돼지 신장세포(PK15)의 이종이식 거부반응에 대한 재조합 IL-18의 영향

최연실,김은미,김영관,박상연,심정현,윤도영,강형식,명평근 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8

Various cytokines including IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-r, and TNF-α have been recently reported to play important roles in both host and donor cell activations during xenotransplantation. Interleukin (IL)-18, a proinflammatory cytokine, can induce IL-4 and IL-13 production in T cells, NK cells, B cells, mast cells, and basophils. IL-18 has the capacity to stimulate innate immunity and both Th1-and Th2- mediated responses, but little is known to involve in the xenograft rejection. In order to investigate the role of IL-18 in xenograft rejection, we transplanted the pig kidney (PK15) cells to C57BL/6 mouse with or without intraperitoneal injection of mouse recombinatant IL-18, It was analyzed the population of T cell, B cell and NK cell in the mice transplanted with PK 15 cells and recombinant IL-18 by flow cytometry. We found that splenic CD3+ T cells were increased in mice injected PKl5 cells with recombinant IL-18. These results suggest that recombinant IL-18 is critical in the xenograft rejection by increasing T cell population of the recipients.

돼지 신장세포(PK15)의 이종이식 거부반응에 대한 재조합 IL-18의 영향

최연실,김은미,김영관,박상연,심정현,윤도영,강형식,명평근 충남대학교 생물공학연구소 2004 생물공학연구지 Vol.10 No.1

Various cytokines including IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-γ, and TNF-α have been recently reported to play important roles in both host and donor cell activations during xenotransplantation. Interleukin (IL)-18, a proinflammatory cytokine, can induce IL-4 and IL-13 production in T cells, NK cells, B cells, mast cells, and basophils. IL-18 has the capacity to stimulate innate immunity and both Th1-and Th2- mediated responses, but little is known to involve in the xenograft rejection. In order to investigate the role of IL-18 in xenograft rejection, we transplanted the pig kidney (PK15) cells to C57BL/6 mouse with or without intraperitoneal injection of mouse recombinatant IL-18. It was analyzed the population of T cell, B cell and NK cell in the mice transplanted with PK 15 cells and recombinant IL-18 by flow cytometry. We found that splenic CD3+ T cells were increased in mice injected PK15 cells with recombinant IL-18. These results suggest that recombinant IL-18 is critical in the xenograft rejection by increasing T cell population of the recipients.

eSports 관심도가 해당 대회 포스터 정보탐색에 미치는 영향분석

이순혁,서우리,박사엘,심윤식 순천향대학교 기초과학연구소 2022 순천향자연과학연구 논문집 Vol.28 No.1,2

The purpose of this study is to identify with visual data whether interest in eSports affects the poster's information search. Scan path and hit map were collected using eye tracker and eye tracking program. As a result, 1) In the case of interest, the event was the first to notice, and in the case of non-interested was the first to see the title. 2) The amount of information collected by interested persons was greater. 3) In the case of interest, the most attention stayed on the event, and in the case of non-interested, the most attention stayed on the title. If additional research on eSports is conducted, various approaches can be used as marketing materials that can be applied to poster design production.

핸드볼 페널티드로우 시 숙련자와 비숙련자 간의 시각적 변이 비교 분석

한재희,박영민,신선미,이준희,심윤식 순천향대학교 기초과학연구소 2022 순천향자연과학연구 논문집 Vol.28 No.1,2

The purpose of this study is to analyze the visual variation of skilled and unskilled people, and to obtain data necessary for skill improvement of effective handball penalty throw. An eye tracker was used to collect eye movements, concentration points, directions, and paths during penalty throws. The results are as follows: 1) For skilled players, the place where they threw and the place where their eyes were focused matched. 2) There is no difference in the presence or absence of eye contact with the goalkeeper.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

체육수업 중 지각한 케어링 분위기, 태도, 만족도 및 재미거리 관계에서 내적 동기의 매개역할 검증

심윤식 ( Yun Sik Shim ) 한국스포츠심리학회 2013 한국스포츠심리학회지 Vol.24 No.2

본 연구는 중·고등학교 학생들이 체육수업 중 지각한 케어링 분위기가 수업 태도, 수업만족도 및 재미 거리와의 관계에서 내적동기의 매개역할을 알아보는데 있었다. 연구의 대상은 총 580명으로 중학생 248명, 고등학생 332명이었다. 연구의 목적을 알아보기 위하여, 부분 매개모형을 이용한 구조방정식 모형 분석이 실시되었다. 구조방정식모형의 분석 결과, 학생들이 지각한 케어링은 내적 동기, 만족도, 재미거리에 직접 영향 미치는 것으로 나타났으며, 체육수업 내적동기가 지각된 케어링 분위기와 태도, 만족도, 재미거리를 매개하는 것으로 나타났다. 전체적인 모형 적합도는 높은 것으로 나타났다(χ2=280.0, df=80, p<.001, Q=3.56, CFI=.964, TLI=.953, RMSEA=.067, RMR=.026). 본 연구의 결과는 자결성 이론의 주요 선행요인인 관계성 요인으로써 지각한 케어링 분위기가 체육수업에 참여하고 있는 학생들의 내적 동기를 향상시켜 수업에 임하는 바람직한 태도의 유도는 물론, 수업에 대한 만족도를 높임을 보여주며, 나아가 체육수업에 내재하는 재미거리 향유를 유도하는 주요 사회 환경적 요인의 역할을 할 수 있음을 보여주고 있다. The purpose of this study was to examine mediational role of intrinsic motivation between perceived caring climate and satisfaction, attitudes, and enjoyment. For this study, a total 580 students were recruited(middle school students: 248, high school students: 332). To answer for the proposed research question, structural equation modeling was utilized. Partial mediational model was adopted to test proposed model. There were statistically significant direct influence of perceived caring climate on satisfaction and enjoyment. For indirect effects, the results of structural equation modeling showed that perceived caring climate predicted intrinsic motivation which, in turn influences students` satisfaction, attitudes, and enjoyment. Findings of the study suggested that further research need to pay attention on social environmental variable which is expected positive psychological and behavior consequences in motivational process.

운동제약 수준에 따른 행동통제지각이 운동참여행동에 미치는 영향 검증

심윤식 ( Yun Sik Shim ),신명진 ( Myoung Jin Shin ) 한국스포츠심리학회 2013 한국스포츠심리학회지 Vol.24 No.3

본 연구의 목적은 TPB모형에 근거하여 운동참여 의도가 높지만, 실제 운동참여로 이어지지 못하는 의도-행동 불일치 현상을 운동제약을 통해서 설명하는 것이다. 이를 검증하기 위해서 대학 교양체육 참여자 319명을 대상으로 운동제약 수준에 따라 행동통제지각에서 운동참여행동에 미치는 영향력차이를 다집단 분석을 통해서 살펴보았다. 그 결과 의도가 운동참여행동에 미치는 영향력은 운동제약 집단 간 동일하지만, 행동통제지각이 운동참여행동에 미치는 영향력은 운동제약 저집단(.73)이 고집단(.50)보다 높았다. 따라서 운동제약을 많이 받는 사람일수록 의도는 높지만, 실제 운동참여 행동으로 이어지지 않는 의도-행동 불일치 현상이 존재할 것으로 판단된다. 지금까지 진행된 의도-행동 불일치 현상을 설명하는 연구들 대부분이 가설적 편향과 같은 측정 오류, 긍정적, 부정적 성향 등과 같은 개인의 특성에 의해 연구가 진행되었다면, 본 연구 결과는 운동제약 요인을 추가하여 의도-행동 불일치 현상이 유발될 가능성을 증명하였다는 점에서 의의가 있다. The purpose of this study was to explain intention-behavior discrepancy with exercise constraints factor which cannot be explained solely with theory of planned behavior(TPB). Data related to TPB and exercise constraints were collected from 319 university students who participated in university physical activity class and multi-group were conducted to verify the research question. As a result from analysis, there was statistical relationship between exercise constraints and effects of perceived behavioral control for exercise participation. This result means that without considering exercise constraint, it is possible to see intention-behavior discrepancy. The result of this study showed that it was possible to see intention-behavior discrepancy if only measurement error was considered without exercise constraint.

남자고등학교 필드하키선수들의 상해실태와 운동스트레스, 집중력과의 관계

심윤식(Shim, Yun-Sik),송진우(Song, Jin-Woo),우상연(Woo, Sang-Yeon),전현수(Jeon, Hyunsoo) 한국웰니스학회 2017 한국웰니스학회지 Vol.12 No.2

본 연구는 남자고등학교 필드하키선수들이 경험하는 스포츠 상해의 전반적인 실태를 분석하고 스포츠 상해 경험과 운동스트레스, 스포츠 집중력의 관계를 규명하고자 하였다. 이를 위하여 남자고등학교 하키선수들 139명의 자료를 바탕으로 연구를 진행하였으며, 질문지의 타당도 및 신뢰도 검증을 거친 후 연구의 목적에 맞게 기초통계분석, 독립표본 t검정을 실시하였다. 첫째, 선수들의 스포츠 상해의 전반적인 실태를 기초통계분석을 통해 살펴본 결과 스포츠 상해를 경험한 선수가 111명(79.9%)로 대다수를 차지하고 있으며, 최근 1년간 상해 경험이 있는 선수 또한 81명(58.3%)으로 나타나 많은 선수들이 스포츠 상해를 경험하고 있음을 알 수 있었다. 또한 겨울철(46.9%)과 여름철(31.5%)에 스포츠 상해를 주로 경험하는 것으로 나타났으며, 주로 무릎(27.4%), 발목(23.2%), 허벅지(15.5%) 등 하체부위에 집중되어 있는 것으로 나타났다. 둘째, 스포츠 상해를 경험하고 있거나 경험한지 1년이 지나지 않은 선수들은 상해를 경험하지 않는 선수들보다 지도력, 기능 및 경기내용, 개인 시간제약, 진로고민 요인 등의 운동스트레스를 높게 지각하는 것으로 나타났다. 셋째, 과거 스포츠 상해를 경험하지 않은 선수들이 상해를 경험한 선수들에 비해 주의집중력이 더 높은 것을 확인하였다. 관련 선행연구들을 통해 본 연구의 결과에 대하여 논의하였으며, 종단적 연구, 다양한 상해 발생 관련 연구, 부상 방지 프로그램의 필요성에 대해 제시하였다. The purpose of study was to investigate the relationship of injury, stress, and concentration among men"s high school hockey players. A total of 139 hockey players were recruited for the study. For the data analysis, after verifying the validity and reliability of the questionnaire, descriptive statistics and independent t-test performed to test proposed research question. The results of the study were as follows: First, result indicated that 81 of 111 injuries occurred within a year. The most frequent occurrence of injury were revealed as winter (46.9%) and summer (31.5%). For the part of injury, knee (27.4%), ankle (23.2%), and thigh (15.5%) were revealed as the most frequent part of injury. Second, injured players showed higher perception of stress (i.e. leadership, game contents, personal time constrain, career concern) compared to uninjured players. Third, uninjured players showed higher level of concentration compared to injured players. In the discussion section, results of the study was discussed with previous research and its implications. Lastly, necessary of longitudinal studies, research on various causes of injury, and development of injury prevention program were suggested for further studies.

집단응집력이 팀중심편향에 미치는 영향

심윤식 ( Yun Sik Shim ),신명진 ( Myoung Jin Shin ) 한국스포츠심리학회 2015 한국스포츠심리학회지 Vol.26 No.3

Purpose: The objectives of the present study were to investigate 189 male athletes playing soccer, rugby and water polo 1) to demonstrate the presence of the team-serving bias and thereby examine the validity of the Causal Dimension Scale for Teams (CDS-T), a measurement tool of team attribution, and 2) to verify the effects of group cohesion on the team-serving bias. Results: A team-serving bias was found in the locus of causality, stability and external control factors of team attribution, thus validating the measurement toolused in the study. Further, the moderating effect between group cohesion and team-serving bias was verified via hierarchical regression analysis. The direction of the moderating effects, as shown in the interaction graphs, indicated that the team-serving bias was higher for Individual-centred Task-oriented cohesion and Group-centred Task-oriented cohesion. Conclusion: we have shown that the team-serving bias tends to be stronger when group cohesion is higher. Further, we found that among the different types of group cohesion, there were moderating effects of task cohesion but not of social cohesion.

심리대처기술의 선행변인으로서 지각된 케어링 분위기의 타당성 고찰

심윤식(Yun-Sik Shim) 인하대학교 스포츠과학연구소 2009 스포츠과학논문집 Vol.21 No.-

본 연구의 목적은 문헌 고찰을 통하여 지각된 케어링 분위기가 심리대처기술의 자원으로써 활용가능성을 재고 해보는데 있다. 심리대처기술은 크게 두 가지 차원으로 구분되며, 평가와 심리대처기술이다. 평가는 다시 1차 평가와 2차 평가로 나누어지며, 1차 평가에서는 스트레스가 될 만한 요소의 실제 스트레스 인지 여부를 판단하며, 2차 평가에서는 스트레스를 해결하기 위한 방법을 찾는 평가 과정이다. 이러한 평가 과정을 통하여 실제 심리대처기술이 실행되며, 이는 다시 문제 중심적인 심리대처기술과 정서 중심적인 심리대처기술로 이루어진다. 심리대처기술에 영향을 주는 요인은 크게 개인적인 능력과 환경적 자원으로 구분 되며, 대표적인 환경적 자원으로 사회적 지지를 예로 들 수 있다. 일반적으로, 사회적 지지는 효과적인 심리대처기술과 그 결과에 긍정적인 영향을 준다. 케어링 개념과 사회적 지지 개념이 각각 논의 되었으며, 결론적으로, 두 개념이 매우 유사하며 케어링 개념이 보다 포괄적인 사회적 지지의 형태를 가진 심리대처기술의 환경적 자원인 것으로 사료된다. Coping is generally defined as ongoing cognitive and behavioral efforts to manage specific external and/or internal demands that are appraised as taxing or exceeding the resources of the person. The process of coping involves two dimensions, the cognitive appraisal of stressors and utilization of coping strategies. There are two types of coping strategies aligned with secondary appraisal. These are termed problem-focused and emotion-focused coping strategies. In addition, resources of coping are discussed to the extent to which an individual is able to buffer or resist the effects of stress. Environmental coping resources exist in addition to the personal determinants. Social support resources of coping are particularly important. Caring is also partially conceptually similar to social support, which has been advocated by lazarus and Folkman as a critical environmental resource for coping. Both caring and social support are interpersonal in nature.