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Top-Down 공법이 적용된 지중연속벽의 설계시 측방토압의 적합성 평가
홍원표(Hong Won-Pyo),강철중(Kang Chul-Joong),윤중만(Yun Jung-Mann) 한국토목섬유학회 2012 한국지반신소재학회 논문집 Vol.11 No.1
본 연구에서는 지중연속벽 설계시 사용되는 범용 해석프로그램에 Rankin(1857)의 이론토압과 홍원표와 윤중만(1995a)의 경험 토압을 각각 적용하여 Top-Down 공법에 적용된 지중연속벽의 수평변위를 분석하였다. 그리고 이들 해석 프로그램에서 산정된 예측변위량과 지중경사계로 측정된 실측변위량을 비교 검토하였다. 현재 지중연속벽 설계에 적용되는 해석프로그램에는 Rankine의 토압이 주로 적용되고 있다. 검토결과, 지중연속벽의 예측수평변위는 적용되는 토압에 따라 상당히 큰 차이를 나타내고 있다. Rankine의 토압을 적용하여 산정된 예측수평변위 형상은 실측결과와 큰 차이를 보이고 있으며 벽체의 하부에서 예측치가 실측치보다 과다하게 산정되었다. 반면, 홍원표·윤중만의 토압을 적용하여 얻은 예측수평변위 형상과 최대수평변위 량은 실측결과와 유사하게 나타났다. 따라서 Top-Down 공법이 적용된 지중연속벽의 설계시 Rankine의 토압보다는 홍원표·윤중만의 경험토압을 적용하는 것이 적합함을 알 수 있다. The Rankine(1857)'s earth pressure and the Hong and Yun(1995a)'s earth pressure was applied to analyze the lateral displacement of diaphragm wall applied to the Top-Down construction method using the computer program, which is a common design program for diaphragm wall. The lateral displacement estimated by the computer program was compared with the lateral displacement measured by inclinometer. The Rankine's earth pressure has been widely used to design the diaphragm wall in the analysis of computer program. As the result of comparison, the lateral displacement of diaphragm wall was predicted differently according to the applied earth pressures. The behavior of lateral displacement predicted by the Rankine's earth pressure was different with displacement measured by inclinometer and the lateral displacement at the bottom part was overestimated. However, the lateral displacement predicted by the Hong and Yun's earth pressure is similar to the behavior and maximum value of real displacement. Therefore, the Hong and Yun's earth pressure is more suitable than the Rankine' earth pressure to design the diaphragm walls applied to the Top-Down Construction Method.
논문 : Top-Down 공법이 적용된 흙막이벽의 역해석을 이용한 거동분석
홍원표 ( Won Pyo Hong ),강철중 ( Chul Joong Kang ),윤중만 ( Jung Mann Yun ) 대한지질공학회 2012 지질공학 Vol.22 No.1
본 연구에서는 흙막이벽 설계시 널리 사용되고 있는 SUNEX 프로그램을 이용하여 Top-Down 공법이 적용된 지중연 속벽, 주열식 흙막이벽 (CIP벽, SCW벽)의 변형거동을 분석하였다. 해석프로그램에 Rankine의 토압(l857), Terzaghi and Peck의 토압(1967), Tschebotarioff의 토압(1973), 홍원표·윤중만의 토압(1995a)을 적용하여 흙막이벽의 수평변위를 예측하였다. 프로그램 해석결과, 흙막이벽의 수평변위량은 토압의 종류에 따라 큰 차이를 나타내고 있다. 홍원표·윤중만의 토압(I995a)을 적용하여 얻은 흙막이벽의 예측수평변위량이 실측수평변위량과 가장 유사하게 나타났다. 따라서 프로 그램 해석시 홍원표·윤중만의 경험토압(l995a)을 적용하면, Top-Down 공법이 적용된 흙막이벽의 변형거동을 비교적 정확히 예측할 수 있다. Abstract: The behaviors of a diaphragm wall and a contiguous pile wall such as CIP (Case-in-place pile) and SCW (Soil-cement wall), applied to the top-down construction method, were analyzed using the SUNEX program, which is widely used to design earth retaining walls. Four types of earth pressures, as described by Rankine (1857), Terzaghi and Peck (1967), Tchbotarioff (1973), and Hong and Yun (1995a), were applied to the analysis program to predict the lateral displacement of walls, The results show that the displacements of an earth retaining walls vary with the applied earth pressure. The predicted lateral displacement based on Hong & Yun`s (1995a) earth pressure is similar to the measured displacement. Therefore, the actual lateral displacement of an earth retaining wall, as applied to top-down construction method, can be accurately predicted by using an analysis program considering Hong and Yun`s (1995a) earth pressure.
Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4
The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway
800㎿급 발전소 복수기의 최적 운전점 및 운전방법에 대한 연구
장철호(Cheol-Ho Jang),홍은기(Eun-Kee Hong),황광원(Kwang-Won Hwang),윤린(Rin Yun) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.5
Along with the recent construction of a 800㎿ thermal power plant it is necessary to check the soundness of the current operation of the condenser, and to investigate the effects of vacuum level of it on the turbine efficiency for the power plant. In this study, the performances of the condenser and the turbine for the 800㎿ thermal power plant were tested based on the ASME PTC 6 and ASME PTC 12.2 with the variation of the vacuum level. When the condenser vacuum levels were 719.91 ㎜Hg, 724.5 ㎜Hg, and 729.6 ㎜Hg, the turbine efficiencies were 47.36%, 47.47%, and 47.55%, respectively. From the regression analysis of the present data, it was estimated that the optimal vacuum point is between 729 ㎜Hg and 731 ㎜Hg. When this optimal point is to be applied to the condenser, the profit of 5.5 billion won/year is expected based on the '09 caloric cost.
( Yun Nah Lee ),( Young Seok Kim ),( Sang Gyune Kim ),( Jae Pil Han ),( Sae Hwan Lee ),( Soung Won Jeong ),( Jae Young Jang ),( Hong Soo Kim ),( Boo Sung Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Clinical usefulness of noninvasive diagnostic methods for the evaluation of liver fibrosis was not fully documented. We evaluated the accuracy of the FibroScan®, acoustic radiation force impulse (ARFI) and real time elastography (RTE) and the efficacy of the addition of the platelet and P2MS to the elastography for predicting liver fibrosis in nonalcoholic liver disease (NALD). Methods: FibroScan®, ARFI and RTE were performed simultaneously at the same day of liver biopsy in 70 patients with various NALD from October 2010 to March 2011. ARFI was performed with SIEMENS ACUSON S2000 ultrasound system and RTE with HITACHI HI VISION-Preirus and EUP-L52 linear probe (3-7MHz). The median values of 10 measurements in ARFI and RTE were calculated, respectively. We used platelet count and P2/MS [platelet count (109/L)]2/ [monocyte fraction(%)×segmented neutrophil fraction (%)] for predicting more accurately liver fibrosis. We defined Vs as velocity of sheer wave (m/s) in ARFI and Es as elasticity score in RTE. Results: From 70 patients, 10 had METAVIR scoring system F0, 4 had F1, 22 had F2, 12 had F3 and 22 had F4. Positive correlations between each methods and fibrosis were found in FibroScan®, ARFI, RTE, P2MS, Vs/PLT, Vs/P2MS, Es/PLT, and Es/P2MS. In the diagnosis of significanct fibrosis (≥F2), the area under the receiver-operating characteristic curve (AUROC)s by FibroScan, ARFI and RTE are 0.689, 0.687 and 0.554. The AUROCs by Vs/PLT and Es/PLT are 0.860 and 0.769. In addition, the AUROCs by P2MS, Vs/P2MS and Es/P2MS are 0.781, 0.778 and 0.746. Comparing with AUROC of each methods for predicting fibrosis (≥F2), Vs/PLT is superior to ARFI (p=0.0018) and Es/PLT is also superior to RTE (p=0.015). Es/P2MS is superior to RTE (p=0.0316), but Vs/P2MS is not significantly different to ARFI (p=0.1491). Moreover, Vs/P2MS is not superior to Vs/PLT (p=0.0084) and not significantly different to Es/PLT (p=0.5481). Conclusion: Both FibroScan® and ARFI are useful noninvasive modalities for the assessment of liver fibrosis. Vs/P2MS and Es/P2MS can be more helpful for predicting liver fibrosis in NALD than elastography alone, but are not superior to Vs/PLT and Es/PLT.
Hong Jo Kim,Jin Yong Song,Tae Il Park,Won Seok Choi,Jong Heon Kim,Oh Seong Kwon,Ji-Yun Lee 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.1
Asian sand dust (ASD), which mainly originatesin China and Mongolia in the spring and blows into Korea,can exacerbate respiratory and immunological diseases. This study aims to observe eff ects of co-exposure to ASD onovalbumin (OVA)-induced asthmatic lung infl ammation andof treatment with a phosphodiesterase 7 (PDE7) inhibitor ina mouse model. The challenge with OVA increased airwayhyperresponsiveness (AHR) and infl ammatory cell infi ltrationinto the lung tissue. Interleukin (IL)-13, tumor necrosisfactor-alpha, monocyte-protein-1, mucin, and antigen-specific IgE and IgG1 production increased in mouse serum. The co-exposure of ASD signifi cantly exacerbated theseeff ects in this asthma model. Notably, the administration ofa PDE7 inhibitor, BRL-50481 (BRL), signifi cantly reducedAHR, infi ltration of infl ammatory cells into the lungs, andthe levels of type 2 T helper cell-related cytokines, antigenspecific immunoglobulins, and mucin. Thus, the administrationof BRL ameliorated OVA-induced allergic asthmaticresponses exacerbated by co-exposure to ASD. This studysuggests that PDE7 inhibition can be a therapeutic strategyfor infl ammatory lung diseases and asthma via the regulation of T lymphocytes and reduction of IL-13, and, consequently,mucin production.
Helicobacter pylori: A Possible Risk Factor for Bone Health
Yun Hee Chung,Jong Seop Gwak,Sung Woo Hong,Jung Hyeon Hyeon,Cheol Min Lee,Seung Won Oh,Hyuktae Kwon 대한가정의학회 2015 Korean Journal of Family Medicine Vol.36 No.5
Background: Helicobacter pylori (H. pylori) infection may cause systemic inflammation and increase the production of tumor necrosis factor-α, interleukin-1, and interleukin-6. Unfortunately, bone mineral density also may be affected by these cytokines. This study aimed to evaluate the association between bone mineral density and H. pylori infection. Methods: A cross-sectional study evaluated 1,126 men undergoing a comprehensive health screening in a private Korean screening center. Subjects’ sera were tested for H. pylori antibodies (immunoglobulin G) using an enzymelinked immunosorbent assay, and bone mineral densities (g/cm2) of the lumbar spine, femoral neck, and total femur were obtained using dual-energy X-ray absorptiometry. To evaluate the difference in bone mineral density according to H. pylori infection status, the adjusted mean bone mineral densities at each site were compared after adjusting for potential confounders, including age, sex, body mass index, smoking, alcohol consumption, and exercise. Results: H. pylori infection was associated with a significant decrease in mean lumbar bone mineral density (H. pylori- positive, 1.190 g/cm2; H. pylori-negative, 1.219 g/cm2; P=0.006), which was greatest among men who were ≥50 years old (H. pylori-positive, 1.193 g/cm2; H. pylori-negative, 1.233 g/cm2; P=0.006). However, no significant association was observed in the bone mineral densities of the total femur and femoral neck. Conclusion: In men, H. pylori infection was negatively associated with lumbar bone mineral density. This association may be useful in the early detection, prevention, and management of male osteoporosis.