Clear cell sarcoma of the kidney : Immunohistochemical study and flow cytometric DNA analysis of 7 cases

Choi, Yoon-Jung,Jung, Woo-Hee,Jung, Soon-Hee,Park, Chanil Yonsei University, College of Medicine 1994 Yonsei medical journal Vol.35 No.3

급성전골수성백혈병에서 백혈구성분채집술에 이은 치명적인 뇌출혈 2예

오윤정,박소윤,김윤정,한동석,김현수,최진혁,남동기,임호영,김효철,주희재 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

The aim of this study is to report 2 cases of acute promyelocytic leukemia who died from intracranial hemorrhage following leukapheresis and to provide proper preventive measures against hemorrhage following leukapheresis. From 1994 to 1997, a total of twenty-six patients with leukemia underwent leukapheresis to control hyperleukocytosis at Ajou University Hospital. Two patients with acute promyelocytic leukemia received all-trans retinoic acid but developed drug-induced hyperleukocytosis. Shortly after leukapheresis, they died from intracranial hemorrhage. The risk factors for fatal hemorrhage are thought to be coexisting disseminated intravascular coagulation(DIC), thrombocytopenia aggravated by leukapheresis, exacerbated coagulopathy related to mechanical trauma through leukapheresis and the excess use of citrate during leukapheresis. To reduce the risk of the bleeding associated with leukapheresis, it is necessary to replace platelet sufficiently before and after leukapheresis and to give calcium to correct coagulopathy induced by excess citrate which is used as anticoagulant as well as the correction of disseminated intravascular coagulation.

서울 및 경기지역 노인의 신체적 건강 및 기능적 건강 실태 조사

최윤정;박유신;이상선 한양대학교 2010 韓國 生活 科學 硏究 Vol.30 No.2

This study was performed to assess anthropometric status, functional health and physical fitness among the elderly in Seoul and Kyunggi-do. Four hundred forty free-living elderly people(127 male, 331 female), aged 65 or more were interviewed by trained interviewers using structured questionnaires including demographic information, activities of daily living(ADL), instrumental activities of daily living(IADL), physical activity. And they measured anthropometic status and physical fitness. All the data were analyzed by student t-test, chi-square analysis using SPSS 9.0 version at p<0.05. The results can be summarized as follow : Of all the subjects, 46.3% were obesity, especially 92.4% of female were abdominal obesity. In functional health status, ADL score was 6.62±1.54, and IADL score was 25.94±6.92. Most of the subjects were difficult to walk and run. Female was a significantly higher flexibility and body fat than male(p<0.001), whereas female was a significantly lower muscular endurance than male(p<0.001).

뉴로메드정(옥시라세탐 800㎎)에 대한 뉴라세탐정의 생물학적동등성

최성업,김종석,윤미경,김정일,박석,한상범,이재휘,최영욱 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.3

The purpose of the present study was designed to evaluate the bioequivalence of two oxiracetam tablets, Neuromed tablet (Korea Drug Co., reference drug) and Neuracetam tablet (Sam Jin Pharmaceutical Co., test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Release of oxiracetam from the tablet in vitro was tested using KP Ⅷ Apparatus Ⅱ method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty-four healthy volunteers, 23.7 ± 2.4 year in age and 68.9 ± 6.2 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was performed. After oral administration of a tablet containing 800 ㎎ of oxiracetam, blood samples were taken at predetermined time intervals and concentrations of oxiracetam in plasma were determined using HPLC-MS-MS. The dissolution profiles of two formulations were very similar at all dissolution media. In addition, pharmacokinetic parameters such as AUCt, C_(max) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC, and C_(max), untransformed T_(max). The results showed that the differences between two formulations based on the reference drug were 0.42%, 0.45% and -12.58% for AUCt, C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log0.94 ~ log1.06 and log 0.90 - log 1.07 for AUCt and C_(max), respectively), indicating that Neuracetam tablet is bioequivalent to Neuromed tablet. The major pharmacokinetic parameters, AUCt, and C_(max), met the criteria set by KFDA for bioequivalence indicating that Neuracetam tablet is bioequivalent to Neuromed tablet.

의료기관의 마케팅전략에 관한 연구

하정수, 최운홍 호남대학교 대학원 2014 호남대학교 대학원 논문집 Vol.9 No.-

These days the supply of national medical market has been continue to exceed since the 2000s, as a response to this situation, investment for medical facility is overgrowing up, but it makes insolvency of medical institutions and the healthcare consumer's complain has been growing up. Accordingly, this study will point out the ineffective response to the changes to the external environment of medical institution as a cause for this situation, through the literature research method to access medical consumer's complain in terms of marketing approach, propose an offering the customer-centric medical service not the doctor-centric focus on technology as a solution, and as an innovative marketing strategy of medical guidelines for the effective service of customer-centric medical service, firstly derive the quality evaluation criteria for medical service with 7P as a central figure, secondly present the design direction of the medical institution's internal organization for offering customer-centric medical service Medical examination is described as physical support(like medical facilities and equipment) and customer contact factor, so the notion of medical service is defined as a composite process of service delivery system conveyed to the customer through the interaction of customer contact factor and the physical support for medical examination, and propose the human rights and social responsibility of medical service by classifying the feature of medical service as general characteristics and unique characteristics. In the processing of deriving medical service's quality evaluation criteria, devide the quality of medical service into technical quality and functional quality based on the definition of user-centered concepts of the views of various scholars, approach the evaluation factors of medical service quality a level of truth, exploring and experience, and customer's final quality recognition is analyzed as being formed through the comparison the expected service with recognized service. For achieving the marketing goal of medical institution, we insist on the need of 7P's marketing mix of medical service adding person, physical evidence and process on the original 4P's marketing mix which means products, price, place and promotion, and presented by total 48 evaluation factors for every 7P, propose the range of improving medical institution's quality and the reason for reasonable judgement for the medical customer about future quality of medical service. In the traditional internal organization focus on manufacturing, marketing departments is composed as marketing-oriented, that marketing department takes responsibility of marketing and accomplishes of it, but the medical institution's internal organization should be designed customer-centric because it's marketing function and marketing departments are related with the customer, so it's marketing is evolved mutually. Medical institution's customer-centric internal organization design is proposed into three categories of marketing, production and management, and we present the role and the perform functions, of each part of design. Finally, marketing strategies of medical institution for overcoming today's excess supply and customer's complain of medical market, are involving the 7P's marketing mix related to medical service for offering to the customer-centric medical service and designing&developing customer-centric internal organization effectively for product the high quality medical service and delivering it to the medical customer effectively.

7두의 개에서 배설성 요로조영술을 통한 신장 기능 평가

최윤정,이기자,최형준,이용진,박성준,송근호,정성목,최호정,이영원 忠南大學校 獸醫科大學 動物醫科學硏究所 2005 動物醫科學硏究誌 Vol.13 No.-

Excretory urography is a type of contrast study used to verify and localize upper urinary tract disease. It is an inexpensive and easy way to visualize of anatomic and functional status of the kidney and has been used as a primary imaging modality for the evaluation of urinary tract abnormalities. We describe urological signs of 7 dogs who examined with excretory urography and ultrasonography. Six cases were referred to veterinary medical teaching hospital. Chungnam national university (VMTH, CNU) to evaluate renal function after the treatment for renal failure and one case was referred showing hematuria. In case 1, 2 and 4, blood test and urinalysis was normal and the results of excretory urography presented that renal function were normal range. In case 3, the results of urinalysis, ultrasonography, and excretory urography except blood test presented abnormal kidney and hydronephrosis was diagnosed. In case 5 and 6, blood test, urinalysis, ultrasonography and excretory urography indicated renal failure. In case 7, blood test, urinalysis and ultrasonography presented partially abnormal signs, however, the results of excretory urography was normal range.

이중보온 온수배관의 부식피로균열 특성에 관한 연구

최윤석,김정구,정민경,이훈 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.2

The corrosion fatigue properties of thermally insulated pipeline were investigated in synthetic groundwater by electrochemical test, corrosion fatigue test and SEM analysis. Since the potential difference between the weldment and the base metal was small, the pipeline steel was not susceptible to galvanic corrosion. No fatigue limit was apparent for corrosion fatigue testing with remarkable reduction of fatigue lifetime. The effects of insulation and stress on the corrosion fatigue resistance of pipeline steel were studied through linear polarization resistance (LPR) and electrochemical impedance spectroscopy (EIS) during corrosion fatigue testing. The result of LPR measurement indicated that the corrosion rate was determined not by the water content of PUR foam but by the magnitude of applied stress. The better corrosion fatigue property of the insulated steel was attributable to the formation of a protective rust layer under the insulation, which reduced the acceleration of corrosion process and the propagation of fatigue crack. This was confirmed by the results of EIS measurements and SEM observation.

비만 개선 효과를 지닌 탄수화물 및 지방 흡수 억제 기능성 식이조성물 개발

윤유식,최선미,홍순복,홍정미,김정원,이홍석,홍성길 한국조리과학회 2002 한국식품조리과학회지 Vol.18 No.3

In a previous study, we developed a new food additive as an egg yolk antibody (IgY) against carbohydrate digestion enzymes for the regulation of blood glucose level and weight control. The IgY delayed and decreased the increment of blood glucose level after administration of sucrose in human being by 30% in 20∼30 min. We also developed a lipase inhibitor as a water extract of two kinds of herb, Platycodon grandiflorum and Solanum melongena. Twenty three volunteers were subjected to the intake of the egg yolk IgY plus the herbal extracts for 50 days. In average, the treated subjects appeared to lose 1.96 ㎏ of body weight and 3.4 ㎏ of body fat mass during the treated period. Furthermore, Panniculus adiposus and breech size were significantly decreased during the experimental period. Above results suggested that the administration of the dietary additives composed of egg yolk IgY and natural herbal extract improve the obesity by the decrement of body weight and body fat mass.

자궁적출술 후 통증에 Gabapentin 의 진통효과

최종호,김창성,김은성,유건희,이윤기,문동언,윤건중 대한마취과학회 2001 Korean Journal of Anesthesiology Vol.41 No.6

소형아파트 전면발코니에 의한 실내온열환경 조절효과

최윤정 충북대학교 교육 ·생활연구소 생활과학연구센터 2002 생활과학연구논총 Vol.6 No.1

This study is a preliminary research on redesigns and remodeling for environmentally friendly housing. The purpose of this study was to compare the effect of indoor thermal environment by having or not having the front balcony in apartment houses. The field measurements of the thermal elements were carried out at an ordinary house having the front balcony and a renovated house converting the front balcony into the livingroom. The measurement at two-subject houses were taken on simultaneously the 27th of May, 2001. The indoor temperature showed 24.0~26.5℃(average 25.7℃) at the ordinary house having the front balcony and 24.5~27.5℃(average 26.3℃) at the renovated house without the balcony. The indoor temperature of the renovated house was 0.6℃ higher than the average of the ordinary house. The globe temperature ranged 22.0~27.0℃(average 25.6℃) at the ordinary house, and 24.0~28.0℃(averag 26.9℃) at the renovated house. The globe temperature of the renovated house was 1.3℃ higher than the average of the ordinary house. It was found that the ordinary house was on the whole in the comfortable condition except for the mid-day. In the renovated house, however, higher temperature continued throughout the day time due to no block-effect of solar radiation. So, the renovated house seemed to be lower energy efficient for refrigerating. From the results of this study, it is undesirable to remodel or convert the front balcony into the livingroom.