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RISS 인기검색어
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- 저자 : Yunyun Huang (검색결과 5 건)
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Growth of Single-Walled Carbon Nanotubes from Well-Defined POSS Nanoclusters Structure
Yunyun Liu,Yali Hu,Qiran Cai,Xiangju Xu,Yin Chen,SHAOMING HUANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.1
High-quality single-walled carbon nanotubes (SWNTs) with narrow diameter distribution can be generated from well-defined Si8O12 nanoclusters structure which form from thermal decomposition of chemically modi¯ed polyhedral oligomeric silsesquioxane (POSS). The nanosized SixOy particles were proved to be responsible for the SWNT growth and believed to be the reason for the narrow diameter distribution of the as-grown SWNTs. This could be extended to other POSS. The SWNTs grown from the nanosized SixOy particles were found to be semiconducting enriched SWNTs (s-SWNTs). A facile patterning technology, direct photolithography, was developed for generating SWNT pattern, which is compatible to industrial-level fabrication of SWNTs pattern for device applications. The metal-free growth together with preferential growth of s-SWNTs and patterning in large scale from the structure-defined silicon oxide nanoclusters not only represent a big step toward the control growth of SWNTs and fabrication of devices for applications particularly in nanoelectronics and biomedicine but also provide a system for further studying and understanding the growth mechanism of SWNTs from nanosized materials and the relationship between the structure of SWNT and nonmetal catalysts.
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Molecularly Imprinted Polymer Coating with Fluorescence on Magnetic Particle
Jing Huang,Haiqing Liu,Haifen Men,Yunyun Zhai,Qihui Xi,Zulei Zhang,Jian Zhang,Zhengzhi Yin,Lei Li 한국고분자학회 2013 Macromolecular Research Vol.21 No.9
In this research, molecular imprinting technology was employed to prepare magnetic, fluorescent molecularly imprinted polymer microspheres (fluorescent M-MIP) for recognition and separation of endocrine disrupting chemicals. The fluorescent M-MIP were prepared using Fe3O4@SiO2 magnetic nanoparticles combined with fluorescein (isothiocyanate) as fluorescent material with the surface molecularly imprinting method. The magnetic fluorescent molecularly imprinted polymers were characterized by fluorescence spectrophotometer, X-ray powder diffraction,vibration sample magnetic field meter, scanning and transmission electron microscopic methods. The results showed that the fluorescent M-MIP not only had excellent superparamagnetism and maintained the crystalline structure of the magnetic nanoparticles, but also stable fluorescence. The recognition selectivity of the magnetic fluorescence polymer was studied for template molecule and analogues. The results indicated that the fluorescent quenches of bisphenol A (the selective target) for fluorescent M-MIP were higher than that of the structural analogues, which illustrated the recognition selectivity for bisphenol A. Simultaneously, the fluorescent magnetic non-imprinted polymers (M-NIPs) had much higher fluorescent quenches than the fluorescent M-NIPs in the processes of rebinding. Therefore, the fluorescent M-MIP technology can be used for the recognition, magnetic separation and detection of bisphenol A by fluorescence spectrometry without any time-consuming elution.
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Effect of Tea Polysaccharides on Thermal and Pasting Properties of Wheat Starch
Haihua Zhang,Shikang Zhang,Chunyuan Zhang,Yuejin Zhu,Yunyun Huang 한국차학회 2015 한국차학회지 Vol.- No.S
The thermal and pasting properties of wheat starch (WS)/tea polysaccharides (TPS) composite system were investigated. Significant increases of transition temperatures (To, Tp, Tc) and the enthalpy of gelatinization (ΔH1) of WS/TPS (2 wet% and 4 wet%) were found as TPS content increased. The lower ΔH2 (endothermic enthalpy under reheating) and R2 (degree of retrogradation of WS) were also detected in WS/TPS in storage of 3,7,14 days when compared with those of WS. The agreements were shown by RVA with the lower total setback and by Texture Analyzer with lower gel firmness. The results of TPS affecting the thermal and pasting properties could be generally explained with Avrami equation of WS/TPS. The Avrami equation exposed that TPS affect the primary nucleation in early stage and the decreased nucleation rate announced by the constant k. The overall results demonstrated that the TPS has an inhibitory effect on the recrystallization of pasting WS in storage.
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Gastric Cancer Stem Cells: Mechanisms and Therapeutic Approaches
Yan Fu,Peizhun Du,Jing Zhao,Cheng’en Hu,Yunyun Qin,Guangjian Huang 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.10
Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. GC stem-like cells (GCSCs), with unlimitedself-renewal, differentiation, and tumor-regenerating capacities, contribute significantly to the refractory features of GC and havegained increasing attention for their role in GC drug resistance, relapse, and metastasis. Therapies targeting GCSCs seem to beone of the most promising methods to improve the outcomes of GC patients. Extensive investigations have attempted to outlinethe regulatory mechanisms in GCSCs and to develop GCSCs-targeting therapies with which to diminish GC drug resistance, metastasisand relapse. To the best of our knowledge, there is a lack of reviews summarizing these studies. In this review, we systematicallyrecapitulated findings regarding the regulatory mechanisms of GCSCs, as well as therapies that target GCSCs, hoping tosupport the development of prognostic biomarkers and GCSCs-targeting anticancer therapies in GC.
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Ruilian Xiu,Jie Jia,Qing Zhang,Fengjiao Liu,Yaxin Jia,Yuanyuan Zhang,Beibei Song,Xiaodan Liu,Jingwei Chen,Dongyang Huang,Fan Zhang,Juanjuan Ma,Honglin Li,Xuan Zhang,Yunyun Geng 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.6
Transmembrane protein TMEM16A, which encodes calcium-activated chloride channel has been implicated in tumorigenesis. Overexpression of TMEM16A is associated with poor prognosis and low overall survival in multiple cancers including lung adenocarcinoma, making it a promising biomarker and therapeutic target. In this study, three structure-related sesquiterpene lactones (mecheliolide, costunolide and dehydrocostus lactone) were extracted from the traditional Chinese medicine Aucklandiae Radix and identified as novel TMEM16A inhibitors with comparable inhibitory effects. Their effects on the proliferation and migration of lung adenocarcinoma cells were examined. Whole-cell patch clamp experiments showed that these sesquiterpene lactones potently inhibited recombinant TMEM16A currents in a concentration- dependent manner. The half-maximal concentration (IC50) values for three tested sesquiterpene lactones were 29.9 ± 1.1 μM, 19.7 ± 0.4 μM, and 24.5 ± 2.1 μM, while the maximal effect (Emax) values were 100.0% ± 2.8%, 85.8% ± 0.9%, and 88.3% ± 4.6%, respectively. These sesquiterpene lactones also significantly inhibited the endogenous TMEM16A currents and proliferation, and migration of LA795 lung cancer cells. These results demonstrate that mecheliolide, costunolide and dehydrocostus lactone are novel TMEM16A inhibitors and potential candidates for lung adenocarcinoma therapy.
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