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- 저자 : Zhao Cao (검색결과 208 건)
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Cao, Ke,Li, Jingjing,Zhao, Yong,Wang, Qi,Zeng, Qinghai,He, Siqi,Yu, Li,Zhou, Jianda,Cao, Peiguo Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.2
miR-101 is considered to play an important role in hepatocellular carcinoma (HCC), but the underlying molecular mechanism remains to be elucidated. Here, we aimed to confirm whether Girdin is a target gene of miR-101 and determine the tumor suppressor of miR-101 through Girdin pathway. In our previous studies, we firstly found Girdin protein was overexpressed in HCC tissues, and it closely correlated to tumor size, T stage, TNM stage and Edmondson-Steiner stage of HCC patients. After specific small interfering RNA of Girdin was transfected into HepG2 and Huh7.5.1 cells, the proliferation and invasion ability of tumor cells were significantly inhibited. In this study, we further explored the detailed molecular mechanism of Girdin in HCC. Interestingly, we found that miR-101 significantly low-expressed in HCC tissues compared with that in matched normal tissues while Girdin had a relative higher expression, and miR-101 was inversely correlated with Girdin expression. In addition, after miR-101 transfection, the proliferation, migration and invasion abilities of HepG2 cells were weakened. Furthermore, we confirmed that Girdin is a direct target gene of miR-101. Finally we confirmed Talen-mediated Girdin knockout markedly suppressed cell proliferation, migration and invasion in HCC while downregulation of miR-101 significantly restored the inhibitory effect. Our findings suggested that miR-101/Girdin axis could be a potential application of HCC treatment.
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Limin Cao,Jin Si,Weiyu Wang,Xiaorong Zhao,Xiaomei Yuan,Huifen Zhu,Xiaolong Wu,Jianzhong Zhu,Guanxin Shen 한국분자세포생물학회 2006 Molecules and cells Vol.21 No.1
Gene therapy with nonviral vectors using the suicide gene/prodrug activating system of herpes simplex virus type-1 thymidine kinase (HSV1-TK)/ganciclovir (GCV) is inefficient in killing malignant tumor cells due to two major factors: (a) an unsatisfactory bystander effect; (b) short-lived expression of the protein. To study the capacity of the protein transduction domain (PTD) of HIV-1 TAT protein to enhance HSV1-TK/GCV cancer gene therapy, we constructed three fusion proteins TAT-TK, TK-TAT and TK. TATTK retained as much enzyme activity as TK, whereas that of TK-TAT was much lower. TAT-TK can enter HepG2 cells and much of it is translocated to the nucleus. The transduced HepG2 cells are killed by exogenously added GCV and have bystander effects on untransduced HepG2 cells. Most importantly, the introduced recombinant protein is stable and remains functional for several days at least, probably because nuclear localization protects it from the cytoplasmic degradation machinery and provides access to the nuclear transcription machinery. Our results indicate that TAT fusion proteins traffic intercellularly and have enhanced stability and prodrug cell killing activity. We conclude that TAT has potential for enhancing enzyme prodrug treatment of liver cancers.
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Yajun Zhao,Jintao Chen,Xiaorui Li,Jiaqing Zhang,Yanan Li,Yajun Zhao,Liye Cao,Xiaoshi Jin 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2020 NANO Vol.15 No.02
Cu-N-C electrocatalyst was successfully prepared with Cu-BTC and polyacrylonitrile as templates by electrospinning and in-situ growth method. The effect of various N-doped content on the electrochemical performance of the catalyst were investigated and the Cu-N-C-0.25 exhibited the best OER/ORRcatalytic activities. When it was applied to the cathode of the zinc-air batteries, the power density of Cu-N-C-0.25 was 209.1 mW cm -2, which exceeded that of the commercial Pt/C + IrO2 hybrid catalyst (157 mW cm -2). The excellent electrochemical performance may be attributed to large number of active sites and high specific surface area on Cu-N-C electrocatalyst. It will be a promising alternative to precious metal catalysts containing Pt, Ir or Ru and their oxides.
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Peiguo Cao,Ke Cao,Jingjing Li,Yong Zhao,Qi Wang,Qinghai Zeng,Siqi He,Li Yu,Jianda Zhou 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.2
miR-101 is considered to play an important role in hepatocellular carcinoma (HCC), but the underlying molecular mechanism remains to be elucidated. Here, we aimed to confirm whether Girdin is a target gene of miR-101 and determine the tumor suppressor of miR-101 through Girdin pathway. In our previous studies, we firstly found Girdin protein was overexpressed in HCC tissues, and it closely correlated to tumor size, T stage, TNM stage and Edmondson-Steiner stage of HCC patients. After specific small interfering RNA of Girdin was transfected into HepG2 and Huh7.5.1 cells, the proliferation and invasion ability of tumor cells were significantly inhibited. In this study, we further explored the detailed molecular mechanism of Girdin in HCC. Interestingly, we found that miR-101 significantly low-expressed in HCC tissues compared with that in matched normal tissues while Girdin had a relative higher expression, and miR-101 was inversely correlated with Girdin expression. In addition, after miR-101 transfection, the proliferation, migration and invasion abilities of HepG2 cells were weakened. Furthermore, we confirmed that Girdin is a direct target gene of miR-101. Finally we confirmed Talen-mediated Girdin knockout markedly suppressed cell proliferation, migration and invasion in HCC while down-regulation of miR-101 significantly restored the inhibitory effect. Our findings suggested that miR-101/Girdin axis could be a potential application of HCC treatment.
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Improved Switching Ripple Suppression Strategy for Multi-Paralleled Grid-Connected Inverters System
Wu Cao,Haotian Kang,Kangli Liu,Shunyu Wang,Jianfeng Zhao,Xiaochun Ji,Jun Zhao 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
The switching operations of inverters in the distributed system inevitably introduce high-frequency harmonics into grid, which may make influences on electrical devices. To address it, this paper proposes a ripple suppression strategy based on active cancellation combined with passive filtering. The active cancellation is realized by carrier-phase-shift (CPS) technique and the passive filtering is achieved by filters. Furthermore, two component-shared LCL-type filters improved by traditional LCL filters are studied from the points of resonance and accuracy of gridinjected current. To valid the effectiveness of the proposed strategy, simulations and experimental test are carried out. The results show that the proposed strategy can effectively suppress high-frequency harmonics and two componentshared LCL-type filters can become promising filters for the multi-paralleled grid-connected inverters.
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Haiyan Zhao,Yaping Zhao,Xin Li,Leiqian Xu,Fangxin Jiang,Wanju Hou,Lixia Dong,Jie Cao 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.9
Purpose: Obstructive sleep apnea and chronic obstructive pulmonary disease are independent risk factors of cardiovascular disease(CVD), and their coexistence is known as overlap syndrome (OS). Endothelial dysfunction is the initial stage of CVD; however,underlying mechanisms linking OS and CVD are not well understood. The aim of this study was to explore whether OS canlead to more severe inflammation and endothelial apoptosis by promoting endothelial dysfunction, and to assess the interventioneffects of antioxidant tempol. Materials and Methods: Male Wistar rats (n=66) were exposed to normal oxygen [normal control (NC) group], intermittent hypoxia(IH group), cigarette smoke (CH group), as well as cigarette smoke and IH (OS group). Tempol intervention was assessed inOS group treated with tempol (OST group) or NaCl (OSN group). After an 8-week challenge, lung tissues, serum, and fresh bloodwere harvested for analysis of endothelial markers and apoptosis. Results: The levels of intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, and apoptosis in circulating epithelialcells were the highest in OS group and the lowest in NC group. These levels were all greater in IH group than in CH group,and were lower in OST group than in OS and OSN groups (all p<0.001). Conclusion: Synergistic effects of IH with cigarette smoke-induced emphysema produce a greater inflammatory status and endothelialapoptosis. OS-related inflammation and endothelial cell apoptosis may play important roles in promoting cardiovasculardysfunction, and antioxidant tempol could achieve a partial protective effect.
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Dendritic porous SnO2/SiO2@polymer nanospheres for pH-controlled styptic drug release
Na Cao,Xin Xie,Yu Zhang,Yanbao Zhao,Liuqin Cao,Lei Sun 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.34 No.-
Dendritic porous tin oxide/silica (DTS) nanospheres (NSs) were prepared by emulsion-condensationroute. DTS NSs have an average diameter of 80 nm and possess accessible center-radial large porechannels, which endow them high surface area, less drug diffusion resistance and more mass transport. SnO2 quantum dots (QDs) embedded in silica skeleton can be used to track the drug release behavior. DTS NSs were coated by chitosan/polymethacrylic acid and polymer shell would make them achievegreat loading capacity and pH-sensitive release for aminomethylbenzoic acid (AMBA).
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Xue Zhao,Ruina Ma,An Du,Yinan Zhang,Xue Zhao,Yongzhe Fan,Xiaoming Cao 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.7
The charge recombination caused by surface defects limits photovoltaic properties of quantum dot-sensitized solar cells (QDSSCs), which can be suppressed by modifying organic or inorganic molecules and atomic ligands. In this paper, octa-aminopropyl polyhedral oligomeric silsesquioxane (OA-POSS) connected and modified near-infrared absorption CdSeTe quantum dots (QDs) through coupling agent (1-ethyl-3-3-dimethylaminopropyl carbodiimide hydrochloride). The results suggest that OA-POSS reduces the surface defects of CdSeTe QDs and suppresses charge recombination. Therefore, the power conversion efficiency improves nearly 41%, which increases from 2.00% to 2.82%.
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Ya Cao,Fei Yang,Zhao Dong,Xusheng Huang,Bingzhen Cao,Shengyuan Yu 대한신경과학회 2018 Journal of Clinical Neurology Vol.14 No.4
Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) is a primary headache syndrome with an unclear pathogenesis. However, there is increasing evidence in the literature for secondary SUNCT being attributable to certain known lesions. We explored the possible neurobiological mechanism underlying SUNCT based on all reported cases of secondary SUNCT for which detailed information is available. Here we report a case of neuromyelitis optica spectrum disorders that had typical symptoms of SUNCT that might have been attributable to involvement of the spinal nucleus of the trigeminal nerve. We also review cases of secondary SUNCT reported in the English-language literature and analyze them for demographic characteristics, clinical features, response to treatment, and imaging findings. The literature review shows that secondary SUNCT can derive from a neoplasm, vascular disease, trauma, infection, inflammation, or congenital malformation. The pons with involvement of the trigeminal root entry zone was the most commonly affected region for inducing secondary SUNCT. In conclusion, the neurobiology of secondary SUNCT includes structures such as the nucleus and the trigeminal nerve with its branches, suggesting that some cases of primary SUNCT have underlying mechanisms that are related to existing focal damage that cannot be visualized.
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PREPARATION AND PHOTOCHROMISM OF SINGLE AG-TCNQ MICROSTRUCTURE
Guanying Cao,Limin Ma,Xiuyan Zhao,Xin Zhao,Xueheng Tao 한국멀티미디어학회 2006 한국멀티미디어학회 국제학술대회 Vol.2006 No.-
The micro/nanostructures of metal-organic complex Ag-TCNQ were successfully synthesized via the reaction between Ag film and TCNQ dissolved in acetonitrile solution. X-ray diffraction and scanning electron microscopy confirmed that the as-obtained Ag-TCNQ was crystalline one-dimensional micro/nanowires or tubes. The reversible photochromic property of single Ag-TCNQ microstructure was investigated both by home-made optical testing system and Raman
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