Neutrophil to lymphocyte ratio as a predictor of myocardial damage and cardiac dysfunction in acute coronary syndrome patients

Chen Chen,Bai Lin Cong,Min Wang,Muhammad Abdullah,Xiao Long Wang,Yin Hua Zhang,Shun Ji Xu,Lan Cui 한국한의학연구원 2018 Integrative Medicine Research Vol.7 No.2

Background: Neutrophil to lymphocyte ratio (NLR) in peripheral blood is established to correlate with the morbidity and mortality of heart disease patients. We aimed to define the severity of inflammation (NLR) by observing the association of NLR with cardiac functions or myocardial damage parameters in patients with acute myocardial infarction. Methods: Data from 715 patients who underwent percutaneous coronary intervention (PCI) within 72 hours of incidence in 2016 were analysed retrospectively. Results: The NLR ranges from 0.50 to 46 (medium ± SD, 2.76 ± 2.96) in 715 patients. NLR positively correlated with myocardial damage (NLR vs. CK-mB: p < 0.0001) but negatively correlated with myocardial function (NLR vs. EF: p < 0.0001; NLR vs. FS: p < 0.0001). Myocardial damage markers (CK, CK-mB, ASL, LDH) were significantly increased, and cardiac contractile parameters (EF and FS) were reduced at NLR > 2.76 compared to those of NLR < 2.76. ELISA analysis has shown that IL-10 was significantly increased when NLR ≥ 4.6 and TGF-β was increased at NLR > 4. The correlation was diminished between NLR and CK-mB at NLR > 2.76 or at NLR > 4, but that of NLR and EF or FS was maintained in NLR > 2.76 and at NLR > 4. EF and FS were comparable between NLR > 2.76 and NLR > 4. But myocardial damage parameters increased significantly at NLR > 4 compared to those of NLR > 2.76. Conclusion: NLR is a strong predictor of myocardial damage in acute myocardial patients. High NLR are associated with myocardial dysfunction in all the patients. Severe inflammation (NLR) can predict the consequence of the heart in patients with coronary syndrome.

China`s Pension Reform Process and the Future Options

( Chen Yin Hua ) 한국행정학회 2009 한국행정학회 학술발표논문집 Vol.2009 No.-

taken as soon as possible. China`s pension reform, Notional Refined-benefit, Individual Account, contribution rate, replacement rate, reform options, With the rapid demographic dynamic and economic development China have to face the old age problems. After several reform since 1986, especially the milestone reform in 1997, until now, China still apparently need reform in pension system. This paper analyzed the main problems about China`s current pension system and showed out the trade-off of different possible options. As regard to the finial selection, political and other factors will affect meantime. As the conclusion, the continuous pension reform in China should be

A Retrospective Study of the Effect of Spinopelvic Parameters on Fatty Infiltration in Paraspinal Muscles in Patients With Lumbar Spondylolisthesis

Jia-Chen Yang,Jia-Yu Chen,Yin Ding,Yong-Jie Yin,Zhi-Ping Huang,Xiu-Hua Wu,Zu-Cheng Huang,Yi-Kai Li,Qing-An Zhu 대한척추신경외과학회 2024 Neurospine Vol.21 No.1

Objective: The effect on fat infiltration (FI) of paraspinal muscles in degenerative lumbar spinal diseases has been demonstrated except for spinopelvic parameters. The present study is to identify the effect of spinopelvic parameters on FI of paraspinal muscle (PSM) and psoas major muscle (PMM) in patients with degenerative lumbar spondylolisthesis. Methods: A single-center, retrospective cross-sectional study of 160 patients with degenerative lumbar spondylolisthesis (DLS) and lumbar stenosis (LSS) who had lateral full-spine x-ray and lumbar spine magnetic resonance imaging was conducted. PSM and PMM FIs were defined as the ratio of fat to its muscle cross-sectional area. The FIs were compared among patients with different pelvic tilt (PT) and pelvic incidence (PI), respectively. Results: The PSM FI correlated significantly with pelvic parameters in DLS patients, but not in LSS patients. The PSM FI in pelvic retroversion (PT > 25°) was 0.54 ± 0.13, which was significantly higher in DLS patients than in normal pelvis (0.41 ± 0.14) and pelvic anteversion (PT < 5°) (0.34 ± 0.12). The PSM FI of DLS patients with large PI ( > 60°) was 0.50 ± 0.13, which was higher than those with small ( < 45°) and normal PI (0.37 ± 0.11 and 0.36 ± 0.13). However, the PSM FI of LSS patients didn’t change significantly with PT or PI. Moreover, the PMM FI was about 0.10–0.15, which was significantly lower than the PSM FI, and changed with PT and PI in a similar way of PSM FI with much less in magnitude. Conclusion: FI of the PSMs increased with greater pelvic retroversion or larger pelvic incidence in DLS patients, but not in LSS patients.

Stable and Recyclable SERS Substrates Based on Au-Loaded PET Nanocomposite Superhydrophobic Surfaces

Hua-Xiang Chen,Yu-Ting Wang,Ting-Ting You,Jin Zhai,Peng-Gang Yin 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.5

Novel surface-enhanced Raman scattering (SERS) substrates with stable and recyclable properties have been prepared by assembling gold nanoparticles-loaded PET (AuNPs/PET) nanocomposite superhydrophobic surfaces. After a physical vapor deposition process, the AuNPs/PET surfaces with vast plasmonic "hot spots" showed superhydrophobic properties, and it can hold target molecules droplets for rapid SERS detection. From blown off droplets and rinsed substrates with water after detection, we found that no probe molecules remained on the surfaces from Raman spectra. The prepared substrates were not contaminated in the detection process. Furthermore, the new SERS substrates were used for rapidly detecting droplets of crystal violet (CV) and the lowest detection concentration was about 1 x 10 -9 M. The as-prepared AuNPs/PET substrates also have good performance in terms of reproducibility and recyclability.

S100A4 Gene is Crucial for Methionine-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

Yin-Hua Zhang,De-Ping Ding,De-Qiang Ma,Juan Li,Lin-Li Chen,Kang-Jian Ao,You-You Tian 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.9

Purpose: To explore the influence of S100 calcium binding protein A4 (S100A4) knockout (KO) on methionine-choline-deficient(MCD) diet-induced non-alcoholic fatty liver disease (NAFLD) in mice. Materials and Methods: S100A4 KO mice (n=20) and their wild-type (WT) counterparts (n=20) were randomly divided into KO/MCD, Ko/methionine-choline-sufficient (MCS), WT/MCD, and WT/MCS groups. After 8 weeks of feeding, blood lipid and liverfunction-related indexes were measured. HE, Oil Red O, and Masson stainings were used to observe the changes of liver histopathology. Additionally, expressions of S100A4 and proinflammatory and profibrogenic cytokines were detected by qRT-PCR andWestern blot, while hepatocyte apoptosis was revealed by TUNEL staining. Results: Serum levels of aminotransferase, aspartate aminotransferase, triglyceride, and total cholesterol in mice were increasedafter 8-week MCD feeding, and hepatocytes performed varying balloon-like changes with increased inflammatory cell infiltrationand collagen fibers; however, these effects were improved in mice of KO/MCD group. Meanwhile, total NAFLD activity scoresand fibrosis were lower compared to WT+MCD group. Compared to WT/MCS group, S100A4 expression in liver tissue of WT/MCD group was enhanced. The expression of proinflammatory (TNF-α, IL-1β, IL-6) and profibrogenic cytokines (TGF-β1, COL1A1,α-SMA) in MCD-induced NAFLD mice were increased, as well as apoptotic index (AI). For MCD group, the expressions ofproinflammatory and profibrogenic cytokines and AI in KO mice were lower than those of WT mice. Conclusion: S100A4 was detected to be upregulated in NAFLD, while S100A4 KO alleviated liver fibrosis and inflammation, inaddition to inhibiting hepatocyte apoptosis.

AN EXTREMAL PROBLEM ON POTENTIALLY $K_{r,r}$-ke-GRAPHIC SEQUENCES

Chen, Gang,Yin, Jian-Hua The Korean Society for Computational and Applied M 2009 Journal of applied mathematics & informatics Vol.27 No.1

For $1{\leq}k{\leq}r$, let ${\sigma}$($K_{r,r}$ - ke, n) be the smallest even integer such that every n-term graphic sequence ${\pi}$ = ($d_1$, $d_2$, ..., $d_n$) with term sum ${\sigma}({\pi})$ = $d_1$ + $d_2$ + ${\cdots}$ + $d_n\;{\geq}\;{\sigma}$($K_{r,r}$ - ke, n) has a realization G containing $K_{r,r}$ - ke as a subgraph, where $K_{r,r}$ - ke is the graph obtained from the $r\;{\times}\;r$ complete bipartite graph $K_{r,r}$ by deleting k edges which form a matching. In this paper, we determine ${\sigma}$($K_{r,r}$ - ke, n) for even $r\;({\geq}4)$ and $n{\geq}7r^2+{\frac{1}{2}}r-22$ and for odd r (${\geq}5$) and $n{\geq}7r^2+9r-26$.

An extremal problem on potentially Kr,r-ke-graphic sequences

Gang Chen,Jian-Hua Yin 한국전산응용수학회 2009 Journal of applied mathematics & informatics Vol.27 No.1

For 1≤ k≤ r, let σ(Kr,r −ke, n) be the smallest even integer such that every n-term graphic sequence π= (d1, d2, . . . , dn) with term sum σ(π) = d1 + d2 + · · · + dn ≥ (Kr,r − ke, n) has a realization G containingKr,r − ke as a subgraph, where Kr,r − ke is the graph obtained from the r × r complete bipartite graph Kr,r by deleting k edges which form a matching. In this paper, we determine σ(Kr,r − ke, n) for even r (≥4) and n 7r2 + ½ r − 22 and for odd r (≥5) and n≥ 7r2 + 9r −26. For 1≤ k≤ r, let σ(Kr,r −ke, n) be the smallest even integer such that every n-term graphic sequence π= (d1, d2, . . . , dn) with term sum σ(π) = d1 + d2 + · · · + dn ≥ (Kr,r − ke, n) has a realization G containingKr,r − ke as a subgraph, where Kr,r − ke is the graph obtained from the r × r complete bipartite graph Kr,r by deleting k edges which form a matching. In this paper, we determine σ(Kr,r − ke, n) for even r (≥4) and n 7r2 + ½ r − 22 and for odd r (≥5) and n≥ 7r2 + 9r −26.

Adsorption mechanism of lead ions at ilmenite/water interface and its influence on ilmenite flotability

Pan Chen,Jihua Zhai,Wei Sun,Yue-hua Hu,Zhigang Yin,Xiangsheng Lai 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.53 No.-

In order to get further understanding of lead ions adsorption onto ilmenite surface, zeta potential analysis, adsorption density calculation, FT-IR and XPS analysis were employed. The results showed that the adsorption of lead ions onto ilmenite surface was a chemically dominating process. Lead species could interact with iron-hydroxyl complex compounds to form a Fe–O–Pb complex. The hydrophobic complex of Pb(OL)2 was also observed. Iron and adsorbed lead ions on ilmenite surface served as the main active-sites via chemisorption with oleate species. Introducing lead ions, as a surface modification means, can efficiently improve ilmenite flotability.

BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells

Yan Hua Gong,Jing Wu,Hua Qiang,Ben Liu,Zhi Kai Chi,Tao Chen,Bin Yin,Xiao Zhong Peng,Jian Gang Yuan 한국생화학분자생물학회 2008 BMB Reports Vol.41 No.4

Tazarotene-Induced Gene 1 Interacts with DNAJC8 and Regulates Glycolysis in Cervical Cancer Cells

Chun-Hua Wang,Rong-Yaun Shyu,Chang-Chieh Wu,Mao-Liang Chen,Ming-Cheng Lee,Yi-Yin Lin,Lu-Kai Wang,Shun-Yuan Jiang,Fu-Ming Tsai 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.6

The tazarotene-induced gene 1 (TIG1) protein is a retinoid-inducible growth regulator and is considered a tumor suppressor. Here, we show that DnaJ heat shock protein family member C8 (DNAJC8) is a TIG1 target that regulates glycolysis. Ectopic DNAJC8 expression induced the translocation of pyruvate kinase M2 (PKM2) into the nucleus, subsequently inducing glucose transporter 1 (GLUT1) expression to promote glucose uptake. Silencing either DNAJC8 or PKM2 alleviated the upregulation of GLUT1 expression and glucose uptake induced by ectopic DNAJC8 expression. TIG1 interacted with DNAJC8 in the cytosol, and this interaction completely blocked DNAJC8-mediated PKM2 translocation and inhibited glucose uptake. Furthermore, increased glycose uptake was observed in cells in which TIG1 was silenced. In conclusion, TIG1 acts as a pivotal repressor of DNAJC8 to enhance glucose uptake by partially regulating PKM2 translocation.