중국실학의 함의와 현대적 의의

張學智,池俊鎬 한국철학사연구회 2003 한국 철학논집 Vol.12 No.-

실학에 관한 대부분의 저서와 논문들은 일반적으로 明·淸시기에 일어난 ‘經世致用’ 思潮를 실학으로 정의하고 있다. 그러나 역사적인 문헌에서 드러나는 ‘실학’이라는 두 글자의 의미와 그리고 중국 역사에서 실제로 일어났던 사상조류의 변천을 살펴보면, 실학은 실제적으로 더욱 광범위한 내용을 포괄하고 있다. 실학은 도덕적인 측면에서의 ‘독실한 수양(篤實修養)’, 경제적인 측면에서의 ‘유가의 경전에 능통하여 실질적인 쓸모 있는 것에 정통함(通經致用)’, 事功이라는 측면에서의 ‘나라를 경영하여 세상을 구제함(經邦濟世)’이라는 세 가지 주요한 측면을 포괄하고 있다. 본 논문에서는 이러한 세 가지 측면을 역사적인 문헌과 사상사의 발전이라는 면으로 나누어 그 의미를 설명하였으며, 明·淸시기에 經世致用의 學이 왜 특별히 表彰되어 ‘실학’으로 불리게 되었는지 그 원인에 관하여도 검토하였다. 아울러 王陽明 心學의 변천과 明代 中·後期에 왕양명의 제자들이 토론한 주요 문제들이 갖는 의의를 탐구함으로써 明淸之際에 이르러 학풍이 크게 변화된 이유를 살펴보았다. 修德과 明經 그리고 經世의 세 가지 측면은 종합된 하나의 틀을 갖추고 있으며, 明德은 統領이 되고 明經과 致用은 輔翼이 된다. 그렇기 때문에 미래에 과학기술이 모든 것을 지배하고 모든 것을 제약하는 시대에 이르러서도 가치적인 理想을 수립할 수 있으며 사람의 최후까지도 배려하고 보살필 수 있게 된다. 이러한 점은 실학이 갖고 있는 현대적인 의의이기도 하다. 경제의 세계화 그리고 문화의 多元化시대인 오늘날 전통의 계승과 창조적인 발전은 중시되어야 한다. 아울러 전통에 관한 총체적인 이해와 설명을 통하여 새로운 學統도 형성하여야 한다. 중국 문화의 우수한 점을 흡수하고, 서양 민주제의 장점을 받아들이고, 지식인들의 憂患意識과 현실 정치에 대한 비판정신을 간직함으로써 정치적인 면에서도 새로운 政治文明을 건설하여야 할 것이다. Real Learning (Shixue) in Chinese classics and its historical context can be actually interpreted as a term which includes more comprehensive meaning than its literal meaning. Real Learning should be interpreted in three aspects: religious cultivating in morality, understanding the classics and making them be useful in social practice in Confucian studies, and administering the country and succoring the masses in the public affairs. This paper tries to articulate these three aspects of the connotation of Real Learning in terms of its meaning in texts and in the progress of the history of thought. According to this paper, these three aspects of the connotation of Real Learning played important roles in Chinese traditions of morality, learning, and politics. The ideological trend of practice in Ming and Qing Dynasties is not a totally new one but the continuation of Chinese traditional thought. Real Learning cannot be understood as an ideology which is similar to the Confucianism in the two Han Dynasties, Metaphysics in Wei and Jin Dynasties, Buddhism in Sui and Tang Dynasties, or Neo- Confucianism in Song and Ming Dynasties. 一般硏究實學的著作和論文都以明淸時期興起的經世致用思潮來定義實學本文則認爲, 從“實學”這兩個字在歷史典籍里的意思和中國歷史中實際發生的思想潮流的變遷來看, 實學實際上包括着更爲廣闊的內容. 實學應該包括三個主要的方面: 道德上的篤實修養, 經學上的通經致用和事功上的經邦濟世. 本文對這三個方面分別從歷史文獻和思想史的發展說明타們的眞實義涵. 着重梳理這三個方面對中國道統、學統、政統發生的巨大影響, 認爲明淸經世思潮是中國源遠流長的利用、厚生傳統的延續, 不是明淸時期特有的. “實學”只是一個標志學術思潮或學風轉型的槪念, 不能把타作爲和兩漢經學、魏晋玄學、隋唐佛學、宋明理學平行的思潮. 本文還檢討了明淸經世致用之學爲什요特別被表彰爲實學的原因, 幷從王陽明心學的演變及王陽明弟子所討論的主要問題在明代中後期的意義說明明淸之際學風丕變的根据. 在實學的現代意義方面, 本文認爲, 修德、明經、經世三個方面應當組成一個광架, 明德是統領, 明經、致用爲輔翼, 在未來科技宰制一切、規約一切的時代樹立价値理想, 完成人的終極關懷. 在當今經濟全球化、文化多元化的時代中重視對傳統的繼承與創造性轉化, 幷經過詮釋形成新的學統. 在政統方面, 吸收中國文化的優良成分, 吸納西方的民主制度的長處, 保持知識分子的憂患意識和對現實政治的批判精神, 建設新的政治文明.

Phosphorylation of DYNLT1 at Serine 82 Regulates Microtubule Stability and Mitochondrial Permeabilization in Hypoxia

Xue Xu,Yue-sheng Huang,Qiong Zhang,Jiong-yu Hu,Dong-xia Zhang2,Xu-pin Jiang,jie-zhi Jia,Jing-ci Zhu 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.4

Hypoxia-induced microtubule disruption and mitochondrial permeability transition (mPT) are crucial events leading to fatal cell damage and recent studies showed that microtubules (MTs) are involved in the modulation of mitochondrial function. Dynein light chain Tctex-type 1 (DYNLT1) is thought to be associated with MTs and mitochondria. Previously we demonstrated that DYNLT1 knockdown aggravates hypoxia-induced mitochondrial permeabilization, which indicates a role of DYNLT1 in hypoxic cytoprotection. But the underlying regulatory mechanism of DYNLT1 remains illusive. Here we aimed to investigate the phosphorylation alteration of DYNLT1 at serine 82 (S82) in hypoxia (1% O2). We therefore constructed recombinant adenoviruses to generate S82E and S82A mutants, used to transfect H9c2 and HeLa cell lines. Development of hypoxia-induced mPT (MMP examining, Cyt c release and mPT pore opening assay), hypoxic energy metabolism (cellular viability and ATP quantification), and stability of MTs were examined. Our results showed that phosph-S82 (S82-P) expression was increased in early hypoxia; S82E mutation (phosphomimic) aggravated mitochondrial damage, ele-vated the free tubulin in cytoplasm and decreased the cellular viability; S82A mutation (dephosphomimic) seemed to diminish the hypoxia-induced injury. These data suggest that DYNLT1 phosphorylation at S82 is involved in MTs and mitochondria regulation, and their interaction and cooperation contribute to the cellular hypoxic tolerance. Thus, we provide new insights into a DYNLT1 mechanism in stabilizing MTs and mitochondria, and propose a potential therapeutic target for hypoxia cytoprotective studies.

Personalized Context-aware Recommendation Approach for Web Services

Zhang Xue-Jie,Wang Zhi-Jian,Zhang Wei-Jiang 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.8

With the increasing number of Web services, the goal of consumers becomes to discover and use services that lead to their experiencing the highest quality. Quality of Service (QoS) is important to evaluate the QoS performance of services to differentiate the qualities of service candidates. QoS is highly related to context information since service consumers are typically distributed in different geographical locations. Their experience is usually different. Invoking a huge number of Web services for consumers to predict the quality is time-consuming, resource- consuming, and sometimes even impractical. To address the challenge, this paper proposes a personalized context-aware recommendation approach for predicting the QoS of Web services and designs a prediction framework. This algorithm is a hybrid of the model-based and memory-based collaborative filtering algorithms. In our experiment, we collect QoS information from geographically distributed service consumers through the framework. Based on the QoS and context information, we predict the quality of services. As a result, we can obtain a list of recommended services for selection. Finally, the experiment shows that the algorithm using context information achieves better prediction.

2D Geometric Constraint Optimum Solving Based on Problem Decomposition

Xue-Yao Gao,Chun-Xiang Zhang,Zhi-Mao Lu 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.1

Constraint solving is widely applied to many fields including computer aided design, 2 dimension (2D) model design and computer aided manufacturing. Geometric constraint solution is a difficult problem because there are a large number of entities and related parameters in 2D sketches. In this paper, a new method which decomposes geometric constraint relations based on entity-parameter graphs is proposed for reducing the size of constraint solution. A geometric constraint problem is decomposed into many independent sub-problems. Then, particle swarm optimization algorithm is used to solve constraint equations in each sub-problem. Solutions of all sub-problems are integrated to obtain the original problem’s solution. In experiments, the proposed method is applied to HUST-CAID system. Experimental results show that the method can effectively solve 2 dimension geometric constraints.

Study on Soil Eco-hydrological Function during the Degradation Process of Mountain Meadow

Zhang Xue-Ling,Guo Xiao-Min,Niu De-Kui,Zhang Wen-Yuan,Li Zhi 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Study on molten salt oxidation process of simulated Co doped cation exchange resins

Yun Xue,Yue-Lin Wang,Yu Li,Wen-Da Xu,Fu-Qiu Ma,Yang-Hai Zheng,Qing-Guo Zhang,Zhi Zhang,Mi-lin Zhang,Yong-De Yan 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.126 No.-

Cation exchange resins (CERs) are widely applied to purify waste liquids generated during the operationof nuclear reactors. The radioactive nuclides 60Co and 58Co are important corrosion activation products inreactor cooling water. In this study, the simulated Co doped CERs were oxidized with ternary carbonate. According to the thermogravimetric analysis (TG), the decomposition of Co doped CERs includes threeprocesses: 1. Elimination of the osmotic water; 2. Pyrolysis of sulfonic acid group; 3. Destruction of styrene–divinylbenzene copolymer. The X-Ray Diffraction (XRD) patterns indicate that sulfur mainly exists inthe form of sulfate in waste salt. The Co2+ undergoes the path of CoS2 ? Co3O4 with the increase of temperatureand the transition point is 650 C. Combined with Fourier Transform Infrared Spectrometer (FTIR)spectra and X-ray Photoelectron Spectroscopy (XPS) analysis, sulfonic acid groups begin to decomposeat 350 C. During the molten salt oxidation process, most of the sulfur in sulfonic acid groups is entrappedby carbonate as the form of sulfate, and a little of which remains as sulfone group, sulfoxide group andsulfur bridge in residue. When the resins are oxidized at 800 C, the retention rate of Co2+ is 97.3%, indicatingthat the molten salt oxidation can effectively remain Co2+ and convert it into a more stablesubstance.

Disambiguate Chinese Word Sense Based on Linguistics Knowledge

Chun-Xiang Zhang,Long Deng,Xue-Yao Gao,Zhi-Mao Lu 보안공학연구지원센터 2014 International Journal of Database Theory and Appli Vol.7 No.6

Word sense disambiguation (WSD) is important to many application problems in natural language processing fields, such as machine translation, parsing analysis and information retrieval. In this paper, we propose a new method to determine correct sense categories of Chinese words based on linguistics knowledge. The left word string and the right word string around the ambiguous word are respectively analyzed. Their syntactic structures are obtained for determining its intended sense. Syntactic category and part of speech are extracted as disambiguation features. A naive bayesian model is used as the classifier. Experimental results showed that the accuracy rate of classification arrives at 64%. The performance of disambiguation is improved.

Reduction of the contact resistance in copper phthalocyanine thin film transistor with UV/ozone treated Au electrodes

Jun Li,Liang Zhang,Xiao-Wen Zhang,Hao Zhang,Xue-Yin Jiang,Dong-bin Yu,Wen-Qing Zhu,Zhi-Lin Zhang 한국물리학회 2010 Current Applied Physics Vol.10 No.5

Bottom-contact (BC) copper phthalocyanine (CuPc) thin film transistor with UV/ozone treated Au as a source/drain electrode was fabricated and the contact resistance was estimated from the transmission line method (TLM). Comparing the properties of OTFT with untreated Au electrode, the performance of the BC CuPc-TFT with the UV/ozone treated Au electrodes was significantly improved: saturation mobility increased from 4.69 × 10−3 to 2.37 × 10−2 ㎠/V s, threshold voltage reduced from −29.1 to −6.4 V, and threshold swing varied from 5.08 to 2.25 V/decade. The contact resistance of the device with UV/ozone treated Au electrodes was nearly 20 times smaller than that of the device with untreated Au electrodes at the gate voltage of −20 V. This result indicated that using the UV/ozone treated Au electrode is an effective method to reduce the contact resistance. The present BC configuration with UV/ozone treated Au electrodes could be a significant step towards the commercialization of OTFT technology.

Lack of Influence of an XRCC3 Gene Polymorphism on Oral Cancer Susceptibility: Meta-analysis

Zhang, En-Jiao,Cui, Zhi-Gang,Xu, Zhong-Fei,Duan, Wei-Yi,Huang, Shao-Hui,Tan, Xue-Xin,Yin, Zhi-Hua,Sun, Chang-Fu,Lu, Li Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

Background: To systematically summarize the association between the X-ray repair cross complementing 3 (XRCC3) gene polymorphism and oral cancer susceptibility by meta-analysis. Materials and Methods: Databases including PubMed, EMbase, CNKI, VIP and WanFang Data were searched to identify case-control studies concerning the association between an XRCC3 gene polymorphism and the risk of oral cancer from the inception to June 2014. Two reviewers independently screened the literature according to the criteria, extracted the data and assessed the quality. Then meta-analysis was performed using Stata 11.0 software. Results: Seven published case-control studies including 775 patients with oral cancer and 1922 controls were selected. Associations between the rs861539 polymorphism and overall oral cancer risk were not statistically significant in all kinds of comparison models (CT vs CC: OR=0.94, 95%CI=0.74-1.18; TT vs CC: OR=0.94, 95%CI=0.64-1.38; dominant model: OR=0.95, 95%CI=0.76-1.18; recessive model: OR=0.94, 95%CI=0.69-1.29; allele T vs C: OR=0.97, 95%CI=0.84-1.11). In the stratified analysis by ethnicity, no significant associations were found among Asians and Caucasians. On stratification by tumor type, no significant associations were found for cancer and oral premalignant lesions. Conclusions: The XRCC3 gene polymorphism was not found to be associated with the risk of oral cancer. Considering the limited quality of the included case-control studies, more high quality studies with large sample size are needed to verify the above conclusion.

Regulatory Network of MicroRNAs, Target Genes, Transcription Factors and Host Genes in Endometrial Cancer

Xue, Lu-Chen,Xu, Zhi-Wen,Wang, Kun-Hao,Wang, Ning,Zhang, Xiao-Xu,Wang, Shang Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

Genes and microRNAs (miRNAs) have important roles in human oncology. However, most of the biological factors are reported in disperse form which makes it hard to discover the pathology. In this study, genes and miRNAs involved in human endometrial cancer(EC) were collected and formed into regulatory networks following their interactive relations, including miRNAs targeting genes, transcription factors (TFs) regulating miRNAs and miRNAs included in their host genes. Networks are constructed hierarchically at three levels: differentially expressed, related and global. Among the three, the differentially expressed network is the most important and fundamental network that contains the key genes and miRNAs in EC. The target genes, TFs and miRNAs are differentially expressed in EC so that any mutation in them may impact on EC development. Some key pathways in networks were highlighted to analyze how they interactively influence other factors and carcinogenesis. Upstream and downstream pathways of the differentially expressed genes and miRNAs were compared and analyzed. The purpose of this study was to partially reveal the deep regulatory mechanisms in EC using a new method that combines comprehensive genes and miRNAs together with their relationships. It may contribute to cancer prevention and gene therapy of EC.