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      • KCI등재

        A NOTE ON PSEUDO-RIEMANNIAN ASSOCIATIVE FERMIONIC NOVIKOV ALGEBRAS

        Zhiqi Chen,Fuhai Zhu 대한수학회 2012 대한수학회보 Vol.49 No.2

        In this paper, we focus on pseudo-Riemannian associative fermionic Novikov algebras. We prove that the underlying Lie algebras of pseudo-Riemannian associative fermionic Novikov algebras are 2-step nilpotent and that pseudo-Riemannian associative fermionic Novikov algebras are 3-step nilpotent. Moreover, we construct a pseudo-Riemannian associative fermionic Novikov algebra in dimension 14, which is not a Novikov algebra. It implies that the inverse proposition of Corollary 2 in the paper "Pseudo-Riemannian Novikov algebras" [J. Phys. A: Math. Theor. 41 (2008), 315207] does not hold.

      • KCI등재

        Elevated Expression of RIOK1 Is Correlated with Breast Cancer Hormone Receptor Status and Promotes Cancer Progression

        Zhiqi Huang,Xingyu Li,Tian Xie,Changjiang Gu,Kan Ni,Qingqing Yin,Xiaolei Cao,Chunhui Zhang 대한암학회 2020 Cancer Research and Treatment Vol.52 No.4

        Purpose RIOK1 has been proved to play an important role in cancer cell proliferation and migration in various types of cancers—such as colorectal and gastric cancers. However, the expression of RIOK1 in breast cancer (BC) and the relationship between RIOK1 expression and the development of BC are not well characterized. In this study, we assessed the expression of RIOK1 in BC and evaluated the mechanisms underlying its biological function in this disease context. Materials and Methods We used immunohistochemistry, western blot and quantitative real-time polymerase chain reaction to evaluate the expression of RIOK1 in BC patients. Then, knockdown or overexpression of RIOK1 were used to evaluate the effect on BC cells in vitro and in vivo. Finally, we predicted miR-204-5p could be a potential regulator of RIOK1. Results We found that the expression levels of RIOK1 were significantly higher in hormone receptor (HR)–negative BC patients and was associated with tumor grades (p=0.010) and p53 expression (p=0.008) and survival duration (p=0.011). Kaplan-Meier analysis suggested a tendency for the poor prognosis. In vitro, knockdown of RIOK1 could inhibit proliferation, invasion, and induced apoptosis in HR-negative BC cells and inhibited tumorigenesis in vivo, while overexpression of RIOK1 promoted HR-positive tumor progression. MiR-204-5p could regulate RIOK1 expression and be involved in BC progression. Conclusion These findings indicate that RIOK1 expression could be a biomarker of HR-negative BC, and it may serve as an effective prognostic indicator and promote BC progression.

      • “MY OWN DESIGN IS BETTER”:A CO-CREATION PERSPECTIVE ON THE ONLINE LUXURY DESIGN

        Zhiqi Dong,Shiquan Wang,Hao Zhang 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07

        Nowadays, customers have become increasingly dissatisfied with accepting products and services offered by suppliers. Instead, they are involved in product development as co-productor (Prahalad & Ramaswamy, 2004). There are diverse types ranging from online discussion to virtual design enabling customer involved in co-creation activities related to product support. “Customer design” enables the firm to have possibilities enhancing the whole value of product design during development process (Fuchs & Schreier, 2011). However, some of scholars have found that customers cannot always play a useful role in luxury product design. Fuchs and Schreier (2011) studied that buyers can easily observe the source of design, which damage the image of co-designed product. That is because luxury product always played as a specific label of wealth and states to some extend (Ko & Phau, Aiello, 2016). Thus, this study draws from co-creation theory to investigate the specificity of online luxury design, using an experimental method. We analyze and discuss the diverging affection of luxury design held by co-creation idea innovativeness and behavior intensity, and the role played by sponsoring firm and community members.

      • KCI등재

        Algebras with pseudo-Riemannian bilinear forms

        Zhiqi Chen,Ke Liang,Fuhai Zhu 대한수학회 2011 대한수학회지 Vol.48 No.1

        The purpose of this paper is to study pseudo-Riemannian al-gebras, which are algebras with pseudo-Riemannian non-degenerate sym-metric bilinear forms. We find that pseudo-Riemannian algebras whose left centers are isotropic play a curial role and show that the decomposi-tion of pseudo-Riemannian algebras whose left centers are isotropic into indecomposable non-degenerate ideals is unique up to a special automor-phism. Furthermore, if the left center equals the center, the orthogonal decomposition of any pseudo-Riemannian algebra into indecomposable non-degenerate ideals is unique up to an isometry.

      • SCIESCOPUSKCI등재

        THE CLASSIFICATION OF ω-LEFT-SYMMETRIC ALGEBRAS IN LOW DIMENSIONS

        Zhiqi Chen,Yang Wu Korean Mathematical Society 2023 대한수학회보 Vol.60 No.3

        ω-left-symmetric algebras contain left-symmetric algebras as a subclass and the commutator defines an ω-Lie algebra. In this paper, we classify ω-left-symmetric algebras in dimension 3 up to an isomorphism based on the classification of ω-Lie algebras and the technique of Lie algebras.

      • KCI등재

        Hsp20 Promotes Endothelial Progenitor Cell Angiogenesis via Activation of PI3K/Akt Signaling Pathway under Hypoxia

        Han Zhiqi,He Xuan,Feng Yuan,Jiang Weidong,Zhou Nuo,Huang Xuanping 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.6

        BACKGROUND: Mandibular distraction osteogenesis (MDO) is a kind of endogenous tissue engineering technology that lengthens the jaw and opens airway so that a patient can breathe safely and comfortably on his or her own. Endothelial progenitor cells (EPCs) are crucial for MDO-related angiogenesis. Moreover, emerging evidence suggests that heat shock protein 20 (Hsp20) modulates angiogenesis under hypoxic conditions. However, the specific role of Hsp20 in EPCs, in the context of MDO, is not yet known. The aim of this study was to explore the expression of Hsp20 during MDO and the effects of Hsp20 on EPCs under hypoxia. METHODS: Mandibular distraction osteogenesis and mandibular bone defect (MBD) canine model were established. The expression of CD34, CD133, HIF-1a, and Hsp20 in callus was detected by immunofluorescence on day 14 after surgery. Canine bone marrow EPCs were cultured, with or without optimal cobalt chloride (CoCl2) concentration. Hypoxic effects, caused by CoCl2, were evaluated by means of the cell cycle, cell apoptosis, transwell cell migration, and tube formation assays. The Hsp20/KDR/PI3K/Akt expression levels were evaluated via immunofluorescence, RT-qPCR, and western blot. Next, EPCs were incorporated with either Hsp20-overexpression or Hsp20-siRNA lentivirus. The resulting effects were evaluated as described above. RESULTS: CD34, CD133, HIF-1a, and Hsp20 were displayed more positive in the callus of MDO compared with MBD. In addition, hypoxic conditions, generated by 0.1 mM CoCl2, in canine EPCs, accelerated cell proliferation, migration, tube formation, and Hsp20 expression. Hsp20 overexpression in EPCs significantly stimulated cell proliferation, migration, and tube formation, whereas Hsp20 inhibition produced the opposite effect. Additionally, the molecular mechanism was partly dependent on the KDR/PI3K/Akt pathway. CONCLUSION: In summary, herein, we present a novel mechanism of Hsp20-mediated regulation of canine EPCs via Akt activation in a hypoxic microenvironment.

      • SCIESCOPUSKCI등재

        A NOTE ON PSEUDO-RIEMANNIAN ASSOCIATIVE FERMIONIC NOVIKOV ALGEBRAS

        Chen, Zhiqi,Zhu, Fuhai Korean Mathematical Society 2012 대한수학회보 Vol.49 No.2

        In this paper, we focus on pseudo-Riemannian associative fermionic Novikov algebras. We prove that the underlying Lie algebras of pseudo-Riemannian associative fermionic Novikov algebras are 2-step nilpotent and that pseudo-Riemannian associative fermionic Novikov algebras are 3-step nilpotent. Moreover, we construct a pseudo-Riemannian associative fermionic Novikov algebra in dimension 14, which is not a Novikov algebra. It implies that the inverse proposition of Corollary 2 in the paper "Pseudo-Riemannian Novikov algebras" [J. Phys. A: Math. Theor. 41 (2008), 315207] does not hold.

      • SCIESCOPUSKCI등재

        ALGEBRAS WITH PSEUDO-RIEMANNIAN BILINEAR FORMS

        Chen, Zhiqi,Liang, Ke,Zhu, Fuhai Korean Mathematical Society 2011 대한수학회지 Vol.48 No.1

        The purpose of this paper is to study pseudo-Riemannian algebras, which are algebras with pseudo-Riemannian non-degenerate symmetric bilinear forms. We nd that pseudo-Riemannian algebras whose left centers are isotropic play a curial role and show that the decomposition of pseudo-Riemannian algebras whose left centers are isotropic into indecomposable non-degenerate ideals is unique up to a special automorphism. Furthermore, if the left center equals the center, the orthogonal decomposition of any pseudo-Riemannian algebra into indecomposable non-degenerate ideals is unique up to an isometry.

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