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Effects of Sulfur Introduction on the UV and the Visible Emission Properties of ZnO
Hongying Guo,Feihong Jiang,Run Yuan,Jun Zhang,Yuanping Sun,Yifan Liu,Yongxin Qiu,Taofei Zhou,Xionghui Zeng,Baoshun Zhang,Ke Xu,Hui Yang 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.4
Hexagonal ZnO particles have been synthesized by using the hydrothermal method with differentsulfur concentrations in the reaction solutions. Structural and optical characterizations have beenconducted to study the effects of the sulfur in the reaction solutions on the properties of thesynthesized ZnO in the ultraviolet (UV) and the visible (VIS) bands. The existance of sulfur inthe solutions can help to introduce compression strain along the a axis and an opposite trend forthe parameter c with strain inside the formed ZnO particles, which means the total strain in thesamples is presented along the c axis. The average size of the ZnO particles, as calculated fromSEM images, shows the same trend as the strain in the samples. The increasing incorporation ofsulfur causes an increase in the VIS luminescence band, which can be attributed to an increase inthe number of sulfur-induced defects.
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The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside
Xin Sun,Yeting Hong,Yuhan Shu,Caixia Wu,Guiqin Ye,Hanxiao Chen,Hongying Zhou,Ruilan Gao,Jianbin Zhang 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.2
Colon cancer, the third most frequent occurred cancer, has high mortality and extremely poor prognosis. Ginsenoside, the active components of traditional Chinese herbal medicine Panax ginseng, exerts antitumor effect in various cancers, including colon cancer. However, the detailed molecular mechanism of Ginsenoside in the tumor suppression have not been fully elucidated. Here, we chose the representative ginsenoside Rg3 and reported for the first time that Rg3 induces mitophagy in human colon cancer cells, which is responsible for its anticancer effect. Rg3 treatment leads to mitochondria damage and the formation of mitophagosome; when autophagy is inhibited, the clearance of damaged mitochondria can be reversed. Next, our results showed that Rg3 treatment activates the PINK1-Parkin signaling pathway and recruits Parkin and ubiquitin proteins to mitochondria to induce mitophagy. GO analysis of Parkin targets showed that Parkin interacts with a large number of mitochondrial proteins and regulates the molecular function of mitochondria. The cellular energy metabolism enzyme GAPDH is validated as a novel substrate of Parkin, which is ubiquitinated by Parkin. Moreover, GAPDH participates in the Rg3-induced mitophagy and regulates the translocation of Parkin to mitochondria. Functionally, Rg3 exerts the inhibitory effect through regulating the nonglycolytic activity of GAPDH, which could be associated with the cellular oxidative stress. Thus, our results revealed GAPDH ubiquitination by Parkin as a crucial mechanism for mitophagy induction that contributes to the tumor-suppressive function of ginsenoside, which could be a novel treatment strategy for colon cancer.
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