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Shin, D.Y.,Sung Kang, H.,Kim, G.Y.,Kim, W.J.,Yoo, Y.H.,Choi, Y.H. Masson Pub. USA, Inc 2013 Biomedicine & pharmacotherapy Vol.67 No.4
Decitabine (5-aza-2'-deoxycytidine), an inhibitor of DNA methyltransferases, has a wide range of anti-metabolic and anti-cancer activities. Decitabine also induces cell cycle arrest at G2/M phase and apoptosis in human cancer cells. However, the cellular and molecular mechanisms of this cell cycle arrest are poorly understood. In the present study, we investigated the roles of the tumor suppressor p53 and the cyclin-dependent kinase (Cdk) inhibitor p21 following decitabine-induced G2/M arrest in human cancer cells. DNA flow cytometric analyses indicated that decitabine induced a G2/M arrest in AGS gastric and A549 lung carcinoma cell lines, which have wild type p53. Western blot analyses using whole cell lysates from AGS cells demonstrated that decitabine treatment did not change the steady-state level of Cdks and Cdk inhibitor p27, but it partially inhibited expression of cyclin A, cyclin B1, and Cdc25C proteins. However, similar results were found using the A549 cell line, where decitabine induced a dramatic up-regulation of both p53 and p21 expression, and the increased levels of p21 were associated with increased binding of p21 with Cdks, cyclin A, and cyclin B1. Knockdown of p53 by small interfering RNA (siRNA) markedly abolished p53 induction by decitabine in AGS cells, yet p53 siRNA had no attenuating effect on p21 induction. In addition, depletion of p21 expression with siRNA, but not p53, significantly attenuated decitabine-induced G2/M arrest. We also observed that decitabine strongly induced G2/M arrest associated with p21 induction in both p53 allele-null (-/-) HCT116 and wild type p53 (+/+) HCT116 cell lines. Therefore, our data indicated that p21 plays a crucial role in decitabine-induced G2/M arrest and operates in a p53-independent manner.
Identification of Novel SNPs in Bovine Insulin-like Growth Factor Binding Protein-3 (IGFBP3) Gene
Kim, J.Y.,Yoon, D.H.,Park, B.L.,Kim, L.H.,Na, K.J.,Choi, J.G.,Cho, C.Y.,Lee, H.K.,Chung, E.R.,Sang, B.C.,Cheong, I.J.,Oh, S.J.,Shin, Hyoung Doo Asian Australasian Association of Animal Productio 2005 Animal Bioscience Vol.18 No.1
The insulin-like growth factors (IGFs), their receptors, and their binding proteins play key roles in regulating cell proliferation and apoptosis. Insulin-like growth factor binding protein-3 (IGFBP3, OMIM #146732) is one of the proteins that bind to the IGFs. IGFBP3 is a modulator of IGF bioactivity, and direct growth inhibitor in the extravascular tissue compartment. We identified twenty-two novel single nucleotide polymorphisms (SNPs) in IGFBP3 gene in Korean cattle (Hanwoo, Bos taurus coreanae) by direct sequencing of full gene including -1,500 bp promoter region. Among the identified SNPs, five common SNPs were screened in 650 Korean cattle; one SNP in promoter (IGFBP3 G-854C), one in 5'UTR region (IGFBP3 G-100A), two in intron 1 (IGFBP3 G+421T, IGFBP3 T+1636A), and one in intron 2 (IGFBP3 C+3863A). The frequencies of each SNP were 0.357 (IGFBP3 G-854C), 0.472 (IGFBP3 G-100A), 0.418 (IGFBP3 G+421T), 0.363 (IGFBP3 T+1636A) and 0.226 (IGFBP3 C+3863A), respectively. Haplotypes and their frequencies were estimated by EM algorithm. Six haplotypes were constructed with five SNPs and linkage disequilibrium coefficients (|D'|) between SNP pairs were also calculated. The information on SNPs and haplotypes in IGFBP3 gene could be useful for genetic studies of this gene.
農村學生과 都市學生의 運動適性에 關한 調査硏究 : 運動適性 要因分析을 中心으로
成鍾林,申吉洙,李商鍾 圓光大學校 1973 論文集 Vol.7 No.-
The present study attempted to know the next two things by administering physical fitness tests to students. First, physical fitness for high school boys in rural and urban area. Second, factors attributable to regional differences in fphysical fitness for high school boys. Number of subjects were 274 boy students, 156 of Daw Kwang High School and 118 of Iun Buk Young Sun High School. Results of the study can be summarized as follows. 1. Physique of students in rural area showed bigger than that of students in urban area. 2. Development of the body continued from 16 years of age to 19 years ooage. However, a little development showed between age of 19 and age of 20. 3. Strength of muscles increased from 16 years of age to 20 years of age. Measurement scores indicated that rural students were stronger than urban students. 4. Flexibliity decreased as students grew older. Urban students showed high tests scores in flexibility than rural students. 5. Rural students showed much better in cardio-pulmonary function than urban students. 6. Urban students showed better in agility and starting power than rural stul dents. 7. In analizing results above, rural students showed better tests scores in physique, cardio-pulmonary function, and muscle strength. On the other hand, Urban students showed better tests scores in agility, starting power, and balance than rural students.
성부현,이창효,김정기 漢陽大學校 基礎科學硏究所 1986 基礎科學論文集 Vol.5 No.-
다결정 ??의 자기적인 성질과 Morin전이를 상온에서의 X선 방법과85~300K의 온도범위에서 Mossbauer 효과에 의해서 연구하였다. X선 회절선은 ??가 단일결정상을 나타내며 결정구조는 α-Fe₂O₃와 같은 trigonal구조를 갖는다는 것을 보인다. 또한 초미세자기장의 온도 의존성과 사중극자 분열의 온도에 따른 변화는 본 연구의 온도범위에서는 Morin전이를 나타내지 않으며, 단일 자기상인 약강자성을 갖는다. 초미세자기장의 온도에 따른 변화에 스핀이론을 적용하였다. 그 결과식은 H(T)=543.42(??)이다. 통계역학적 분석에서, 측정된 이성핵이동의 온도의존성을 잘 설명하는 특성온도 ??를 구하였는데, 이 값들은 α-Fe₂O₃에서 철이온 대신에 In이온을 소량 첨가하는 경우에 감소하였다. 또한 각 온도에서의 이성핵이동값이 0.4~0.5mm/s를 나타내므로 ?? 결정에서의 Fe 이온은 +3라고 말할 수 있다. The magnetic properties and the Morin transition of the ?? have been studied by the methods of X-ray at room temperature and Mossbauer effect in the temperature ranges of 85~300K. The X-ray diffraction patterns show that the crystal is a single phase and the crystal structure is same structure is same structure as that of Alpha-Fe₂O₃. The temperature dependence of the magnetic hyperfine field and the quadrupole splitting tell us that the ?? has no Morin transition and is in a weak ferromagnetic phase within the temperature range of 85~300K. The spinwave theory has been applied to the temperature dependence of the magnetic hyperfine field H(T). The relation obtained from the theory is H(T)=542.42(??). According to the statistical analysis of the temperature dependence of isomer shift, the charateristic temperatures ?? decrease in case replacing a small amount of Fe ions by In ions. The values of 0.4~0.5mm/s in isomer shift tell us that the Fe ions of ?? are ferric.
성기영,최옥식,경천수,곽종훈 嶺南大學校 基礎科學硏究所 1997 基礎科學硏究 Vol.17 No.-
We fabricated photopolymer hologram and explained hologram formation processes. Dynamic self-diffraction oscillation of photopolymer is observed by two wave mixing experiment and it is well explained by the modified Kogelnik's coupled wave equation.