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- 저자 : Zhang Zhaoqiang (검색결과 3 건)
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Zhang Zhaoqiang,Yuxin Yi,Tian Liao,Xiaowei Li 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.4
To investigate the seismic performance of RC circular column strengthened with self-compacting concrete (SCC) -filled steel tubes (SCFST), nine specimens of height 1200 mm, varying with a cross-section shape of steel tube (external diameter: 218 mm, cross-section dimensions: 200 mm × 200 mm) were tested under axial load and cyclic lateral load. Three parameters, including the axial compression ratio, the cross-section shape of steel tube, and the embedding rebars ratio, were considered in the tests. The failure mode, hysteresis curves, skeleton curves, ductility, stiffness degradation, and energy-dissipation capacity were analysed. Experimental results showed that the bearing capacity and stiffness of the strengthened column were 5.4 and 9.08 times than that of the unstrengthened column respectively, and the improvement ratio of ductility and energy dissipation reached 123% and 85.7% respectively. The bearing capacity and stiffness of the square SCFST strengthened column was enhanced by 28.57% and 42.11% respectively, compared with the circular SCFST strengthened column. With the designed axial compression ratio increasing, the bearing capacity, initial stiffness, and energy dissipation capacity of strengthened columns increased by 17–39%, 21–60%, and 15–40% respectively, but the ductility coefficient decreased by 8.56–32.4%. The bearing capacity and energy dissipation of the specimen with an embedding rebars ratio of 0.06% increased by 7.5% and 9.31% respectively, but the ductility decreased by 12.81%. When the embedding rebars ratio was 0.1%, the reinforcement effect can be basically negligible.
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Qingxia Huang,Jing Li,Jinjin Chen,Zepeng Zhang,Peng Xu,Hongyu Qi,Zhaoqiang Chen,Jiaqi Liu,Jing Lu,Mengqi Shi,Yibin Zhang,Ying Ma,Daqing Zhao,Xiangyan Li The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.3
Background: Ginsenoside compound K (CK), the main active metabolite in Panax ginseng, has shown good safety and bioavailability in clinical trials and exerts neuroprotective effects in cerebral ischemic stroke. However, its potential role in the prevention of cerebral ischemia/reperfusion (I/R) injury remains unclear. Our study aimed to investigate the molecular mechanism of ginsenoside CK against cerebral I/R injury. Methods: We used a combination of in vitro and in vivo models, including oxygen and glucose deprivation/reperfusion induced PC12 cell model and middle cerebral artery occlusion/reperfusion induced rat model, to mimic I/R injury. Intracellular oxygen consumption and extracellular acidification rate were analyzed by Seahorse multifunctional energy metabolism system; ATP production was detected by luciferase method. The number and size of mitochondria were analyzed by transmission electron microscopy and MitoTracker probe combined with confocal laser microscopy. The potential mechanisms of ginsenoside CK on mitochondrial dynamics and bioenergy were evaluated by RNA interference, pharmacological antagonism combined with co-immunoprecipitation analysis and phenotypic analysis. Results: Ginsenoside CK pretreatment could attenuate mitochondrial translocation of DRP1, mitophagy, mitochondrial apoptosis, and neuronal bioenergy imbalance against cerebral I/R injury in both in vitro and in vivo models. Our data also confirmed that ginsenoside CK administration could reduce the binding affinity of Mul1 and Mfn2 to inhibit the ubiquitination and degradation of Mfn2, thereby elevating the protein level of Mfn2 in cerebral I/R injury. Conclusion: These data provide evidence that ginsenoside CK may be a promising therapeutic agent against cerebral I/R injury via Mul1/Mfn2 mediated mitochondrial dynamics and bioenergy.
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Xie Zhongyu,Yu Wenhui,Ye Guiwen,Li Jinteng,Zheng Guan,Liu Wenjie,Lin Jiajie,Su Zepeng,Che Yunshu,Ye Feng,Zhang Zhaoqiang,Wang Peng,Wu Yanfeng,Shen Huiyong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Mesenchymal stem cells (MSCs) are a common kind of multipotent cell in vivo, but their heterogeneity limits their further applications. To identify MSC subpopulations and clarify their relationships, we performed cell mapping of bone-marrow-derived MSCs through single-cell RNA (scRNA) sequencing. In our study, three main subpopulations, namely, the stemness subpopulation, functional subpopulation, and proliferative subpopulation, were identified using marker genes and further bioinformatic analyses. Developmental trajectory analysis showed that the stemness subpopulation was the root and then became either the functional subpopulation or the proliferative subpopulation. The functional subpopulation showed stronger immunoregulatory and osteogenic differentiation abilities but lower proliferation and adipogenic differentiation. MSCs at different passages or isolated from different donors exhibited distinct cell mapping profiles, which accounted for their corresponding different functions. This study provides new insight into the biological features and clinical use of MSCs at the single-cell level, which may contribute to expanding their application in the clinic.
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