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Overview of Computer Simulation on Laser Fusion in China
shao-ping Zhu,W. Y. Zhang 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III
Laser fusion research in China is organized by the National High-Tech Inertial Confinement Fusion Committee. Computer simulation is one of the most important research fields supported by the Committee. In the last decade, much effort has been made to develop the computer simulation code series named LARED. In recent years, a number of numerical simulations using LARED have been carried out and the simulation is checked by experiments done at the laser facility SG-II. In the present paper, we introduce the basic physics models used in LARED, the code structures, and some simulation results given by the code series.
Shao, Juan,Fang, Peng-Hua,He, Biao,Guo, Li-Li,Shi, Ming-Yi,Zhu, Yan,Bo, Ping,Zhang, Zhen-Wen Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.5
Circulatory miR-133a is a marker shared by several types of cancer. In this study we evaluated the feasibility of using miR-133a levels in gastric juice to screen for gastric cancer. A total of 204 samples of gastric juice and mucosa from gastric cancer, atrophic gastritis, gastric ulcer, superficial gastritis and healthy cases were collected by gastroscopy. The results showed that miR-133a levels in gastric juice and carcinoma tissues of patients with gastric cancer were significantly downregulated and positively correlated. Moreover, miR-133a in gastric juice has high operability, high reliability, high sensitivity, high specificity and relative stability, fit for clinical diagnosis of gastric cancer.
Shao-Ge Cheng,Yi-Xiu Zhu,Kui Sun,Wei-Ping Zhang 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.79 No.3
This paper presents a shaking table test carried out on a 1:5 reduced-scale five-story masonry-infilled reinforced concrete (RC) frame model. Multi-level simulated earthquake motions with increasing shaking severity were used as input to deform the model structure from an elastic to a near-collapse state. The dynamic characteristics, acceleration response, displacement response, damage state, energy dissipation behavior and stiffness degradation of each story were summarized for each stage. The tests indicate that cracks developed at the masonry-frame interface during minor shaking that caused infill to separate from the frame; however, its in-plane load bearing capacity was maintained. Moreover, the infill was able to resist infrequent earthquakes without causing instability or collapse of the structure. Thus, it is rational to consider masonry infill as a structural element in the seismic design of structures. Moreover, the story drift ratio of 1/400 can be regarded as the performance criterion for controlling frame structure cracking, and the story drift ratio of 1/100 can be regarded as the performance criterion for the peak bearing capacity of a frame structure. The test results could provide a reference not only for the seismic appraisal of existing buildings, but also for the seismic design of new buildings.
Research on Control Strategy of Hybrid Energy Storage System with Optical Storage Microgrid
Zhu Zuo-Bin,Sun Shu-Min,Ding Yue-Ming,Huang Shao-Ping 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.4
With the aim of improving the robustness of the hybrid energy storage system(HESS) and avoiding overcharging and reasonably managing state of charge (SOC), this paper proposed a HESS control strategy employing integral backstepping (IBS) method based on SOC. Firstly, on the basis of the hybrid energy storage control strategy of conventional filtering technology (FT), the current inner loop PI controller was changed into an controller employing IBS method to improve the robustness shown by the energy storage system (ESS) against system parameter perturbation or external disturbance. The current controller of the HESS employing inner loop integral backstepping method was designed and the Lyapunov stability was proven. Secondly, to avoid overcharging and over-discharging of the HESS and to reasonably manage SOC, an energy management strategy based on SOC was proposed to generate the current reference value of the inner loop controller employing integral backstepping method, and the energy management strategy based on SOC was designed as well. Finally, the simulation model of the HESS employing integrated backstepping method based on SOC was established, and the feasibility of this method was verified through simulation. It was shown by the results obtained from the simulation that the HESS control strategy employing integrated backstepping method based on SOC had greater anti-interference ability and improved the robustness of the system, in comparison with the control strategy of FT (PI) and FT (IBS) hybrid energy storage. In the meanwhile, the upper and lower limits of SOC of the ESS are supposed to be managed to avoid overcharging and over-discharging and to extend the life of the ESS.
Yuan, Shao-Fei,Chen, Wen-Jun,Zhu, Lin-Jia,Zheng, Wei-E.,Chen, Hua,Xiong, Jian-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6
Objective: To explore whether monoclonal antibodies against stathmin and the chemotherapuetic agent paclitaxel have synergenic effects in inhibiting growth and inducing apoptosis in human QG-56 cells. Methods: QG-56 cells were treated with monoclonal antibodies against stathmin or paclitaxel alone or in combination, with untreated cells used as controls. After 24, 48, 72 and 96 hours the cell growth condition was observed under an inverted microscope and inhibition was studied by MTT assay; apoptosis was analyzed by flow cytometry. Results: The populations decreased and cell shape and size changed after the various treatments. Monoclonal antibodies against stathmin and paclitaxel used alone or incombination inhibited the proliferation of QG-56 cells, especially in combination with synergism (P<0.05). Combined treatment also resulted in a significantly higher apoptosis rate than in the other groups (P<0.05). Conclusions: Monoclonal antibodies against stathmin and paclitaxel used alone or in combination can inhibit proliferation of QG-56 cells and induce apoptosis when applied together. The observed synergistic effects may have important implications for clinical application.
Phase II Clinical Study on the GEMOX Regimen as Second-line Therapy for Advanced Ovarian Cancer
Yuan, Shao-Fei,Zhang, Lian-Ping,Zhu, Lin-Jia,Chen, Wen-Jun,Zheng, Wei-E,Xiong, Jian-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
Aim: To investigate the effectiveness and adverse effects of gemcitabine by fixed-dose rate infusion plus oxaliplatin (GEMOX regimen) as second-line therapy for advanced ovarian cancer. Methods: 64 patients with advanced ovarian cancer were divided into an experimental group (44 cases) and a control group (20 cases). The experimental group was treated with continuous intravenous infusion of gemcitabine at 1000 $mg/m^2$ with a fixed-dose rate of 10 $mg/m^2/min$, on days 1 and 8 and oxaliplatin at 100 $mg/m^2$ on day 1, IVGTT, repeated every 3 weeks. The control group was treated with intravenous infusion of gemcitabine at 1000 $mg/m^2$ within 30 min on days 1 and and oxaliplatin at 100 $mg/m^2$ on day 1, IVGTT, again repeated every 3 weeks. CT scans or MRI were used for review every 1-2 cycles. Results: The effective rate in the experimental group was significantly high than control group (43.2% vs 35.0%; P < 0.05), with no obvious difference of hematologic or non-hematologic toxicity between the two groups (P > 0.05). Conclusion: GEMOX regimen is very effective to treat advanced ovarian cancer, with low toxicity, good tolerance and improved life quality in patients.
Yuan, Chun-Hui,Yang, Xue-Qin,Zhu, Cheng-Liang,Liu, Shao-Ping,Wang, Bi-Cheng,Wang, Fu-Bing Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Interleukin-7 (IL-7) is a potent anti-apoptotic cytokine that enhances immune effector cell functions and is essential for lymphocyte survival. While it known to induce differentiation and proliferation in some haematological malignancies, including certain types of leukaemias and lymphomas, little is known about its role in solid tumours, including breast cancer. In the current study, we investigated whether IL-7 could enhance the in vivo antitumor activity of tumor-reactive $CD8^+$ T cells with induction of IFN-${\gamma}$ in a murine breast cancer model. Human IL-7 cDNA was constructed into the eukaryotic expression plasmid pcDNA3.1, and then the recombinational pcDNA3.1-IL-7 was intratumorally injected in the TM40D BALB/C mouse graft model. Serum and intracellular IFN-${\gamma}$ levels were measured by ELISA and flow cytometry, respectively. $CD8^+$ T cell-mediated cytotoxicity was analyzed using the MTT method. Our results showed that IL-7 administration significantly inhibited tumor growth from day 15 after direct intratumoral injection of pcDNA3.1-IL-7. The anti-tumor effect correlated with a marked increase in the level of IFN-${\gamma}$ and breast cancer cells-specific CTL cytotoxicity. In vitro cytotoxicity assays showed that IL-7-treatment could augment cytolytic activity of $CD8^+$ T cells from tumor bearing mice, while anti-IFN-${\gamma}$ blocked the function of $CD8^+$ T cells, suggesting that IFN-${\gamma}$ mediated the cytolytic activity of $CD8^+$ T cells. Furthermore, in vivo neutralization of $CD8^+$ T lymphocytes by CD8 antibodies reversed the antitumor benefit of IL-7. Thus, we demonstrated that IL-7 exerts anti-tumor activity mainly through activating $CD8^+$ T cells and stimulating them to secrete IFN-${\gamma}$ in a murine breast tumor model. Based on these results, our study points to a potential novel way to treat breast cancer and may have important implications for clinical immunotherapy.