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Yu, S.J.,Bae, S.,Kang, J.S.,Yoon, J.H.,Cho, E.J.,Lee, J.H.,Kim, Y.J.,Lee, W.J.,Kim, C.Y.,Lee, H.S. North-Holland ; Elsevier Science Ltd 2015 european journal of pharmacology Vol.762 No.-
<P>Prevention and restoration of hepatic fibrosis from chronic liver injury is essential for the treatment of patients with chronic liver diseases. Vitamin C is known to have hepatoprotective effects, but their underlying mechanisms are unclear, especially those associated with hepatic fibrosis. Here, we analyzed the impact of vitamin Con bile acid induced hepatocyte apoptosis in vitro and lithocholic acid (LCA) induced liver injury in vitamin C-insufficient Gulo(-/-) mice, which cannot synthesize vitamin C similarly to humans. When Huh BAT cells were treated with bile acid, apoptosis was induced by endoplasmic retiiculum stress related JNK activation but vitamin C attenuated bile acid induced hepatocyte apoprosis in vitro. In our in vivo experiments. LCA feeding increased plasma marker of cholestasis and resulted in more extensive liver damage and hepatic fibrosis by more prominent apoptotic cell death and recruiting more intrahepatic inflammatory CD11b(+) cells in the liver of vitamin C-insufficient Gulo(-/-) mice compared to wild type mice which have minimal hepatic fibrosis. However, when vitamin C was supplemented to vitamin C-insufficient Gulo(-/-) mice, hepatic fibrosis was significantly attenuated in the liver of vitamin C-sufficient Gulo(-/-) mice like in wild type mice and this hepatoprotective effect of vitamin C was thought to be associated with both decreased hepatic apoptosis and necrosis. These results suggested that vitamin C had hepatoprotective effect against cholestatic liver injury. (C) 2015 Elsevier B.V. All rights reserved.</P>
Jung, W.Y.,Yu, S.L.,Seo, D.W.,Jung, K.C.,Cho, I.C.,Lim, H.T.,Jin, D.I.,Lee, Jun-Heon Asian Australasian Association of Animal Productio 2012 Animal Bioscience Vol.25 No.10
Pigs may need to be exploited as xenotransplantation donors due to the shortage of human organs, tissues and cells. Porcine endogenous retroviruses (PERVs) are a significant obstacle to xenotransplantation because they can infect human cells in vitro and have the potential for transmission of unexpected pathogens to humans. In this research, 101 pigs, including four commercial breeds (23 Berkshire, 13 Duroc, 22 Landrace and 14 Yorkshire pigs), one native breed (19 Korean native pigs) and one miniature breed (10 NIH miniature pigs) were used to investigate insertional variations for 11 PERV loci (three PERV-A, six PERV-B and two PERV-C). Over 60% of the pigs harbored one PERV-A (907F8) integration and five PERV-B (B3-3G, B3-7G, 742H1, 1155D9 and 465D1) integrations. However, two PERV-A loci (A1-6C and 1347C1) and one PERV-B locus (B3-7F) were absent in Duroc pigs. Moreover, two PERV-C loci (C2-6C and C4-2G) only existed in Korean native pigs and NIH miniature pigs. The results suggest that PERV insertional variations differ among pig breeds as well as among individuals within a breed. Also, the results presented here can be used for the selection of animals that do not have specific PERV integration for xenotransplantation research.
정태수,김현숙,유평렬,신영진,신현길,김택성,정철훈,이훈,신영신,강신국,정경수,홍광준,Jeong, T. S.,Kim, H. S.,Yu, P. Y.,Shin, Y. J.,Shin, H. K.,Kim, T. S.,Jeong, C. H.,Lee, H.,SHin, Y. S.,Kang, S. K.,Jeong, K. S.,Hong, K. J. 한국결정성장학회 1993 韓國結晶成長學會誌 Vol.3 No.2
수직 2단 전기로를 제작하고 결정성장관에 꼬리관을 연결하여 seed 결정없이 승화 방법으로 CdS 결정을 성장하였다. 이때 시료부분과 성장부분의 온도차 ${\Delta}T$가 이론적인 값 $14.7^{\circ}C$와 비교해서 실험적으로 얻은 값이 $15^{\circ}C$ 로 아주 일치하는 값을 나타내었다. 이때 꼬리관의 온도를 $110^{\circ}C$로 시간당 0.38mm 정도로 빨리 결정성장관을 끌어 올려 결정을 성장하였다. 분말법의 X-선 회절무늬와 Laue 배면 반사법의 Laue 무늬로부터 성장된 결정이 육방정이고 결정성장관의 길이 방향으로 c축을 갖는 단결정임을 확인하였다. 또한 CdS 단결정은 상온에서 전자 이동도와 운반자 밀도는 각각 $316cm^2/V{\cdot}sec$와 $2.90{\times}10^{16}cm^{-3}$정도이였다. We has made 2-zone vertical electric furnace and has been grown CdS single crystal by sublimation method in crystal growth tube with tail tube without seed crystal for growth. While it has been growing, temperature difference ${\Delta}T$ of source and growth part has nearly agreed with theoritical value $14.7^{\circ}C$and experimental value $15^{\circ}C$ Then, crystal of best quality has been grown, when temperature of tail tube has been $110^{\circ}C$, in spite of quickly pulling up crystal growth tube a degree O.38mm per hour. The grown crystal have had hexagonal structure and single crystal with c-axis to length of crystal growth tube from X- ray diffraction pattern of powder method and Laue pattern of back reflection Laue method. Also, the mobility and carrier density from Hall effect measurement have been $316cm^2/V{\cdot}sec$ and $2.90{\times}10^{16}cm^{-3}$ at the room temperature, respectively.
Yu, K‐,H.,Hong, K‐,S.,Lee, B‐,C.,Oh, M‐,S.,Cho, Y‐,J.,Koo, J‐,S.,Park, J‐,M.,Bae, H‐,J.,Han, M‐,K.,Ju, Y‐,S.,Kang, D‐,W.,Appelros, P. Blackwell Publishing Ltd 2011 Acta neurologica Scandinavica Vol.123 No.5
<P>Yu K‐H, Hong K‐S, Lee B‐C, Oh M‐S, Cho Y‐J, Koo J‐S, Park J‐M, Bae H‐J, Han M‐K, Ju Y‐S, Kang D‐W, Appelros P, Norrving B, Terent A. Comparison of 90‐day case‐fatality after ischemic stroke between two different stroke outcome registries using propensity score matching analysis. Acta Neurol Scand: 2011: 123: 325–331. © 2010 John Wiley & Sons A/S.</P><P><B>Background – </B> It has not been clarified whether the disparity in ischemic stroke outcome between populations is caused by ethnic and geographic differences or by variations in case mix. Propensity score matching (PSM) analysis can overcome some analytical problems but is rarely used in stroke outcome research. This study was to compare the ischemic stroke case‐fatality between two PSM cohorts of Sweden and Korea.</P><P><B>Methods – </B> Prognostic variables related to baseline characteristics and stroke care were included in our PSM model. Then, we selected 7675 Swedish and 1220 Korean patients with ischemic stroke from each stroke registers and performed one‐to‐one matching based on propensity scores of each patient.</P><P><B>Results – </B> After PSM, all measured variables were well balanced in 1163 matched subjects, and the 90‐day case‐fatality was identical 6.2% (HR 0.997, 95%CI 0.905–1.099) in Sweden and Korea.</P><P><B>Conclusions – </B> No difference is found in the 90‐day case‐fatality in propensity score‐matched Swedish and Korean patients with ischemic stroke.</P>
Yu, S.,Kim, J.,Choi, Y.,Lim, C.,Seo, B. THE POLYMER SOCIETY OF KOREA 2016 Macromolecular Research Vol.24 No.1
<P>Polypropylene (PP) is widely used in many industrial applications, including the preparation of interior parts for automotive vehicles. However, the poor adhesion between PP and PP or leather is problematic. In addition, adhesives that contain organic solvents could emit hazardous gases inside a vehicle if used for interior parts. Therefore, waterborne adhesives are required to bond leather to PP. While waterborne adhesives prepared with 2-hydroxyethylmethacrylate- grafted styrene-butadiene rubber (SBR-g-HEMA) have shown good peel strengths (3.0 kgf/2.5 cm(2)), its long curing time (2 days at 80 A degrees C) greatly reduces the production rate. In this study, we prepared a novel waterborne adhesive composed of SBR modified with PP-grafted maleic anhydride (PP-g-MAH). This adhesive exhibited a higher peel strength (3.6 kgf/2.5 cm(2)) than that of pre-existing adhesives after curing for only 15 min at 80 A degrees C. Furthermore, this adhesive exhibited a similar peel strength (2.78 kgf/2.5 cm(2)) when cured for 15 min at 70 A degrees C.</P>
Spectroscopic Ellipsometric Analysis of a Si Grating Pattern Made by Photolithography
Y. D. Kim,S.-H. Han,T. H. Ghong,J.-M. Chung,Y. Y. Yu,K. C. Park 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.3
We performed spectroscopic ellipsometry (SE) measurements to investigate the possibility of a nondestructive in-situ monitoring tool for determining the critical dimension (CD) of patterned structures. A simple 1D patterned c-Si periodic structure was measured from the zeroth-order diraction response at a fixed angle of incidence, whose result agreed with the theoretical prediction made by using a rigorous coupled-wave analysis (RCWA) calculation for the reflected light. To investigate the SE's advantage over atomic force microscopy we also prepared a c-Si periodic structure with a Cr hat on the top. We observed that the theoretical result could also explain the measured spectra quantitatively even when the metallic hat structure on the top acted as a strong obstacle to the probing light.
Analysis on the Grating Structure of Si by Using Spectroscopic Elipsometry
Y. D. Kim,S.-H. Han,T. H. Ghong,J. S. Byun,Y. Y. Yu,K. C. Park 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.4
Spectroscopic ellipsometry (SE) has come to be an important method to determine the critical dimension(CD) of patterned structures by measuring the zeroth-order diffraction response at a fixed angle of incidence. To investigate the possibility of an in-situ monitoring tool for a complicated multilayer, we performed SE measurements on a one-dimensional patterned c-Si periodic structure with SiO2 hat on Si substrate. Rigorous coupled-wave analysis(RCWA)calculation for the reflected light could explain the measured spectrum quantitatively even when the hat structure on the top acted as a strong obstacle to the probing light.
생물반응기 배양에 의한 산삼 수확 후 배양액이 무의 초기 생장에 미치는 효과
유창연 ( C. Y. Yu ),이재근 ( J. K. Lee ),성은수 ( E. S. Seong ),김병준 ( B. J. Kim ),권순성 ( S. S. Kwon ),고은정 ( E. J. Gho ),안형신 ( H. S. Ahn ),이종윤 ( J. Y. Lee ) 강원대학교 농업생명과학연구원(구 농업과학연구소) 2009 강원 농업생명환경연구 Vol.20 No.-
In order to investigate the optimal conditions for using recycled liquid medium after cultured a wild Panax ginseng C. A. Meyer, we examined the effect of 100% distilled water and several diluted culture medium on the growth of radish seedlings. Of six conditions tested, in 1:3diluted culture medium, fresh weight was extremely higher and 141.42 g while in distilled water the fresh weight was the lowest. Dry weight of radish was higher in condition of 100% culture medium and as the ratio of cultured medium increased, the dry weight of radish was gradually increased. In this results, culture medium was effective on the growth, fresh weight and dry weight of radish. These results suggested that recycled culture medium of Panax ginseng adventitious roots could be used for producing vegetable radish sprouts, and improving their the functional activity.