The Blood Oxygenation T2* Values of Resectable Esophageal Squamous Cell Carcinomas as Measured by 3T Magnetic Resonance Imaging: Association with Tumor Stage

Yu-lian Tang,Xiao-ming Zhang,Zhi-gang Yang,Yu-cheng Huang,Tian-wu Chen,Yan-li Chen,Fan Chen,Nan-lin Zeng,Rui Li,Jiani Hu 대한영상의학회 2017 Korean Journal of Radiology Vol.18 No.4

Objective: To explore the association between the blood oxygenation T2* values of resectable esophageal squamous cell carcinomas (ESCCs) and tumor stages. Materials and Methods: This study included 48 ESCC patients and 20 healthy participants who had undergone esophageal T2*-weighted imaging to obtain T2* values of the tumors and normal esophagi. ESCC patients underwent surgical resections less than one week after imaging. Statistical analyses were performed to identify the association between T2* values of ESCCs and tumor stages. Results: One-way ANOVA and Student-Newman-Keuls tests revealed that the T2* value could differentiate stage T1 ESCCs (17.7 ± 3.3 ms) from stage T2 and T3 tumors (24.6 ± 2.7 ms and 27.8 ± 5.6 ms, respectively; all ps < 0.001). Receiver operating curve (ROC) analysis showed the suitable cutoff T2* value of 21.3 ms for either differentiation. The former statistical tests demonstrated that the T2* value could not differentiate between stages T2 and T3 (24.6 ± 2.7 ms vs. 27.8 ± 5.6 ms, respectively, p > 0.05) or between N stages (N1 vs. N2 vs. N3: 24.7 ± 6.9 ms vs. 25.4 ± 4.5 ms vs. 26.8 ± 3.9 ms, respectively; all ps > 0.05). The former tests illustrated that the T2* value could differentiate anatomic stages I and II (18.8 ± 4.8 ms and 26.9 ± 5.9 ms, respectively) or stages I and III (27.3 ± 3.6 ms). ROC analysis depicted the same cutoff T2* value of 21.3 ms for either differentiation. In addition, the Student’s t test revealed that the T2* value could determine grouped T stages (T0 vs. T1–3: 17.0 ± 2.9 ms vs. 25.2 ± 6.2 ms; T0–1 vs. T2–3: 17.3 ± 3.0 ms vs. 27.1 ± 5.3 ms; and T0–2 vs. T3: 18.8 ± 4.2 ms vs. 27.8 ± 5.6 ms, all ps < 0.001). ROC analysis indicated that the T2* value could detect ESCCs (cutoff, 20 ms), and discriminate between stages T0–1 and T2–3 (cutoff, 21.3 ms) and between T0–2 and T3 (cutoff, 20.4 ms). Conclusion: The T2* value can be an additional quantitative indicator for detecting ESCC except for stage T1 cancer, and can preoperatively discriminate between some T stages and between anatomic stages of this tumor.

The Clinicopathological and Prognostic Impact of 14-3-3 Protein Isoforms Expression in Human Cholangiocarcinoma by Immunohistochemistry

Wu, Qiao,Liu, Chang-Zheng,Tao, Lian-Yuan,Yu, Lan,Liu, Wei,Chen, Song-Sen,He, Xiao-Dong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

The 14-3-3 proteins are highly conserved, ubiquitous molecules involved in a variety of biologic phenomena, such as cell cycle control, and apoptosis. However, their expression in cholangiocarcinoma has not been previously characterized. In this paper, immunohistochemistry using specific anti-14-3-3 monoclonal antibodies was performed on formalin-fixed;, paraffin embedded archival tissue from 86 patients of cholangiocarcinoma. We also examined the correlation between expression and survival rate and clinicopathologic factors such as tumor location, tumor size, pathologic differentiation, lymphatic permeation, lymph node metastasis, and tumor stage. Positive 14-3-3 proteins expression was observed for 6 isoforms (${\beta}$, ${\sigma}$, ${\gamma}$, ${\theta}$, ${\delta}$, ${\eta}$) of these proteins in 86 patients of cholangiocarcinoma. ${\beta}$ and ${\sigma}$ isoform immunoreactivity was correlated with lymph node metastasis, tumor stage and patients' survival rate. In addition, ${\delta}$ isoform immunoreactivity showed trends with tumor location, tumor size, pathologic differentiation and tumor stage, while the ${\theta}$ isoform was correlated with pathologic differentiation. These results indicated that upregulated expression of some isoforms of 14-3-3 may be a common mechanism for evading apoptosis in cholangiocarcinoma, so that targeting 14-3-3 may be a novel promising strategy for the treatment of this tumor.

The Metabolic Syndrome and Risk Factors for Biliary Tract Cancer: A Case-control Study in China

Wu, Qiao,He, Xiao-Dong,Yu, Lan,Liu, Wei,Tao, Lian-Yuan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Objectives: Recent data show that the metabolic syndrome may play a role in several cancers, but the etiology for biliary tract cancer is incompletely defined. The present aim was to evaluate risk factors for biliary tract cancer in China. Methods: A case-control study in which cases were biliary tract cancer patients referred to Peking Union Medical College Hospital (PUMCH). Controls were randomly selected from an existing database of healthy individuals at the Health Screening Center of PUMCH. Data on the metabolic syndrome, liver diseases, family history, and history of diabetes and hypertension were collected by retrospective review of the patients' records and health examination reports or by interview. Results: A total of 281 patients (102 intrahepatic cholangiocarcinoma (ICC), 86 extrahepatic cholangiocarcinoma (ECC) and 93 gallbladder carcinoma (GC)) and 835 age- and sex-matched controls were enrolled. $HBsAg^+/anti-HBc^+$ (P=0.002), history of diabetes (P=0.000), cholelithiasis (P=0.000), TC (P=0.003), and HDL (P=0.000) were significantly related to ICC. Cholelithiasis (P=0.000), Tri (P=0.001), LDL (P=0.000), diabetes (P=0.000), Apo A (P=0.000) and Apo B (P=0.012) were significantly associated with ECC. Diabetes (P=0.017), cholelithiasis (P=0.000) and Apo A (P=0.000) were strongly inversely correlated with GC. Conclusion: Cholelithiasis, HBV infection and metabolic symptoms may be potential risk factors for the development of biliary tract cancer.

Several factors affecting hypericin production of Hypericum perforatum during adventitious root culture in airlift bioreactors

Wu, S. Q.,Yu, X. K.,Lian, M. L.,Park, S. Y.,Piao, X. C. POLISH ACADEMY SCIENCES WARSAW 2014 Acta physiologiae plantarum Vol.36 No.4

Hypericum perforatum L. is a traditional medicinal plant for the treatment of depression and wound healing, and hypericin is one of the main effective active substances. To optimize the culture system for producing hypericin in adventitious root, this study used balloon-type airlift bioreactors to investigate the effect of air volume, inoculation density, indole-3-butyric acid (IBA) concentration and methyl jasmonate (MeJA) concentration on hypericin content and productivity during adventitious root culture. Hypericin content and productivity were improved with increasing air volume, and 0.1 vvm (air volume/culture volume/min) was optimal for hypericin production. Inoculation density also had a great effect on hypericin accumulation. Hypericin content and productivity were favorable in an inoculation density of 5.0 g l(-1) and decreased when inoculation densities were lower or higher than 5.0 g l(-1). Furthermore, 1.25 mg l(-1) IBA enhanced hypericin content and productivity, but too low (a parts per thousand currency sign0.50 mg l(-1)) or too high (a parts per thousand yen1.50 mg l(-1)) IBA concentrations decreased hypericin accumulation. MeJA concentration significantly affected biomass accumulation and hypericin production. The biomass decreased and hypericin production increased with increasing MeJA concentration. Optimum hypericin content (1.61 mg g(-1) DW) and productivity (15.57 mg l(-1)) were obtained at 350 mu M MeJA. The hypericin content in bioreactor-grown adventitious roots was lower than in 3-year field-grown plants, but significantly higher than that in in vitro-grown plantlets and 1-year field-grown plants. Thus, the bioreactor culture of adventitious roots can realize rapid and mass production of hypericin in H. perforatum.

A numerical study on the correlation between the evolution of propeller trailing vortex wake and skew of propellers

Lian-Zhou Wang,Chun-Yu Guo,Yu-Min Su,Tie-Cheng Wu 대한조선학회 2018 International Journal of Naval Architecture and Oc Vol.10 No.2

The characteristics of the relationship between the evolution of propeller trailing vortex wake and skew angle are numerically examined based on four different five-blade David Taylor Model Basin (DTMB) model propellers with different skew angles. Numerical simulations are based on Reynolds-averaged NaviereStokes (RANS) equations combined with SST k u turbulence model. Results show that the contraction of propeller trailing vortex wake can be restrained by increasing skew angle and loading conditions, and root vortices fade away when the propeller skew angle increases. With the increase of the propeller's skew angle, the deformation of the hub vortex and destabilization of the tip vortices are weakening gradually because the blade-to-blade interaction becomes weaker. The transition trailing vortex wake from stability to instability is restrained when the skew increases. Furthermore, analyses of tip vortice trajectories show that the increasing skew can reduce the difference in trailing vortex wake contraction under different loading conditions.

Vertical Migration of Sound Scatterers in the Southern Yellow Sea in Summer

Lian-Gang Lü,Jianjun Liu,Fei Yu,Wei Wu,Xiaodong 한국해양과학기술원 2007 Ocean science journal Vol.42 No.1

Acoustic volume backscattering strength data were collected and Conductivity Temperature Depth (CTD) measurements were conducted in the southern Yellow Sea in summer 2005 and 2006. The high temporal and vertical resolution acoustic data measured with a 307 kHz Acoustic Doppler Current Profiler (ADCP) and a 250 kHz acoustic Doppler profile (ADP) had dominant diel variation, which resulted from vertical migration of sound scatterers. Some scatterers congregating in the bottom layer in the daytime migrated upward at dusk, and migrated downward into the bottom layer at dawn. The migration speeds were estimated. More than 33 days data show that the diel migration varies with time. The feature of migration measured with ADCP and ADP is consistent to some extent with what is described in the study on vertical migration of zooplankton in the southern Yellow Sea with conventional net samples.

Vertical Migration of Sound Scatterers in the Southern Yellow Sea in Summer

Lu, Lian-Gang,Liu, Jianjun,Yu, Fei,Wu, Wei,Yang, Xiaodong The Korean Society of Oceanography 2007 Ocean science journal Vol.42 No.1

Acoustic volume backscattering strength data were collected and Conductivity Temperature Depth (CTD) measurements were conducted in the southern Yellow Sea in summer 2005 and 2006. The high temporal and vertical resolution acoustic data measured with a 307 kHz Acoustic Doppler Current Profiler (ADCP) and a 250 kHz acoustic Doppler profile (ADP) had dominant diel variation, which resulted from vertical migration of sound scatterers. Some scatterers congregating in the bottom layer in the daytime migrated upward at dusk, and migrated downward into the bottom layer at dawn. The migration speeds were estimated. More than 33 days data show that the diel migration varies with time. The feature of migration measured with ADCP and ADP is consistent to some extent with what is described in the study on vertical migration of zooplankton in the southern Yellow Sea with conventional net samples.

A numerical study on the correlation between the evolution of propeller trailing vortex wake and skew of propellers

Wang, Lian-Zhou,Guo, Chun-Yu,Su, Yu-Min,Wu, Tie-Cheng The Society of Naval Architects of Korea 2018 International Journal of Naval Architecture and Oc Vol.10 No.2

The characteristics of the relationship between the evolution of propeller trailing vortex wake and skew angle are numerically examined based on four different five-blade David Taylor Model Basin (DTMB) model propellers with different skew angles. Numerical simulations are based on Reynolds-averaged Naviere-Stokes (RANS) equations combined with SST $k-{\omega}$ turbulence model. Results show that the contraction of propeller trailing vortex wake can be restrained by increasing skew angle and loading conditions, and root vortices fade away when the propeller skew angle increases. With the increase of the propeller's skew angle, the deformation of the hub vortex and destabilization of the tip vortices are weakening gradually because the blade-to-blade interaction becomes weaker. The transition trailing vortex wake from stability to instability is restrained when the skew increases. Furthermore, analyses of tip vortice trajectories show that the increasing skew can reduce the difference in trailing vortex wake contraction under different loading conditions.

Performances of the Effervescent Atomizer for Water Mist Fire Extinguishing

( Jin Xiang Wu ),( Qiang Liang ),( Lian Sheng Liu ),( Yun Zhong Yan ),( En Yu Wang ),( Qing Miao ) 한국액체미립화학회 2005 한국액체미립화학회 학술강연회 논문집 Vol.2005 No.-

Based on the mechanism of effervescent atomization, a new effervescent atomization system of water mist was designed. In this system, the gas medium is carbon dioxide, which is soluble and can be used in fire suppression. High pressure saturated carbon dioxide-water solution flowed through the throttle orifice, carbon dioxide was bubbled, and the two-phase flow was formed in the mixing chamber of nozzle. At last, the water mist was formed downstream of the exit orifice of nozzle. In order to examine the feasibility of this system, data were collected, processed and analyzed with DUAL PDA. The velocity profile and drop-size distribution (D10, D32, Dv0.9) downstream of the effervescent atomizer were gained. The efficiency of fire suppression of this system were experimentally investigated by putting out the fire of industry alcohol and diesel oil. The experimental results showed that this water mist system is feasible for fire suppression.

A new power supply strategy for high power rectifying units in electrolytic copper process

Liu He-Miao,Zhao Yu-Lian,Cheng Yan-Ming,Wu Jing,Al Shurafa Mahmoud A. M.,Liu Cheng,Lee Il-Kyoo 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.2

For achieving the minimum energy consumption in electrolytic copper process, this paper proposes a power supply optimization strategy based on the improved BP neural network for high-power electrolytic copper rectifying units to eff ectively improve the utilization rate of electric energy, reduce the production cost, and achieve high effi ciency and energy saving. Aiming to operation scenarios including normal operation of rectifi ers, fault of random one rectifi er, fault of random two rectifi ers and number change of electrolytic tanks, the output current of each rectifi er, transformer gears and control angle of thyristor are obtained under these four scenarios by the proposed power supply strategy. The simulation results indicate that compared with BP neural network and PSO optimizing BP(PSO-BP)neural network, the prediction error of power supply strategy of GA optimizing BP (GA-BP) neural network is the minimum. Consequently, the optimal control of the output current of each rectifi er is obtained by using GA-BP neural network, and the stabilized current precision of total output current can be kept at 0.003–0.005, which verifi es the eff ectivity and feasibility of the proposed power supply optimization strategy, which provides valuable guidance and reference for the future design of high-power power supply system in electrolytic copper or other electrolytic metals.