수종의 광독성 약물투여 후 시간에 따른 피부농도 및 최소 광독량에 관한 연구

박윤기,조무연,한승경,임성빈 ( Yoon Kee Park,Moo Yon Cho,Seung Kyung Hann,Sung Bin Im ) 대한피부과학회 1991 大韓皮膚科學會誌 Vol.29 No.5

N/A The Skin Concentration and Minimal Phototoxic Dose Following Administration of Phototoxic Drugs as a Function of Time Yoon-Kee Park, M.D., Moo Yon Cho, M.D., Saung Kyung Hann, M.D., Sungbin im, M.D. Department of Dermatology Yonsei Univeraity College of Medicine, Seoul, Korea Psoralen photochemotherapy(PUVA) is defined as a treatment that depends on the interaction of a photosensitizing substance, psoralen, and long wave jltraviolet(UVA) radiation that results in therapeutically beneficial effects. The rationale of its use is to clear skin disease by repeated controlled phototoxic reactions. The efficacy of PUVA depends on the drug, the UVA dose and wave length, the individual sensitivity to the phototoxic reaction and on the disease to be treated. However, the major factor is the amount of psoralen at the site of photochemical reaction in skin. Daspite the extensive experiences which have now accumulated in the use of PUVA, the relationship between the therapeutic response and phototoxicity as it occurs in normal skin is not established. Comparative data on different psoralen molecules and their skin sensitizing ability are required. From studies on the skin concentration using HPLC and minimal phototoxic dose following oral administration, intraperitoneal administration, a bath of phototoxic drugs as a function of time in guinea pigs, the following results are obtained. 1. The skin concentration of phototoxic drugs after oral administration peaked at 1.5 hours, and the concentration of 8-methoxypsoralen(8-MOP) was 3.7 times greater than that of 5-methoxypsoralen(5-MOP). The skin concetration of 4,5,8-trimethylpsoralen(TMP) was not detected in this study(limit of sensitivity 5ng/g). 2. The skin conentration of phototoxic drugs after intraperitoneal administration peaked at 30 minutes, and the concentration of 8-MOP was slightly greater than that of 5-MOP. The skin concentration of TMP was not detected in this study(limit of sensitivity 5ng/g). 3. The skin concentration of phototoxic drugs after bathing peaked immediately after bathing, and the skin concentrations of phototoxic drugs after bathing decreased in the order of 5-MOP, TMP, and 8-MOP. 4. The minimal phototoxic dose of phototoxic drugs after oral administration was lowest at 1.5 hours, and the minimal phototoxic dose of 8-MOP was 8 times less than 5-MOP, 24 times less than TMP. The phototoxicity of 8-Mop after oral administration was strongest. The time of lowest phototoxic dose and highest skin concentration was the same. 5. The minimal phototoxic dose of phototoxic drugs after intraperitoneal administration was lowest at 30 minutes, and the minimal phototoxic dose of 8-MOP was 1.3 times less than 5-MOP, 5.7 times less than TMP. The phototoxicity of 8-MOP after intraperitoneal administration was strongest. The time of lowest phototoxic dose and highest skin concentration was same. 6. The minimal phototoxic dose of phototoxic drugs after bathing was lowest at 15 minutes. The minimal phototoxic dose of 8-MOP was not significantly different but was significantly greater than that of 5-MOP.

The outcome of hematopoietic stem cell transplantation in Korean children with hemophagocytic lymphohistiocytosis

Yoon, Hoi Soo,Im, Ho Joon,Moon, Hyung Nam,Lee, Jae Hee,Kim, Hee-Jin,Yoo, Keon Hee,Sung, Ki Woong,Koo, Hong Hoe,Kang, Hyung Jin,Shin, Hee Young,Ahn, Hyo Seop,Cho, Bin,Kim, Hack Ki,Lyu, Chuhl Joo,Lee, M Blackwell Publishing Ltd 2010 Pediatric transplantation Vol.14 No.6

<P>Yoon HS, Im HJ, Moon HN, Lee JH, Kim H-J, Yoo KH, Sung KW, Koo HH, Kang HJ, Shin HY, Ahn HS, Cho B, Kim HK, Lyu CJ, Lee MJ, Kook H, Hwang TJ, Seo JJ. The outcome of hematopoietic stem cell transplantation in Korean children with hemophagocytic lymphohistiocytosis.Pediatr Transplantation 2010: 14:735–740. © 2010 John Wiley & Sons A/S.</P><P>Abstract: </P><P>Chemoimmunotherapy-based treatments have improved the survival of patients with HLH, but outcomes of the patients are still unsatisfactory. We report here the outcome of Korean children with HLH who underwent HSCT, which was analyzed from the data of a nation-wide HLH registry. Retrospective nation-wide data recruitment for the pediatric HLH patients diagnosed between 1996 and 2008 was carried out by the Histiocytosis Working Party of the Korean Society of Hematology. Nineteen patients who received HSCT among the total of 148 enrolled children with HLH were analyzed for the transplant-related variables and events. The probability of five-yr survival after HSCT was 73.3% with a median follow-up of 57. Two months compared to 54.3% for the patients who were treated with chemoimmunotherapy only (p<I> </I>=<I> </I>0.05). The reasons for HSCT were active disease after eight wk of initial treatment (n = 9), relapsed disease (n = 5), and FHL (n = 5). Fourteen patients are currently alive without disease after HSCT, four patients died of treatment-related events (infection in two and graft failure in two) at early post-transplant period, and one patient died of relapse at one yr post transplantation. The survival of patients who were transplanted because of active disease after eight wk of initial treatment was worse compared to those patients who had inactive state at that time (60.6% vs. 100%, respectively, p<I> </I>=<I> </I>0.06). Of the four patients who received transplants using cord blood, three died of graft failure (n = 2) and relapse (n = 1). The five-yr probability of survival after HSCT according to the donor type was 85.7% for the MRDs (n = 6), 87.5% for the MUDs (n = 8), and 40% for the MMUDs (n = 5) (p<I> </I>=<I> </I>0.03). Other variables such as age, CNS involvement at the time of diagnosis, the etiology of HLH (familial or secondary), and the conditioning regimens had no influence on the five-yr OS of the HLH patients who underwent HSCT. HSCT improved the survival of the patients who had familial, relapsed, or severe and persistent SHLH in the Korean nation-wide HLH registry. Although numbers were small, these results are similar to other reports in the literature. The disease state after initial treatment, the stem cell source of the transplant, and the donor type were the important prognostic factors that affected the OS of the HLH patients who underwent HSCT.</P>

생태유아교육 프로그램에 대한 학부모의 인식 및 유아의 친사회적 행동발달에 미치는 영향

임갑빈(Im Gap-Bin),윤난호(Yoon Nan-Ho) 한국열린유아교육학회 2006 열린유아교육연구 Vol.11 No.2

본 연구는 생태유아교육 프로그램에 대한 학부모의 인식 및 유아의 친사회적 행동발달에 미치는 영향에 대하여 검증하는 것을 목적으로 하여 산업문명 피해자인 우리 아이들에게 인성이 풍부하고 서로 돕고 더불어 사는 상생능력, 공생능력을 배양하는데 도움을 주고 아이들의 삶의 질을 향상시키는데 도움을 주고자 하였다. 이러한 연구의 목적을 달성하기 위하여 연구대상인 만6세 아동의 부모 중 설문에 응답한 부모 39명을 대상으로 생태유아교육 프로그램에 대한 부모인식을 알아보았으며 만6세 아동 48명을 실험집단 24명과 통제집단 24명을 대상으로 2005년 5월 17일부터 12월 30일까지 생태유아교육 프로그램을 실시하였다. 연구결과 생태유아교육 프로그램의 필요성에 대한 인식이 높은 것으로 나타났으며 생태유아교육 프로그램은 유아의 친사회적 행동 발달에 효과가 있는 것으로 나타났다. 이러한 연구결과를 토대로 유아교육 현장에서 생태유아교육 프로그램을 도입ㆍ확산하는데 본 연구의 의의가 있다고 할 수 있다. The main purpose of this study is to find the recognition of parents of Eco centered early childhood education program and the effects of the program on young children's prosocial behavior in order to verify if the program can be applied to preschool life, The research questions are as follows; 1)What is the parents' recognition about eco centered early childhood education program? 2)After the program taken, how does the young children's prosocial behavior change? The object of this study were 48 young children at the age of 6 and 39 parents who have six-years-old young children. The study was performed from May 17, 2005 to December 30, 2005. The major results of the study arc as follows; 1) The result of the experimented parents' recognition about the program showed that there are a lot of parents who want the program to be performed for infants and recognize the necessity of eco centered early childhood education program. 2) After the program taken, the experimented young children's prosocial behavior showed a significant difference between pre-test and post-test. In conclusion, the program proposed in this study turned out to be effective This study aimed at presenting an adoption of Eco centered early childhood education program bin to the early childhood education agencies based on the results of the study.

공원에서의 장소정체성 분포와 공간요소 만족도의 관련성 연구

임승빈(Im, Seung-Bin),정윤희(Jeong, Yoon-Hee),허윤선(Hue, Youn-Sun),권윤구(Kwon, Yoon-Ku),변재상(Byeon, Jae-Sang),최형석(Choi, Hyung-Seok) 대한국토·도시계획학회 2012 國土計劃 Vol.47 No.7

Experimental Inhibition of Corneal Neovascularization by Photodynamic Therapy with Verteporfin

Yoon, Kyung-Chul,Ahn, Kyu,Lee, Song,Kim, Kyung,Im, Seong-Kyu,Oh, Han-Jin,Jeong, In-Young,Park, Sang-Woo,Park, Yeoung-Geol,Nah, Hyeon-Ju,Im, Wook-Bin IRL Press 2006 Current eye research Vol.31 No.3

<P>Purpose : To investigate the anti-angiogenic effects of photodynamic therapy with verteporfin in a rabbit model of corneal neovascularization. Methods : One week after suturing, the localization of verteporfin in the neovascularized cornea was examined through fluorescent microscopy 1 hr after administration. Rabbits were treated with one or two times of photodynamic therapy with verteporfin at 1-week intervals. Analysis of corneal neovascularization was performed by biomicroscopic and histological examinations. Results : Fluorescent microscopy showed green fluorescence in the vascular walls and interstitial tissue of the corneal stroma. The mean percentages of neovascularized corneal area at 3 days, 1 week, and 2 weeks after one time of photodynamic therapy were 90.3% ± 3.5%, 71.6% ± 6.2%, and 43.6% ± 15.1% in treated eyes and 96.4% ± 1.9% (p = 0.10), 88.6% ± 4.6% (p = 0.01), and 76.8% ± 4.4% (p</P>

올레산의 비율에 따른 아데노신의 경피 투과의 영향

남현빈,정세진,구민석,오예진,김용민,이훈희,윤수정,임정균 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

In addition to the development of functional cosmetics, technology to increase percutaneous absorption rate when applied to the skin is an important task. In this experiment, oleic acid was used as a skin absorption promoter, and its effect on transdermal permeability of adenosine was studied and analyzed using a skin-like membrane. As a result of the experiment, it was investigated that the permeability coefficient and concentration of adenosine are proportional to the content of oleic acid. This indicates that a high proportion of oleic acid is effective as a skin absorption promoter.

High Doses of UVA Suppress Contact Hypersensitivity

( Yoon Kee Park ),( Seung Kyung Hann ),( Sung Bin Im ),( Hae Eul Lee ),( Ik Byeong Ham ) 대한피부과학회 1991 Annals of Dermatology Vol.3 No.2

勉學雰圍氣造成을 위한 學生問題의 心理 社會的 硏究 : 釜産大學校學生을 中心으로

全閏植,張赫杓,任能彬,金基兌 부산대학교 학생생활연구소 1977 硏究報 Vol.13 No.1

The present survey is purported to investigate the factors contributing to the academic atmosphere. The areas to be surveyed are as follows; Family situation, socioeconomic status, attitude toward campus and academic activitives, personality variables and, value system etc. The method used was the questionnaire technique to find the factors related to the academic atmoshpere. The subjects are B.N.U college students. The number of subjects were 460 in total, consisting of higher achievers(230)(those students with an average grade of 3.5 or higher) and low achievers(230)(those students with an average grade of 2.2 or lower) The results of the study are summarized as follows: 1. There is no special relationship between academic achievement and such factors as birth order and the absence of parents. High achievers tend to be more satisfied with their family life in comparison with low achievers. 2. Socioeconomic status. There are no significant differences between high-achievers and low-achievers with regard to the socioeconomic status. The educational level of higher achieving group's fathers are found to be a little higher than those of lower achieving group's fathers. 3. Attitudes towards campus and academic activities. Higher achievers tend to have a more positive attitude towards compus life and their academic activities and their specialities. The most discouraging factor in campus life is reported to be the inappopriatness of their major field. The particulars of that dissatisfying fact are as follows:the expected information is quite different from the current curriculum. Furthermore, the prospect of getting a job after graduation does not seem to be bright. Cultural backwardness of the provincial areas is pointed out as another factor hindering academic achievement. The inadequacy of curriculum was also pointed out by low achievrs as an important factor of achievement, while the high-achievers complained about the insufficient educational facilities and reference books available at the library. Most of all students tend to attribuute their learning difficulties to their lack of effort. This tendency is especially noticed in the higher achieving group. The financial difficulties are pointed out by many students regardless of their achievement level. 4. Personality factors. As the achieving level becomes higher, the personality structure seems to be more stable and the level of test anxiety is lower. Highachiever tend to have a more optimistic outlook in the future and tend to be more self-confident compared to those lower achievers. 5. Value System While higher achievers tend to give highest value to friendship, love and altruism, the low achievers tend to value money as an important factor in life. 6. Other variables The happiness at home life seems to be related to the satisfaction in school and subsequently to academic success. The high achievers insist that the needs of family and society must be taken into consideration in choosing a professional career. In contrast, low achievers tend to with for a job that gurantees security and that reflects their aptitude and interest.

CNT 혼입율에 따른 모르타르의 플로우, 미소수화열 및 강도 특성

윤주호(Yoon, Joo Ho),임수빈(Im, Soo Bin),김채영(Kim, Chae Young),이재인(Lee, Jae In),최세진(Choi, Se Jin) 한국콘크리트학회 2023 한국콘크리트학회 학술대회 논문집 Vol.35 No.1

발음 연계 어휘 학습을 통한 중학생의 어휘 기억 신장 방안

임병빈(Im, Byung-Bin),윤상돈(Yoon, Sang-Don),안희성(Ahn, Hee-Seong),안미숙(Ahn, Mi-Sook) 한국영어교과교육학회 2011 영어교과교육 Vol.10 No.1

The purpose of this study is to examine the effect of pronunciation-related vocabulary learning on middle school students' ability to memorize vocabulary. For this study 24 students in the third grade were selected as subjects. They were divided into two even numbered groups. For the students in the experimental group, pronunciation-related vocabulary learning program was implemented while the activities for the students in the control group were less related to the pronunciation. Three tests were conducted. To verify the effectiveness of pronunciation-related vocabulary learning program for short-term memorization, two types of test were carried out before and after the experiment. Test 1 was based on word list 1 and test 2 on word list 2. And test 3 was administered three weeks after the experiment to find out the effectiveness of pronunciation-related vocabulary learning program for long-term memorization. The analysis of three tests suggested that the pronunciation-related vocabulary learning on middle school students' ability to memorize vocabulary proved to be remarkably positive on both short-term and long-term memorization.