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천연식품 추출 혼합물인 디콜을 이용한 마우스와 랫드에서의 LDL-콜레스테롤, 중성지질 및 체중 감소효과
김지훈,김경범,이유진,정종문 수원대학교 기능성생명소재연구소 2004 자연과학연구논문집 Vol.3 No.1
This study was performed to investigate the effects of natural source extracts, Dechol. The effects of Dechol were investigated an the blood LDL-cholesterol, triglyceride, and body weights in the Sprague Dawley rats, transgenic mice (B6, 129-Ldlr^(tm1Her)), and ICH mice. Hyperlipidemia was induced in SD rats and ICR mice by feeding them with high-fat food. Transgenic mice were tested by feeding them with normal food. All animal experiments were divided into 2 groups. One group was treated in drinking 0.5% Dechol whereas the other group was fed with tap water. Dechol-treated SD rat group could be returned to normal blood LDL-cholesterol level almost in 9 days. ICR mice determination of LDL-cholesterol level showed that the difference after 4 weeks between two groups was 43 mg/dl. Transgenic mice indicated that the blood cholesterol concentration in the subject group was decreasing everyday whereas the one in the control group was increasing, resulting in the difference of 280 mg/dl between two groups just after 20 day-treatment. These results suggest that Dechol may be efficiently used for primary prevention of cardiovascular diseases.
전분의 첨가가 자몽 종자 추출물 DF-100의 항균 활성에 미치는 영향
이유진,김지훈,김영식,정영재,김경범,정종문 수원대학교 기능성생명소재연구소 2003 자연과학연구논문집 Vol.2 No.1
Recent testimonials report grapefruit seed extract DF-100 to be successful in combating a variety of common infectious agents. This study investigated DF-100 for antimicrobial activites at containing 3% corn starch, 3% wheat flour and 0.5~5% starch contents to determine if antimicrobial activity of DF-100 keeps almost constant or is sometimes decreased by the addition of various types of starch. In our study, grapefruit seed extract DF-100 was tested for antibacterial properties against 5 strains. Gram-negative and gram-positive isolates {Escherichia coli, Bacillus cereus, Staphylococcus aureus, Candida albians, and Yeast (be often contaminated strain in confectionery factory)} were introduced into various dilutions of DF-100 (0, 250, 500, 1,000, 2,000, 4,000, 8,000, 16,000 ppm) for determination of antimicrobial activity. The antibacterial effect of the DF-100 appears to suppress the. growth of the 5 strains used for experiment. However, antimicrobial activity of DF-100 was reduced 1/4 to 1/16 when added into foods (such as bread, noodle, and biscuits) containing corn starch, wheat flour, or potato starch. It was evident that the antimicrobial activity DF-100 was decreased by addition of starch.
90-Day Inhalation Toxicity of Dimethylamine in F344 Rats
Kyung Seuk Song,Kun Ho Park,Jeong Hyun Kim,Dong Un Han,Chan Hee Chae,Sung Jin Park,Hyun Woo Kim,Jun Sung Kim,Jin Hong Park,Guk Joung Eu,Jin Hua,Hyun Sun Cho,Soon Kyung Hwang,Seung Hee Chang,Kyeong Nam 한국독성학회 2005 Toxicological Research Vol.21 No.2
Dimethylamine (DMA) is a widely used commodity chemical with few toxicity data. Groups of 10 male and female F-344 rats were exposed by inhalation to 0, 5, 10, 20, 40 and 80 ppm of DMA for 6 hrs/day, 5 days/week for 90 days. The changes of body weight, organ weight, hematology, clinical chemistry, and histopathological changes were evaluated after the exposure. As the results, the body weight was significantly decreased at 80 ppm in male and female rats (p<0.05). The absolute lung weight showed no statistically significant changes in any group. In contrast, the relative lung weight significantly increased at 80 ppm in male and female rats (p<0.05). Erythrocytes, mean cell hemoglobin, leukocytes, neutrophil, and platelet numbers were significantly increased in male and female at 40 or 80 ppm of DMA (p<0.05, p<0.01). In addition, the serum values of total protein, urea nitrogen were increased in male and creatine kinase, total protein were increased in female rats at 40 or 80 ppm (p<0.05, p<0.01). Histopathological examinations of the male and female lung samples showed slight hyperplasia and congestion at 80 ppm. Taken together, our study revealed that maximum tolerated dose of DMA would be over 40 ppm
Resveratrol Induces Apoptosis of KB Human Oral Cancer Cells
Kim, Seong-Hoon,Kim, Heung-Joong,Lee, Myoung-Hwa,Yu, Sun-Kyoung,Kim, Chun-Sung,Kook, Joong-Ki,Chun, Hong-Sung,Park, Eu-Teum,Lee, Sook-Young,Kim, Su-Gwan,Kim, Hye-Ryun,Kim, Do-Kyung The Korean Society for Applied Biological Chemistr 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.6
Resveratrol (trans-3,4',5,-trihydroxystilbene), a phytoalexin present in grape skin and red wine, suppresses many types of cancers by regulating cell proliferation and apoptosis through a variety of mechanisms. However, the effects of resveratrol on oral cancer are not completely understood. Thus, effects of resveratrol on cell growth and apoptosis induction were examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, DNA fragmentation, immunoblotting, and determination of caspase activation in KB human oral cancer cells. Treatment with resveratrol induced inhibition of cell growth depending on the resveratrol treatment time and concentration in KB cells. Treatment with resveratrol induced DNA ladder formation in KB cells and promoted proteolytic cleavage of procaspase-3 and procaspase-7 with increases in the amount of cleaved caspases-3 and -7. Proteolytic processing of caspase-9 in KB cells was increased by resveratrol treatment. Activation of caspase-3/-7 was detected in living KB cells by fluorescence microscopy. These results suggest that the resveratrol can suppress cell growth and induce cell apoptosis in KB human oral cancer cells, and may have potential as an anti-cancer drug.
DNA methylation and not allelic variation regulates STAT6 expression in human T cells
Kim, Eu-Gene,Shin, Hyun-Jin,Lee, Chang Geun,Park, Hye-Young,Kim, Yoon-Keun,Park, Heung-Woo,Cho, Sang-Heon,Min, Kyung-Up,Cho, Mi-La,Park, Sung-Hwan,Lee, Chang-Woo Springer-Verlag 2010 Clinical and experimental medicine Vol.10 No.3
Kyung Seuk Song,Kun Ho Park,Gi Yong Yoo,Sung-Ok Song,Hyun Woo Kim,Jun Sung Kim,Jin Hong Park,Guk Joung Eu,Jin Hua,Hyun Sun Cho,Soon Kyung Hwang,Seung Hee Chang,Arash Minai Tehrani,Kyeong Nam Yu,Chan H 한국독성학회 2004 Toxicological Research Vol.20 No.4
Inhalation toxicity, mutagenicity, and immunotoxicity tests were performed using a smoke generation system to investigate the safety of Herbrette, a tobacco substitute made with the leaves of Perilla frutescens. ICR mice were exposed to nicotine-free Herbrette smoke with concentrations of 0 (control), 4.08 ± 1.32 mg/㎥ (low dose), 7.72 ± 2.14 mg/㎥ (medium dose) and 12.83 ± 1.69 mg/㎥ (high dose) total particulate matters (TPM) for 4 weeks. When compared to the control group, the body weights, organ weights in the exposed groups did not show any significant differences. However, certain change of several serum chemical data and biochemical parameters were observed, however, the changes were within normal physiological ranges. Moreover, no changes in organ weight, and no gross/microscopic changes were observed between the exposed and control groups. Salmonella typhimurium reverse mutation, in vivo chromosomal aberration and micronucleus assays revealed that Herbrette did not induce mutagenicity. Upon evaluation of peripheral cellular immunity of mice through in vitro lymphocyte proliferation assay, no significant difference was observed in mean stimulation index between the exposed and control groups. Taken together, our results strongly suggest that Herbrette may not cause toxicity on mice under current condition.
Kim, Nak-Hyun,Park, Wan Beom,Cho, Jeong Eun,Choi, Yoon Jeong,Choi, Su Jin,Jun, Soo Youn,Kang, Chang Kyung,Song, Kyoung-Ho,Choe, Pyoeng Gyun,Bang, Ji-Hwan,Kim, Eu Suk,Park, Sang Won,Kim, Nam-Joong,Oh, American Society for Microbiology 2018 Antimicrobial Agents and Chemotherapy Vol.62 No.10
<P>Phages and their derivatives are increasingly being reconsidered for use in the treatment of bacterial infections due to the rising rates of antibiotic resistance. We assessed the antistaphylococcal effect of the endolysin SAL200 in combination with standard-of-care (SOC) antibiotics. The activity of SAL200 when it was combined with SOC antibiotics was assessed in vitro by checkerboard and time-kill assays and in vivo with murine bacteremia and Galleria mellonella infection models. SAL200 reduced the SOC antibiotic MICs and showed a >= 3-log(10)-CFU/ml reduction of Staphylococcus aureus counts within 30 min in time-kill assays. Combinations of SAL200 and SOC antibiotics achieved a sustained decrease of >2 log(10) CFU/ml. SAL200 significantly lowered the blood bacterial density within 1 h by >1 log(10) CFU/ml in bacteremic mice (P < 0.05 versus untreated mice), and SAL200 and SOC antibiotic combinations achieved the lowest levels of bacteremia. The bacterial density in splenic tissue at 72 h postinfection was the lowest in mice treated with SAL200 and SOC antibiotic combinations. SAL200 combined with SOC antibiotics also improved Galleria mellonella larva survival at 96 h postinfection. The combination of the phage endolysin SAL200 with SOC antistaphylococcal antibiotics showed synergistic effects in vitro and in vivo. The combination of SAL200 with SOC antibiotics could help in the treatment of difficult-to-treat S. aureus infections.</P>
Kim, Chung-Jong,Kang, Seung-Ji,Yoon, Doran,Lee, Myung Jin,Kim, Moonsuk,Song, Kyoung-Ho,Jang, Hee-Chang,Jung, Sook-In,Kim, Eu Suk,Kim, Hong Bin,Oh, Myoung-don,Park, Kyung-Hwa,Kim, Nam Joong American Society for Microbiology 2015 Antimicrobial Agents and Chemotherapy Vol.59 No.4
<P>We conducted a retrospective cohort study to evaluate factors influencing tissue culture positivity in patients with pyogenic vertebral osteomyelitis exposed to antibiotics before diagnosis. Tissue culture was positive in 48.3% (28/58) of the patients, and the median antibiotic-free period was 1.5 days (range, 0.7 to 5.7 days). In a multivariate analysis, a higher C-reactive protein (CRP) level (adjusted odds ratio [aOR], 1.18; 95% confidence interval, 1.07 to 1.29) and open surgical biopsy (aOR, 6.33; 95% confidence interval, 1.12 to 35.86) were associated with tissue culture positivity.</P>