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      • KCI등재

        An Improved SPWM Strategy to Reduce Switching in Cascaded Multilevel Inverters

        Xiucheng Dong,Xiaomei Yu,Zhiwen Yuan,Yankun Xia,Yu Li 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.2

        The analysis of the switch status of each unit module of a cascaded multi-level inverter reveals that the working condition of the switch of a chopper arm causes unnecessary switching under the conventional unipolar sinusoidal pulse width modulation (SPWM). With an increase in the number of cascaded multilevel inverters, the superposition of unnecessary switching gradually occurs. In this work, we propose an improved SPWM strategy to reduce switching in cascaded multilevel inverters. Specifically, we analyze the switch state of the switch tube of a chopper arm of an H-bridge unit. The redundant switch is then removed, thereby reducing the switching frequency. Unlike the conventional unipolar SPWM technique, the improved SPWM method greatly reduces switching without altering the output quality of inverters. The conventional unipolar SPWM technique and the proposed method are applied to a five-level inverter. Simulation results show the superiority of the proposed strategy. Finally, a prototype is built in the laboratory. Experimental results verify the correctness of the proposed modulation strategy.

      • Graphitization of graphene oxide films under pressure

        Chen, Xianjue,Deng, Xiaomei,Kim, Na Yeon,Wang, Yu,Huang, Yuan,Peng, Li,Huang, Ming,Zhang, Xu,Chen, Xiong,Luo, Da,Wang, Bin,Wu, Xiaozhong,Ma, Yufei,Lee, Zonghoon,Ruoff, Rodney S. Elsevier 2018 Carbon Vol.132 No.-

        <P><B>Abstract</B></P> <P>Lightweight, flexible graphite foils that are chemically inert, high-temperature resistant, and highly electrically and thermally conductive can be used as component materials in numerous applications. “Graphenic” foils can be prepared by thermally transforming graphene oxide films. For this transformation, it is desirable to maintain a densely packed film structure at high heating rates as well as to lower the graphitizing temperatures. In this work, we discuss the pressure-assisted thermal decomposition of graphene oxide films by hot pressing at different temperatures (<I>i.e.</I>, 300 °C, 1000 °C, or 2000 °C). The films pressed at 1000 °C or 2000 °C were subsequently heated at 2750 °C to achieve a higher degree of graphitization. The combination of heating and pressing promotes the simultaneous thermal decomposition and graphitic transformation of G-O films. Films pressed at 2000 °C as well as films further graphitized at 2750 °C show high chemical purity, uniformity, and retain their flexibility. For films pressed at 2000 °C and then further heated at 2750 °C, the mechanical performances outperform the reported values of the “graphite” foils prepared by calendering exfoliated graphite flakes; the electrical conductivity is ∼3.1 × 10<SUP>5</SUP> S/m and the in-plane thermal conductivity is ∼1.2 × 10<SUP>3</SUP> W/(m·K).</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

      • SCIESCOPUSKCI등재

        An Improved SPWM Strategy to Reduce Switching in Cascaded Multilevel Inverters

        Dong, Xiucheng,Yu, Xiaomei,Yuan, Zhiwen,Xia, Yankun,Li, Yu The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.2

        The analysis of the switch status of each unit module of a cascaded multi-level inverter reveals that the working condition of the switch of a chopper arm causes unnecessary switching under the conventional unipolar sinusoidal pulse width modulation (SPWM). With an increase in the number of cascaded multilevel inverters, the superposition of unnecessary switching gradually occurs. In this work, we propose an improved SPWM strategy to reduce switching in cascaded multilevel inverters. Specifically, we analyze the switch state of the switch tube of a chopper arm of an H-bridge unit. The redundant switch is then removed, thereby reducing the switching frequency. Unlike the conventional unipolar SPWM technique, the improved SPWM method greatly reduces switching without altering the output quality of inverters. The conventional unipolar SPWM technique and the proposed method are applied to a five-level inverter. Simulation results show the superiority of the proposed strategy. Finally, a prototype is built in the laboratory. Experimental results verify the correctness of the proposed modulation strategy.

      • KCI등재

        Intracellular Localization and Sustained Prodrug Cell Killing Activity of TAT-HSVTK Fusion Protein in Hepatocelullar Carcinoma Cells

        Limin Cao,Jin Si,Weiyu Wang,Xiaorong Zhao,Xiaomei Yuan,Huifen Zhu,Xiaolong Wu,Jianzhong Zhu,Guanxin Shen 한국분자세포생물학회 2006 Molecules and cells Vol.21 No.1

        Gene therapy with nonviral vectors using the suicide gene/prodrug activating system of herpes simplex virus type-1 thymidine kinase (HSV1-TK)/ganciclovir (GCV) is inefficient in killing malignant tumor cells due to two major factors: (a) an unsatisfactory bystander effect; (b) short-lived expression of the protein. To study the capacity of the protein transduction domain (PTD) of HIV-1 TAT protein to enhance HSV1-TK/GCV cancer gene therapy, we constructed three fusion proteins TAT-TK, TK-TAT and TK. TATTK retained as much enzyme activity as TK, whereas that of TK-TAT was much lower. TAT-TK can enter HepG2 cells and much of it is translocated to the nucleus. The transduced HepG2 cells are killed by exogenously added GCV and have bystander effects on untransduced HepG2 cells. Most importantly, the introduced recombinant protein is stable and remains functional for several days at least, probably because nuclear localization protects it from the cytoplasmic degradation machinery and provides access to the nuclear transcription machinery. Our results indicate that TAT fusion proteins traffic intercellularly and have enhanced stability and prodrug cell killing activity. We conclude that TAT has potential for enhancing enzyme prodrug treatment of liver cancers.

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