High-efficiently and rapidly capturing cesium from water with Prussian blue@expanded graphite as adsorbent

Kangkang Sun,Muyu Liu,Kaige Sun,Hongxia Zhang,Yuhan Song,Yangshuai Qiu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.125 No.-

The removal of radioactive 137Cs from nuclear wastewater is still needed to mitigate their high radiologicaltoxicity to living creatures. However, the industrial application of adsorbents is still challengingowing to the complex and costly preparation and slow adsorption rate for Cs wastewater with low concentration. Herein, cost-effective and fast removal of Cs+ is achieved by vermiform expanded graphite(EG) immobilized with potassium copper hexacyanoferrate (KCuHCF) via the in-situ synthesis method. We revealed that the nano-scale KCuHCF granules are dispersed homogeneously on the EG interlayers. With this design, it achieves an excellent Cs removal capacity of 16.24 mg/g within 30 min in ultralowCs concentration and shows high selectivity among various competing ions. We systematically studiedthe associated adsorption mechanism by XPS and ICP, which revealed that ion exchange between the latticeK and Cs played critical roles. Our work paves the way for the design of economical adsorbents forradioactive Cs remediation.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun,Yeting Hong,Yuhan Shu,Caixia Wu,Guiqin Ye,Hanxiao Chen,Hongying Zhou,Ruilan Gao,Jianbin Zhang 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.2

Colon cancer, the third most frequent occurred cancer, has high mortality and extremely poor prognosis. Ginsenoside, the active components of traditional Chinese herbal medicine Panax ginseng, exerts antitumor effect in various cancers, including colon cancer. However, the detailed molecular mechanism of Ginsenoside in the tumor suppression have not been fully elucidated. Here, we chose the representative ginsenoside Rg3 and reported for the first time that Rg3 induces mitophagy in human colon cancer cells, which is responsible for its anticancer effect. Rg3 treatment leads to mitochondria damage and the formation of mitophagosome; when autophagy is inhibited, the clearance of damaged mitochondria can be reversed. Next, our results showed that Rg3 treatment activates the PINK1-Parkin signaling pathway and recruits Parkin and ubiquitin proteins to mitochondria to induce mitophagy. GO analysis of Parkin targets showed that Parkin interacts with a large number of mitochondrial proteins and regulates the molecular function of mitochondria. The cellular energy metabolism enzyme GAPDH is validated as a novel substrate of Parkin, which is ubiquitinated by Parkin. Moreover, GAPDH participates in the Rg3-induced mitophagy and regulates the translocation of Parkin to mitochondria. Functionally, Rg3 exerts the inhibitory effect through regulating the nonglycolytic activity of GAPDH, which could be associated with the cellular oxidative stress. Thus, our results revealed GAPDH ubiquitination by Parkin as a crucial mechanism for mitophagy induction that contributes to the tumor-suppressive function of ginsenoside, which could be a novel treatment strategy for colon cancer.

Stability analysis of the ball after contacting with the earth in the volleyball game: A multi-physics simulation

Yang Sun,Yuhan Lin,Yuehong Ma 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.85 No.6

In this work, dynamic stability analysis of the ball after contacting with the earth in the volleyball game is presented. Via spherical shell coordinate, the governing equations and general boundary conditions of the ball after contacting with the earth in the volleyball game is studied. Via Comsol multi-physics simulation, some results are presented and a verification between the outcomes is studied. Harmonic differential quadrature method (HDQM) is utilized to solve the dynamic equations with the aid of boundary nodes of the current spherical shell structure. Finally, the results demonstrated that thickness, mass of the ball and internal pressure of the ball alters the frequency response of the structure. One important results of this study is influence of the internal pressure. Higher internal pressure causes lower frequency and hence reduces the stability of the ball.

si-Tgfbr1-loading liposomes inhibit shoulder capsule fibrosis via mimicking the protective function of exosomes from patients with adhesive capsulitis

Yaying Sun,Yisheng Chen,Jinrong Lin,Yuhan Zhang,Beijie Qi,Jiwu Chen 한국생체재료학회 2022 생체재료학회지 Vol.26 No.3

Background: Adhesive capsulitis is a common shoulder disorder inducing joint capsule fibrosis and pain. When combined with rotator cuff tear (RCT), treatments can be more complex. Currently, targeted therapy is lacking. Since adhesive capsulitis is reported to be related to circulating materials, we analyzed the contents and biology of circulating exosomes from RCT patients with and without adhesive capsulitis, in an attempt to developing a targeting treatment. Methods: Samples from a consecutive cohort of patients with RCT for surgery were collected. Circulating exosomal miRNAs sequencing were used to detect differentially expressed miRNAs in patients with and without adhesive capsulitis. For experiments in vitro, Brdu staining, CCK-8 assay, wound healing test, collagen contraction test, real-time quantitative polymerase chain reaction, and western blot were conducted. Histological and immunofluorescent staining, and biomechanical analysis were applied in a mouse model of shoulder stiffness. The characteristics of liposomes loaded with siRNA were measured via dynamic light scattering or electron microscopy. Results: Circulating exosomal miRNAs sequencing showed that, compared to exosomes from patients without adhesive capsulitis, miR-142 was significantly up-regulated in exosomes from adhesive capsulitis (Exo-S). Both Exo-S and miR-142 could inhibit fibrogenesis, and the anti-fibrotic effect of Exo-S relied on miR-142. The target of miR-142 was proven to be transforming growth factor β receptor 1 (Tgfbr1). Then, liposomes were developed and loaded with si-Tgfbr1. The si-Tgfbr1-loading liposomes exhibited promising therapeutic effect against shoulder stiffness in mouse model with no evidence toxicity. Conclusion: This study showed that, in RCT patients with adhesive capsulitis, circulating exosomes are protective and have anti-fibrotic potential. This effect is related to the contained miR-142, which targets Tgfbr1. By mimicking this biological function, liposomes loaded with si-Tgfbr1 can mitigate shoulder stiffness pre-clinically

Carbon dispersed iron-manganese catalyst for light olefin synthesis from CO hydrogenation

Jianli Zhang,Kegong Fang,Kan Zhang,Wenhuai Li,Yuhan Sun 한국화학공학회 2009 Korean Journal of Chemical Engineering Vol.26 No.3

High performance iron-manganese catalysts dispersed with carbon to produce light olefins from CO hydrogenation were prepared by sol-gel method using citric acid as precursor. The effects of carbon content on the bulk structure, the water gas shift reaction, the chain propagation ability and the activity and selectivity of the catalysts were investigated. The results showed that the catalysts were gradually reduced during the decomposition of the precursor when calcined under pure N2. The formation of iron-manganese mixed crystallites was favored and stabilized because of the enhanced interaction of iron and manganese with increasing carbon content. During the subsequent CO hydrogenation reaction, all the catalysts showed high activity and olefin selectivity. With increasing carbon content, the water gas shift (WGS) reaction was restrained and the chain propagation ability was inhibited. Catalysts with higher carbon content showed much lighter hydrocarbon products; however, the selectivity of CH4 was almost unchanged.

Kinetics studies of dimethyl carbonate synthesis from urea and methanol over ZnO catalyst

Wei Wei,Junliang Zhang,Feng Wang,Fukui Xiao,Yuhan Sun 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.6

A kinetic experiment of dimethyl carbonate (DMC) synthesis by urea methanol over ZnO catalyst was carried out in an isothermal fixed-bed reactor. A kinetic model based on the mole fraction was proposed and the kinetic parameters were estimated from the experimental results. The model predictions were compared with the experimental data and fair agreements were found. The effects of the reaction temperature (443-473 K), space time (0-4.7 h mol−1kgcat) and urea mass percent (5-9%) in feed on DMC mole fraction were investigated. It was found that the reactions are mainly influenced by the reaction temperature and space time rather than urea mass percent in feed. The experimental and simulated results indicated that the reaction from MC to DMC was the rate-controlling step in the DMC synthesis process from urea and methanol. It is important to remove the DMC and byproduct ammonia to achieve a high selectivity of DMC. This implies that reactive distillation might be used in the DMC synthesis on an industrial scale to achieve a higher selectivity of DMC.

Characterization, activity and selectivity of ethylenediamine modified Co/SiO2 FT catalyst prepared by sol-gel method

Yuelun Wang,Bo Hou,Jiangang Chen,Litao Jia,Debao Li,Yuhan Sun 한국화학공학회 2009 Korean Journal of Chemical Engineering Vol.26 No.3

Co/SiO2 catalysts were prepared by sol-gel method with varied en (ethylenediamine)/Co molar ratios under the same pH. Their physical-chemical properties were compared with those prepared with similar en/Co molar ratios at natural pH or without adding ethylenediamine. Regardless of pH, the catalysts prepared using ethylenediamine possessed high microporosity, which led to a better selectivity to C5-18 hydrocarbons, versus the catalyst possessing higher mesoporosity which showed slightly higher C18+ selectivity. As enough positions in the coordination sphere were blocked by ethanediamine ligands, the formation of cobalt silicate disfavored for (en/Co=2) catalysts, which resulted in the higher activity in FT reaction. Whereas the catalysts prepared with lower or higher en/Co molar ratio both showed lower activity due to the formation of [(SiO)Co(en)(EtOH)3] species or the electronic adsorption of cobalt complexes in the negatively charged silica surface, respectively. However, for the catalyst without using ethylenediamine, the lowest activity and the highest CH4 selectivity obtained due to its much lower reducibility.

Textual properties of Cu–Mn mixed oxides and application for methyl formate synthesis from syngas

Haijun Zhao,Kegong Fang,Fang Dong,Minggui Lin,Yuhan Sun,Zhicheng Tang 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.54 No.-

Cu–Mn mixed oxides with different calcination temperatures were prepared using ammonia complexing method and evaluated for methyl formate (MF) synthesis from syngas with CaO–ZrO2 as co-catalyst. The influence of calcination temperature on the structure and properties of Cu–Mn mixed oxides was investigated by appropriate characterizations. Cu1.5Mn1.5O4 formed during the calcination of Cu–Mn catalyst at 450 C and played a significant role in the MF synthesis. However, it partially decomposed into CuO and MnO2 when the calcination temperature exceeded 550 C. Results showed that the optimum MF selectivity was obtained on Cu–Mn catalyst calcined at 450 C, and the highest CO conversion was obtained on the Cu–Mn sample with calcination temperature of 550 C. The reaction mechanism of MF synthesis from syngas over Cu–Mn mixed oxides and CaO–ZrO2 co-catalyst was thoroughly studied via typical model reactions, and the nucleophilic addition–elimination reaction mechanism was proposed.

Methanol selective oxidation to dimethoxymethane on H3PMo12O40/SBA-15 supported catalysts

Heqin Guo,Debao Li,Haicheng Xiao,Jianli Zhang,Wenhuai Li,Yuhan Sun 한국화학공학회 2009 Korean Journal of Chemical Engineering Vol.26 No.3

A series of SBA-15 supported H3PMo12O40 catalysts were prepared for the one-step oxidation of methanol to dimethoxymethane (DMM). The evaluation and characterization revealed that higher DMM selectivity obtained on the incipient wetness impregnation (IM) catalyst was related to the instability of H3PMo12O40 on it. Raman spectra showed that 12-molybdophosphoric acid was more stable on the direct synthesis (DS) catalyst than on the IM catalyst and the existence of SBA-15 support enhanced the stability of H3PMo12O40. Moreover, higher H3PMo12O40 loading resulted in more acid sites and low DMM selectivity, furthermore the thermal pretreatment on H3PMo12O40 influenced its structure and thus affected DMM selectivity.