MicroRNA 34c Gene Down-regulation via DNA Methylation Promotes Self-renewal and Epithelial-Mesenchymal Transition in Breast Tumor-initiating Cells

Yu, Fengyan,Jiao, Yu,Zhu, Yinghua,Wang, Ying,Zhu, Jingde,Cui, Xiuying,Liu, Yujie,He, Yinghua,Park, Eun-Young,Zhang, Hongyu,Lv, Xiaobin,Ma, Kelong,Su, Fengxi,Park, Jong Hoon,Song, Erwei American Society for Biochemistry and Molecular Bi 2012 The Journal of biological chemistry Vol.287 No.1

Experimental study of a pretensioned connection for modular buildings

Yujie Yu,Zhihua Chen,Aoyi Chen 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.31 No.3

Modular steel buildings consist of prefabricated room-sized structural units that are manufactured offsite and installed onsite. The inter-module connections must fulfill the assembly construction requirements and soundly transfer the external loads. This work proposes an innovative assembled connection suitable for modular buildings with concrete-filled steel tube columns. The connection uses pretensioned strands and plugin bars to vertically connect the adjacent modular columns. The moment-transferring performance of this inter-module connection was studied through monotonic and cyclic loading tests. The results showed that because of the assembly construction, the connected sections were separated under lateral bending, and the prestressed inter-module connection performed as a weak semirigid connection. The moment strength at the early loading stage originated primarily from the contact bonding mechanism with the infilled concrete, and the postyield strength depended mainly on the tensioned strands. The connection displayed a self-centering-like behavior that the induced deformation was reversed during unloading. The energy dissipation originated primarily from frictional slipping of the plugin bars and steel strands. The moment transferring ability was closely related to the section dimension and the arrangements of the plugin bars and steel strands. A simplified strength calculation and evaluation method was also proposed, and the effectiveness was validated with the test data.

Seismic Performance of Precast Concrete Columns with Improved U-type Reinforcement Ferrule Connections

Zhiwu Yu,Xiaoyong Lv,Yujie Yu,Faxing Ding,Xiaodan Peng 한국콘크리트학회 2019 International Journal of Concrete Structures and M Vol.13 No.7

This paper proposes a new kind of U-type reinforcement ferrule (URF) connection for the assembly of precast concrete (PC) components, which has a good fault-tolerance ability and low cost of construction with a simple postgrouting process. The modified connection features welded U ferrules, which can increase the bonding mechanism and internal stress transmission in the spliced region. A series of quasi-static cyclic tests were performed on URF-connected PC columns with different welding patterns. Comprehensive comparisons were performed on the load-bearing capacity, the plastic energy dissipation ability, the internal force transmission, the column ductility and the stiffness. The results indicated that PC columns with welded URF connections can ensure better lateral resistance than the cast-in-place concrete column. The weld type and length influence the connection performance, and the 15d-welded and full-length welded URF connections presented better connection performance and were suggested for the assembly of PC columns. Then, finite element analyses were performed to further reveal the working and failure mechanisms and the affecting mechanism of some working parameters. Parametric simulations indicated that the increase in the axial load ratio and the concrete strength in the postcast region had a slight but limited effect on improving the lateral resistance of the column connection.

Esophageal Intramural Spread of Adenocarcinoma of Esophagogastric Junction

Yu Imamura,Shiro Iwagami,Takatsugu Ishimoto,Ryuichi Karashima,Satoshi Ida,Yoshifumi Baba,Yasuo Sakamoto,Yuji Miyamoto,Naoya Yoshida,Hideo Baba 대한종양외과학회 2014 대한임상종양학회 학술대회지 Vol.2014 No.3

Preparation of nano-sized Mg-doped copper silicate materials using coal gangue as the raw material and its characterization for CO2 adsorption

Yu Wu,Zhaojun Wu,Kai Liu,Fu Li,Yujie Pang,Jianbin Zhang,Huayan Si 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.10

This work presents a simple method for the preparation of the Mg-doped nanocomposite copper silicates (Mgx-Cu1x-SiO3) (x=0.25, 0.5, 0.75 and 0.9) using coal gangue waste as the silicon source for CO2 capture at low temperature. The as-prepared Mgx-Cu1x-SiO3 was systemically characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller surface area analysis (BET). The results suggest that all Mgx-Cu1x-SiO3 possess large surface areas, micropores and mesoporous structures composed of the agglomerates of small nanoparticles. They exhibit high CO2 adsorption capacity at 298.15 K under 1 bar, and that of Mg0.9-Cu0.1-SiO3 was the highest with the value of 16.73 cm3/g. The Freundlich isotherm model fits the CO2 adsorption isotherm well. Thermodynamic analysis indicates that the CO2 adsorption on Mg0.9-Cu0.1-SiO3 is exothermic (Ho<0), chaotic (So<0), and spontaneous (Go<0). This work highlights the low-temperature adsorption behavior of silicate materials on CO2, which can provide some research basis for the utilization of silica in coal gangue.

An Estimation Method (EM) of Generalized Displacement of Points of Interest (POIs) Using Critical Modes

Yujie Li,Yu Zhu,Ming Zhang,Xin Li,Leijie Wang 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.3

More lightweight structure and higher control bandwidth are highly desirable in next-generation motion stages, satisfying the continuously increasing requirements in throughput and accuracy. However, these lead to more severe flexible deformation, causing that the estimation accuracy of the generalized displacements of a point of interest (POI) cannot be guaranteed under the rigid-body assumption. In this paper, a method for estimating the generalized displacement of the POI using critical modes is proposed. This method can realize a more accurate estimation under the limited measurement points. In this method, since the number of measurement points is limited, the selection criterion of the critical modes is firstly proposed for the over-actuator system; then, with regard to the estimation accuracy, the influences of the measurement layout and the residual modes on the estimation matrix are analyzed mathematically, and a performance measure is proposed for evaluating this method from the perspective of system control. In the verification section, the validity of the estimation method is demonstrated through numerical simulation and an experiment on a representative but straightforward case using a plate structure.

Unitarity meets channel-duality for rolling/decaying D-branes

Nakayama, Yu,Rey, Soo-Jong,Sugawara, Yuji IOP Publishing Ltd 2006 Journal of high energy physics Vol.2006 No.8

Investigations for decay of unstable D-brane and rolling of accelerated D-brane dynamics have revealed that various proposed prescriptions give different result for spectral amplitudes and observables. Here, we study them with particular attention to unitarity and open-closed channel duality. From <I>ab initio</I> derivation in the open string channel, both in Euclidean and Lorentzian worldsheet approaches, we find heretofore overlooked contribution to the spectral amplitudes and obervables. The contribution is fortuitously absent for decay of unstable D-brane, but is present for rolling of accelerated D-brane. We finally show that the contribution is imperative for ensuring unitarity and optical theorem at each order in string loop expansion.

Daam1 regulates fascin for actin assembly in mouse oocyte meiosis

Lu, Yujie,Zhang, Yu,Pan, Meng-Hao,Kim, Nam-Hyung,Sun, Shao-Chen,Cui, Xiang-Shun Landes Bioscience 2017 Cell Cycle Vol.16 No.14

<P>As a formin protein, Daam1 (Dishevelled-associated activator of morphogenesis 1) is reported to regulate series of cell processes like endocytosis, cell morphology and migration via its effects on actin assembly in mitosis. However, whether Daam1 plays roles in female meiosis remains uncertain. In this study, we investigated the expression and functions of Daam1 during mouse oocyte meiosis. Our results indicated that Daam1 localized at the cortex of oocytes, which was similar with actin filaments. After Daam1 morpholino (MO) microinjection, the expression of Daam1 significantly decreased, which resulted in the failure of oocyte polar body extrusion. These results might be due to the defects of actin assembly, since the decreased fluorescence intensity of actin filaments in oocyte cortex and cytoplasm were observed. However, Daam1 knockdown seemed not to affect the meiotic spindle movement. In addition, we found that fascin might be the down effector of Daam1, since the protein expression of fascin decreased after Daam1 knockdown. Thus, our data suggested that Daam1 affected actin assembly during oocyte meiotic division via the regulation of fascin expression.</P>

A national survey on how to improve traditional Chinese medicine learning internationally: Perceptions from both teachers and students

Zhu Yu-Hang,Yan Wu,Hao Zhang,Yanfei Zhao,Yule Ren,Wei Hu,Pan Li,Huiyi Wang,Ying Wang,Boda Zhang,Yujie Wang,Hongwen Yuan,Jiping Zhang,Wenqiang Li,Yufang Zhao,Jie Zhao,Yedong Shi,Yanye Shu,Xiao Zhang,Ya 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.4

Background With the increasing popularity of traditional Chinese medicine (TCM) by the global community, how to teach basic knowledge of TCM to international students and improve the teaching quality are important issues for teachers of TCM. The present study was to analyze the perceptions from both students and teachers on how to improve TCM learning internationally. Methods A cross-sectional national survey was conducted at 23 universities/colleges across China. A structured, self-reported on-line questionnaire was administered to 34 Chinese teachers who taught TCM course in English and to 1016 international undergraduates who were enrolled in the TCM course in China between 2017 and 2021. Results Thirty-three (97.1%) teachers and 900 (88.6%) undergraduates agreed Chinese culture should be fully integrated into TCM courses. All teachers and 944 (92.9%) undergraduates thought that TCM had important significance in the clinical practice. All teachers and 995 (97.9%) undergraduates agreed that modern research of TCM is valuable. Thirty-three (97.1%) teachers and 959 (94.4%) undergraduates thought comparing traditional medicine in different countries with TCM can help the students better understand TCM. Thirty-two (94.1%) teachers and 962 (94.7%) undergraduates agreed on the use of practical teaching method with case reports. From the perceptions of the undergraduates, the top three beneficial learning styles were practice (34.3%), teacher's lectures (32.5%), case studies (10.4%). The first choice of learning mode was attending to face-to-face teaching (82.3%). The top three interesting contents were acupuncture (75.5%), Chinese herbal medicine (63.8%), and massage (55.0%). Conclusion To improve TCM learning among international undergraduates majoring in conventional medicine, integration of Chinese culture into TCM course, comparison of traditional medicine in different countries with TCM, application of the teaching method with case reports, and emphasization of clinical practice as well as modern research on TCM should be fully considered.

D-brane propagation in two-dimensional black hole geometries

Nakayama, Yu,Rey, Soo-Jong,Sugawara, Yuji IOP Publishing Ltd 2005 Journal of high energy physics Vol.2005 No.9

We study propagation of D0-brane in two-dimensional lorentzian black hole backgrounds by the method of boundary conformal field theory of SL(2,&BbbR;)/U(1) supercoset at level <I>k</I>. Typically, such backgrounds arise as near-horizon geometries of <I>k</I> coincident non-extremal NS5-branes, where 1/<I>k</I> measures curvature of the backgrounds in string unit and hence size of string worldsheet effects. At classical level, string worldsheet effects are suppressed and D0-brane propagation in the lorentzian black hole geometry is simply given by the Wick rotation of D1-brane contour in the euclidean black hole geometry. Taking account of string worldsheet effects, boundary state of the lorentzian D0-brane is formally constructible via Wick rotation from that of the euclidean D1-brane. However, the construction is subject to ambiguities in boundary conditions. We propose exact boundary states describing the D0-brane, and clarify physical interpretations of various boundary states constructed from different boundary conditions. As it falls into the black hole, the D0-brane radiates off to the horizon and to the infinity. From the boundary states constructed, we compute physical observables of such radiative process. We find that part of the radiation to infinity is in effective thermal distribution at the Hawking temperature. We also find that part of the radiation to horizon is in the Hagedorn distribution, dominated by massive, highly non-relativistic closed string states, much like the tachyon matter. Remarkably, such distribution emerges only after string worldsheet effects are taken exactly into account. From these results, we observe that nature of the radiation distribution changes dramatically across the conifold geometry <I>k</I> = 1 (<I>k</I> = 3 for the bosonic case), exposing the `string - black hole transition' therein.