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국내에서 유행하는 HIV의 전파 경로에 따른 Subtype 분포
이주실,남정구,김성순,강춘,최병선,김옥진,박미선,성봉모,서순덕,전수경,변승옥,신영오,조해월 대한감염학회 2001 감염 Vol.33 No.5
Background : Previous data have been reported that subtype B is prevalent in South Korea, but neither the extent nor the proportion of subtypes could be evaluated. This study was designed to analyze the distribution of HIV-1 subtypes, temporal instructions and transmission dynamics between epidemiological groups. Methods : 1,280 Koreans had been diagnosed as HIV seropositive during the period 1985 to 2000. Among them, 134 individuals were selected for this molecular epidemiological study. 134 DNAs were isolated from uncultured or cultured peripheral blood mononuclear cells. V3-V5 (0.7 kb) fragment of HIV-1 env gene was amplified by nested polymerase chain reaction and was sequenced. Results : HIV-1 isolates from thirty-seven homosexuals were all subtype B (100%). On the other hand, 66 isolates from 94 heterosexuals were subtype B (70%) and 28 were non B subtypes (30% : 13 A, 4 C, 2 D, 8 E , 1 G). Only subtype B strains were isolated from 73 males who were infected with HIV inside Korea while 16 B and 20 non B subtype strains were isolated from 36 males who were HIV infected outside of Korea. However, B and non B strains were isolated half and half from females who were infected inside Korea except one. Conclusion : The HIV-1 subtype B strains are prevalent in Korea from the early HIV infection until present in both homo and heterosexuals. Non B strains have been transmitted from men who were infected outside Korea to their spouses and casual partners. So, we need further study to monitor subtype B and non B HIV transmission in epidemiological groups of Korea, (Korean J Infect Dis 33:311∼318, 2001)
서동진,윤광희,정영화,이영상,주광로,방성조,송병철,주연호,양수현,김기락 대한소화기학회 1999 대한소화기학회지 Vol.33 No.5
Backgrounds/Aims: We examined the serologic markers of hepatitis B virus (HBV) infection inclu ding anti-HBc (IgG) among Korean adults in the late 1990s to analyze the changing trends of HBV infection. Methods: For 70,347 adults who visited Asan Medical Center for general health screening from July, 1995 to December, 1997, HBsAg, anti-HBs and anti-HBc were tested by radioimmunoas say and serum alanine aminotransferase (ALT) was examined. Results: The overall prevalence of HBsAg was 5.7% and was increased with age (2.5% in teens, 5.4% in twenties, 6.8% in thirties) The overall prevalence of anti-HBc was 61.6%, which was significantly different below and above thirties. The proportion of persons who were negative for all HBV markers was 12.6% and this rate was similar in all age group. The prevalence of anti-HBc among persons who were negative in HBsAg and anti-HBs increased markedly with age. The percentage of persons with elevated ALT (≥2x upper normal limit) was higher in HBsAg-positive subjects than n HBsAg-negative subjects (7.4% vs 2.4%). The rare combination of HBV markers (+/-/-) which were positive in HBsAg and negative in anti-HBs and anti-HBC was found in 0.06% of entire subjects. Conclusions: The prevalence of HBsAg was decreasing and the percentage of subjects who were anti-HBc-negative was high in younger age group ( 30 years). Although the aquisition of anti-HBs was increasing through HBV vaccination, a significant proportion ($gt;10%) without any HBV markers was still susceptible to HBV infection.
호흡곤란을 주소로 내원하여 원발성 간세포암에 의한 폐동맥 색전증이 확인된 1예
서동진,정영화,이영상,주광로,박형주,김도하,원선영 대한소화기학회 1998 대한소화기학회지 Vol.32 No.3
Pulmonary embolism is a life threatening disease that needs early and accurate diagnosis and prompt management. We have experienced a case of hepatocellular carinoma with pulmonary embolism and subsequent puhnonary infarction. The abdominal CT showed multiple geographic low-density masses in the liver. The masses were extended to the inferior vena cava. The amount of alpha-fetoprotein was 1,150 ng/ml. The chest CT revealed almost complete obstruction of left main pulmonary artery and right inferior lobar artery by emboli and subsequent pulmonary infarction. The evidence of deep vein thrombosis and any other risk factor of pulmonary embolism was not found. He died of sudden cardiac arrest on the 12th day after admission.
( Joo Ho Lee ),( Yung Sang Lee ),( Pyo Nyun Kim ),( Beom Hee Lee ),( Gu Whan Kim ),( Han Wook Yoo ),( Nae Yun Heo ),( Young Suk Lim ),( Han Chu Lee ),( Young Hwa Chung ),( Dong Jin Suh ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.4
This is a case report of a 68-year-old man with hepatocellular carcinoma (HCC) accompanied by hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu disease, and hepatic vascular malformation. HHT is an autosomal dominant disorder of the fibrovascular tissue that is characterized by recurrent epistaxis, mucocutaneous telangiectasias, and visceral arteriovenous malformations. HHT is caused by mutation of the genes involved in the signaling pathway of transforming growth factor-β, which plays an important role in the formation of vascular endothelia1. Hepatic involvement has been reported as occurring in 30-73% of patients with HHT. However, symptomatic liver involvement is quite rare, and the representative clinical presentations of HHT in hepatic involvement are high-output heart failure, portal hypertension, nodular regenerative hyperplasia, and symptoms of biliary ischemia. Some cases of HCC in association with HHT have been reported, but are very rare. We present herein the characteristic radiologic and genetic findings of HHT that was diagnosed during the evaluation and treatment of HCC. (Korean J Hepatol 2011;17:313-318)
Immunomodulating Activity of a Fucoidan Isolated from Korean Undaria pinnatifida Sporophyll
Yoo, Yung-Choon,Kim, Woo-Jung,Kim, So-Yeon,Kim, Sung-Min,Chung, Mi-Kyung,Park, Joo-Woong,Suh, Hyun-Hyo,Lee, Kyung-Bok,Park, Yong-Il The Korean Society of Phycology 2007 ALGAE Vol.22 No.4
A fucoidan, isolated from Korean Undaria pinnatifida spoprophyll (UP-F), was investigated for its immunomodulating activity on murine macrophages and splenocytes, and its activity was compared with that of fucoidan from Fucus vesiculosus (FV-F). Treatment of UP-F resulted in inhibition of the growth of murine macrophage RAW 264.7 cells, but its cytotoxicity was not observed in normal murine splenocytes. FV-F was shown to be highly cytotoxic to both immune cells, and its cytotoxic activity was higher than that of UP-F. Treatment of UP-F induced TNF-α in a dose-dependent manner from two types of macrophages, RAW 264.7 cells and murine peritoneal macrophages. The TNF-α-inducing activity of UP-F was higher than that of FV-F. UP-F also actively induced chemokines (RANTES and MIP-1α) from RAW 264.7 cells. Furthermore, treatment of UP-F gave rise to activation of murine splenocytes to produce cytokine (IL-6) and chemokines (RANTES and MIP-1α), showing significantly higher activity than that of FV-F. These results indicate that UP-F is less cytotoxic to immune cells than FV-F, and possesses immunomodulating activity to produce cytokines and chemokines from macrophages and splenocytes.