흰쥐태아 구개돌기의 융합에 관여하는 E-cadherin과 세포자사에 관한 연구

엄기일,차지훈,김우신,김잉곤,정호삼 大韓成形外科學會 2001 Archives of Plastic Surgery Vol.28 No.5

農業技術 弘報用 印刷媒體의 製作活用改善에 관한 硏究

金性洙,崔敏浩,鄭址雄,權一男 서울大學校 農科大學 1986 서울대농학연구지 Vol.11 No.1

The objectives of the study were to: 1) analyze the structure and styles of the printed media for agricultural information, 2) review the utilization of the magazine by farmers and extension workers, 3) survey the needs of subscribers for the printed media, 4) find ways for improvement in putting out the magazine, and 5) recommend effective methods for publication and utilization of the printed media. Data were collected by mail and group interview from 179 of the randomly sampled farmers and from 148 of the extension agents in selected areas in Korea. The data were analyzed by HP 3000 computer in the College of Agriculture, Seoul National University. Major statistical techniques used for the study were frequency distrbution, percentile. The results of the study were as follows: 1. Communication exposure of the farmers to the printed media was lower than that of the extension agents, however the level of exposure was considerably high considering limited number of copy for farmers. 2. Farmers' major channel for acquisition of new farming technology was personal communication with extension agents, and extension agents' major channel for advanced technology was printed media. 3. It was revealed that the farmers did not have any difficulty in understanding contents of the printed media. 4. The printed media had been providing long range information for the farmers and extension agents. The farmers and extension agents responded that the consistency in the table of contents and the articles was good, and they liked the idea of emphasis by adopting the box style editing. 5. The farmers responded that the topics of the magazine should reflect the current change in agriculture. 8. The farmers responded that they would like to see articles on horticulture and successful case stories in farming. 9. The farmer-subscriber fully utilized information on farming and rural life in the printed media. Extended distrubution of the printed media would be necessary to enlarge the benefit from the advanced farming technology and improved rural home life.

Optimization of Physical Conditions for Caviar Analog Preparation Using Calcium-alginate Gel Capsules

Ji, Cheong-Il,Cho, Sueng-Mock,Yun, Young-Soo,Kim, Seon-Bong The Korean Society of Fisheries and Aquatic Scienc 2007 Fisheries and Aquatic Sciences Vol.10 No.3

High prices, overfishing, and contamination have limited the availability of natural caviar as a food product. We attempted to apply encapsulation by calcium-alginate gel membranes to caviar analog preparation in an effort to produce a high-quality replacement for natural caviar. Physical conditions of stirring speed $(X_1,\;rpm)$ and gelation time $(X_2,\;min)$ as the independent variables for gelation were optimized by response surface methodology. Sphericity $(Y_1,\;%)$, diameter $(Y_2,\;mm)$, membrane thickness $(Y_3,\;mm)$, rupture strength $(Y_4,\;g)$, and rupturing deformation $(Y_5,\;mm)$ were used as the dependent variables to compare characteristics of the capsules for caviar analogs with natural caviar. The values of the independent variables as evaluated by multiple response optimization were $X_1=-0.1271 (278 rpm) and $X_2=0.4436$ (12.2 min), respectively. Predicted values of the four dependent variables were $Y_1=97.7%,\;Y_2=2.97mm,\;Y_4=1,465g,\;and\;Y_5=1.15mm$. Membrane thickness $(Y_3)$ was eliminated from the dependent variables for multiple response optimization because it could not be measured with an image analyzer. The experimental values prepared under the optimal conditions for verification nearly coincided with the predicted values and satisfied the conditions of natural caviar.

The Processing Optimization of Caviar Analogs Encapsulated by Calcium-Alginate Gel Membranes

Cheong-Il Ji,Sueng-Mock Cho,Yeun-Suk Gu,Seon-Bong Kim 한국식품과학회 2007 Food Science and Biotechnology Vol.16 No.4

We prepared caviar analogs encapsulated by calcium-alginate gel membranes as a means to replace higher priced natural caviars. Processing the caviar analogs (beluga type) was optimized by response surface methodology with central composite design. Concentrations of sodium alginate (X₁) and CaCl₂ (X₂) were chosen as the independent variables. In order to compare characteristics of the caviar analogs with the natural caviar, sphericity (Y₁), diameter (Y₂), membrane thickness (Y₃), rupture strength (Y₄), rupturing deformation (Y₅), and sensory score (Y₆) were used as the dependent variables. The sphericity of the caviar analogs showed a similar value to that of natural caviar (over 94%) in the range of independent variables. Generally, the CaCl₂ concentration (X₂) affected all dependent variables to a greater extent than the sodium alginate concentration (X₁). For the multiple response optimization of the 5 dependent variables (Y₁, Y₂, Y₄, Y₅, and Y₆), the desirability function was defined as the following conditions: target values (Y₁ = 100%, Y₂ = 3.0 mm, Y₄ = 1,470 g, Y₅ = 1.1 mm, and Y₆ = 10 points). Membrane thickness (Y₃) was eliminated from the dependent variables for multiple response optimization because it could not be measured with an image analyzer. The values of the independent variables as evaluated by multiple response optimization were X₁ = -0.093 (0.78%) and X₂ = -0.322 (1.07%), respectively.

Reninoma: a rare cause of curable hypertension

Ji-Hye Kim,Ji Hyun Kim,Myung Hyun Cho,Eujin Park,Hye Sun Hyun,Yo Han Ahn,Hee Gyung Kang,Kyung Chul Moon,Il-Soo Ha,Hae Il Cheong 대한소아청소년과학회 2019 Clinical and Experimental Pediatrics (CEP) Vol.62 No.4

The most common type of refractory hypertension found in children is secondary hypertension, which is a potentially curable disease. Reninoma, a renin-secreting juxtaglomerular cell tumor, is a rare cause of severe hypertension that is usually diagnosed in adolescents and young adults. Surgical resection of the tumor completely cures the hypertension of patients with reninoma. The typical clinical presentation of reninoma includes hypokalemia, metabolic alkalosis, and features secondary to the increased activation of the renin-angiotensin system without renal artery stenosis. We report a case of reninoma in a female adolescent with a typical clinical presentation, in which surgical removal of the tumor completely cured hypertension. We discuss here the clinical features, imaging studies, and immunohistochemical examination of the tumor used to establish the diagnosis of reninoma and for the management of the condition.

멸치 가공선 자숙폐액 Pepsin 가수분해물의 Angiotensin 전환효소 저해작용

지청일(Cheong-Il Ji),이지혜(Ji-Hye Lee),박덕천(Douck-Choun Park),구연숙(Yeun-Suk Gu),김인수(In-Soo Kim),이태기(Tae-Gee Lee),정규진(Kyoo-Jin Jung),박영호(Yeung-Ho Park),김선봉(Seon-Bong Kim) 한국식품과학회 2002 한국식품과학회지 Vol.34 No.3

Reninoma: a rare cause of curable hypertension

Kim, Ji Hye,Kim, Ji Hyun,Cho, Myung Hyun,Park, Eujin,Hyun, Hye Sun,Ahn, Yo Han,Kang, Hee Gyung,Moon, Kyung Chul,Ha, Il-Soo,Cheong, Hae Il The Korean Pediatric Society 2019 Clinical and Experimental Pediatrics (CEP) Vol.62 No.4

The most common type of refractory hypertension found in children is secondary hypertension, which is a potentially curable disease. Reninoma, a renin-secreting juxtaglomerular cell tumor, is a rare cause of severe hypertension that is usually diagnosed in adolescents and young adults. Surgical resection of the tumor completely cures the hypertension of patients with reninoma. The typical clinical presentation of reninoma includes hypokalemia, metabolic alkalosis, and features secondary to the increased activation of the renin-angiotensin system without renal artery stenosis. We report a case of reninoma in a female adolescent with a typical clinical presentation, in which surgical removal of the tumor completely cured hypertension. We discuss here the clinical features, imaging studies, and immunohistochemical examination of the tumor used to establish the diagnosis of reninoma and for the management of the condition.

Long-term repeated rituximab treatment for childhood steroid-dependent nephrotic syndrome

( Ji Hyun Kim ),( Eujin Park ),( Hye Sun Hyun ),( Myung Hyun Cho ),( Yo Han Ahn ),( Hyun Jin Choi ),( Hee Gyung Kang ),( Il-soo Ha ),( Hae Il Cheong ) 대한신장학회 2017 Kidney Research and Clinical Practice Vol.36 No.3

Background: Rituximab (RTX) can be used as a rescue therapy for steroid-dependent nephrotic syndrome (SDNS). However, the efficacy and safety of long-term, repeated use of RTX are not established. This study was conducted to assess the efficacy and safety of long-term, repeated RTX treatment in children. Methods: Eighteen consecutive child patients with SDNS who were treated with three or more cycles of RTX for one year or longer were recruited, and their medical records were retrospectively reviewed. Results: The patients were followed for 4.7 ± 1.9 years and received 5.2 ± 2.3 cycles of RTX over 2.8 ± 1.1 years. Approximately 70% of the additional RTX cycles were administered due to recovery of B-cells without relapse. The relapse rate decreased from 3.4 ± 2.0 per year initially to 0.4 ± 0.8 per year at the third year after RTX treatment. Approximately 10% of the RTX infusions were accompanied by mild infusion reactions. Eight patients showed sustained remission without any oral medication after the last cycle of RTX, while 10 patients had one or more episodes of relapse after the last cycle of RTX. The relapse rate in the latter group decreased from 2.8 ± 1.5 per year before RTX treatment to 1.3 ± 0.8 per year after cessation of RTX treatment. No significant differences in clinical parameters were found between the two groups. Conclusion: This retrospective study showed that pre-emptive and long-term, repeated RTX treatment is relatively effective and safe in children with SDNS. However, well-designed prospective studies are needed to confirm these findings.

Incorporation of amorphous TiO₂ into one-dimensional SnO₂ nanostructures as superior anodes for lithium-ion batteries

Cheong, Jun Young,Kim, Chanhoon,Jung, Ji-Won,Yun, Tae-Gwang,Youn, Doo Young,Cho, Su-Ho,Yoon, Ki Ro,Jang, Hye-Yeon,Song, Seok Won,Kim, Il-Doo Elsevier 2018 Journal of Power Sources Vol.400 No.-

<P><B>Abstract</B></P> <P>Lithium-ion batteries (LIBs) with higher energy density are necessary to meet the increasing demands of energy storage system (ESS) in near future. Tin (IV) oxide, SnO<SUB>2</SUB>, is one of highly promising anode candidates due to its high theoretical capacity (782 mAh g<SUP>−1</SUP>), abundance, environmental friendliness, and safety with organic electrolytes. However, a rapid capacity fading and poor rate capabilities arising from the large volume expansion and subsequent agglomeration of Sn nanoparticles have been major issues of SnO<SUB>2</SUB>. Here, we have synthesized one-dimensional (1D) SnO<SUB>2</SUB>-amorphous titanium (IV) oxide NTs (SnO<SUB>2</SUB>-a-TiO<SUB>2</SUB> NTs), which allow both facile ionic and electron transport as well as easy penetration of electrolytes. The resultant SnO<SUB>2</SUB>-a-TiO<SUB>2</SUB> NTs not only alleviate volume expansion by maintaining their structural integrity but also possess minimal charge transfer resistance even after a number of cycles. SnO<SUB>2</SUB>-a-TiO<SUB>2</SUB> NTs exhibit both excellent cycle retention characteristics (1050.2 mAh g<SUP>−1</SUP> after 250 cycles) and outstanding rate capability (522.3 mAh g<SUP>−1</SUP> at a current density of 5000 mA g<SUP>−1</SUP>), which is attributed to the introduction of amorphous TiO<SUB>2</SUB> that not only acts as buffer agent for volume changes of SnO<SUB>2</SUB> but also allows fast surface-controlled diffusion process due to its pseudocapacitive charge storage mechanisms.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Introduction of amorphous TiO<SUB>2</SUB> into SnO<SUB>2</SUB> nanotubes (SnO<SUB>2</SUB>-a-TiO<SUB>2</SUB> NTs). </LI> <LI> SnO<SUB>2</SUB>-a-TiO<SUB>2</SUB> NTs fabricated by one-step electrospinning and calcination. </LI> <LI> Incorporation of amorphous TiO<SUB>2</SUB> leads to higher Li diffusivity. </LI> <LI> SnO<SUB>2</SUB>-a-TiO<SUB>2</SUB> NTs exhibit excellent cycle retention and rate capabilities. </LI> <LI> Amorphous TiO<SUB>2</SUB> effectively alleviates the volume changes of SnO<SUB>2</SUB>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Ag-coated one-dimensional orthorhombic Nb₂O₅ fibers as high performance electrodes for lithium storage

Cheong, Jun Young,Youn, Doo Young,Kim, Chanhoon,Jung, Ji-Won,Ogata, Alana F.,Bae, Jin Gook,Kim, Il-Doo Elsevier 2018 ELECTROCHIMICA ACTA Vol.269 No.-

<P><B>Abstract</B></P> <P>In the recent times, pseudocapacitive electrode materials have received great attention due to their considerable capability in storing ions at relatively fast charging rates. Among various candidates, niobium (V) pentoxide (Nb<SUB>2</SUB>O<SUB>5</SUB>) has gained much attraction for lithium-ion batteries (LIBs) due to its insertion/extraction reaction with Li, safe redox potential, and considerably good capacity (about 200 mAhg<SUP>−1</SUP>). Nevertheless, low conductivity of Nb<SUB>2</SUB>O<SUB>5</SUB> has so far prevented its use as a viable electrode material for LIBs. In this study, we have successfully coated silver (Ag) nanoparticles (NPs) on the surface of one-dimensional orthorhombic Nb<SUB>2</SUB>O<SUB>5</SUB> fiber (1D T-Nb<SUB>2</SUB>O<SUB>5</SUB>) using simple electrospinning processing. Ag NPs coated Nb<SUB>2</SUB>O<SUB>5</SUB> fibers (Ag-1D T-Nb<SUB>2</SUB>O<SUB>5</SUB>) provided faster electron pathways, resulting in much improved capacity at a given current density with superior rate capabilities compared with pristine 1D T-Nb<SUB>2</SUB>O<SUB>5</SUB>. In addition, 1D T-Nb<SUB>2</SUB>O<SUB>5</SUB> was more suitable for coating Ag NPs compared with T-Nb<SUB>2</SUB>O<SUB>5</SUB> NPs, where its structural integrity was maintained even after cycling. As a result, effective coating of conductive Ag NPs on the 1D T-Nb<SUB>2</SUB>O<SUB>5</SUB> resulted in excellent cycle retention characteristics (179.7 mAhg<SUP>−1</SUP> after 500 cycles at 500 mA g<SUP>−1</SUP>) as well as superior rate capabilities (103.6 mAhg<SUP>−1</SUP> at a current density of 5000 mA g<SUP>−1</SUP>).</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ag NPs were decorated on 1D T-Nb<SUB>2</SUB>O<SUB>5</SUB>. </LI> <LI> Decoration of Ag NPs resulted in enhanced reversible capacity. </LI> <LI> Ag-1D T-Nb<SUB>2</SUB>O<SUB>5</SUB> exhibited excellent rate capabilities. </LI> <LI> 1D T-Nb<SUB>2</SUB>O<SUB>5</SUB> served as effective platforms for decoration of Ag NPs. </LI> <LI> The structural integrity of Ag-1D T-Nb<SUB>2</SUB>O<SUB>5</SUB> was maintained after cycles. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>