소셜미디어에서 관찰되는 Helicobacter pylori에 대한 정보의 특성 및 전달방식 분석

방창석,백광호 대한상부위장관ㆍ헬리코박터학회 2016 Korean Journal of Helicobacter Upper Gastrointesti Vol.16 No.4

Background/Aims: Current production of knowledge and distribution of data is frequently mediated by social media in the form of unstructured text data rather than classical newspaper or journal format. Management of Helicobacter pylori infection is an important issue in Korea. However, there has been no study on the characteristics of information regarding H. pylori consumed and distributed in the social media by general population. Materials and Methods: This study evaluated characteristics of social media data regarding H. pylori in Korea using semantic network analysis with Textom and NodeXL Pro (2015.8.11∼2016.8.11, Naver, Daum, Youtube, and Twitter searching). Results: Total collected data in the Textom analysis about '헬리코박터' was 10,061. TF-IDF (term frequency × inverse document frequency) was as follows: ‘위암’, ‘위’, ‘감염’, ‘윌’, ‘균’, ‘치료’, ‘위궤양’, ‘원인’, ‘프로젝트’, ‘음식’, ‘세균’, ‘검사’, ‘예방’, ‘증상’, ‘건강’, ‘약’, ‘효과’. In the Twitter analysis, 96 nodes and 120 edges, and 86 unique edges were detected, suggesting low distribution of data. Misinformed data such as ‘헬리코박터-파이로리’, ‘라는-바이러스때문에’, ‘헬리코박터-프로젝트’, ‘위궤양이나-위’, ‘점막-출혈을’, ‘비 롯하여-각종’, ‘부종을-억제하고’, ‘치료하는데-효과가’, ‘있습니다-또한’, ‘장티푸스-이질’, ‘등-전염성’, ‘세균이나-장’, ‘속의-세균 을’, ‘억제하는-효과가’, ‘프로젝트-윌’ were found. The most viewed movie in the Youtube analysis was ‘한국야쿠르트 헬리코박터 프로젝 트 윌 그 한입을 경계하라_15초’ (210,577). Conclusions: Relative insufficiency, low distribution, and some misinformed data were found in some part of social media. Participation of healthcare professional is warranted to solve these issues

위축성 위염과 장상피화생의 자연 경과

김범진 대한상부위장관ㆍ헬리코박터학회 2020 Korean Journal of Helicobacter Upper Gastrointesti Vol.20 No.2

Atrophic gastritis (AG) and intestinal metaplasia (IM) are considered the main precursor lesions of gastric cancer, and the risk of gastric cancer in the gastric mucosa increases in the presence of AG and IM. The development of intestinal-type gastric adenocarcinoma represents the last step of an inflammation-metaplasia-dysplasia-carcinoma sequence, called the Correa cascade of multistep gastric carcinogenesis. The incidences of both AG and IM tend to increase with age. Helicobacter pylori is regarded the most important factor in the development of IM; the progression of AG to IM is also affected by numerous environmental factors and individual genetic factors. Therefore, understanding the natural course of AG and IM is very important, especially in areas with a high prevalence of gastric cancer such as Korea.

기능성 소화불량증에서 헬리코박터 파일로리 제균과 모티리톤정 투여 효과 비교: 무작위 배정․이중 눈가림 연구

박재용,김재규,홍수진,전성우,김광하,김현수,김상균 대한상부위장관ㆍ헬리코박터학회 2019 Korean Journal of Helicobacter Upper Gastrointesti Vol.19 No.2

Background/Aims: Helicobacter pylori (H. pylori) infection is one of the etiologies of functional dyspepsia (FD). The aim of this study was to compare the efficacy of H. pylori eradication therapy and motilitone monotherapy in patients with FD. Materials and Methods: We prospectively performed a multicenter randomized double-blind study between August 2014 and June 2017. FD patients with H. pylori infection randomly received either the standard triple therapy or motilitone. Global and individual symptom improvements, and changes in quality of life score were assessed. Results: We failed to enroll as many candidates as we had planned. A study to evaluate the efficacy of medications in FD patients according to the Rome III criteria is difficult to perform in Korea because of the early medication therapy at local hospitals and reluctance to discontinue digestive medications. Of the 35 patients enrolled, 30 (18 in the H. pylori eradication group and 12 in the motilitone group) completed the trial. The success rate of H. pylori eradication was 44.4% (8/18). The symptom improvement rate using the 7-point Likert scale at week 12 was 66.7% (12/18) in the H. pylori eradication group and 91.7% (11/12) in the motilitone group (P=0.193). At week 12, the symptom improvement rate was not significantly different between the patients with successful eradication (87.5%, 7/8) and those in the motilitone group (91.7%, 11/12; P=1.000). Conclusions: Eradication therapy could be an effective treatment for H. pylori-positive FD. However, our results should be cautiously interpreted, as we failed to recruit the intended number of subjects.

표재성 식도암 내시경 절제 후 발생하는 이시성 암

Gyu Young Pih,Do Hoon Kim 대한상부위장관ㆍ헬리코박터학회 2020 Korean Journal of Helicobacter Upper Gastrointesti Vol.20 No.4

Esophageal cancer has a relatively high prevalence of local recurrence, which is associated with a poor prognosis. Superficial esophageal cancer has shown a metachronous recurrence rate of 2.6~35.8% with the cumulative overall 3-year and 5-year metachronous cancer incidence being 9.9~15.5% and 20.6~24.5%, respectively. In addition to recurrences in the remnant esophagus, second metachronous primary tumors have been reported to arise in 4.0~37.4% of esophageal cancer survivors. The second primary cancers arising after a diagnosis of esophageal cancer are most commonly detected in the head and neck area, followed by the lungs and stomach. The field cancerization theory explains the high prevalence of head and neck cancer among esophageal cancer patients. The reported risk factors for metachronous esophageal recurrences include scattered-type Lugol staining, circumferential endoscopic resection of the primary lesion, heavy alcohol use, smoking, inactive aldehyde dehydrogenase-2 genes, alcohol dehydrogenase-1B genes, and young age at diagnosis of the primary cancer. The risk factors for metachronous second primary tumors include heavy alcohol use, smoking, and a previous history of radiation therapy. Consequently, periodic follow-up endoscopy using narrow-band imaging is essential for the screening of metachronous esophageal cancers and second primary tumors after endoscopic resection for superficial esophageal cancer.

소화성 궤양 출혈의 내시경 치료

최연화,박준철 대한상부위장관ㆍ헬리코박터학회 2018 Korean Journal of Helicobacter Upper Gastrointesti Vol.18 No.4

Peptic ulcer bleeding is a common complication of peptic ulcer disease and the most common cause of upper gastrointestinal bleeding. Despite advances in drug usage and endoscopic modalities, no significant improvement is observed in the mortality rate of bleeding ulcers. The purpose of this review is to discuss various endoscopic hemostatic methods to treat peptic ulcer bleeding. Endoscopic hemostatic techniques can be classified into injection, mechanical, electrocoagulation, hemostatic powder, and endoscopic Doppler-guided hemostatic therapies (the last mentioned being a newly developed technique). Endoscopic hemostasis can be performed as mono or combination therapy using the aforementioned methods. Endoscopic hemostasis is the most important treatment for patients with peptic ulcer bleeding. Endoscopists should consider the treatment approach for peptic ulcer bleeding based on patient characteristics, the size and shape of the lesion, the endoscopist’s expertise, and the resources and circumstances at each hospital. Follow-up studies are needed to evaluate the efficacy of newly developed hemostatic powder therapy and endoscopic Doppler-guided hemostasis. (Korean J Helicobacter Up Gastrointest Res 2018;18:235-241)

위 종양의 내시경 점막하 박리술 후 발생하는 궤양 반흔에 대해 조직검사가 필요한가?

Do Hoon Kim 대한상부위장관ㆍ헬리코박터학회 2021 Korean Journal of Helicobacter Upper Gastrointesti Vol.21 No.1

무증상 환자에서 상부위장관 내시경으로 우연히 발견된 바터팽대부의 소세포 신경내분비암종 1예

주종석,김주석,신해진,김기대,문희석,강선형,성재규,정현용,김경희,송인상 대한상부위장관ㆍ헬리코박터학회 2015 Korean Journal of Helicobacter Upper Gastrointesti Vol.15 No.3

바터팽대부의 소세포 신경내분비암종은 매우 드문 질환으로 국내에서는 3예가 보고되었다. 이전에 보고된 3예의 경우 황달이나 복통으로 내원하여 내시경적 역행성 담췌관 조영술을 통한 조직검사로 소세포 신경내분비암종이 확진되어 수술적 치료를 시행하였다. 최근 저자들은 무증상 환자에서 검진 목적으로 시행한 상부위장관 내시경에서 바터팽대부의 궤양성 병변이 관찰되어 시행한 조직검사에서 소세포 신경내분비암종으로 진단된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Small cell neuroendocrine carcinoma in the ampulla of Vater is a rare disease and there have only been three cases reported in Korea. In these three cases, the patients had symptoms of abdominal pain and jaundice. A biopsy via endoscopic retrograde cholangiopancreatography confirmed a small cell neuroendocrine carcinoma; thus, each patient underwent surgical treatment. Recently, we experienced a case of small cell neuroendocrine carcinoma in an asymptomatic patient. An ulcerative lesion was identified during screening gastroduodenoscopy. Here, we report this case and review the relevant literature.

한국인에서 흔한 위 상피하 종양들

유대곤,최철웅 대한상부위장관ㆍ헬리코박터학회 2022 Korean Journal of Helicobacter Upper Gastrointesti Vol.22 No.1

Gastric subepithelial tumors (SETs) are often discovered incidentally and are usually benign. Their subepithelial location complicates accurate diagnosis; however, most lesions can be differentiated using either endoscopy or endoscopic ultrasonography. Gastric SETs location, color, surface change, size, consistency, and movability are evaluated during endoscopy. Endoscopic ultrasound assesses their originating layer, echogenicity, and homogeneity. Common gastric SETs in Koreans include ectopic pancreas, lipoma, leiomyoma, other benign lesions, neuroendocrine tumors, and gastrointestinal stromal tumors with malignant potential. Furthermore, extraluminal compression by normal organs or benign lesions as well as other malignant tumors may have a similar appearance to gastric SET. Understanding the endoscopic and endoscopic ultrasound characteristics of common gastric subepithelial lesions can reduce the rate of unnecessary examinations and excessive treatment. In this article, these characteristics are reviewed through various images that are common in the Korean population.

헬리코박터의 제균 치료 후 과증식 위용종 환자에서 용종의 크기 변화: 전향적 연구

유아영,박종재,주문경,이범재,전훈재,이상우 대한상부위장관ㆍ헬리코박터학회 2019 Korean Journal of Helicobacter Upper Gastrointesti Vol.19 No.4

Background/Aims: Helicobacter pylori (H. pylori) eradication is known to be effective for reducing the size of gastric hyperplastic polyps (HPPs). This study investigated the change in size of gastric HPPs after H. pylori eradication. Materials and Methods: This was a prospective study that enrolled 25 H. pylori-positive patients diagnosed as having HPPs at Korea University Guro Hospital between July 2015 and July 2016. If the patient wanted to receive eradication therapy, medication was given. If the patients refused eradication, only clinical follow-up was performed. All patients were subsequently followed up with endoscopic examination to determine any change in polyp size. Results: Eighteen of the 25 H. pylori-positive patients diagnosed as having HPPs were given an eradication regimen, and 17 were confirmed to have achieved successful eradication. Twelve (70.8%) of the 17 patients in the eradication group showed ≥50% reduction in size, while two (25.0%) of the eight patients in the non-eradication group showed 50% reduction. The polyp regression rate was significantly higher in the eradication group (P=0.03). A multivariate analysis revealed that H. pylori eradication (OR, 40.047; 95% CI, 1.112~1442.767; P=0.044) and female sex (OR, 12.947; 95% CI, 1.038~161.503; P=0.047) were significant predictive factors of HPP regression. Conclusions: H. pylori eradication is an effective therapeutic modality for gastric HPP regression.

헬리코박터 파일로리균 감염에 대한 IMMULITE2000®의 GENEDIA®와의 정확성 비교

임선희,김나영,김성은,백광호,이주엽,박경식,신정은,송현주,명대성,최석채,김현진 대한상부위장관ㆍ헬리코박터학회 2020 Korean Journal of Helicobacter Upper Gastrointesti Vol.20 No.1

Background/Aims: In serological tests for Helicobacter pylori (H. pylori), an enzyme-linked immunosorbent assay (GENEDIA®) and a solid-phase, two-step chemiluminescent enzyme immunoassay (IMMULITE®), which are easy to perform, inexpensive, and widely available, are commonly used. However, local validation of the test performance of IMMULITE® is required. This study aimed to examine the performance of IMMULITE® in comparison with that of GENEDIA® in a Korean health checkup population. Materials and Methods: The sera of 300 subjects among those who underwent health checkup were analyzed using IMMULITE®, and results were compared with those of GENEDIA®. The two serological tests were compared for their ability to predict atrophic gastritis (AG) or intestinal metaplasia (IM) on endoscopy. Results: We found significant correlation (Pearson correlation coefficient=0.903, P<0.0001) and an almost perfect agreement (Cohen’s Kappa coefficient=0.987, P<0.0001) between the results of GENEDIA® and IMMULITE®. The area under the receiver operating characteristics curve (AUC) for AG using GENEDIA® and IMMULITE® were 0.590 and 0.604, respectively, and showed no statistically significant difference in predictive ability for AG (Z-statistics=-0.517, P=0.605). The AUC for IM by GENEDIA® and IMMULITE® were 0.578 and 0.593, respectively, with no statistically significant difference in predictive ability for IM between the two values (Z-statistics=-0.398, P=0.691). Conclusions: No statistically significant difference in diagnostic value for H. pylori infection was found between GENEDIA® and IMMULITE®.