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실험동물 랫드를 이용한 미세먼지 기도노출에 따른 호흡기계 독성에 대한 마늘의 예방효과 탐색
이윤범(YoonBum Lee),김근우(GeunWoo Kim),송영민(YoungMin Song),한영훈(YoungHoon Han),하창수(ChangSu Ha),이지선(JiSun Lee),김민희(MinHee Kim),손혜영(HyeYoung Son),이기용(GiYong Lee),허 용(Yong Heo),김창열(ChangYul Kim) 한국환경보건학회 2020 한국환경보건학회지 Vol.46 No.6
Objectives: Exposure to fine dust (PM10) could contribute to the occurrence of cardiovascular disease or respiratory abnormalities. Since garlic is known to possess an anti-oxidative stress effect, the present study was performed to evaluate the effect of garlic intake on fine dust-mediated pulmonary toxicity. Methods: Rats were intratracheally instilled with fine dust at 15 mg/kg body weight (BW)/day for five days following five-day intragastric intubation of garlic at 0.7 or 1.4 g/kgBW/day, or 13.1 mg/kgBW/day S-allyl-cysteine (SAC) as a reference component in garlic. Blood and bronchoalveolar lavage fluid (BALF) were collected. Results: Deposit of fine dust was visually and histopathologically observed in the lungs. Body weight gain during the instillation period was significantly lowered in all the groups instilled with fine dust. Neutrophil numbers in blood were significantly elevated in the fine dust alone group, but this alteration was diminished in the groups administered with garlic. Levels of serum glutathione were lower in the rats instilled with fine dust alone, and this decrease in the glutathione level seems dose-dependently compensated among the groups administered with garlic. Similar findings were observed in the BALF with statistical significance. Typical pulmonary histopathological observation related with inflammation was demonstrated in the lungs of the rats exposed to fine dust alone, whereas such histopathologic findings were not improved in the groups administered with garlic. Conclusion: The present study suggests that garlic intake could alleviate fine dust-mediated pulmonary or systemic toxicities. Further investigation is necessary to delineate the mechanism of garlic-mediated effects on pulmonary function.
Gweon, Tae-Geun,Kim, Sang Woo,Noh, Yong-Sun,Hwang, Seawon,Kim, Na-Young,Lee, Yoonbum,Lee, Soon-Wook,Lee, Sung Won,Lee, Jong Yul,Lim, Chul-Hyun,Hun Kim, Hyung,Kim, Jin Su,Kyung Cho, Yu,Myung Park, Jae Wolters Kluwer Health 2015 Medicine Vol.94 No.13
<P><B>Abstract</B></P><P>For afternoon colonoscopy, same-day administration of sodium picosulfate, magnesium oxide, and citric acid (PM/Ca) is recommended. However, few studies have evaluated the bowel-cleansing efficacy and safety of this regimen. The aim of this study was to compare the bowel-cleansing efficacy, side effects, and patient's tolerability of a same-day split administration of PM/Ca with polyethylene glycol (PEG) for afternoon colonoscopy.</P><P>Patients were randomly assigned to a PM/Ca group or a PEG group. The PM/Ca group consumed 1 sachet of PM/Ca at 06:00 and 1 sachet of PM/Ca 4 hours before the colonoscopy. They also took 2 tablets of bisacodyl before sleep on the night before. The PEG group consumed 2 L of PEG at 06:00 and 2 L of PEG 4 hours before the colonoscopy. All subjects were instructed to finish the bowel cleanser or fluid at least 2 hours before colonoscopy. All colonoscopic examinations were performed in the afternoon on the same day. The bowel-cleansing efficacy was scored using 2 scales: the Ottawa Bowel Preparation Scale (OBPS) and the Aronchick scale. Ease of using the bowel cleanser was rated from 1 (very easy) to 5 (very difficult).</P><P>Two hundred nine patients underwent colonoscopy. The bowel-cleansing scores by OBPS did not differ between groups (5.0 vs 4.9, <I>P</I> = 0.63). Ease of using the bowel cleanser was superior in the PM/Ca group (<I>P</I> < 0.01).</P><P>The cleansing efficacy of PM/Ca administered on the day of colonoscopy is comparable to that of PEG. Patients prefer PM/Ca.</P>
The prevalence of musculoskeletal symptoms and related factors among a general hospital workers
Yoonbum Choi,Soojin Lee,Hwanjin Park 대한인간공학회 2012 대한인간공학회 학술대회논문집 Vol.2012 No.5
Objective: The purpose of this study was to investigate the prevalence of musculoskeletal symptoms in general hospital workers and to evaluate related factors. Background: Hospital workers are highly exposed to musculoskeletal disease risk factors. But, enough studies have not been performed in Korea. Method: A questionnaire was performed to workers who work at the general hospital. A self-reported questionnaire include following information: general characteristics, health behaviors, job-related factors, ergonomic factor, job stress, and musculoskeletal symptoms. Ergonomic factor was measured by ANSI Z-365. Job stress was measured by KOSS-26 and musculoskeletal symptoms were measured by NIOSH questionnaire. Results: The prevalence of musculoskeletal symptoms was 631(53.3%). The prevalence per body part for shoulder, lower back, leg/foot, and neck were 393(33.2%), 330 (27.9%), 266(22.5%), and 250(21.1%) respectively. After adjusting for confounding factors, three shift workers were at higher risk compared to daytime workers(OR=1.8, 95%CI=1.32-2.54), nurses were at higher risk compared to other position(OR=1.7, 95%CI=1.18-2.49), and high risk group were at higher risk compared to normal group(OR=3.7, 95%CI=2.10-6.68). In the domains of job stress, job demand(OR=2.0, 95%CI=1.46-2.61), job insecurity(OR=1.5, 95%CI=1.09-2.07), organizational system(OR=2.0, 95%CI=1.51-2.65), lack of reward(OR=1.6, 95%CI=1.20-2.16), occupational climate(OR=1.6, 95%CI=1.20-2.19), and physical environment(OR=2.7, 95%CI=2.02-3.63) showed statistically association with musculoskeletal symptoms. Conclusion: Musculoskeletal symptoms were highly prevalent in the general hospital workers. Authors concluded shift work, ANSI high risk group, job stress were seem to be related with musculoskeletal symptoms. Application: Our study suggest it is important to make a safety plan to prevent musculoskeletal diseases.