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Berberine protects against palmitate induced beta cell injury via promoting mitophagy
Li Mo,She Jiang,Ma Louyan,Ma Li,Ma Xiaorui,Zhai Jiajia 한국유전학회 2022 Genes & Genomics Vol.44 No.7
Background: Destruction of pancreatic beta cells is the most typical characteristic of diabetes. Objective: We aimed to evaluate the effect of berberine (BBR), a bioactive isoquinoline derivative alkaloid, on beta cell injury. Methods: Rodent pancreatic beta cell line INS-1 was treated with 0.5 mM palmitate (PA) for 24 h to establish an in vitro beta cell injury model. Results: BBR at 5 µM promoted cell viability, inhibited cell apoptosis and enhanced insulin secretion in PA-induced INS-1 cells. BBR treatment also suppressed PA-induced oxidative stress in INS-1 cells, as evidenced by the decreased ROS production and increased activities of antioxidant enzymes. In addition, suppressed ATP production and reduced mitochondrial membrane potential were restored by BBR in PA-treated INS-1 cells. It was further determined that BBR affected the expressions of mitophagy-associated proteins, suggesting that BBR promoted mitophagy in PA-exposed INS-1 cells. Meanwhile, we found that BBR facilitated nuclear expression and DNA-binding activity of Nrf2, an antioxidative protein that can regulate mitophagy. Finally, a rescue experiment was performed and the results demonstrated that the effect of BBR on cell viability, apoptosis and mitochondrial function in PA-induced INS-1 cells were cancelled by PINK1 knockdown. Conclusions: BBR protects islet β cells from PA-induced injury, and this protective effect may be achieved by regulating mitophagy. The present study may provide a novel therapeutic strategy for β cell injury in diabetes mellitus.
2D Adjacency Matrix Generation using DCT for UWV contents
Xiaorui Li,Euisang Lee,Dongjin Kang,Kyuheon Kim 한국방송·미디어공학회 2016 한국방송공학회 학술발표대회 논문집 Vol.2016 No.11
Since a display device such as TV or signage is getting larger, the types of media is getting changed into wider view one such as UHD, panoramic and jigsaw-like media. Especially, panoramic and jigsaw-like media is realized by stitching video clips, which are captured by different camera or devices. In order to stich those video clips, it is required to find out 2D Adjacency Matrix, which tells spatial relationships among those video clips. Discrete Cosine Transform (DCT), which is used as a compression transform method, can convert the each frame of video source from the spatial domain (2D) into frequency domain. Based on the aforementioned compressed features, 2D adjacency Matrix of images could be found that we can efficiently make the spatial map of the images by using DCT. This paper proposes a new method of generating 2D adjacency matrix by using DCT for producing a panoramic and jigsaw-like media through various individual video clips.
Li, Qian,Wang, Shuyu,Lee, Dong‐,Kyou,Tang, Jianping,Niu, Xiaorui,Hui, Pinhong,Gutowski Jr., William J.,Dairaku, Koji,McGregor, John L.,Katzfey, Jack,Gao, Xuejie,Wu, Jia,Hong, Song‐,You,Wan Wiley 2016 International journal of climatology Vol.36 No.13
<P><B>ABSTRACT</B></P><P>Under the framework of an project ‘Building Asian Climate Change Scenarios by Multi‐Regional Climate Models Ensemble’, the ability of eight regional climate models and two fine‐resolution global climate models to reproduce late 20th century (1981–2000) precipitation climatology is assessed. Future precipitation change (2041–2060) under the A1B scenario is also quantified by applying four different ensemble methods: equal weighting, weighted mean (WM), reliability ensemble averaging (REA) and performance‐based ensemble averaging, after applying fourfold cross‐validation using observation and multi‐model‐simulated precipitation. The results indicate that the ensemble of simulated precipitation outperforms any single RCM in many aspects. Among the four ensemble approaches, the WM and REA methods show better skill in improving the simulation results, and are used for ensemble prediction of regional climate in Asia. Under the A1B scenario, the WM method estimates future precipitation change of approximately 0.2 mm day<SUP>−1</SUP> with less precipitation in northern and western China and northern India, and more precipitation in most other areas in Asia. The future annual precipitation will decrease by 0.1‐0.5 mm day<SUP>−1</SUP> in northern India, Pakistan and the central area of southern China. No significant change is found over eastern Kazakhstan, Mongolia, north‐central and western China.</P>
Molecular-resolution micro-resonant biosensor with adjustable natural frequency
Xiaorui Fu,Ming Zhang,Dezhi Hou,Chong Li 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.10
Modern sensors are becoming increasingly small in size while their sensitivity requirements remain relatively strict, to the point that the processing technology and test technology are highly difficult and costly. This paper proposes a micro-resonant biosensor with adjustable natural frequency. A positive feedback signal with a phase difference of 180 degrees is used to reduce the equivalent mass of the resonator, yielding an ultrahigh resonant frequency. The biosensor is formed by a coating bovine blood solution on the surface of the resonator of a cantilever sensor. The instantaneous frequency equation of the biosensor is established using a coupling dynamic calculation. The changes in instantaneous frequency during hemoglobin oxygen absorption and deoxygenation, are then measured. The proposed millimeter micro-resonant biosensor system measures the molecular weight of a single oxygen molecule quality at 5.7619×10 -23 g, only deviating by 8.306 % from the theoretical value. Finally, the potential of the micron scale sensor is deeply taped.
Xiaorui Ren,Huanhuan Li,Ke Liu,Hongyi Lu,Jingshuai Yang,Ronghuan He 한국섬유공학회 2018 Fibers and polymers Vol.19 No.12
Poly(vinylpyrrolidone) (PVP), as the low-cost and commercial material, exhibits superior phosphoric acid doping capability due to the presence of heterocycle and carbonyl groups in the repeat unit. However, it can’t be used as the high temperature polymer electrolyte membrane (HT-PEM) alone because of its significant hydrophilicity and poor mechanical stability. In the present work, polyethersulfone (PES), polysulfone (PSU), polyetherketone-cardo (PEK-c), polyvinylidene fluoride (PVDF) and poly(vinylidene fluoride-co-hexafluoropropylene) (PHFP), five kinds of engineering thermoplastics with excellent mechanical properties and chemical inertness, are chosen to prepare a series of PVP blend membranes by the polymer blending method in order to enhance the dimensional and mechanical stabilities of PVP based membranes. The influence of structures of enhanced polymers on properties of HT-PEMs was investigated systematically. PVP blend membranes with aromatic polymers (i.e. PES, PSU and PEK-c) exhibited decreased volume swellings, increased acid doping contents, superior conductivities and improved mechanical strengths, which determined that they are more suitable for electrolytes of fuel cell applications comparing with PVP/PVDF and PVP/PHFP membranes blended with aliphatic polymers.
Nonlinear primary resonance and bifurcation analyses of a micro-resonant pressure sensor
Xiaorui Fu,Chong Li 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.2
The micro-resonant pressure sensor outputs frequency signals for which distortion does not take place over long-distance transmission. As the dimensions of the sensor decrease, the nonlinear coupling effects caused by the van der Waals force, electrostatic force, and air damping force should be considered. Here, based on the nonlinear dynamic equation, the amplitude-frequency characteristics near resonance and the equation on the displacement response far away from resonance are obtained. Using these equations, changes in the sensor’s amplitude-frequency characteristics and the vibration amplitude far away from resonance, along with the system parameters, are investigated. The variations of the chaotic vibration characteristics of the sensor with the thickness of the resonator are studied by the numerical method. The results show that the relevant parameters of the resonator have a great influence on the primary resonance and bifurcation of the sensor. The sensor changes from periodic vibration to chaotic vibration through period-doubling bifurcation in a certain range of parameters. These results can be used to determine the measurements of the resonators to ensure sensor performance.
Topological Alterations of the Intrinsic Brain Network in Patients with Functional Dyspepsia
( Jiaofen Nan ),( Li Zhang ),( Fubao Zhu ),( Xiaorui Tian ),( Qian Zheng ),( Karen M Von Deneen ),( Jixin Liu ),( Ming Zhang ) 대한소화기기능성질환·운동학회 2016 Journal of Neurogastroenterology and Motility (JNM Vol.22 No.1
Background/Aims Previous studies reported that integrated information in the brain ultimately determines the subjective experience of patients with chronic pain, but how the information is integrated in the brain connectome of functional dyspepsia (FD) patients remains largely unclear. The study aimed to quantify the topological changes of the brain network in FD patients. Methods Small-world properties, network efficiency and nodal centrality were utilized to measure the changes in topological architecture in 25 FD patients and 25 healthy controls based on functional magnetic resonance imaging. Pearson`s correlation assessed the relationship of each topological property with clinical symptoms. Results FD patients showed an increase of clustering coefficients and local efficiency relative to controls from the perspective of a whole network as well as elevated nodal centrality in the right orbital part of the inferior frontal gyrus, left anterior cingulate gyrus and left hippocampus, and decreased nodal centrality in the right posterior cingulate gyrus, left cuneus, right putamen, left middle occipital gyrus and right inferior occipital gyrus. Moreover, the centrality in the anterior cingulate gyrus was significantly associated with symptom severity and duration in FD patients. Nevertheless, the inclusion of anxiety and depression scores as covariates erased the group differences in nodal centralities in the orbital part of the inferior frontal gyrus and hippocampus. Conclusions The results suggest topological disruption of the functional brain networks in FD patients, presumably in response to disturbances of sensory information integrated with emotion, memory, pain modulation, and selective attention in patients. (J Neurogastroenterol Motil 2016;22:118-128)