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- 저자 : Yaxin Jia (검색결과 3 건)
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Jia Yang,Jiajia Hao,Chen Tang,Yaxin Guo,Mingxin Guo,Zhipeng Li,Shuzheng Liu,Hui Yu,Gang Qin,Qiang Chen 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.116 No.-
Although many hydrogels have been applied to wearable sensors, it is still challenging to simultaneouslyrealize hydrogels with optical transparency, superior mechanical properties, excellent sensing performance,and anti-freezing by using inexpensive raw materials and an easy preparation process. Herein,using ethylene glycol/H2O (EG/ H2O) as a solvent, poly(vinyl alcohol)/EG organohydrogel (PVA/EGOHG) was prepared by a simple heating and frozen-thawing method. Owing to the multifunctionalityof EG (i.e., physical cross-linker, anti-freezer and co-solvent), PVA/EG OHG demonstrated excellent integratedproperties, including high strength, high toughness, and anti-freezing performances. Besides, PVA/EG OHG also showed low friction, self-cleaning, and frost resistance properties. After the introduction ofLiCl, ionically conductive PVA/EG @LiCl organohydrogel was served as a self-cleaning strain sensor, whichcould be long-term stable to detect the motions of human under room and low temperatures. The studyprovides to further understanding of the organohydrogel, which will help us design next-generationhigh-performance organohydrogels.
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Ruilian Xiu,Jie Jia,Qing Zhang,Fengjiao Liu,Yaxin Jia,Yuanyuan Zhang,Beibei Song,Xiaodan Liu,Jingwei Chen,Dongyang Huang,Fan Zhang,Juanjuan Ma,Honglin Li,Xuan Zhang,Yunyun Geng 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.6
Transmembrane protein TMEM16A, which encodes calcium-activated chloride channel has been implicated in tumorigenesis. Overexpression of TMEM16A is associated with poor prognosis and low overall survival in multiple cancers including lung adenocarcinoma, making it a promising biomarker and therapeutic target. In this study, three structure-related sesquiterpene lactones (mecheliolide, costunolide and dehydrocostus lactone) were extracted from the traditional Chinese medicine Aucklandiae Radix and identified as novel TMEM16A inhibitors with comparable inhibitory effects. Their effects on the proliferation and migration of lung adenocarcinoma cells were examined. Whole-cell patch clamp experiments showed that these sesquiterpene lactones potently inhibited recombinant TMEM16A currents in a concentration- dependent manner. The half-maximal concentration (IC50) values for three tested sesquiterpene lactones were 29.9 ± 1.1 μM, 19.7 ± 0.4 μM, and 24.5 ± 2.1 μM, while the maximal effect (Emax) values were 100.0% ± 2.8%, 85.8% ± 0.9%, and 88.3% ± 4.6%, respectively. These sesquiterpene lactones also significantly inhibited the endogenous TMEM16A currents and proliferation, and migration of LA795 lung cancer cells. These results demonstrate that mecheliolide, costunolide and dehydrocostus lactone are novel TMEM16A inhibitors and potential candidates for lung adenocarcinoma therapy.
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Ao Sheng,Hao Wang,Haoji Jiang,Yaxin Zhao,Hao Li,Hao Jia,Zhong Wei,Heyun Wang 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.9
The incorporation of various nanofillers into the interfacial polymerization (IP) process is widely applied to prepare higher performance NF membranes. However, few studies have reported the influence of nanofillers on nanocomposite membrane formation in the IP process. Here, an optical microscope was employed to study the change rule in the 8-NH2-POSS/PSA nanocomposite membrane formation process due to the addition of 8-NH2-POSS nanoparticles. First, the addition of 8-NH2-POSS reduced the diffusion rate of the polyacrylamide hydrochloride (PAH) water phase on the surface against the oil phase because of the interaction with the PAH molecules. Furthermore, the 8-NH2- POSS/PSA nanocomposite membrane structure was more homogeneous and exhibited uniform pinhole defects distribution due to the interaction of the 8-NH2-POSS nanoparticles to the PAH segment. A significant separation performance was observed in the 8-NH2-POSS/PSA nanocomposite membrane due to the hydrophilicity and positive charge of the 8-NH2-POSS nanoparticles. The permeation flux and MgCl2 rejection of the 8-NH2-POSS/PSA nanocomposite membrane increased up to 50.5 L/m2 h at 0.5MPa and 94.8%, respectively, which corresponded to increases of 73.5% and 8.7% as compared to the pristine PSA membrane. 8-NH2-POSS/PSA nanocomposite membranes have great application potential in the water softening and treatment of divalent metals ions under acidic conditions.
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