelated radioimmunotherapy promoters enable local radiotherapy/chemodynamic therapy to discourage cancer progression

Jiajia Zhang,Feize Li,Yuzhen Yin,Ning Liu,Mengqin Zhu,Han Zhang,Weihao Liu,Mengdie Yang,Shanshan Qin,Xin Fan,Yuanyou Yang,Kun Zhang,Fei Yu 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4

Background: Astatine-211 is an α-emitter with high-energy α-ray and high cytotoxicity for cancer cells. However, the targeted alpha therapy (TAT) also suffers from insufficient systematic immune activation, resulting in tumor metastasis and relapse. Combined immune checkpoint blockade (ICB) with chemodynamic therapy (CDT) could boost antitumor immunity, which may magnify the immune responses of TAT. This study aims to discourage tumor metastasis and relapse by tri-model TAT-CDT-ICB strategy. Methods: We successfully designed Mn-based radioimmunotherapy promoters (211At-ATE-MnO2-BSA), which are consisting of 211At, MnO2 and bovine serum albumin (BSA). The efficacy of 211At-ATE-MnO2-BSA was studied as monotherapy or in combination with anti-PD-L1 in both metastatic and relapse models. The immune effects of radioimmunotherapy promoters on cytotoxic T lymphocytes and dendritic cells (DCs) were analyzed by flow cytometry. Enzymelinked immunosorbent assay and immunofluorescence were used to explore the underlying mechanism. Results: Such radioimmunotherapy promoters could not only enhance the therapeutic outcomes of TAT and CDT, but also induce robust anti-cancer immune activity by activating dendritic cells. More intriguingly, 211At-ATE-MnO2-BSA could effectively suppress the growths of primary tumors and distant tumors when combined with immune checkpoint inhibitors. Conclusions: The tri-model TAT-CDT-ICB strategy provides a long-term immunological memory, which can protect against tumor rechallenge after eliminating original tumors. Therefore, this work presents a novel approach for TATCDT-ICB tri-modal cancer therapy with repressed metastasis and relapse in clinics.

False Information Diffusion in Public Crisis on Interpersonal Network and Intervention Strategies

Zhu Xiaoxia,Hao Jiajia,Hu Haiju 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.10

With the development of economy, the public crisis has been increasing frequently and false information took shape because of the public’s assentation and lack of recognition. The diffusion of false information has intensified the public panic and anxiety. Beside, it may cause secondary damage easily. Therefore, the management department of false information in public crisis information should control the diffusion of the false information quickly in order to reduce the loss. By the diffusion of the network of false information in public crisis based on the scale-free network (BA), this paper defines the nature of each social individual from the perspective of multi-agent. On the basis of these properties, this paper defines the individual opinion interaction rules when communicating. The research concludes that active individuals of information diffusion on interpersonal network are not the people with a great amount of friends, but the ones who have few friends. Nevertheless, the management department of false information in public crisis should maintain a circuitous neutral attitude rather than the “all-or nothing” coercive measures when intervene the diffusion process of the false information diffusion. Besides, the influencing social individuals are the “opinion leaders” who have a wide range of interpersonal communication.

Improved oral bioavailability of capsaicin via liposomal nanoformulation: preparation, in vitro drug release and pharmacokinetics in rats

Yuan Zhu,Miaomiao Wang,Jiajia Zhang,Wei Peng,Caleb Kesse Firempong,Wenwen Deng,Qilong Wang,Shicheng Wang,Feng Shi,Jiangnan Yu,Ximing Xu,Weiming Zhang 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.4

This study innovatively prepared an effectivecapsaicin-loaded liposome, a nanoformulation with fewerirritants, for oral administration. The in vitro and in vivoproperties of the liposomal encapsulation were investigatedand the potential possibility of oral administration evaluated. The liposomal agent composed of phospholipid, cholesterol,sodium cholate and isopropyl myristate was prepared usingfilm-dispersion method. A level A in vitro–in vivo correlation(IVIVC) was established for the first time, which demonstratedan excellent IVIVC of both formulated and freecapsaicin in oral administration. Physicochemical characterizationsincluding mean particle size, zeta (f) potentialand average encapsulation efficiency of capsaicin-loadedliposome were found to be 52.2 ± 1.3 nm, -41.5 ±2.71 mv and 81.9 ± 2.43 %, respectively. In vivo, liposomalencapsulation allowed a 3.34-fold increase in relativebioavailability compared to free capsaicin. The gastricmucosa irritation studies indicated that the liposomal systemwas a safe carrier for oral administration. These resultssupport the fact that capsaicin, an effective drug for thetreatment of neuropathic pain, could be encapsulated inliposome for improved oral bioavailability. The excellentIVIVC of capsaicin-loaded liposome could also be a promisingtool in liposomal formulation development with anadded advantage of reduced animal testing.

Damage localization and quantification of a truss bridge using PCA and convolutional neural network

Xinqun Zhu,Jiajia Hao,Yang Yu,Chunwei Zhang,Jianchun Li 국제구조공학회 2022 Smart Structures and Systems, An International Jou Vol.30 No.6

Deep learning algorithms for Structural Health Monitoring (SHM) have been extracting the interest of researchers and engineers. These algorithms commonly used loss functions and evaluation indices like the mean square error (MSE) which were not originally designed for SHM problems. An updated loss function which was specifically constructed for deep-learningbased structural damage detection problems has been proposed in this study. By tuning the coefficients of the loss function, the weights for damage localization and quantification can be adapted to the real situation and the deep learning network can avoid unnecessary iterations on damage localization and focus on the damage severity identification. To prove efficiency of the proposed method, structural damage detection using convolutional neural networks (CNNs) was conducted on a truss bridge model. Results showed that the validation curve with the updated loss function converged faster than the traditional MSE. Data augmentation was conducted to improve the anti-noise ability of the proposed method. For reducing the training time, the normalized modal strain energy change (NMSEC) was extracted, and the principal component analysis (PCA) was adopted for dimension reduction. The results showed that the training time was reduced by 90% and the damage identification accuracy could also have a slight increase. Furthermore, the effect of different modes and elements on the training dataset was also analyzed. The proposed method could greatly improve the performance for structural damage detection on both the training time and detection accuracy.

Currency Substitution of RMB

Yan Jiajia,Zhu Mengnan 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10

Becasue of changes in economic institution, evironment and market advencement, currency substitution has profoundly influenced Chinese economy. Hence, it is sensible to analyze its present situation, major caused and relevant measures to maintain positive development of Chinese economy.

Resource Allocation for Relay-Aided Cooperative Systems Based on Multi-Objective Optimization

( Runze Wu ),( Jiajia Zhu ),( Hailin Hu ),( Yanhua He ),( Liangrui Tang ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.5

This paper studies resource allocation schemes for the relay-aided cooperative system consisting of multiple source-destination pairs and decode-forward (DF) relays. Specially, relaying selection, multisubcarrier pairing and assignment, and power allocation are investigated jointly. We consider a combinatorial optimization problem on quality of experience (QoE) and energy consumption based on relay-aided cooperative system. For providing better QoE and lower energy consumption we formulate a multi-objective optimization problem to maximize the total mean opinion score (MOS) value and minimize the total power consumption. To this end, we employ the nondominated sorting genetic algorithm version II (NSGA-II) and obtain sets of Pareto optimal solutions. Specially, two formulas are devised for the optimal solutions of the multi-objective optimization problems with and without a service priority constraint. Moreover, simulation results show that the proposed schemes are superior to the existing ones.

Experimental study of vibration characteristics of FRP cables based on Long-Gauge strain

Qi Xia,JiaJia Wu,XueWu Zhu,Jian Zhang 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.63 No.6

Steel cables as the most important components are widely used in the certain types of structures such as cablesupported bridges, but the long-span structures may result in an increase in fatigue under high stress and corrosion of steel cables. The traditional steel cable is becoming a more evident hindrance. Fiber Reinforced Polymer (FRP) cables with lightweight, high-strength are widely used in civil engineering, but there is little research in vibrational characteristics of FRP cables, especially on the damping characteristic. This article studied the two methods to evaluate dynamical damping characteristic of basalt FRP(BFRP) and glass FRP(GFRP) cables. First, the vibration tests of the B/G FRP cables with different diameter and different cable force were executed. Second, the cables forces were calculated using dynamic strain, static strain and dynamic acceleration respectively, which were further compared with the measured force. Third, experimental modal damping of each cables was calculated by the half power point method, and was compared with the calculation by Rayleigh damping theory and energy dissipation damping theory. The results indicate that (1) The experimental damping of FRP cables decreases with the increase of cable force, and the trend of experimental damping changes is roughly similar with the theoretical damping. (2) The distribution of modal damping calculated by Rayleigh damping theory is closer to the experimental results, and the damping performance of GFRP cables is better than BFRP cables.

Improved Kalman filter with unknown inputs based on data fusion of partial acceleration and displacement measurements

Lijun Liu,Jiajia Zhu,Ying Su,Ying Lei 국제구조공학회 2016 Smart Structures and Systems, An International Jou Vol.17 No.6

The classical Kalman filter (KF) provides a practical and efficient state estimation approach for structural identification and vibration control. However, the classical KF approach is applicable only when external inputs are assumed known. Over the years, some approaches based on Kalman filter with unknown inputs (KF-UI) have been presented. However, these approaches based solely on acceleration measurements are inherently unstable which leads poor tracking and so-called drifts in the estimated unknown inputs and structural displacement in the presence of measurement noises. Either on-line regularization schemes or post signal processing is required to treat the drifts in the identification results, which prohibits the real-time identification of joint structural state and unknown inputs. In this paper, it is aimed to extend the classical KF approach to circumvent the above limitation for real time joint estimation of structural states and the unknown inputs. Based on the scheme of the classical KF, analytical recursive solutions of an improved Kalman filter with unknown excitations (KF-UI) are derived and presented. Moreover, data fusion of partially measured displacement and acceleration responses is used to prevent in real time the so-called drifts in the estimated structural state vector and unknown external inputs. The effectiveness and performance of the proposed approach are demonstrated by some numerical examples.

Kinetic modeling of C2–C7 olefins interconversion over ZSM-5 catalyst

Lei Ying,Jiajia Zhu,Youwei Cheng,Lijun Wang,Xi Li 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.33 No.-

The kinetics of C2–C7 olefins interconversion were studied by feeding individual olefin into industrialZSM-5 catalyst at temperatures of 400–490 8C, space time of 0.0046–0.34 h and partial pressure of13.1 kPa. A kinetic model involving oligomerization, cracking and aromatization of olefins wasestablished. The results showed that the calculated apparent activation energy was negative foroligomerization reactions and positive for cracking reactions. The proposed kinetic model was able topredict the product concentrations in the C2–C7 olefins interconversion over ZSM-5 catalyst, with R2values ranged from 0.969 to 0.996 for the major species.