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( Jane Oh ),( David Scott ),( Elizabeth Marcus ),( Yi Wen ),( George Sachs ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Helicobacter pylori is a gastric-dwelling pathogen responsible, with acid secretion, for peptic ulcer and a 20-fold increase in the risk of gastric cancer. Several transcriptomes have been described after short-term exposure to acidity in vitro, but there are no data identifying the effects of chronic gastric exposure on bacterial gene expression. Comparison of the in vivo to the in vitro transcriptome at pH 7.4 identified several groups of genes of Known function that increased expression >2-fold, and three of these respond both to acidity in vitro and to gastric infection. Methods: Mongolian gerbils were inoculated by gavage with H. pylori strain 69a expressing green fluorescent protein (GFP-Hp). Ten days after inoculation, the animals were killed, and their stomachs were rapidly removed, H. pylori RNA from the fundic and antral mucosae was isolated and enriehed by using MICROBEnrich and MICROBExpress BacterialmRNAenrichment kits (Ambion, Austin, TX). cDNA was synthesized by reverse transcription from in vivo H. pylori RNA in the presence of Cy5-dCTP and from in vitro cultured H. pylori RNA with Cy3-dCTP and hybridized to glass slides containing the 1,534 predicted ORFs of H. pylori strain 26695 (5). Microarray analysis was performed by using Phoretix Array software (Nonlinear Dynamic, Durham, NC). Results: Almost all known acid acclimation genes are highly up-regulated. There is also up-regulation of two groups of motility and chemotaxis genes and for pathogenicity island genes, especially cagA, a predictor for pathogenicity. Most of these genes interact with HP0166, the response element of the pH-sensing two-component histidine kinase. Conclusions: Based on the pH profile of survival of urel deletion mutants in vitro and their inability to survive in gastric acidity, the habitat of the organism at the gastric surface is acidic with a pH<4.0. Hence, the pH of the habitat of H. pylori on the surface of the stomach largely determines the regulation of these specific groups of genes.
오재진 ( Jane C. Oh ),이계성 ( Gye Sung Lee ),김재수 ( Jae Su Kim ),박열 ( Yol Park ),이성훈 ( Sung Hoon Lee ),김안나 ( An Na Kim ),이종민 ( Jong Min Lee ),김규순 ( Kyu Soon Kim ) 대한소화기학회 2004 대한소화기학회지 Vol.44 No.3
Gastric metastasis of lung carcinoma is a rare entity which is detected mostly at autopsy. Patients diagnosed as having those on lifetime are extremely rare. In addition to our case, 54 cases of lung carcinoma metastasis to the gastro-intestinal tract hav
Novel characteristics of a carbohydrate-binding module 20 from hyperthermophilic bacterium.
Oh, Il-Nam,Jane, Jay-Lin,Wang, Kan,Park, Jong-Tae,Park, Kwan-Hwa Springer 2015 Extremophiles Vol.19 No.2
<P>In this study, a gene fragment coding carbohydrate-binding module 20 (CBM20) in the amylopullulanase (APU) gene was cloned from the hyperthermophilic bacteria Thermoanaerobacter pseudoethanolicus 39E and expressed in Escherichia coli. The protein, hereafter Tp39E, possesses very low sequence similarity with the CBM20s previously reported and has no starch binding site 2. Tp39E did not demonstrate thermal denaturation at 50 C; however, thermal unfolding of the protein was observed at 59.5 C. A binding assay with Tp39E was conducted using various soluble and insoluble substrates, and starch was the best binding polysaccharide. Intriguingly, Tp39E bound, to a lesser extent, to soluble and insoluble xylan as well. The dissociation constant (K d) and the maximum specific binding (B max) of Tp39E to corn starch granules were 0.537 μM and 5.79 μM/g, respectively, at pH 5.5 and 20 C. 99APU1357 with a Tp39E domain exhibited 2.2-fold greater activity than a CBM20-truncation mutant when starch granules were the substrate. Tp39E was an independently thermostable CBM and had a considerable effect on APU activity in the hydrolysis of insoluble substrates.</P>
The Fates of Heavy Metals in Electrocoagulation Process
Ronna Jane S. Palacios,Do-Gun Kim,Seok-Oh Ko 한국폐기물자원순환학회 2013 한국폐기물자원순환학회 학술대회 Vol.2013 No.2
In this study, HA removal by electrocoagulation (EC) using Aluminum (Al) electrodes was evaluated based on Al species and HA was characterized to investigate the HA removal mechanisms. Results showed that Al electrodes were better than Fe electrodes, wherein Al flocs were found to be positively charged by which the negatively charged HA can be attracted. HA removal was 88.9% at 10 min and 91.3% at 20 min, at the initial pH of 4.5 and 6.5, respectively. The Ferron analysis showed that the formation of monomeric Al species (Ala), medium polymer Al species (Alb), and colloidal or solid Al species (Alc) was dependent on initial pH and current density (CD). At higher pH, higher concentration of colloidal or solid Al species (Alc)wasobserved. At higher CD, the HA removal was faster than at low CD, and Alcspecie in the floc was dominant. The spectroscopic analysis of the residual soluble HA showed the preferential removal of highly condensed structures of HA, regardless of CD. The results in this study showed that Alb and Alc, especially Alc, contribute much to the HA removal and that the highly conjugated moieties of HA are readily removed by EC. Specific UV absorbance (SUVA) analysis reveals that aromatic compounds were decreased by the oxidation at the anode. Size exclusion chromatography reveals that high molecular weight (MW) fractions were preferentially removed by EC than the low MW component.
Sohng, Jane-Kyung,Oh, Tae-Jin,Kim, Chun-Gyu The Korea Science and Technology Center 1998 BMB Reports Vol.31 No.5
Many antibiotics contain partially deoxygenated sugar components that are usually essential for biological activity, affinity, structural stability, and solubility of antibiotics. Gene probes of the biosynthetic genes related with the deoxysugar were obtained from PCR. Primers were designed from the conserved peptide sequences of the known dTDP-d-glucose 4,6-dehydratases, which are the key step enzymes in the biosynthesis of deoxysugar. The primers were applied to amplify parts of dehydratase genes to 27 actinomycetes that produce the metabolites containing deoxysugar as structural constituents. About 180 and 340 bp DNA fragments from all of the actinomycetes were produced by PCR and analyzed by Southern blot and DNA sequencing. The PCR products were used as gene probes to clone the biosynthetic gene clusters for the antibiotic mithramycin, rubradirin, spectinomycin, and elaiophyrin. This method allow for detecting of the biosynthetic gene clusters of a vast array of secondary metabolites isolated from actinomycetes because of the widespread existence of deoxysugar constituents in secondary metabolites.
IS-13 : The Fates of Heavy Metals in Electrocoagulation Process
( Ronna Jane S Palacios ),( Do Gun Kim ),( Seok Oh Ko ) 한국폐기물자원순환학회(구 한국폐기물학회) 2013 한국폐기물자원순환학회 추계학술발표논문집 Vol.2013 No.-
In this study, HA removal by electrocoagulation (EC) using Aluminum (Al) electrodes was evaluated based on Al species and HA was characterized to investigate the HA removal mechanisms. Results showed that Al electrodes were better than Fe electrodes, wherein Al flocs were found to be positively charged by which the negatively charged HA can be attracted. HA removal was 88.9% at 10 min and 91.3% at 20 min, at the initial pH of 4.5 and 6.5, respectively. The Ferron analysis showed that the formation of monomeric Al species (Ala), medium polymer Al species (Alb), and colloidal or solid Al species (Alc) was dependent on initial pH and current density (CD). At higher pH, higher concentration of colloidal or solid Al species (Alc)wasobserved. At higher CD, the HA removal was faster than at low CD, and Alcspecie in the floc was dominant. The spectroscopic analysis of the residual soluble HA showed the preferential removal of highly condensed structures of HA, regardless of CD. The results in this study showed that Alb and Alc, especially Alc, contribute much to the HA removal and that the highly conjugated moieties of HA are readily removed by EC. Specific UV absorbance (SUVA) analysis reveals that aromatic compounds were decreased by the oxidation at the anode. Size exclusion chromatography reveals that high molecular weight (MW) fractions were preferentially removed by EC than the low MW component.
Sladojevic, Nikola,Oh, Goo Taeg,Kim, Hyung-Hwan,Beaulieu, Lea M.,Falet, Hervé,Kamiń,ski, Karol,Freedman, Jane E.,Liao, James K. Oxford University Press 2017 Cardiovascular research Vol.113 No.11
<P>Conclusion These findings indicate that platelet ROCK2 plays important role in platelet function and thrombosis, but does not contribute to the pathogenesis of atherosclerosis and vascular remodeling.</P>