Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality

임정훈,Lee Ga Young,Jeon Yena,Jung Hee-Yeon,Choi Ji Young,CHO, JANG-HEE,Park Sun Hee,김용림,Kim Hyung-Kee,Huh Seung,유은상,Won Dong Il,Kim Chan-Duck 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the clinical outcomes of elderly KT recipients and analyzed the impact of elderly donors. Methods: This retrospective cohort study included patients who underwent KT between 2000 and 2019. KT recipients were divided into four groups according to a combination of recipient and donor age (≥60 or <60 years); elderly recipients: old-to-old (n = 46) and young-to-old (n = 83); young recipients: old-to-young (n = 98) and young-to-young (n = 796). We compared the risks of mortality, graft failure, and acute rejection between groups using Cox regression analysis. Results: The incidence of delayed graft function, graft failure, and acute rejection was not different among groups. Annual mean tacrolimus trough level was not lower in elderly recipients than young recipients during 10-year follow-up. Mortality was significantly higher in elderly recipients (p = 0.001), particularly infection-related mortality (p < 0.001). In multivariable Cox regression analysis, old-toold and young-to-old groups had increased risk of mortality (adjusted hazard ratio [aHR], 2.89; 95% confidence interval [CI], 1.14– 7.32; p = 0.03; aHR, 3.06; 95% CI, 1.51–6.20; p = 0.002). However, graft failure and acute rejection risks were not increased in elderly recipients. Conclusion: In elderly recipients, graft survival and acute rejection-free survival were not inferior to those of young recipients. However, mortality, especially risk of infection-related death, was increased in elderly recipients. Thus, low immunosuppression intensity might help decrease mortality in elderly recipients.

An ESP Instructional Approach: Setting up a model for Tourism Major

( Huh¸ Seonmin ),( Lee¸ Kang-young ) 현대영미어문학회 2019 현대영미어문학회 추계학술대회 발표논문집 Vol.2019 No.-

This presentation starts from a strong need to understand ESP instructional model that can develop students’ English competence as well as their content knowledge for their future field of career required them to have. While there are much research on ESP education, there is a lack of attention on how actual classroom teaching is conducted and how an ESP instructional model is discrete from general English programs. Some ESP courses introduced special pedagogical techniques, however, many activities or instructional moves do not seem to reflect ESP-specific approach. Therefore, this presentation introduces one class engagement that the presenter actually taught to develop students’ tourism knowledge and English skills that are filed-specific. This presentation will discuss an ESP instructional model that can help both students’ professional content knowledge as well as their purpose-specific English communication skills.

40세 미만 환자에서 발생한 심부정맥 혈전증의 특징

허승,권상휘,김영욱 대한혈관외과학회 2003 Vascular Specialist International Vol.19 No.1

Effect of the use of a ready-made plastic stent on the peri-implant soft tissue

Huh, Jung-Bo,Yang, Ki-Bin,Choi, Jeomil,Jeon, Young-Chan,Lee, Jeong-Yeol,Shin, Sang-Wan Informa Healthcare 2013 Acta odontologica scandinavica Vol.71 No.3

<P><B><I>Objective.</I></B> This study compared the effect of the use of a ready-made plastic stent on the width of peri-implant keratinized mucosa with that of conventional methods and examined the effects of a plastic stent on peri-implant soft tissue. <B><I>Materials and methods.</I></B> Five young-adult beagle dogs were used. Forty titanium implants were placed in the mandibular alveolar ridge. Stage 2 surgery was performed 8 weeks after implant installation. Each dog received a full-thickness, apically positioned flap (fAPF) with a lingual crestal incision using a suture material in the control group (<I>n</I> = 20) and a ready-made plastic stent in the test group (<I>n</I> = 20). The keratinized mucosa width after stage 2 surgery was measured in each group. The pocket depth, length of connective-tissue contact and biological width were measured in the tissue samples. A student's <I>t</I>-test was used to test the differences between the groups (95% confidence level). <B><I>Results.</I></B> The width of the keratinized mucosa was significantly higher and the distance from the top of the implant platform to the mucogingival junction was significantly longer in the test group than the control group. Histometric observations revealed the pocket depth and biological width to be significantly lower in the test group than the control group. <B><I>Conclusion.</I></B> The use of a fAPF with a lingual crestal incision using a ready-made plastic stent can effectively preserve or enhance the width of the keratinized mucosa and might restore a more optimal biological environment at the early soft-tissue healing stage.</P>

불확실한 환경에서 미디어 기업의 전략 변화와 동적역량

김아영(Kim, A-Young),허문구(Huh, Moon-Goo) 한국경영교육학회 2020 경영교육연구 Vol.35 No.6

[연구목적] 본 연구는 단일사례연구를 통해 급변하는 환경에서 기업의 동적역량과 전략선택의 관계를 탐구하고, 더 나아가 기업의 성장단계에 따른 동적역량의 영향을 분석하였다. [연구방법] 사례기업은 방송, 영화, 음악, 공연 등 다양한 미디어 플랫폼 서비스를 제공하는 국내 C기업으로 선정하였다. 사례연구의 신뢰성과 타당성을 높이기 위해 인터뷰, 내부자료, 보도자료, IR 자료 등 다양한 자료원을 활용하였으며, 기업 외부환경의 변화와 내부자원과 역량, 환경 대응을 위한 활동 등을 분석하였다. [연구결과] 본 연구의 결과는 다음과 같다. 첫째, 변화하는 환경에서 동적역량 관점이 기업의 전략선택을 이해, 분석하는데 효과적으로 활용될 수 있다. 둘째, 동적역량의 하위요소인 환경감지, 기회구현, 변형/재구성 역량이 기업의 성장 단계에 따라 기업의 전략선택 및 성과에 차별적 영향을 미치는 것을 확인하였다. [연구의 시사점] 본 연구는 동적역량에 대한 탐색적 연구로, 경영전략의 새로운 패러다임인 동적역량이 불확실한 환경에서 기업의 전략선택과 성과를 설명하는데 유용하게 활용될 수 있다는 것을 확인하였다. 특히 동적역량의 세 가지 하위 역량을 구분하고 각 역량이 어떻게 기업 분석에 적용될 수 있는지를 구체적 명제로 제시하였다는 점에서 의의가 있다. [Purpose] This study aims to analyze the relativeness between dynamic capabilities and choice of stretegies in the context of the growing step of the company through the single case study. [Methodology] In order to do this, this study select C corporation as an example which is providing various media-platform service like broadcasting, movies, music, performances, and so on. To increase validity and reliability. this study uses a variety of sources such as interview, firm data, IR, etc. [Findings] The results are as follows. First, this study suggests that the perspective of the dynamic capabilities is suitable for analyzing the choice of stretegies in an uncertain environment. Second, the sub-elements of the dynamic capabilities(sensing, seizing, transforming) affects the choice of stretegies and performances of the company in accordance with the growing step of company. [Implications] This study is an exploratory study of dynamic capabilities. The results show us that the dynamic capabilities as a new paradigm of business strategy is useful framework to explain the strategic choices and performance of the company in an uncertain environment. Especially, this study reason out several proposition in reference to dynamic capabilities.

탄소나노튜브를 이용한 고강도 나노복합재료

박영수(Young Su Park),허몽영(Mong Young Huh),안계혁(Kay-hyeok An),김은성,강신재(Shinjae Kang) 한국자동차공학회 2008 한국자동차공학회 지부 학술대회 논문집 Vol.2008 No.11

With major causes of exhaustion and global warming of limited fossil fuel, according to policy of saveenergy and nature-friendly products, it is needed for gas milage to beb increased by compulsion regulation (Corporate Average Fuel Economy, CAFE). For this regulation solution, the diverse and hard tries such as light-weight vehicle, electric car, and fuel cell have carried out to elevate engine efficiency and to reach to a next generation zero-emission vehicle. In light-weight field, it has been tried to find or make much stronger and lighter materials or composites, magnesium alloy and carbon fiber would be a powerful candidate in metals and reinforced plastic composites for light weight vehicles. But, we here introduced carbon nanotube (CNT), which is one of the highest Young’s modulus and strength, and its nanocomposite which would be a new and powerful material to make light weight vehicle. CNT reinforced nanocomposite would solve waste disposal to make up environmental problem and have the advantage in recycling problem that would be or has been occurred in other reinforced composites.

급성 췌장염의 합병이 추정되는 한국형 출혈열 1예

박영수,김창오,김영근,홍성관,장경희,허애정,염준섭,송영구,김준명 대한감염학회 2001 감염 Vol.33 No.5

The Korean hemorrhagic fever (KHF) is an acute febrile disease with characteristic of fever, bleeding tendency, and renal failure. There are many complications of Korean hemorrhagic fever such as infection, anemia, internal bleeding, hypopituitarism, respiratory, and neurologic complication. A few cases were reported on acute pancreatitis with hemorrhagic fever abroad, but there was no case about Korean hemorrhagic fever with acute pancreatitis in this country. We experienced a case of Korean hemorrhagic fever associated with suspected acute pancreatits. With review of articles, we report a case of 51 year-old woman with KHF, where acute pancreatitis developed during management, (Korean J Infect Dis 33:376∼379, 2001)

ApoB/ApoA-I ratio is independently associated with carotid atherosclerosis in type 2 diabetes mellitus with well-controlled LDL cholesterol levels

( Ji Eun Jun ),( Young Ju Choi ),( Yong-ho Lee ),( Dae Jung Kim ),( Seok Won Park ),( Byung Wook Huh ),( Eun Jig Lee ),( Sun-ha Jee ),( Kyu Yeon Hur ),( Sung Hee Choi ),( Kap Bum Huh ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.1

Background/Aims: This study aimed to investigate whether the apolipoprotein (Apo) B/ApoA-I ratio is associated with carotid intima-media thickness (CIMT) in type 2 diabetes mellitus (T2DM) subjects with low density lipoprotein cholesterol (LDL-C) levels less than 100 mg/dL. Methods: This cross-sectional study included 845 subjects aged with T2DM 40 to 75 years who had visited Huh’s Diabetes Center in Seoul, Republic of Korea for CIMT measurement. Traditional fasting lipid profiles, ApoB and ApoA-I levels were examined. CIMT was measured at three points on the far wall of 1 cm long section of the common carotid artery in the proximity of the carotid bulb. The mean value of six measurements from right and left carotid arteries were used as the mean CIMT. In this study, carotid atherosclerosis was defined as having a focal plaque or diffuse thickening of the carotid wall (mean CIMT ≥ 1.0 mm) Results: The prevalence of carotid atherosclerosis increased with ApoB/ApoA-I ratio. The ApoB/ApoA-I ratio, expressed as both quartiles (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.21 to 3.79; p for trend = 0.014) and continuous values (OR, 10.05; 95% CI, 3.26 to 30.97; p < 0.001), was significantly associated with a higher risk for carotid atherosclerosis, regardless of conventional cardiovascular disease risk factors. The optimal ApoB/ApoA-I ratio cutoff value for detecting carotid atherosclerosis was 0.57, based on receiver operating characteristic curve analysis with a sensitivity of 58.0% and a specificity of 55.1%. Conclusions: A high ApoB/ApoA-I ratio was significantly associated with carotid atherosclerosis in T2DM patients with LDL-C levels less than 100 mg/dL.

제2형 당뇨병환자에서 ApoB/ApoA-I Ratio와 대사증후군 및 대사증후군 각 요소와의 관계

김정은 ( Jung Eun Kim ),김화영 ( Wha Young Kim ),이윤정 ( Yoon Jung Lee ),박지은 ( Ji Eun Park ),최영주 ( Young Ju Choi ),허갑범 ( Kap Bum Huh ),황지윤 ( Ji Yun Hwang ) 대한당뇨병학회 2009 Diabetes and Metabolism Journal Vol.33 No.2

연구배경: Apolipoprotein B/apolipoprotein A-I 비율(ApoB/ApoA-I)은 대사증후군의 중요한 임상적 지표이다. 하지만, 한국인 제2형 당뇨병환자들을 대상으로 ApoB/ApoA-I과 대사증후군의 관련성을 살펴본 연구는 미미하다. 따라서 본 연구에서는 ApoB/ApoA-I과 ApoB/ApoA-I 사분위에 따른 대사증후군 및 대사증후군 각 요소별 위험도를 보았다. 방법: 대상자는 서울의 당뇨병 전문 클리닉 허내과를 방문한 제2형 당뇨병환자 812명 (남자 424명, 여자 388명)이다. 이들을 성별로 ApoB/ApoA-I의 사분위에 따라 네 군으로 나누었다(가장 낮은 군:Q1-가장 높은 군:Q4). 체위, 혈액성상 및 식품섭취 빈도조사지를 통한 식이섭취량이 측정되었다. 결과: 대사증후군의 유병률은 남자 47.9%, 여자 66.5%였다. 대사증후군과 대사증후군의 각 위험요소에 대한 OR은 남녀 모두 ApoB/ApoA-I의 Q2에서 Q4로 갈수록 유의하게 증가했다(남자: OR=5.37; 95% CI=2.98-9.65 and OR=7.41; 95% CI=4.04-13.6; 여자: OR=2.57; 95% CI=1.28-5.15 and OR=8.49; 95% CI=4.28-16.8). 이러한 경향은 남녀 모두에서 연령, 당뇨 유병기간, 공복 혈당, 대량영양소를 보정한 후에도 변하지 않았다(남자: OR=5.24; 95% CI=2.80-9.24 and OR=7.98; 95% CI=4.09-15.6; 여자: OR=3.54; 95% CI=1.84-6.81, OR=4.41; 95% CI=2.26-8.61, and OR=8.29; 95% CI=3.85-17.8). 결론: 본 연구에서는 당뇨병환자에서 가장 중요한 인자 중 하나인 다량 영양소 섭취량을 포함한 대사증후군의 위험요인을 보정하기 전과 후 모두 ApoB/ApoA-I이 증가 할수록 대사증후군 및 대사증후군 각 요소의 위험도가 증가했다. 향후, ApoB/ApoA-I 증가와 대사증후군 및 대사증후군 각 요소의 위험도에 대한 정확한 평가를 위해 ApoB/ApoA-I과 관련한 식이위험요인에 대한 전향적인 연구가 필요할 것으로 사료된다. Background: The Apolipoprotein B/apolipoprotein A-I ratio (apoB/apoA-I) is a powerful clinical indicator of metabolic syndrome. However, few studies have searched for an association between ApoB/ApoA-I and metabolic syndrome in Korean patients with type 2 diabetes. We investigated the relation between ApoB/ApoA-I and the risk of metabolic syndrome and its components. Methods: Subjects were 812 (424 males and 388 females) Korean patients who were being treated for type 2 diabetes at Huh`s Diabetes Center in Seoul. The patients were classified into quartiles (lowest:Q1- highest:Q4) of ApoB/ApoA-I by gender. Anthropometric and hematological characteristics and dietary intake using a food frequency questionnaire were assessed. Results: The prevalence of metabolic syndrome in our sample was 47.9% in males and 66.5% in females. The odds ratios (OR) for metabolic syndrome and for having its components were significantly increased from Q2 to Q4 quartiles of ApoB/ApoA-I in males (OR = 5.37; 95% CI = 2.98-9.65 and OR = 7.41; 95% CI = 4.04-13.6) and females (OR = 2.57; 95% CI = 1.28-5.15 and OR = 8.49; 95% CI = 4.28-16.8). These trends withstood adjustment for age, duration of type 2 diabetes, fasting blood glucose levels, and macronutrient intake both in males (OR = 5.24; 95% CI = 2.80-9.24 and OR = 7.98; 95% CI = 4.09-15.6) and in females (OR=4.41; 95% CI = 2.26-8.61 and OR = 8.29; 95% CI = 3.85-17.8). Conclusion: ApoB/ApoA-I appeared to be independently associated with risk of having metabolic syndrome and its components in Korean patients with type 2 diabetes after adjustment for putative risk factors including macronutrient intake, a particularly important lifestyle factor for patients with type 2 diabetes. A follow-up study of this population should evaluate the mechanisms underlying the relation between ApoB/ApoA-I and metabolic syndrome and its components. (Korean Diabetes J 33:143-154, 2009)

중환자실 병원감염에 대한 다기관 공동 조사연구

박은숙,박미라,진혜영,김정은,최정실,송영구,최영화,이위교,홍성관,허애정,양동규,김준명 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1