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Organelle DNA Editing in Plants
Beum-Chang Kang,Su-Ji Bae,Jeung-Sul Han,Jin-Soo Kim 한국원예학회 2021 한국원예학회 학술발표요지 Vol.2021 No.10
Plant organelle gene editing has been hampered by the lack of suitable tools in chloroplasts and mitochondria. In this study, we developed a Golden Gate cloning system to assemble DddA-derived cytosine base editor (DdCBE) plasmids composing of bacterial cytidine deaminase fused to transcription activator-like effector (TALE) array proteins. Our DdCBEs induced base editing at frequencies of up to 25% (mitochondria) and 38% (chloroplasts) in lettuce or rapeseed calli. We also applied DNA-free base editing in chloroplasts by delivering DdCBE mRNA to avoid off-target effects. Furthermore, we generated antibiotics-resistant lettuce calli and plantlets with edit frequencies of up to 99% by introducing a point mutation in the chloroplast 16S rRNA gene.
( Ye Rim Chang ),( Jin Young Jang ),( Wooil Kwon ),( Jae Woo Park ),( Mee Joo Kang ),( Ji Kon Ryu ),( Yong Tae Kim ),( Young Beum Yun ),( Sun Whe Kim ) The Editorial Office of Gut and Liver 2013 Gut and Liver Vol.7 No.6
Background/Aims: The aim of this study was to investigate changes in the clinical and demographical characteristics of gallstone disease in Korea, based on 30 years of surgically treated patients at a single institute. Methods: In total, 7,949 gallstone patients who underwent surgery between 1981 and 2010 were analyzed. Patients were divided into six time periods: period I (1981 to 1985, n=831), period II (1986 to 1990, n=888), period III (1991 to 1995, n=1,040), period IV (1996 to 2000, n=1,261), period V (2001 to 2005, n=1,651) and period VI (2006 to 2010, n=2,278). Results: The total number and mean age of the patients gradually increased, and the male/female ratio decreased. The proportion of gallbladder (GB)-stone cases increased, whereas the propor-tions of common bile duct (CBD)- and intrahepatic duct (IHD)-stone cases decreased. Differences in patient geographical origins also decreased. Based on the relationship between changes in the prevalence of gallstone disease and socioeco-nomic status, the prevalence of CBD stones showed a strong correlation with Engel`s coefficient (p<0.001). Conclusions: Our study indicates that although the total number of cases and the mean age of gallstone patients have continuously in-creased, there are trends of increasing GB-stone cases and decreasing CBD- and IHD-stone cases. (Gut Liver 2013;7:719-724)
Spatial Cluster Analysis for Earthquake on the Korean Peninsula
Kang, Chang-Wan,Moon, Sung-Ho,Cho, Jang-Sik,Lee, Jeong-Hyeong,Choi, Seung-Bae,Beum, Soo-Gyun 한국데이터정보과학회 2006 한국데이터정보과학회지 Vol.17 No.4
In this study, we performed spatial cluster analysis which considered spatial information using earthquake data for Korean peninsula occurred on 1978 year to 2005 year. Also, we look into how to be clustered for regions using earthquake magnitude and frequency based on spatial scan statistic. And, on the basis of the results, we constructed earthquake map by earthquake outbreak risk and gave a possible explanation for the results of spatial cluster analysis.
수술 후 암 재발 판정에 있어서 전신 F - 18 FDG - PET의 유용성
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),강원준(Won Jun Kang),정재민(Jae Min Jeong),소영(Young So),곽철은(Cheol Eun Kwark),강순범(Soon Beum Kang),정희원(Hee Won Jung),김광현(Kwang Hyu 대한핵의학회 1997 핵의학 분자영상 Vol.31 No.3
N/A he purpose of this study was to evaluate the usefulness of whole body F-18 FDG PET scan for deceting postoperative recurrence of cancer. One hundred four cancer patients after operation were enrolled(l4 brain tumor, 15 head and neck cancer, 23 gynecologic cancer). Besides conventional images(CI) including CT and MRI, F-18 FDG PET scan was obtained on ECAT EXACT 47 scanner(Siemens-CTI), beginning 60 minutes after injection of 370MBq(10mCi) of F-18 FDG. Regional scan was also obtained with emission image. Transmission images using Ge-68 were carried out for attenuation correction in both whole body and regional images. Findings of PET and CI were confirmed by pathology or clinical follow up. The sensitivity and specificity of PET for detecting recurrence were 94% and 92%, respectively. Contrarily, the sensitivity and specific it of CI were 78% and 68% CI results were negative and PET results were positive in 11 cases. The biopsy or clinical follow-up of those cases confirmed recurrence of tumor. False negative cases of CI were frequent in patients with gynecologic cancers. Also we measured the Serum concentration of tumor markers in patients with gynecologic cancer(CA125), thyroid cancer(thyroglobulin), and colorectal cancer(CEA). The sensitivity and specificity of tumor markers were 71% and 84%, respectively. We conclude that F-18 FDG PET can be used valuably in detecting recurrent foci of a wide variety of malignancy compared to conventional diagnositic methods.
대학교양 댄스스포츠 참가자의 여가태도와 재미요인이 심리적행복감과 삶의 질에 미치는 영향
강신범(Kang, Shin-Beum),장재용(Jang, Jae-Yong),김창숙(Kim, Chang-Suk),정상훈(Jeong, Sang-Hoon) 한국체육과학회 2018 한국체육과학회지 Vol.27 No.1
The purpose of this study was to investigate the relationship between leisure attitude and fun factors on the psychological well-being and quality of life of college students in dance sports. The subject of this study is to find out the questionnaire by using the nominal sampling method for the students who took the liberal dance sports lessons to setting the university in B metropolitan city as the population in 2017. Data processing methods were frequency analysis, exploratory factor analysis, reliability analysis, correlation analysis and multiple regression analysis. In this way the results are as follows. First, cognitive, positive, and behavioral attitudes of leisure attitude showed a static effect on feeling of flow, and cognitive and behavioral attitude had a positive effect on happiness. Second, the cognitive, positive and behavioral attitudes of leisure attitude showed a statistically significant effect on the psychological domain and the positive and behavioral attitudes on the living environment and self satisfaction. Third, all the sub factors of fun factor had a positive effect on the feeling of flow and happiness of psychological well-being. Fourth, all the sub factors of fun factors showed a statistically significant effect on the psychological domain, life environment and self satisfaction of the quality of life. In other words, leisure attitude and fun were predictive factors in improving psychological well-being and quality of life.