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Ling‑Hong Miao,Wen‑Jing Pan,Yan Lin,Bo Liu,Ming‑Chun Ren,Qun‑Lan Zhou,Xian‑Ping Ge 한국유전학회 2017 Genes & Genomics Vol.39 No.12
The objective of this study was to analyze the target genes and regulatory function of miR-34a in Megalobrama amblycephala using second-generation highthroughput sequencing and bioinformatic tools. Functional enrichment analysis was performed by gene ontology. MiR- 34a and target gene expression levels were measured in M. amblycephala fed normal and high-carbohydrate diets. The results revealed that miR-34a was highly conserved in several species, and miR-34a of M. amblycephala has a close evolutionary relationship to that of zebrafish and common carp. miRanda, TargetScan, RNAhybrid predicted 5,185, 6,282 and 2,168 target genes, respectively, and 645 target genes were in common. According to annotation information, the target genes were enriched in phosphate metabolism, glycerophospholipid metabolism, Golgi vesicle transport, cell division, and other biological processes (P < 0.05). Pathway enrichment analysis revealed that these target genes were mainly enriched in alpha-linolenic acid and linoleic acid metabolism, ether lipid metabolism, VEGF signaling pathway, Fc epsilon RI signaling pathway, GnRH signaling pathway, and MAPK signaling pathway (P < 0.05). The regulatory role of miR-34a was more significant in the liver than in the brain of M. amblycephala. MiR-34a regulates glucose lipid homeostasis induced by high glucose diets by upregulating hepatic PI3K/Akt, FOXO, and TOR signaling pathways.
An intelligent method to design die profile for rubber forming of complex curved flange part
Ling‑Yun Zhang,Shuai Zhou,Tian‑Zhang Zhao,Yi‑Pan Zeng 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.1
Rubber forming is an important forming process for the manufacture of aircraft sheet metal parts. The springback is one of the main defects in rubber forming. Classical springback compensation by displacement adjustment method using finite simulation is not satisfactory. In this research, the algorithms of compensating the arc and flange surface of complex curved flange with correction formula are proposed by experiment. The correction formula was developed based on the CATIA V5 R19 using Component Application Architecture. Compensate profile is presented including surface pick up, line pick up, division, compensation, extending, and trimming. The die profile of part with complex curved flanges in aircraft could be designed rapidly. It was found that the forming pressure has a little effect on the springback. This is within the tolerance limits of the part. The results reveal the method can achieve the industrial part precisely. The method is demonstrated on an aircraft wing rib part.
Zhou Ling,Li Ying-tao,Chen Jin,Yang Chao-shan,Deng Zhi-ping 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.10
In order to locate damage posotion and quantify damage degree of transmission tower, the method of damage identification of transmission tower based on flexibility matrix and signalterm amplitude vector was proposed, by combining flexibility matrix method of damage identification and time-frequency analysis method of domain vibration signal. Firstly, the coefficient equation about modal parameters and damage parameters was established, according to the linear relationship between flexibility matrix elements and structure parameters. Then, by Wigner-Ville Distribution (WVD) signalterm analytical deduction of free vibration response of the damping structure, the responding function relation between signalterm amplitude and model parameters was founded. Finally, the coefficient equation was solved by substituting mode shape vector with signalterm amplitude vector, avoiding the structural modal parameters identification, the damage location and extent of transmission tower was detected once and for all. The numerical example analysis of single tower model and tower-line system shows that, the proposed method with good anti-noise performance can accurately detect the extent of single or multiple damage of current structure by a single measurement.
중국 무역보험 민영화문제에 관한 연구: 선진국과의 비교분석을 중심으로
주령커(Ling-Ke Zhou),김해진(Hai-Zhen Jinb) 한국무역연구원 2016 무역연구 Vol.12 No.6
Although China has become a major trade power in the world, there are many shortcomings in the Chinese trade support systems including Chinese trade insurance system. Therefore, how to improve the Chinese trade insurance system has become a hot issue nowadays. In some of the latest studies, a method of privatization of trade insurance companies has been proposed. Up to now, there are three biggest privatized trade insurance companies in the world. They are Euler Hermes in Germany, Atradius in Netherlands, and COFACE in France. In this paper, necessary conditions for trade insurance privatization are examined according to the experiences of three privatized trade insurance companies: Euler Hermes (Germany), Atradius (Netherlands) and COFACE (France). These privatization requirements are then compared with trade insurance companies in China, in particular, whether Chinese trade insurance companies possess the necessary requirements for privatization or not. Consequently, we answer the question as to whether privatization is the right way to improve the Chinese trade insurance system in this study.
Zhengzhong Zhou,Lingli Zhou,Yi Liu,Qian Wang,Xiaoshan Meng,Qigang Wu,Taoli Huhe 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-
The technologies for enantiomeric resolution are essential to the development of pharmaceutical industry. The membrane technology has great potential in chiral separation owing to its low cost and highthroughput; however, the enantioselective of membrane is limited by the thickness of the active layer,which is closely related to the number of theoretical separation plates. In this work, the layered doublehydroxides (LDH) are synthesized by hydrothermal process and then vacuum filtrated with bcyclodextrin(b-CD) and polyvinyl alcohol (PVA) on a porous substrate to fabricate chiral selective membranes. 2D channels with increased number of separation stages are formed in the selective layer afterheat post-treatment. The enantiomeric excesses value is enhanced from 10.95% to 24.32% for racemicL/D- tryptophan resolution. This work provides a new approach for designing high performance chiralseparation membranes from the aspect of increasing the transport path.
주령커(Ling Ke ZHOU),박광서(Kwang So PARK) 한국무역상무학회 2016 貿易商務硏究 Vol.71 No.-
Anumber of Chinese studentswhoare studying inKorea have been gradually increasing since Korea and China established diplomatic relations. Many of themsale Korean products to Chinawhile studying for their degree programs in colleges. This kind of transactions can be named C2C overseas direct sales. C2Coverseas direct saleswhich are being performed byChinese student are good for exportation of Korean products. However Some of these transactions are not legal according to present law, First, Chinese student don’t have legal status tomake the transactions. Second, Chinese students usuallymake false declarations for evading the taxes, including tariff and VAT, Third, Chinese students can not offer the after-sale service for the goods for the Chinese consumers. Although C2C transactions have some legal matters, they should not be banned by a one-size-fits-allmethod. In this study, we highly recommend for the development of C2C transactions, First, Korean government should give Chinese students legal status. Second, China customs must strictly prohibit illegal activities of smuggling by taking advantage of postal route. Third, sellers inChina can offer the after-sale service to consumers through some specialist A/S firms.
Relationship Between ACE Insertion/Deletion Genotype, Telomere Length and Diabetes Mellitus Type Ii
( Yu Ling Zhou ),( Ya Xin Lu ),( Herbert Jelinek ),( Hassan Assareh ),( Craig S Mclachlan ),( Brett D Hambly ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Telomere length has been used as a surrogate biomarker for biological aging. Chronic diseases, i.e. Type 2 Diabetes mellitus (DMT2), resulting in infl ammation have been reported to shorten telomere length. The deletion allele of the angiotensin- converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been associated with infl ammation and susceptibility and severity of DMT2. We aimed to examine the interactions of ACE I/D genotype and DMT2 on telomere length. Methods: A total of 195 healthy controls and 80 patients with DMT2 were recruited from the Charles Sturt University Diabetes Screening Research Initiative in Australia. We measured leukocyte telomere length (LTL) by monochrome multiplex quantitative PCR and genotyped ACE I/D polymorphism by PCR and electrophoresis. Multivariate linear regression was used to determine the relationship between telomere length and ACE I/D genotype, covariates controlled for diabetic status. Results: Total population data demonstrated ACE DD or ID genotype carriers have longer mean LTL (1.091 and 1.095, respectively) than II genotype carriers (1.063, P=0.036). When stratifi ed on the basis of diabetes or no diabetes, a signifi cant increase in LTL was maintained in control subjects, but not in the DMT2 subjects. In control subjects, mean relative LTL for DD plus ID carriers is 1.090 and II carriers is 1.043 (P=0.009). In DMT2 patients, the mean relative LTL of samples carrying at least one D allele is 1.089 and II genotype carriers is 1.083 (P=0.868). In control but not DMT2 patients, female gender is associated with longer relative LTL (1.103, P=0.010). Conclusions: The II genotype is associated with shorter telomere length in a control population, but this association is lost in DMT2 patients. These findings support a hypothesis that ACE DD or ID genotype increases telomere length but that diabetes mellitus status alters this effect.