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Kim, Ji Yeon,Hwang, Joo-Yeon,Lee, Dae Yeon,Song, Eun Hyun,Park, Keon Jae,Kim, Gyu Hee,Jeong, Eun Ae,Lee, Yoo Jeong,Go, Min Jin,Kim, Dae Jin,Lee, Seong Su,Kim, Bong-Jo,Song, Jihyun,Roh, Gu Seob,Gao, Bi American Society for Biochemistry and Molecular Bi 2014 The Journal of biological chemistry Vol.289 No.39
<▼1><P><B>Background:</B> Chronic ethanol consumption induces pancreatic β-cell dysfunction and metabolic syndrome.</P><P><B>Results:</B> Ethanol-induced Atf3 inhibits glucokinase transcriptional activity through direct binding or Atf3/Pdx-1/Hdac1 axis on glucokinase promoter.</P><P><B>Conclusion:</B> ATf3 fosters β-cell dysfunction via <I>Gck</I> down-regulation and triggers T2D, which is ameliorated by <I>in vivo Atf3</I> silencing.</P><P><B>Significance:</B> The presented data uncover a new role for Atf3 as a potential therapeutic target in treating type 2 diabetes.</P></▼1><▼2><P>Chronic ethanol consumption induces pancreatic β-cell dysfunction through glucokinase (Gck) nitration and down-regulation, leading to impaired glucose tolerance and insulin resistance, but the underlying mechanism remains largely unknown. Here, we demonstrate that <I>Gck</I> gene expression and promoter activity in pancreatic β-cells were suppressed by chronic ethanol exposure <I>in vivo</I> and <I>in vitro</I>, whereas expression of activating transcription factor 3 (Atf3) and its binding to the putative Atf/Creb site (from −287 to −158 bp) on the <I>Gck</I> promoter were up-regulated. Furthermore, <I>in vitro</I> ethanol-induced Atf3 inhibited the positive effect of Pdx-1 on <I>Gck</I> transcriptional regulation, enhanced recruitment of Hdac1/2 and histone H3 deacetylation, and subsequently augmented the interaction of Hdac1/Pdx-1 on the <I>Gck</I> promoter, which were diminished by <I>Atf3</I> siRNA. <I>In vivo Atf3</I>-silencing reversed ethanol-mediated <I>Gck</I> down-regulation and β-cell dysfunction, followed by the amelioration of impaired glucose tolerance and insulin resistance. Together, we identified that ethanol-induced <I>Atf3</I> fosters β-cell dysfunction via <I>Gck</I> down-regulation and that its loss ameliorates metabolic syndrome and could be a potential therapeutic target in treating type 2 diabetes. The <I>Atf3</I> gene is associated with the induction of type 2 diabetes and alcohol consumption-induced metabolic impairment and thus may be the major negative regulator for glucose homeostasis.</P></▼2>
Eun Ju Bae,Eun Bi Kim,Bo Ram Choi,Sun Ho Won,Ji Hwan Kim,Sun Min Kim,Hyun Jeong Yoo,Sung Man Bae,Myung Ho Lim 대한소아청소년정신의학회 2019 소아청소년정신의학 Vol.30 No.4
Objectives: This study aimed to evaluate the addiction to highly caffeinated drinks among university students, and we investigated the relationships between smartphone addiction, depression, anxiety, attention-deficit/hyperactivity disorder (ADHD), burnout, self-esteem, impulsiveness in high caffeine drink addiction risk group (high caffeine group). We also compared these mental health factors differences between the high caffeine group and the control group; and, investigated the relative risk between the independent variables of the high caffeine group. Methods: This study was conducted in Korea, from June 2015 to July 2016. A set of questionnaires was administered on 511 college students. Results: The participants who belonged to the high caffeine group were more likely to demonstrate the symptoms of ADHD and higher levels of burnout and impulsiveness. Further, the results of logistic regression analysis confirmed the association between the high caffeine group and burnout. Conclusion: These behaviors among university students addicted to highly caffeinated drinks suggests the need for timely and effective interventions for those at risk of addiction.
Eun-Bi Park(박은비),Hye-Sun Kim(김혜선),So-Yun Shin(신소연),In-Ae Ji(지인해),Ji-Hyun Kim(김지현),Sung-Goo Kim(김성구),Byung Hong Yoo(유병홍),Byung-Woo Kim(김병우),Inseok Kwak(곽인석),Moon-Moo Kim(김문무),Kyung Tae Chung(정경태) 한국생명과학회 2012 생명과학회지 Vol.22 No.11
산수유는 다양한 생리적 기능을 가지는 것으로 보고되어 있으며 또한 최근에 관심의 증가로 산수유로부터 유효성분의 추출 방법 개발은 산업적으로 매우 중요하며, 유효성분의 존재 여부를 분석하는 것은 산업적 상품의 진위와 품질을 판정하는데 중요한 수단이 된다. 본 연구는 loganin을 지표 물질로 하여 산수유로부터 유효성분을 추출하는 여러 방법을 비교 분석하였으며, 각 방법에 따라 추출한 시료의 기능성의 차이를 항산화 작용으로 분석하였다. 산수유로부터 항산화 성분을 추출하기 위하여 네 가지 방법을 적용하였다. 추출된 유효성분 지표물질로 loganin의 함량을 HPLC로 분석하였을 때 열수를 사용한 추출 방법이 알코올 추출 또는 효소 처리 방법 보다효율적인 결과를 보여 주었다. 각 추출 시료의 항산화 기능은 DPPH radical 소거능, hydrogen peroxide scavenging assay, reducing power 측정으로 분석하였다. 추출 방법에 따라 항산화 기능이 차이가 있었으며, 열수 추출 시료가 DPPH radical 소거능과 hydrogen peroxide scavenging 효과가 우수하였고, 효소 처리 추출 시료는 reducing power가 우수하게 나타났다. 추출 방법에 따라 시료에 함유된 성분의 차이가 항산화 기능이 차이와 연관이 있다고 생각된다. 이 연구에서 얻은 결과는 산수유는 대조군으로 사용한 vitamin C에 준하는 항산화 성분을 함유하고 있으며, 이들 성분은 열수 추출 방법으로 효율적으로 추출되었으며, 열수 추출 방법은 산업적으로 응용 될 수 있음을 제시하고 있다. Oxidative stress leads to damage in all components of the cell, including proteins, lipids, and DNA due to imbalance between reactive oxygen species production and cellular detoxification. Phytochemicals are well-known to contain antioxidants, and their physiological role has been intensively studied. The fruit of Cornus officianalis has been used in oriental medicine and has been reported to have many functions. In this study, four different extraction techniques were applied to extract functional components from the fruit of Cornus officianalis, and the content of loganin, which is an antioxidant having DPPH radical and hydrogen peroxide scavenging activity and reducing power, was analyzed in each extract. Extraction techniques employed in this study were heat extraction by water, 70% ethanol extraction, enzyme treatment, and combination of enzyme treatment and heat extraction by water. All extracts contained 11.8-18.0 mg/g loganin and showed antioxidation function assayed by measuring DPPH radical and hydrogen peroxide scavenging activity and reducing power. Among them, heat extraction was the most effective technique, showing a maximum amount of loganin (18.0 mg/g) and antioxidative activity at 100 mg/ml concentration. Each extract showed very low cytotoxicity up to at 500 mg/ml but 10-20% cytotoxicity at 1,000 mg/ml by in vitro MTT assay.
( Eun-bi Jeon ),( Nayoung Kim ),( Beom Joon Kim ),( In-chang Hwang ),( Sang Bin Kim ),( Ji-hyun Kim ),( Yonghoon Choi ),( Yu Kyung Jun ),( Hyuk Yoon ),( Cheol Min Shin ),( Young Soo Park ),( Dong Ho L 대한소화기학회 2024 Gut and Liver Vol.18 No.4
Background/Aims: A few studies have suggested the association between Helicobacter pylori (HP) infection and ischemic stroke. However, the impact of HP eradication on stroke risk has not been well evaluated. This study aimed to assess the influence of HP eradication on the incidence of ischemic stroke, considering the potential effect of sex. Methods: This prospective observational cohort study was conducted at Seoul National University Bundang Hospital, from May 2003 to February 2023, and involved gastroscopy-based HP testing. Propensity score (PS) matching was employed to ensure balanced groups by matching patients in the HP eradicated group (n=2,803) in a 3:1 ratio with patients in the HP non-eradicated group (n=960). Cox proportional hazard regression analysis was used to evaluate the risk of ischemic stroke. Results: Among 6,664 patients, multivariate analysis after PS matching indicated that HP eradication did not significantly alter the risk of ischemic stroke (hazard ratio, 0.531; 95% confidence interval, 0.221 to 1.270; p=0.157). Sex-specific subgroup analyses, both univariate and multivariate, did not yield statistically significant differences. However, Kaplan-Meier analysis revealed a potential trend: the females in the HP eradicated group exhibited a lower incidence of ischemic stroke than those in the HP non-eradicated group, although this did not reach statistical significance (p=0.057). Conclusions: This finding suggests that HP eradication might not impact the risk of ischemic stroke. However, there was a trend showing that females potentially had a lower risk of ischemic stroke following HP eradication, though further investigation is required to establish definitive evidence.
Kim, Eun-Bi,Ameen, Sadia,Akhtar, M. Shaheer,Shin, Hyung Shik Elsevier 2018 Sensors and actuators. B Chemical Vol.275 No.-
<P><B>Abstract</B></P> <P>The nickel (Ni) and iron (Fe) co-doped zinc oxide nanoparticles, Zn<SUB>0.97</SUB>Fe<SUB>0.01</SUB>Ni<SUB>0.02</SUB>O NPs, were synthesized by a simple hydrothermal method and used for the fabrication of a highly sensitive, reliable and reproducible field effect transistor (FET) sensor for the detection of hexahydropyridine chemical. The highly dense spherical NPs of well-defined crystalline structure of the typical wurtzite hexagonal phase were obtained. The energy-dispersive X-ray spectroscopy (EDS) analysis confirmed the synthesis of Zn<SUB>0.97</SUB>Fe<SUB>0.01</SUB>Ni<SUB>0.02</SUB>O NPs. The highly accessible FET-sensor was fabricated by depositing Zn<SUB>0.97</SUB>Fe<SUB>0.01</SUB>Ni<SUB>0.02</SUB>O NPs on SiO<SUB>2</SUB>/Si substrate and the sensing performances were measured towards the detection of different concentrations of hexahydropyridine chemical. Zn<SUB>0.97</SUB>Fe<SUB>0.01</SUB>Ni<SUB>0.02</SUB>O NPs modified FET-sensor showed the high sensitivity of ∼62.28 μA μM<SUP>−1</SUP> cm<SUP>-2</SUP> and the good detection limit of ∼79 μM with correlation coefficient (R) of ∼0.96405 and a short response time (10 s) towards hexahydropyridine chemical.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ni and Fe co-doped ZnO nanoparticles (NPs), Zn<SUB>0.97</SUB>Fe<SUB>0.01</SUB>Ni<SUB>0.02</SUB>O NPs, are synthesized. </LI> <LI> Zn<SUB>0.97</SUB>Fe<SUB>0.01</SUB>Ni<SUB>0.02</SUB>O NPs modified FET-sensor is fabricated towards the detection of hexahydropyridine chemical. </LI> <LI> A high sensitivity of ∼62.28 μA μM<SUP>−1</SUP> cm<SUP>-2</SUP> is obtained. </LI> <LI> FET-sensor shows a good detection limit of ∼79 μM with correlation coefficient (R) of ∼0.96405. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>